Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Barrier-to-autointegration factor-like protein

Gene

BANF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.

Caution

In contrast to BANF1, it does not seems to bind DNA.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Barrier-to-autointegration factor-like protein
Short name:
BAF-L
Alternative name(s):
Barrier-to-autointegration factor 2
Gene namesi
Name:BANF2
Synonyms:BAFL, C20orf179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125888.14
HGNCiHGNC:16172 BANF2
neXtProtiNX_Q9H503

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140836
OpenTargetsiENSG00000125888
PharmGKBiPA162377348

Polymorphism and mutation databases

BioMutaiBANF2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210301 – 90Barrier-to-autointegration factor-like proteinAdd BLAST90

Proteomic databases

PaxDbiQ9H503
PeptideAtlasiQ9H503
PRIDEiQ9H503
ProteomicsDBi80887

PTM databases

iPTMnetiQ9H503
PhosphoSitePlusiQ9H503

Expressioni

Tissue specificityi

Expressed strongly in testis and pancreas. Also detected in brain, colon, liver, lung, ovary, placenta, prostate, small intestine, spleen and thymus. Not detected in heart, kidney and skeletal muscle.

Gene expression databases

BgeeiENSG00000125888
CleanExiHS_BANF2
ExpressionAtlasiQ9H503 baseline and differential
GenevisibleiQ9H503 HS

Organism-specific databases

HPAiHPA042635

Interactioni

Subunit structurei

Homodimer. Heterodimerizes with BANF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
SERTAD1Q9UHV24EBI-11977289,EBI-748601

Protein-protein interaction databases

CORUMiQ9H503
IntActiQ9H503, 15 interactors
STRINGi9606.ENSP00000439128

Structurei

3D structure databases

ProteinModelPortaliQ9H503
SMRiQ9H503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAF family.Curated

Phylogenomic databases

eggNOGiKOG4233 Eukaryota
ENOG4111URU LUCA
GeneTreeiENSGT00390000018613
HOGENOMiHOG000231927
HOVERGENiHBG029345
InParanoidiQ9H503
OMAiCCGATEC
OrthoDBiEOG091G109J
PhylomeDBiQ9H503
TreeFamiTF315060

Family and domain databases

Gene3Di1.10.150.40, 1 hit
InterProiView protein in InterPro
IPR004122 BAF_prot
IPR036617 BAF_sf
PANTHERiPTHR12912 PTHR12912, 1 hit
PfamiView protein in Pfam
PF02961 BAF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019964 PD019964, 1 hit
SMARTiView protein in SMART
SM01023 BAF, 1 hit
SUPFAMiSSF47798 SSF47798, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H503-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNMSPRLRA FLSEPIGEKD VCWVDGISHE LAINLVTKGI NKAYILLGQF
60 70 80 90
LLMHKNEAEF QRWLICCFGA TECEAQQTSH CLKEWCACFL
Length:90
Mass (Da):10,309
Last modified:March 1, 2001 - v1
Checksum:iC7FAB57610ADEF87
GO
Isoform 2 (identifier: Q9H503-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLRGTKEM

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,125
Checksum:i242AE78C9142C6F1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0243723N → D1 PublicationCorresponds to variant dbSNP:rs4814640Ensembl.1
Natural variantiVAR_01369378T → S. Corresponds to variant dbSNP:rs1053993Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460801M → MLRGTKEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AW022487 mRNA No translation available.
AL132765 Genomic DNA No translation available.
AL160071 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10271.1
CH471133 Genomic DNA Translation: EAX10272.1
BC054871 mRNA Translation: AAH54871.1
BC062735 mRNA Translation: AAH62735.1
CCDSiCCDS13129.1 [Q9H503-1]
CCDS54449.1 [Q9H503-2]
RefSeqiNP_001014977.2, NM_001014977.3 [Q9H503-1]
NP_001152967.1, NM_001159495.1 [Q9H503-2]
NP_848572.3, NM_178477.4 [Q9H503-1]
XP_005260725.1, XM_005260668.3 [Q9H503-1]
UniGeneiHs.115366

Genome annotation databases

EnsembliENST00000246090; ENSP00000246090; ENSG00000125888 [Q9H503-1]
ENST00000377805; ENSP00000367036; ENSG00000125888 [Q9H503-1]
ENST00000545418; ENSP00000439128; ENSG00000125888 [Q9H503-2]
GeneIDi140836
KEGGihsa:140836
UCSCiuc002wpz.3 human [Q9H503-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBAFL_HUMAN
AccessioniPrimary (citable) accession number: Q9H503
Secondary accession number(s): D3DW25, F5H3F6, Q7Z4M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health