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Q9H4S2 (GSX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GS homeobox 1
Alternative name(s):
Homeobox protein GSH-1
Gene names
Name:GSX1
Synonyms:GSH1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264GS homeobox 1
PRO_0000048894

Regions

DNA binding147 – 20660Homeobox
Region1 – 2020SNAG domain By similarity
Compositional bias111 – 1188Poly-Ala
Compositional bias213 – 22311Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q9H4S2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 25F4C4336E270C00

FASTA26427,883
        10         20         30         40         50         60 
MPRSFLVDSL VLREAGEKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR KAGLLCVCPL 

        70         80         90        100        110        120 
CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS AVSPGVAHGP AAAAAAAALY 

       130        140        150        160        170        180 
QTSYPLPDPR QFHCISVDSS SNQLPSSKRM RTAFTSTQLL ELEREFASNM YLSRLRRIEI 

       190        200        210        220        230        240 
ATYLNLSEKQ VKIWFQNRRV KHKKEGKGSN HRGGGGGGAG GGGSAPQGCK CASLSSAKCS 

       250        260 
EDDDELPMSP SSSGKDDRDL TVTP 

« Hide

References

« Hide 'large scale' references
[1]"Homeobox protein Gsh-1-dependent regulation of the rat GHRH gene promoter."
Mutsuga N., Iwasaki Y., Morishita M., Nomura A., Yamamori E., Yoshida M., Asai M., Ozaki N., Kambe F., Seo H., Oiso Y., Saito H.
Mol. Endocrinol. 15:2149-2156(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-193.
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB044157 mRNA. Translation: BAB78692.1.
AB044158 Genomic DNA. Translation: BAB78693.1.
AL390738 Genomic DNA. Translation: CAC12721.1.
CCDSCCDS9326.1.
RefSeqNP_663632.1. NM_145657.1.
UniGeneHs.351785.

3D structure databases

ProteinModelPortalQ9H4S2.
SMRQ9H4S2. Positions 149-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000304331.

Polymorphism databases

DMDM27923786.

Proteomic databases

PaxDbQ9H4S2.
PRIDEQ9H4S2.

Protocols and materials databases

DNASU219409.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302945; ENSP00000304331; ENSG00000169840.
GeneID219409.
KEGGhsa:219409.
UCSCuc001urr.1. human.

Organism-specific databases

CTD219409.
GeneCardsGC13P028366.
HGNCHGNC:20374. GSX1.
HPAHPA047096.
neXtProtNX_Q9H4S2.
PharmGKBPA162390373.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264927.
HOGENOMHOG000010106.
HOVERGENHBG003555.
InParanoidQ9H4S2.
KOK09310.
OMASCKCASL.
OrthoDBEOG72C514.
PhylomeDBQ9H4S2.
TreeFamTF315938.

Gene expression databases

BgeeQ9H4S2.
CleanExHS_GSX1.
GenevestigatorQ9H4S2.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi219409.
NextBio90587.
PROQ9H4S2.

Entry information

Entry nameGSX1_HUMAN
AccessionPrimary (citable) accession number: Q9H4S2
Secondary accession number(s): Q9UD62
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM