Reviewed, UniProtKB/Swiss-Prot Q9H503 (BAFL_HUMAN)

Names and origin

Protein names

Recommended name:
    Barrier-to-autointegration factor-like protein
      Short name=BAF-L
Alternative name(s):
    Barrier-to-autointegration factor 2

Gene names

Name:	BANF2
Synonyms:	BAFL, C20orf179

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
Subunit structure	Homodimer. Heterodimerizes with BANF1.
Subcellular location	Nucleus. Cytoplasm.
Tissue specificity	Expressed strongly in testis and pancreas. Also detected in brain, colon, liver, lung, ovary, placenta, prostate, small intestine, spleen and thymus. Not detected in heart, kidney and skeletal muscle.
Sequence similarities	Belongs to the BAF family.
Caution	In contrast to BANF1, it does not seems to bind DNA.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Barrier-to-autointegration factor-like protein		PRO_0000221030
Natural variations
	Natural variant	3	1	N → D: dbSNP rs4814640.		VAR_024372
	Natural variant	78	1	T → S: dbSNP rs1053993.		VAR_013693

Sequences

	Sequence		Length	Mass (Da)
	Q9H503-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C7FAB57610ADEF87	FASTA	90	10,309
	10 20 30 40 50 60 MDNMSPRLRA FLSEPIGEKD VCWVDGISHE LAINLVTKGI NKAYILLGQF LLMHKNEAEF 70 80 90 QRWLICCFGA TECEAQQTSH CLKEWCACFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF." Tifft K.E., Segura-Totten M., Lee K.K., Wilson K.L. Exp. Cell Res. 312:478-487(2006) [PubMed: 16337940] [Abstract] Cited for: CHARACTERIZATION, INTERACTION WITH BANF1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL160071 Genomic DNA. Translation: CAC15540.1. BC054871 mRNA. Translation: AAH54871.1. BC062735 mRNA. Translation: AAH62735.1.
IPI	IPI00014735.
RefSeq	NP_001014977.2. NP_001152967.1. NP_848572.3.
UniGene	Hs.115366
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H503.
Proteomic databases
PRIDE	Q9H503.
Genome annotation databases
Ensembl	ENST00000246090; ENSP00000246090; ENSG00000125888; Homo sapiens. [Genome view] ENST00000377805; ENSP00000367036; ENSG00000125888; Homo sapiens. [Genome view]
GeneID	140836.
KEGG	hsa:140836.
UCSC	uc002wpz.1. human.
Organism-specific databases
CTD	140836.
GeneCards	GC20P017630.
H-InvDB	HIX0027767.
HGNC	HGNC:16172. BANF2.
PharmGKB	PA25722.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG381393.
HOVERGEN	Q9H503.
InParanoid	Q9H503.
OMA	CCGATEC.
Gene expression databases
ArrayExpress	Q9H503.
Bgee	Q9H503.
CleanEx	HS_BANF2.
Genevestigator	Q9H503.
GermOnline	ENSG00000125888. Homo sapiens.
Family and domain databases
InterPro	IPR004122. BAF_prot. [Graphical view]
Gene3D	G3DSA:1.10.150.40. BAF_prot. 1 hit.
PANTHER	PTHR12912. BAF_prot. 1 hit.
Pfam	PF02961. BAF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84454.

Entry information

Entry name

BAFL_HUMAN

Accession

Primary (citable) accession number: Q9H503
Secondary accession number(s): Q7Z4M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	March 1, 2001
Last modified:	December 15, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.