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Protein

GS homeobox 1

Gene

GSX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi147 – 206HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GS homeobox 1
Alternative name(s):
Homeobox protein GSH-1
Gene namesi
Name:GSX1
Synonyms:GSH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000169840.4
HGNCiHGNC:20374 GSX1
MIMi616542 gene
neXtProtiNX_Q9H4S2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169840
PharmGKBiPA162390373

Polymorphism and mutation databases

BioMutaiGSX1
DMDMi27923786

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488941 – 264GS homeobox 1Add BLAST264

Proteomic databases

PaxDbiQ9H4S2
PeptideAtlasiQ9H4S2
PRIDEiQ9H4S2

PTM databases

iPTMnetiQ9H4S2
PhosphoSitePlusiQ9H4S2

Expressioni

Gene expression databases

BgeeiENSG00000169840
CleanExiHS_GSX1
GenevisibleiQ9H4S2 HS

Organism-specific databases

HPAiHPA047096

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304331

Structurei

3D structure databases

ProteinModelPortaliQ9H4S2
SMRiQ9H4S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 118Poly-Ala8
Compositional biasi213 – 223Poly-GlyAdd BLAST11

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000010106
HOVERGENiHBG003555
InParanoidiQ9H4S2
KOiK09310
OMAiGSQYCHS
OrthoDBiEOG091G0HAO
PhylomeDBiQ9H4S2
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H4S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR
60 70 80 90 100
KAGLLCVCPL CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS
110 120 130 140 150
AVSPGVAHGP AAAAAAAALY QTSYPLPDPR QFHCISVDSS SNQLPSSKRM
160 170 180 190 200
RTAFTSTQLL ELEREFASNM YLSRLRRIEI ATYLNLSEKQ VKIWFQNRRV
210 220 230 240 250
KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS EDDDELPMSP
260
SSSGKDDRDL TVTP
Length:264
Mass (Da):27,883
Last modified:March 1, 2001 - v1
Checksum:i25F4C4336E270C00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044157 mRNA Translation: BAB78692.1
AB044158 Genomic DNA Translation: BAB78693.1
AL390738 Genomic DNA No translation available.
CCDSiCCDS9326.1
RefSeqiNP_663632.1, NM_145657.2
UniGeneiHs.351785

Genome annotation databases

EnsembliENST00000302945; ENSP00000304331; ENSG00000169840
GeneIDi219409
KEGGihsa:219409
UCSCiuc001urr.2 human

Similar proteinsi

Entry informationi

Entry nameiGSX1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4S2
Secondary accession number(s): Q9UD62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health