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Protein

F-box only protein 44

Gene

FBXO44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 44
Alternative name(s):
F-box protein FBX30
F-box/G-domain protein 3
Gene namesi
Name:FBXO44
Synonyms:FBG3, FBX30, FBX44, FBX6A, FBXO6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24847. FBXO44.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi93611.
OpenTargetsiENSG00000132879.
PharmGKBiPA134863106.

Polymorphism and mutation databases

BioMutaiFBXO44.
DMDMi61252661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199451 – 255F-box only protein 44Add BLAST255

Proteomic databases

EPDiQ9H4M3.
MaxQBiQ9H4M3.
PaxDbiQ9H4M3.
PeptideAtlasiQ9H4M3.
PRIDEiQ9H4M3.

Expressioni

Tissue specificityi

Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.1 Publication

Gene expression databases

BgeeiENSG00000132879.
CleanExiHS_FBXO44.
ExpressionAtlasiQ9H4M3. baseline and differential.
GenevisibleiQ9H4M3. HS.

Organism-specific databases

HPAiHPA003363.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C17orf59Q96GS44EBI-2322644,EBI-10193358
SERTAD3Q9UJW93EBI-2322644,EBI-748621
SKP1P632085EBI-2322644,EBI-307486

Protein-protein interaction databases

BioGridi125038. 16 interactors.
IntActiQ9H4M3. 6 interactors.
STRINGi9606.ENSP00000251547.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi11 – 19Combined sources9
Helixi23 – 28Combined sources6
Helixi30 – 32Combined sources3
Helixi35 – 41Combined sources7
Helixi44 – 53Combined sources10
Helixi68 – 77Combined sources10
Beta strandi82 – 84Combined sources3
Turni88 – 93Combined sources6
Beta strandi95 – 99Combined sources5
Beta strandi105 – 108Combined sources4
Helixi111 – 114Combined sources4
Beta strandi117 – 120Combined sources4
Beta strandi124 – 127Combined sources4
Beta strandi133 – 140Combined sources8
Helixi142 – 144Combined sources3
Helixi148 – 154Combined sources7
Beta strandi157 – 165Combined sources9
Beta strandi171 – 181Combined sources11
Beta strandi187 – 191Combined sources5
Helixi195 – 201Combined sources7
Beta strandi203 – 205Combined sources3
Beta strandi207 – 213Combined sources7
Beta strandi222 – 231Combined sources10
Beta strandi242 – 251Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSOX-ray2.60A1-255[»]
5B4NX-ray2.30A/B94-191[»]
A/B194-247[»]
ProteinModelPortaliQ9H4M3.
SMRiQ9H4M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 50F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini71 – 252FBAPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOVERGENiHBG003593.
InParanoidiQ9H4M3.
KOiK10103.
PhylomeDBiQ9H4M3.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGNINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLVTLWKRK
60 70 80 90 100
CLREGFITED WDQPVADWKI FYFLRSLHRN LLHNPCAEEG FEFWSLDVNG
110 120 130 140 150
GDEWKVEDLS RDQRKEFPND QVKKYFVTSY YTCLKSQVVD LKAEGYWEEL
160 170 180 190 200
MDTTRPDIEV KDWFAARPDC GSKYQLCVQL LSSAHAPLGT FQPDPATIQQ
210 220 230 240 250
KSDAKWREVS HTFSNYPPGV RYIWFQHGGV DTHYWAGWYG PRVTNSSITI

GPPLP
Length:255
Mass (Da):29,747
Last modified:March 15, 2005 - v3
Checksum:i3DA167B70E22A7E8
GO
Isoform 2 (identifier: Q9H4M3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-224: KKYFVTSYYT...NYPPGVRYIW → RSQARLRVQV...TPPEPPSAEP
     225-255: Missing.

Show »
Length:224
Mass (Da):25,698
Checksum:i7016A8750CB6FB71
GO

Sequence cautioni

The sequence CAI20210 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20213 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101G → D in CAH18221 (PubMed:17974005).Curated1
Sequence conflicti251G → R in AAK77940 (PubMed:12383498).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011346123 – 224KKYFV…VRYIW → RSQARLRVQVPAVRSAPVVR ARASGDLPARPGDHPAEERC QVEGGLPHILQLPARRPLHL VSARRRGHSLLGRLVRPEGH QQQHHHRAPAALTPPEPPSA EP in isoform 2. 3 PublicationsAdd BLAST102
Alternative sequenceiVSP_011347225 – 255Missing in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007380 mRNA. Translation: AAG09623.1.
AY040878 mRNA. Translation: AAK77940.1.
AK301418 mRNA. Translation: BAH13479.1.
AK055344 mRNA. Translation: BAG51504.1.
CR749368 mRNA. Translation: CAH18221.1.
AL031731 Genomic DNA. Translation: CAI20210.1. Sequence problems.
AL031731 Genomic DNA. Translation: CAI20211.1.
AL031731 Genomic DNA. Translation: CAI20212.1.
AL031731 Genomic DNA. Translation: CAI20213.1. Sequence problems.
CH471130 Genomic DNA. Translation: EAW71690.1.
CH471130 Genomic DNA. Translation: EAW71691.1.
BC007832 mRNA. Translation: AAH07832.1.
CCDSiCCDS131.1. [Q9H4M3-2]
CCDS132.1. [Q9H4M3-1]
RefSeqiNP_001014765.1. NM_001014765.1. [Q9H4M3-1]
NP_001291719.1. NM_001304790.1. [Q9H4M3-2]
NP_001291720.1. NM_001304791.1. [Q9H4M3-1]
NP_149438.2. NM_033182.5. [Q9H4M3-1]
NP_904319.1. NM_183412.2. [Q9H4M3-2]
NP_904320.1. NM_183413.2. [Q9H4M3-2]
XP_006711108.1. XM_006711045.2. [Q9H4M3-1]
XP_016858332.1. XM_017002843.1. [Q9H4M3-1]
XP_016858333.1. XM_017002844.1. [Q9H4M3-2]
UniGeneiHs.556006.

