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Q9H4L5

- OSBL3_HUMAN

UniProt

Q9H4L5 - OSBL3_HUMAN

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Protein
Oxysterol-binding protein-related protein 3
Gene
OSBPL3, KIAA0704, ORP3, OSBP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cholesterol binding Source: BHF-UCL
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 3
Short name:
ORP-3
Short name:
OSBP-related protein 3
Gene namesi
Name:OSBPL3
Synonyms:KIAA0704, ORP3, OSBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16370. OSBPL3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: BHF-UCL
  2. nuclear membrane Source: BHF-UCL
  3. perinuclear endoplasmic reticulum Source: BHF-UCL
  4. plasma membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Oxysterol-binding protein-related protein 3
PRO_0000100371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei34 – 341Phosphoserine1 Publication
Modified residuei251 – 2511Phosphoserine1 Publication
Modified residuei304 – 3041Phosphoserine3 Publications
Modified residuei372 – 3721Phosphoserine2 Publications
Modified residuei410 – 4101Phosphoserine4 Publications
Modified residuei437 – 4371Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H4L5.
PaxDbiQ9H4L5.
PRIDEiQ9H4L5.

PTM databases

PhosphoSiteiQ9H4L5.

Expressioni

Tissue specificityi

Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung.

Gene expression databases

ArrayExpressiQ9H4L5.
BgeeiQ9H4L5.
GenevestigatoriQ9H4L5.

Organism-specific databases

HPAiHPA000691.
HPA048401.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G45EBI-1051317,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi117497. 9 interactions.
IntActiQ9H4L5. 5 interactions.
MINTiMINT-1631853.

Structurei

3D structure databases

ProteinModelPortaliQ9H4L5.
SMRiQ9H4L5. Positions 49-146, 519-887.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 14696PH
Add
BLAST

Sequence similaritiesi

Belongs to the OSBP family.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG281324.
HOVERGENiHBG058934.
InParanoidiQ9H4L5.
OMAiPLERMVY.
OrthoDBiEOG780RKR.
PhylomeDBiQ9H4L5.
TreeFamiTF320922.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1a (identifier: Q9H4L5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE    50
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 100
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 150
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 200
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 250
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 300
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 350
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR 400
IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE 450
FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP 500
VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN 550
EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 600
GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD 650
VRWKNKFWGK SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI 700
EHYGEIVIKN LHDDSCYCKV NFIKAKYWST NAHEIEGTVF DRSGKAVHRL 750
FGKWHESIYC GGGSSSACVW RANPMPKGYE QYYSFTQFAL ELNEMDPSSK 800
SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR RVLEENHVEH 850
QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW 887
Length:887
Mass (Da):101,224
Last modified:March 1, 2001 - v1
Checksum:i12E16912BD3F2E99
GO
Isoform 1b (identifier: Q9H4L5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.

Show »
Length:856
Mass (Da):97,687
Checksum:i1D56185E3FB98744
GO
Isoform 1c (identifier: Q9H4L5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.

Show »
Length:851
Mass (Da):97,325
Checksum:iDA08C319F2BAEDCE
GO
Isoform 1d (identifier: Q9H4L5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.

Show »
Length:820
Mass (Da):93,788
Checksum:i3D0A8947F6EE4DC5
GO
Isoform 2a (identifier: Q9H4L5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:642
Mass (Da):72,211
Checksum:i7AC19EA7AE07E5E4
GO
Isoform 2b (identifier: Q9H4L5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:611
Mass (Da):68,674
Checksum:i1A92347357A219CE
GO
Isoform 2c (identifier: Q9H4L5-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:606
Mass (Da):68,313
Checksum:iEA72B4600CF3C1B8
GO
Isoform 2d (identifier: Q9H4L5-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:575
Mass (Da):64,776
Checksum:iCD8F92033643E963
GO

Sequence cautioni

The sequence BAA31679.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti354 – 3541M → V.
Corresponds to variant rs11768296 [ dbSNP | Ensembl ].
VAR_053548

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 28931Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d.
VSP_008219Add
BLAST
Alternative sequencei387 – 42236Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d.
VSP_008220Add
BLAST
Alternative sequencei584 – 63148YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d.
VSP_008221Add
BLAST
Alternative sequencei632 – 887256Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d.
VSP_008222Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008372 mRNA. Translation: AAG23400.1.
AF392444 mRNA. Translation: AAL40657.1.
AF491781 mRNA. Translation: AAM27386.1.
AF491782 mRNA. Translation: AAM27387.1.
AF491783 mRNA. Translation: AAM27388.1.
AF491784 mRNA. Translation: AAM27389.1.
AF491785 mRNA. Translation: AAM27390.1.
AF491786 mRNA. Translation: AAM27391.1.
AF515639 mRNA. Translation: AAM74165.1.
AF515640 mRNA. Translation: AAM74166.1.
AB014604 mRNA. Translation: BAA31679.2. Different initiation.
AC003093 Genomic DNA. Translation: AAB83939.1.
AC004008 Genomic DNA. No translation available.
AC004016 Genomic DNA. Translation: AAC26986.2.
AC004239 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24240.1.
CH236948 Genomic DNA. Translation: EAL24241.1.
CH236948 Genomic DNA. Translation: EAL24242.1.
CH236948 Genomic DNA. Translation: EAL24243.1.
CH236948 Genomic DNA. Translation: EAL24244.1.
CH236948 Genomic DNA. Translation: EAL24245.1.
CH471073 Genomic DNA. Translation: EAW93816.1.
CH471073 Genomic DNA. Translation: EAW93817.1.
CH471073 Genomic DNA. Translation: EAW93818.1.
CH471073 Genomic DNA. Translation: EAW93819.1.
CH471073 Genomic DNA. Translation: EAW93820.1.
CH471073 Genomic DNA. Translation: EAW93821.1.
BC017731 mRNA. Translation: AAH17731.1.
AF323727 mRNA. Translation: AAG53408.1.
CCDSiCCDS47564.1. [Q9H4L5-4]
CCDS5390.1. [Q9H4L5-1]
CCDS5391.1. [Q9H4L5-2]
CCDS5392.1. [Q9H4L5-3]
RefSeqiNP_056365.1. NM_015550.3. [Q9H4L5-1]
NP_663160.1. NM_145320.2. [Q9H4L5-2]
NP_663161.1. NM_145321.2. [Q9H4L5-3]
NP_663162.1. NM_145322.2. [Q9H4L5-4]
XP_005249755.1. XM_005249698.1. [Q9H4L5-1]
XP_006715744.1. XM_006715681.1. [Q9H4L5-2]
XP_006715745.1. XM_006715682.1. [Q9H4L5-3]
XP_006715746.1. XM_006715683.1. [Q9H4L5-4]
UniGeneiHs.520259.

Genome annotation databases

EnsembliENST00000313367; ENSP00000315410; ENSG00000070882. [Q9H4L5-1]
ENST00000352860; ENSP00000315331; ENSG00000070882. [Q9H4L5-2]
ENST00000353930; ENSP00000315277; ENSG00000070882. [Q9H4L5-3]
ENST00000396429; ENSP00000379706; ENSG00000070882. [Q9H4L5-3]
ENST00000396431; ENSP00000379708; ENSG00000070882. [Q9H4L5-2]
ENST00000409069; ENSP00000386953; ENSG00000070882. [Q9H4L5-4]
ENST00000409452; ENSP00000386801; ENSG00000070882. [Q9H4L5-5]
ENST00000409555; ENSP00000386990; ENSG00000070882. [Q9H4L5-8]
ENST00000409759; ENSP00000386325; ENSG00000070882. [Q9H4L5-7]
ENST00000409863; ENSP00000386429; ENSG00000070882. [Q9H4L5-6]
ENST00000431825; ENSP00000389779; ENSG00000070882. [Q9H4L5-4]
GeneIDi26031.
KEGGihsa:26031.
UCSCiuc003sxf.3. human. [Q9H4L5-1]
uc003sxg.3. human. [Q9H4L5-3]
uc003sxh.3. human. [Q9H4L5-2]
uc003sxi.3. human. [Q9H4L5-4]
uc003sxj.1. human. [Q9H4L5-7]
uc003sxk.1. human. [Q9H4L5-8]

