Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H4S2

- GSX1_HUMAN

UniProt

Q9H4S2 - GSX1_HUMAN

Protein

GS homeobox 1

Gene

GSX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi147 – 20660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. adenohypophysis development Source: Ensembl
    2. hypothalamus development Source: Ensembl
    3. neuron fate commitment Source: Ensembl
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. spinal cord association neuron differentiation Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GS homeobox 1
    Alternative name(s):
    Homeobox protein GSH-1
    Gene namesi
    Name:GSX1
    Synonyms:GSH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20374. GSX1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390373.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264GS homeobox 1PRO_0000048894Add
    BLAST

    Proteomic databases

    PaxDbiQ9H4S2.
    PRIDEiQ9H4S2.

    Expressioni

    Gene expression databases

    BgeeiQ9H4S2.
    CleanExiHS_GSX1.
    GenevestigatoriQ9H4S2.

    Organism-specific databases

    HPAiHPA047096.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000304331.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4S2.
    SMRiQ9H4S2. Positions 149-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi111 – 1188Poly-Ala
    Compositional biasi213 – 22311Poly-GlyAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG264927.
    HOGENOMiHOG000010106.
    HOVERGENiHBG003555.
    InParanoidiQ9H4S2.
    KOiK09310.
    OMAiSCKCASL.
    OrthoDBiEOG72C514.
    PhylomeDBiQ9H4S2.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H4S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR    50
    KAGLLCVCPL CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS 100
    AVSPGVAHGP AAAAAAAALY QTSYPLPDPR QFHCISVDSS SNQLPSSKRM 150
    RTAFTSTQLL ELEREFASNM YLSRLRRIEI ATYLNLSEKQ VKIWFQNRRV 200
    KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS EDDDELPMSP 250
    SSSGKDDRDL TVTP 264
    Length:264
    Mass (Da):27,883
    Last modified:March 1, 2001 - v1
    Checksum:i25F4C4336E270C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044157 mRNA. Translation: BAB78692.1.
    AB044158 Genomic DNA. Translation: BAB78693.1.
    AL390738 Genomic DNA. Translation: CAC12721.1.
    CCDSiCCDS9326.1.
    RefSeqiNP_663632.1. NM_145657.1.
    UniGeneiHs.351785.

    Genome annotation databases

    EnsembliENST00000302945; ENSP00000304331; ENSG00000169840.
    GeneIDi219409.
    KEGGihsa:219409.
    UCSCiuc001urr.1. human.

    Polymorphism databases

    DMDMi27923786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044157 mRNA. Translation: BAB78692.1 .
    AB044158 Genomic DNA. Translation: BAB78693.1 .
    AL390738 Genomic DNA. Translation: CAC12721.1 .
    CCDSi CCDS9326.1.
    RefSeqi NP_663632.1. NM_145657.1.
    UniGenei Hs.351785.

    3D structure databases

    ProteinModelPortali Q9H4S2.
    SMRi Q9H4S2. Positions 149-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000304331.

    Polymorphism databases

    DMDMi 27923786.

    Proteomic databases

    PaxDbi Q9H4S2.
    PRIDEi Q9H4S2.

    Protocols and materials databases

    DNASUi 219409.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302945 ; ENSP00000304331 ; ENSG00000169840 .
    GeneIDi 219409.
    KEGGi hsa:219409.
    UCSCi uc001urr.1. human.

    Organism-specific databases

    CTDi 219409.
    GeneCardsi GC13P028366.
    HGNCi HGNC:20374. GSX1.
    HPAi HPA047096.
    neXtProti NX_Q9H4S2.
    PharmGKBi PA162390373.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264927.
    HOGENOMi HOG000010106.
    HOVERGENi HBG003555.
    InParanoidi Q9H4S2.
    KOi K09310.
    OMAi SCKCASL.
    OrthoDBi EOG72C514.
    PhylomeDBi Q9H4S2.
    TreeFami TF315938.

    Miscellaneous databases

    GenomeRNAii 219409.
    NextBioi 90587.
    PROi Q9H4S2.

    Gene expression databases

    Bgeei Q9H4S2.
    CleanExi HS_GSX1.
    Genevestigatori Q9H4S2.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
      Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
      Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-193.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiGSX1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4S2
    Secondary accession number(s): Q9UD62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3