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Protein

ESF1 homolog

Gene

ESF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ESF1 homolog
Alternative name(s):
ABT1-associated protein
Gene namesi
Name:ESF1
Synonyms:ABTAP, C20orf6
ORF Names:HDCMC28P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15898. ESF1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
  • nucleoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51575.
OpenTargetsiENSG00000089048.
PharmGKBiPA162385420.

Polymorphism and mutation databases

BioMutaiESF1.
DMDMi25452905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000794102 – 851ESF1 homologAdd BLAST850

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei693PhosphothreonineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H501.
MaxQBiQ9H501.
PaxDbiQ9H501.
PeptideAtlasiQ9H501.
PRIDEiQ9H501.

PTM databases

iPTMnetiQ9H501.
PhosphoSitePlusiQ9H501.

Expressioni

Gene expression databases

BgeeiENSG00000089048.
CleanExiHS_ESF1.
ExpressionAtlasiQ9H501. baseline and differential.
GenevisibleiQ9H501. HS.

Organism-specific databases

HPAiHPA047083.
HPA050396.

Interactioni

Subunit structurei

Interacts with ABT1. Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity).By similarity

Protein-protein interaction databases

BioGridi119620. 24 interactors.
IntActiQ9H501. 17 interactors.
MINTiMINT-252787.
STRINGi9606.ENSP00000202816.

Structurei

3D structure databases

ProteinModelPortaliQ9H501.
SMRiQ9H501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili730 – 824Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 170Lys-richAdd BLAST84
Compositional biasi268 – 321Asp-richAdd BLAST54
Compositional biasi567 – 851Lys-richAdd BLAST285

Sequence similaritiesi

Belongs to the ESF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2318. Eukaryota.
COG5638. LUCA.
GeneTreeiENSGT00390000004881.
HOGENOMiHOG000182523.
HOVERGENiHBG051149.
InParanoidiQ9H501.
OMAiHTEESTR.
OrthoDBiEOG091G0A19.
PhylomeDBiQ9H501.
TreeFamiTF105822.

Family and domain databases

InterProiIPR012580. NUC153.
[Graphical view]
PfamiPF08159. NUC153. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKQEIMSD QRFRRVAKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN
60 70 80 90 100
YAVDKRGRPI SHSTTEDLKR FYDLSDSDSN LSGEDSKALS QKKIKKKKTQ
110 120 130 140 150
TKKEIDSKNL VEKKKETKKA NHKGSENKTD LDNSIGIKKM KTSCKFKIDS
160 170 180 190 200
NISPKKDSKE FTQKNKKEKK NIVQHTTDSS LEEKQRTLDS GTSEIVKSPR
210 220 230 240 250
IECSKTRREM QSVVQLIMTR DSDGYENSTD GEMCDKDALE EDSESVSEIG
260 270 280 290 300
SDEESENEIT SVGRASGDDD GSEDDEEEDE DEEEDEDEDS EDDDKSDSGP
310 320 330 340 350
DLARGKGNIE TSSEDEDDTA DLFPEESGFE HAWRELDKDA PRADEITRRL
360 370 380 390 400
AVCNMDWDRL KAKDLLALFN SFKPKGGVIF SVKIYPSEFG KERMKEEQVQ
410 420 430 440 450
GPVELLSIPE DAPEKDWTSR EKLRDYQFKR LKYYYAVVDC DSPETASKIY
460 470 480 490 500
EDCDGLEFES SCSFIDLRFI PDDITFDDEP KDVASEVNLT AYKPKYFTSA
510 520 530 540 550
AMGTSTVEIT WDETDHERIT MLNRKFKKEE LLDMDFQAYL ASSSEDEEEI
560 570 580 590 600
EEELQGDDGV NVEEDGKTKK SQKDDEEQIA KYRQLLQVIQ EKEKKGKEND
610 620 630 640 650
MEMEIKWVPG LKESAEEMVK NKLEGKDKLT PWEQFLEKKK EKKRLKRKQK
660 670 680 690 700
ALAEEASEEE LPSDVDLNDP YFAEEVKQIG INKKSVKSAK DGTSPEEEIE
710 720 730 740 750
IERQKAEMAL LMMDEDEDSK KHFNYNKIVE HQNLSKKKKK QLMKKKELIE
760 770 780 790 800
DDFEVNVNDA RFQAMYTSHL FNLDPSDPNF KKTKAMEKIL EEKARQRERK
810 820 830 840 850
EQELTQAIKK KESEIEKESQ RKSIDPALSM LIKSIKTKTE QFQARKKQKV

K
Length:851
Mass (Da):98,796
Last modified:March 1, 2001 - v1
Checksum:i1BA283E7A0A65432
GO

Sequence cautioni

The sequence AAF65504 differs from that shown. Reason: Frameshift at position 664.Curated
The sequence BAA91123 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14167 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186R → K in AAF65504 (Ref. 4) Curated1
Sequence conflicti198S → T in BAB14023 (PubMed:14702039).Curated1
Sequence conflicti228S → P in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti298S → G in AAF65504 (Ref. 4) Curated1
Sequence conflicti336L → S in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti351A → V in AAF65504 (Ref. 4) Curated1
Sequence conflicti390G → R in AAF65504 (Ref. 4) Curated1
Sequence conflicti469F → Y in AAF65504 (Ref. 4) Curated1
Sequence conflicti474I → V in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti483V → A in AAF65504 (Ref. 4) Curated1
Sequence conflicti514T → S in BAB14023 (PubMed:14702039).Curated1
Sequence conflicti593E → K in AAH46107 (PubMed:15489334).Curated1
Sequence conflicti829S → P in BAB14167 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053082386P → L.Corresponds to variant rs6079171dbSNPEnsembl.1
Natural variantiVAR_024331550I → T.2 PublicationsCorresponds to variant rs3180370dbSNPEnsembl.1
Natural variantiVAR_053083824I → L.Corresponds to variant rs34414644dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161659 Genomic DNA. Translation: CAC07199.1.
AK000375 mRNA. Translation: BAA91123.1. Sequence problems.
AK022369 mRNA. Translation: BAB14023.1.
AK022670 mRNA. Translation: BAB14167.1. Different initiation.
BC046107 mRNA. Translation: AAH46107.1.
AF068285 mRNA. Translation: AAF65504.1. Frameshift.
CCDSiCCDS13117.1.
RefSeqiNP_001263309.1. NM_001276380.1.
NP_057733.2. NM_016649.3.
XP_016883363.1. XM_017027874.1.
UniGeneiHs.369284.

Genome annotation databases

EnsembliENST00000202816; ENSP00000202816; ENSG00000089048.
GeneIDi51575.
KEGGihsa:51575.
UCSCiuc002woj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161659 Genomic DNA. Translation: CAC07199.1.
AK000375 mRNA. Translation: BAA91123.1. Sequence problems.
AK022369 mRNA. Translation: BAB14023.1.
AK022670 mRNA. Translation: BAB14167.1. Different initiation.
BC046107 mRNA. Translation: AAH46107.1.
AF068285 mRNA. Translation: AAF65504.1. Frameshift.
CCDSiCCDS13117.1.
RefSeqiNP_001263309.1. NM_001276380.1.
NP_057733.2. NM_016649.3.
XP_016883363.1. XM_017027874.1.
UniGeneiHs.369284.

3D structure databases

ProteinModelPortaliQ9H501.
SMRiQ9H501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119620. 24 interactors.
IntActiQ9H501. 17 interactors.
MINTiMINT-252787.
STRINGi9606.ENSP00000202816.

PTM databases

iPTMnetiQ9H501.
PhosphoSitePlusiQ9H501.

Polymorphism and mutation databases

BioMutaiESF1.
DMDMi25452905.

Proteomic databases

EPDiQ9H501.
MaxQBiQ9H501.
PaxDbiQ9H501.
PeptideAtlasiQ9H501.
PRIDEiQ9H501.

Protocols and materials databases

DNASUi51575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202816; ENSP00000202816; ENSG00000089048.
GeneIDi51575.
KEGGihsa:51575.
UCSCiuc002woj.3. human.

Organism-specific databases

CTDi51575.
DisGeNETi51575.
GeneCardsiESF1.
H-InvDBHIX0015649.
HGNCiHGNC:15898. ESF1.
HPAiHPA047083.
HPA050396.
neXtProtiNX_Q9H501.
OpenTargetsiENSG00000089048.
PharmGKBiPA162385420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2318. Eukaryota.
COG5638. LUCA.
GeneTreeiENSGT00390000004881.
HOGENOMiHOG000182523.
HOVERGENiHBG051149.
InParanoidiQ9H501.
OMAiHTEESTR.
OrthoDBiEOG091G0A19.
PhylomeDBiQ9H501.
TreeFamiTF105822.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089048-MONOMER.

Miscellaneous databases

ChiTaRSiESF1. human.
GeneWikiiESF1.
GenomeRNAii51575.
PROiQ9H501.

Gene expression databases

BgeeiENSG00000089048.
CleanExiHS_ESF1.
ExpressionAtlasiQ9H501. baseline and differential.
GenevisibleiQ9H501. HS.

Family and domain databases

InterProiIPR012580. NUC153.
[Graphical view]
PfamiPF08159. NUC153. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H501
Secondary accession number(s): Q86X92
, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.