Q9H4S2 (GSX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GS homeobox 1

Alternative name(s):
Homeobox protein GSH-1

Gene names

Name:	GSX1
Synonyms:	GSH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenohypophysis development Inferred from electronic annotation. Source: Compara hypothalamus development Inferred from electronic annotation. Source: Compara neuron fate commitment Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: MGI spinal cord association neuron differentiation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from direct assay Ref.1. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	GS homeobox 1		PRO_0000048894
Regions
	DNA binding	147 – 206	60	Homeobox
	Region	1 – 20	20	SNAG domain By similarity
	Compositional bias	111 – 118	8	Poly-Ala
	Compositional bias	213 – 223	11	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q9H4S2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 25F4C4336E270C00	FASTA	264	27,883
	10 20 30 40 50 60 MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR KAGLLCVCPL 70 80 90 100 110 120 CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS AVSPGVAHGP AAAAAAAALY 130 140 150 160 170 180 QTSYPLPDPR QFHCISVDSS SNQLPSSKRM RTAFTSTQLL ELEREFASNM YLSRLRRIEI 190 200 210 220 230 240 ATYLNLSEKQ VKIWFQNRRV KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS 250 260 EDDDELPMSP SSSGKDDRDL TVTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homeobox protein Gsh-1-dependent regulation of the rat GHRH gene promoter." Mutsuga N., Iwasaki Y., Morishita M., Nomura A., Yamamori E., Yoshida M., Asai M., Ozaki N., Kambe F., Seo H., Oiso Y., Saito H. Mol. Endocrinol. 15:2149-2156(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of homeobox genes expressed in human haemopoietic progenitor cells." Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R. Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-193. Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB044157 mRNA. Translation: BAB78692.1. AB044158 Genomic DNA. Translation: BAB78693.1. AL390738 Genomic DNA. Translation: CAC12721.1.
IPI	IPI00028199.
RefSeq	NP_663632.1. NM_145657.1.
UniGene	Hs.351785.
3D structure databases
ProteinModelPortal	Q9H4S2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000304331.
Polymorphism databases
DMDM	27923786.
Proteomic databases
PaxDb	Q9H4S2.
PRIDE	Q9H4S2.
Protocols and materials databases
DNASU	219409.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302945; ENSP00000304331; ENSG00000169840.
GeneID	219409.
KEGG	hsa:219409.
UCSC	uc001urr.1. human.
Organism-specific databases
CTD	219409.
GeneCards	GC13P028366.
HGNC	HGNC:20374. GSX1.
HPA	HPA047096.
neXtProt	NX_Q9H4S2.
PharmGKB	PA162390373.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG264927.
HOGENOM	HOG000010106.
HOVERGEN	HBG003555.
InParanoid	Q9H4S2.
KO	K09310.
OMA	HNCKCSS.
OrthoDB	EOG4GTKDV.
Gene expression databases
Bgee	Q9H4S2.
CleanEx	HS_GSX1.
Genevestigator	Q9H4S2.
GermOnline	ENSG00000169840. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	219409.
NextBio	90587.

Entry information

Entry name

GSX1_HUMAN

Accession

Primary (citable) accession number: Q9H4S2
Secondary accession number(s): Q9UD62

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.