Genome annotation databases

EnsembliENST00000251546; ENSP00000251546; ENSG00000132879. [Q9H4M3-2]
ENST00000251547; ENSP00000251547; ENSG00000132879. [Q9H4M3-1]
ENST00000376760; ENSP00000365951; ENSG00000132879. [Q9H4M3-2]
ENST00000376762; ENSP00000365953; ENSG00000132879. [Q9H4M3-2]
ENST00000376770; ENSP00000365961; ENSG00000132879. [Q9H4M3-1]
GeneIDi93611.
KEGGihsa:93611.
UCSCiuc001ask.4. human. [Q9H4M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

FLAG-FBG3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007380 mRNA. Translation: AAG09623.1.
AY040878 mRNA. Translation: AAK77940.1.
AK301418 mRNA. Translation: BAH13479.1.
AK055344 mRNA. Translation: BAG51504.1.
CR749368 mRNA. Translation: CAH18221.1.
AL031731 Genomic DNA. Translation: CAI20210.1. Sequence problems.
AL031731 Genomic DNA. Translation: CAI20211.1.
AL031731 Genomic DNA. Translation: CAI20212.1.
AL031731 Genomic DNA. Translation: CAI20213.1. Sequence problems.
CH471130 Genomic DNA. Translation: EAW71690.1.
CH471130 Genomic DNA. Translation: EAW71691.1.
BC007832 mRNA. Translation: AAH07832.1.
CCDSiCCDS131.1. [Q9H4M3-2]
CCDS132.1. [Q9H4M3-1]
RefSeqiNP_001014765.1. NM_001014765.1. [Q9H4M3-1]
NP_001291719.1. NM_001304790.1. [Q9H4M3-2]
NP_001291720.1. NM_001304791.1. [Q9H4M3-1]
NP_149438.2. NM_033182.5. [Q9H4M3-1]
NP_904319.1. NM_183412.2. [Q9H4M3-2]
NP_904320.1. NM_183413.2. [Q9H4M3-2]
XP_006711108.1. XM_006711045.2. [Q9H4M3-1]
XP_016858332.1. XM_017002843.1. [Q9H4M3-1]
XP_016858333.1. XM_017002844.1. [Q9H4M3-2]
UniGeneiHs.556006.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSOX-ray2.60A1-255[»]
5B4NX-ray2.30A/B94-191[»]
A/B194-247[»]
ProteinModelPortaliQ9H4M3.
SMRiQ9H4M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125038. 16 interactors.
IntActiQ9H4M3. 6 interactors.
STRINGi9606.ENSP00000251547.

Polymorphism and mutation databases

BioMutaiFBXO44.
DMDMi61252661.

Proteomic databases

EPDiQ9H4M3.
MaxQBiQ9H4M3.
PaxDbiQ9H4M3.
PeptideAtlasiQ9H4M3.
PRIDEiQ9H4M3.

Protocols and materials databases

DNASUi93611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251546; ENSP00000251546; ENSG00000132879. [Q9H4M3-2]
ENST00000251547; ENSP00000251547; ENSG00000132879. [Q9H4M3-1]
ENST00000376760; ENSP00000365951; ENSG00000132879. [Q9H4M3-2]
ENST00000376762; ENSP00000365953; ENSG00000132879. [Q9H4M3-2]
ENST00000376770; ENSP00000365961; ENSG00000132879. [Q9H4M3-1]
GeneIDi93611.
KEGGihsa:93611.
UCSCiuc001ask.4. human. [Q9H4M3-1]

Organism-specific databases

CTDi93611.
DisGeNETi93611.
GeneCardsiFBXO44.
HGNCiHGNC:24847. FBXO44.
HPAiHPA003363.
MIMi609111. gene.
neXtProtiNX_Q9H4M3.
OpenTargetsiENSG00000132879.
PharmGKBiPA134863106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOVERGENiHBG003593.
InParanoidiQ9H4M3.
KOiK10103.
PhylomeDBiQ9H4M3.
TreeFamiTF320527.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXO44. human.
GenomeRNAii93611.
PROiQ9H4M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132879.
CleanExiHS_FBXO44.
ExpressionAtlasiQ9H4M3. baseline and differential.
GenevisibleiQ9H4M3. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX44_HUMAN
AccessioniPrimary (citable) accession number: Q9H4M3
Secondary accession number(s): B3KNZ2
, B7Z743, Q5TGX2, Q5TGX4, Q5TGX5, Q68DJ9, Q8WWY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.