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Protein

DNA replication licensing factor MCM7

Gene

MCM7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, HelicaseUniRule annotation, Hydrolase
Biological processCell cycleUniRule annotation, DNA replicationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor MCM7UniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:MCM7UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ9H4N9
PRIDEiQ9H4N9

Structurei

3D structure databases

ProteinModelPortaliQ9H4N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 169MCMInterPro annotationAdd BLAST169

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0482 Eukaryota
COG1241 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008050 MCM7
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF26 PTHR11630:SF26, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PRINTSiPR01657 MCMFAMILY
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H4N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRGNINIC LMGDPGVAKS QLLSYIDRLA PRSQYTTGRG SSGVGLTAAV
60 70 80 90 100
LRDSVSGELT LEGGALVLAD QGVCCIDEFD KMAEADRTAI HEVMEQQTIS
110 120 130 140 150
IAKAGILTTL NARCSILAAA NPAYGRYNPR RSLEQNIQLP AALLSRFDLL
160 170 180 190 200
WLIQDRPDRD NDLRLAQHIT YVHQHSRQPP SQFEPLDMKL MRRYIAMCRE
210 220 230 240 250
KQPMVPESLA DYITAAYVEM RREAWASKDA TYTSARTLLA ILRLSTALAR
260 270 280 290 300
LRMVDVVEKE DVNEAIRLME MSKDSLLGDK GQTARTQRPA DVIFATVREL
310 320 330 340 350
VSGGRSVRFS EAEQRCVSRG FTPAQFQAAL DEYEELNVWQ VNASRTRITF

V
Length:351
Mass (Da):39,244
Last modified:March 1, 2001 - v1
Checksum:iA98BCFB9922E80F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007130 mRNA Translation: AAG01994.1
UniGeneiHs.438720

Similar proteinsi

Entry informationi

Entry nameiQ9H4N9_HUMAN
AccessioniPrimary (citable) accession number: Q9H4N9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.