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Protein

Zinc finger and SCAN domain-containing protein 16

Gene

ZSCAN16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri236 – 25823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 16
Alternative name(s):
Zinc finger protein 392
Zinc finger protein 435
Gene namesi
Name:ZSCAN16
Synonyms:ZNF392, ZNF435
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20813. ZSCAN16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410958.

Polymorphism and mutation databases

BioMutaiZSCAN16.
DMDMi20178228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Zinc finger and SCAN domain-containing protein 16PRO_0000047583Add
BLAST

Proteomic databases

PaxDbiQ9H4T2.
PeptideAtlasiQ9H4T2.
PRIDEiQ9H4T2.

PTM databases

iPTMnetiQ9H4T2.
PhosphoSiteiQ9H4T2.

Expressioni

Gene expression databases

BgeeiQ9H4T2.
CleanExiHS_ZSCAN16.
GenevisibleiQ9H4T2. HS.

Organism-specific databases

HPAiHPA007290.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF446Q96AF54EBI-723596,EBI-740232

Protein-protein interaction databases

BioGridi123252. 4 interactions.
IntActiQ9H4T2. 2 interactions.
MINTiMINT-1367673.
STRINGi9606.ENSP00000366527.

Structurei

Secondary structure

1
348
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi235 – 2373Combined sources
Beta strandi239 – 2413Combined sources
Helixi248 – 2558Combined sources
Turni256 – 2583Combined sources
Beta strandi263 – 2653Combined sources
Beta strandi267 – 2693Combined sources
Beta strandi272 – 2754Combined sources
Helixi276 – 2827Combined sources
Helixi283 – 2853Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2COTNMR-A225-288[»]
ProteinModelPortaliQ9H4T2.
SMRiQ9H4T2. Positions 38-124, 227-344.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4T2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12383SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri236 – 25823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9H4T2.
KOiK09230.
OMAiRRRYKCD.
OrthoDBiEOG7DRJ3C.
PhylomeDBiQ9H4T2.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H4T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTALEPEDQ KGLLIIKAED HYWGQDSSSQ KCSPHRRELY RQHFRKLCYQ
60 70 80 90 100
DAPGPREALT QLWELCRQWL RPECHTKEQI LDLLVLEQFL SILPKDLQAW
110 120 130 140 150
VRAHHPETGE EAVTVLEDLE RELDEPGKQV PGNSERRDIL MDKLAPLGRP
160 170 180 190 200
YESLTVQLHP KKTQLEQEAG KPQRNGDKTR TKNEELFQKE DMPKDKEFLG
210 220 230 240 250
EINDRLNKDT PQHPKSKDII ENEGRSEWQQ RERRRYKCDE CGKSFSHSSD
260 270 280 290 300
LSKHRRTHTG EKPYKCDECG KAFIQRSHLI GHHRVHTGVK PYKCKECGKD
310 320 330 340
FSGRTGLIQH QRIHTGEKPY ECDECGRPFR VSSALIRHQR IHTANKLY
Length:348
Mass (Da):40,792
Last modified:October 1, 2001 - v2
Checksum:iEEF71FB077F93BCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs750071607 [ dbSNP | Ensembl ].
VAR_035604

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025844 mRNA. Translation: BAB15257.1.
AL358933 Genomic DNA. Translation: CAC15900.2.
BC004255 mRNA. Translation: AAH04255.1.
CCDSiCCDS4644.1.
RefSeqiNP_001307484.1. NM_001320555.1.
NP_001307485.1. NM_001320556.1.
NP_001307486.1. NM_001320557.1.
NP_079507.1. NM_025231.2.
UniGeneiHs.656641.

Genome annotation databases

EnsembliENST00000340487; ENSP00000366527; ENSG00000196812.
GeneIDi80345.
KEGGihsa:80345.
UCSCiuc003nkm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025844 mRNA. Translation: BAB15257.1.
AL358933 Genomic DNA. Translation: CAC15900.2.
BC004255 mRNA. Translation: AAH04255.1.
CCDSiCCDS4644.1.
RefSeqiNP_001307484.1. NM_001320555.1.
NP_001307485.1. NM_001320556.1.
NP_001307486.1. NM_001320557.1.
NP_079507.1. NM_025231.2.
UniGeneiHs.656641.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2COTNMR-A225-288[»]
ProteinModelPortaliQ9H4T2.
SMRiQ9H4T2. Positions 38-124, 227-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123252. 4 interactions.
IntActiQ9H4T2. 2 interactions.
MINTiMINT-1367673.
STRINGi9606.ENSP00000366527.

PTM databases

iPTMnetiQ9H4T2.
PhosphoSiteiQ9H4T2.

Polymorphism and mutation databases

BioMutaiZSCAN16.
DMDMi20178228.

Proteomic databases

PaxDbiQ9H4T2.
PeptideAtlasiQ9H4T2.
PRIDEiQ9H4T2.

Protocols and materials databases

DNASUi80345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340487; ENSP00000366527; ENSG00000196812.
GeneIDi80345.
KEGGihsa:80345.
UCSCiuc003nkm.4. human.

Organism-specific databases

CTDi80345.
GeneCardsiZSCAN16.
HGNCiHGNC:20813. ZSCAN16.
HPAiHPA007290.
neXtProtiNX_Q9H4T2.
PharmGKBiPA162410958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9H4T2.
KOiK09230.
OMAiRRRYKCD.
OrthoDBiEOG7DRJ3C.
PhylomeDBiQ9H4T2.
TreeFamiTF338304.

Miscellaneous databases

EvolutionaryTraceiQ9H4T2.
GenomeRNAii80345.
PROiQ9H4T2.

Gene expression databases

BgeeiQ9H4T2.
CleanExiHS_ZSCAN16.
GenevisibleiQ9H4T2. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Solution structure of the first and second ZF-C2H2 domains of zinc finger protein 435."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 224-288.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-137.

Entry informationi

Entry nameiZSC16_HUMAN
AccessioniPrimary (citable) accession number: Q9H4T2
Secondary accession number(s): Q9H6K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.