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Protein

Phosphorylated CTD-interacting factor 1

Gene

PCIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100982-MONOMER.
SignaLinkiQ9H4Z3.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorylated CTD-interacting factor 1
Gene namesi
Name:PCIF1
Synonyms:C20orf67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16200. PCIF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100982.
PharmGKBiPA162398977.

Polymorphism and mutation databases

BioMutaiPCIF1.
DMDMi26392546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760871 – 704Phosphorylated CTD-interacting factor 1Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei152PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H4Z3.
MaxQBiQ9H4Z3.
PaxDbiQ9H4Z3.
PeptideAtlasiQ9H4Z3.
PRIDEiQ9H4Z3.

PTM databases

iPTMnetiQ9H4Z3.
PhosphoSitePlusiQ9H4Z3.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000100982.
CleanExiHS_PCIF1.
ExpressionAtlasiQ9H4Z3. baseline and differential.
GenevisibleiQ9H4Z3. HS.

Organism-specific databases

HPAiHPA049517.

Interactioni

Subunit structurei

Interacts with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.1 Publication

Protein-protein interaction databases

BioGridi122003. 12 interactors.
IntActiQ9H4Z3. 12 interactors.
MINTiMINT-4050951.
STRINGi9606.ENSP00000361486.

Structurei

Secondary structure

1704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 47Combined sources6
Beta strandi51 – 54Combined sources4
Turni55 – 58Combined sources4
Beta strandi59 – 64Combined sources6
Turni65 – 68Combined sources4
Beta strandi69 – 73Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX8NMR-A40-86[»]
ProteinModelPortaliQ9H4Z3.
SMRiQ9H4Z3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4Z3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 77WWPROSITE-ProRule annotationAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 113Nuclear localization signalSequence analysis5
Motifi669 – 684Nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi673 – 684Poly-SerAdd BLAST12

Domaini

The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.

Sequence similaritiesi

Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFAY. Eukaryota.
ENOG410XPH2. LUCA.
GeneTreeiENSGT00390000016206.
HOGENOMiHOG000048178.
HOVERGENiHBG053525.
InParanoidiQ9H4Z3.
KOiK17584.
OMAiLKMWGTS.
OrthoDBiEOG091G03JG.
PhylomeDBiQ9H4Z3.
TreeFamiTF350163.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR022035. PCIF1_WW.
IPR001202. WW_dom.
[Graphical view]
PfamiPF12237. PCIF1_WW. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H4Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANENHGSPR EEASLLSHSP GTSNQSQPCS PKPIRLVQDL PEELVHAGWE
60 70 80 90 100
KCWSRRENRP YYFNRFTNQS LWEMPVLGQH DVISDPLGLN ATPLPQDSSL
110 120 130 140 150
VETPPAENKP RKRQLSEEQP SGNGVKKPKI EIPVTPTGQS VPSSPSIPGT
160 170 180 190 200
PTLKMWGTSP EDKQQAALLR PTEVYWDLDI QTNAVIKHRG PSEVLPPHPE
210 220 230 240 250
VELLRSQLIL KLRQHYRELC QQREGIEPPR ESFNRWMLER KVVDKGSDPL
260 270 280 290 300
LPSNCEPVVS PSMFREIMND IPIRLSRIKF REEAKRLLFK YAEAARRLIE
310 320 330 340 350
SRSASPDSRK VVKWNVEDTF SWLRKDHSAS KEDYMDRLEH LRRQCGPHVS
360 370 380 390 400
AAAKDSVEGI CSKIYHISLE YVKRIREKHL AILKENNISE EVEAPEVEPR
410 420 430 440 450
LVYCYPVRLA VSAPPMPSVE MHMENNVVCI RYKGEMVKVS RNYFSKLWLL
460 470 480 490 500
YRYSCIDDSA FERFLPRVWC LLRRYQMMFG VGLYEGTGLQ GSLPVHVFEA
510 520 530 540 550
LHRLFGVSFE CFASPLNCYF RQYCSAFPDT DGYFGSRGPC LDFAPLSGSF
560 570 580 590 600
EANPPFCEEL MDAMVSHFER LLESSPEPLS FIVFIPEWRE PPTPALTRME
610 620 630 640 650
QSRFKRHQLI LPAFEHEYRS GSQHICKKEE MHYKAVHNTA VLFLQNDPGF
660 670 680 690 700
AKWAPTPERL QELSAAYRQS GRSHSSGSSS SSSSEAKDRD SGREQGPSRE

