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Protein

GS homeobox 1

Gene

GSX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi147 – 206HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GS homeobox 1
Alternative name(s):
Homeobox protein GSH-1
Gene namesi
Name:GSX1
Synonyms:GSH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000169840.4.
HGNCiHGNC:20374. GSX1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169840.
PharmGKBiPA162390373.

Polymorphism and mutation databases

BioMutaiGSX1.
DMDMi27923786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488941 – 264GS homeobox 1Add BLAST264

Proteomic databases

PaxDbiQ9H4S2.
PeptideAtlasiQ9H4S2.
PRIDEiQ9H4S2.

PTM databases

iPTMnetiQ9H4S2.
PhosphoSitePlusiQ9H4S2.

Expressioni

Gene expression databases

BgeeiENSG00000169840.
CleanExiHS_GSX1.
GenevisibleiQ9H4S2. HS.

Organism-specific databases

HPAiHPA047096.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304331.

Structurei

3D structure databases

ProteinModelPortaliQ9H4S2.
SMRiQ9H4S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 118Poly-Ala8
Compositional biasi213 – 223Poly-GlyAdd BLAST11

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000010106.
HOVERGENiHBG003555.
InParanoidiQ9H4S2.
KOiK09310.
OMAiCHSRKAG.
OrthoDBiEOG091G0HAO.
PhylomeDBiQ9H4S2.
TreeFamiTF315938.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H4S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR
60 70 80 90 100
KAGLLCVCPL CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS
110 120 130 140 150
AVSPGVAHGP AAAAAAAALY QTSYPLPDPR QFHCISVDSS SNQLPSSKRM
160 170 180 190 200
RTAFTSTQLL ELEREFASNM YLSRLRRIEI ATYLNLSEKQ VKIWFQNRRV
210 220 230 240 250
KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS EDDDELPMSP
260
SSSGKDDRDL TVTP
Length:264
Mass (Da):27,883
Last modified:March 1, 2001 - v1
Checksum:i25F4C4336E270C00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044157 mRNA. Translation: BAB78692.1.
AB044158 Genomic DNA. Translation: BAB78693.1.
AL390738 Genomic DNA. No translation available.
CCDSiCCDS9326.1.
RefSeqiNP_663632.1. NM_145657.2.
UniGeneiHs.351785.

Genome annotation databases

EnsembliENST00000302945; ENSP00000304331; ENSG00000169840.
GeneIDi219409.
KEGGihsa:219409.
UCSCiuc001urr.2. human.

Similar proteinsi

Entry informationi

Entry nameiGSX1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4S2
Secondary accession number(s): Q9UD62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families