PHPT
Length:704
Mass (Da):80,670
Last modified:March 1, 2001 - v1
Checksum:i83647BC8408BA9E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050014 mRNA. Translation: BAC45238.1.
AL162458 Genomic DNA. Translation: CAC10456.1.
CH471077 Genomic DNA. Translation: EAW75778.1.
CH471077 Genomic DNA. Translation: EAW75780.1.
BC013365 mRNA. Translation: AAH13365.1.
BC010005 mRNA. Translation: AAH10005.1.
AL137473 mRNA. Translation: CAB70757.2.
CCDSiCCDS13388.1.
RefSeqiNP_071387.1. NM_022104.3.
XP_011527282.1. XM_011528980.2.
XP_011527283.1. XM_011528981.2.
XP_016883502.1. XM_017028013.1.
UniGeneiHs.472856.

Genome annotation databases

EnsembliENST00000372409; ENSP00000361486; ENSG00000100982.
GeneIDi63935.
KEGGihsa:63935.
UCSCiuc002xqs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050014 mRNA. Translation: BAC45238.1.
AL162458 Genomic DNA. Translation: CAC10456.1.
CH471077 Genomic DNA. Translation: EAW75778.1.
CH471077 Genomic DNA. Translation: EAW75780.1.
BC013365 mRNA. Translation: AAH13365.1.
BC010005 mRNA. Translation: AAH10005.1.
AL137473 mRNA. Translation: CAB70757.2.
CCDSiCCDS13388.1.
RefSeqiNP_071387.1. NM_022104.3.
XP_011527282.1. XM_011528980.2.
XP_011527283.1. XM_011528981.2.
XP_016883502.1. XM_017028013.1.
UniGeneiHs.472856.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX8NMR-A40-86[»]
ProteinModelPortaliQ9H4Z3.
SMRiQ9H4Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122003. 12 interactors.
IntActiQ9H4Z3. 12 interactors.
MINTiMINT-4050951.
STRINGi9606.ENSP00000361486.

PTM databases

iPTMnetiQ9H4Z3.
PhosphoSitePlusiQ9H4Z3.

Polymorphism and mutation databases

BioMutaiPCIF1.
DMDMi26392546.

Proteomic databases

EPDiQ9H4Z3.
MaxQBiQ9H4Z3.
PaxDbiQ9H4Z3.
PeptideAtlasiQ9H4Z3.
PRIDEiQ9H4Z3.

Protocols and materials databases

DNASUi63935.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372409; ENSP00000361486; ENSG00000100982.
GeneIDi63935.
KEGGihsa:63935.
UCSCiuc002xqs.4. human.

Organism-specific databases

CTDi63935.
GeneCardsiPCIF1.
HGNCiHGNC:16200. PCIF1.
HPAiHPA049517.
neXtProtiNX_Q9H4Z3.
OpenTargetsiENSG00000100982.
PharmGKBiPA162398977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAY. Eukaryota.
ENOG410XPH2. LUCA.
GeneTreeiENSGT00390000016206.
HOGENOMiHOG000048178.
HOVERGENiHBG053525.
InParanoidiQ9H4Z3.
KOiK17584.
OMAiLKMWGTS.
OrthoDBiEOG091G03JG.
PhylomeDBiQ9H4Z3.
TreeFamiTF350163.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100982-MONOMER.
SignaLinkiQ9H4Z3.

Miscellaneous databases

ChiTaRSiPCIF1. human.
EvolutionaryTraceiQ9H4Z3.
GenomeRNAii63935.
PROiQ9H4Z3.

Gene expression databases

BgeeiENSG00000100982.
CleanExiHS_PCIF1.
ExpressionAtlasiQ9H4Z3. baseline and differential.
GenevisibleiQ9H4Z3. HS.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR022035. PCIF1_WW.
IPR001202. WW_dom.
[Graphical view]
PfamiPF12237. PCIF1_WW. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCIF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4Z3
Secondary accession number(s): E1P5P1, Q54AB9, Q9NT85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.