Polymorphism databases

DMDMi20139176.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008372 mRNA. Translation: AAG23400.1 .
AF392444 mRNA. Translation: AAL40657.1 .
AF491781 mRNA. Translation: AAM27386.1 .
AF491782 mRNA. Translation: AAM27387.1 .
AF491783 mRNA. Translation: AAM27388.1 .
AF491784 mRNA. Translation: AAM27389.1 .
AF491785 mRNA. Translation: AAM27390.1 .
AF491786 mRNA. Translation: AAM27391.1 .
AF515639 mRNA. Translation: AAM74165.1 .
AF515640 mRNA. Translation: AAM74166.1 .
AB014604 mRNA. Translation: BAA31679.2 . Different initiation.
AC003093 Genomic DNA. Translation: AAB83939.1 .
AC004008 Genomic DNA. No translation available.
AC004016 Genomic DNA. Translation: AAC26986.2 .
AC004239 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24240.1 .
CH236948 Genomic DNA. Translation: EAL24241.1 .
CH236948 Genomic DNA. Translation: EAL24242.1 .
CH236948 Genomic DNA. Translation: EAL24243.1 .
CH236948 Genomic DNA. Translation: EAL24244.1 .
CH236948 Genomic DNA. Translation: EAL24245.1 .
CH471073 Genomic DNA. Translation: EAW93816.1 .
CH471073 Genomic DNA. Translation: EAW93817.1 .
CH471073 Genomic DNA. Translation: EAW93818.1 .
CH471073 Genomic DNA. Translation: EAW93819.1 .
CH471073 Genomic DNA. Translation: EAW93820.1 .
CH471073 Genomic DNA. Translation: EAW93821.1 .
BC017731 mRNA. Translation: AAH17731.1 .
AF323727 mRNA. Translation: AAG53408.1 .
CCDSi CCDS47564.1. [Q9H4L5-4 ]
CCDS5390.1. [Q9H4L5-1 ]
CCDS5391.1. [Q9H4L5-2 ]
CCDS5392.1. [Q9H4L5-3 ]
RefSeqi NP_056365.1. NM_015550.3. [Q9H4L5-1 ]
NP_663160.1. NM_145320.2. [Q9H4L5-2 ]
NP_663161.1. NM_145321.2. [Q9H4L5-3 ]
NP_663162.1. NM_145322.2. [Q9H4L5-4 ]
XP_005249755.1. XM_005249698.1. [Q9H4L5-1 ]
XP_006715744.1. XM_006715681.1. [Q9H4L5-2 ]
XP_006715745.1. XM_006715682.1. [Q9H4L5-3 ]
XP_006715746.1. XM_006715683.1. [Q9H4L5-4 ]
UniGenei Hs.520259.

3D structure databases

ProteinModelPortali Q9H4L5.
SMRi Q9H4L5. Positions 49-146, 519-887.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117497. 9 interactions.
IntActi Q9H4L5. 5 interactions.
MINTi MINT-1631853.

PTM databases

PhosphoSitei Q9H4L5.

Polymorphism databases

DMDMi 20139176.

Proteomic databases

MaxQBi Q9H4L5.
PaxDbi Q9H4L5.
PRIDEi Q9H4L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313367 ; ENSP00000315410 ; ENSG00000070882 . [Q9H4L5-1 ]
ENST00000352860 ; ENSP00000315331 ; ENSG00000070882 . [Q9H4L5-2 ]
ENST00000353930 ; ENSP00000315277 ; ENSG00000070882 . [Q9H4L5-3 ]
ENST00000396429 ; ENSP00000379706 ; ENSG00000070882 . [Q9H4L5-3 ]
ENST00000396431 ; ENSP00000379708 ; ENSG00000070882 . [Q9H4L5-2 ]
ENST00000409069 ; ENSP00000386953 ; ENSG00000070882 . [Q9H4L5-4 ]
ENST00000409452 ; ENSP00000386801 ; ENSG00000070882 . [Q9H4L5-5 ]
ENST00000409555 ; ENSP00000386990 ; ENSG00000070882 . [Q9H4L5-8 ]
ENST00000409759 ; ENSP00000386325 ; ENSG00000070882 . [Q9H4L5-7 ]
ENST00000409863 ; ENSP00000386429 ; ENSG00000070882 . [Q9H4L5-6 ]
ENST00000431825 ; ENSP00000389779 ; ENSG00000070882 . [Q9H4L5-4 ]
GeneIDi 26031.
KEGGi hsa:26031.
UCSCi uc003sxf.3. human. [Q9H4L5-1 ]
uc003sxg.3. human. [Q9H4L5-3 ]
uc003sxh.3. human. [Q9H4L5-2 ]
uc003sxi.3. human. [Q9H4L5-4 ]
uc003sxj.1. human. [Q9H4L5-7 ]
uc003sxk.1. human. [Q9H4L5-8 ]

Organism-specific databases

CTDi 26031.
GeneCardsi GC07M024836.
HGNCi HGNC:16370. OSBPL3.
HPAi HPA000691.
HPA048401.
MIMi 606732. gene.
neXtProti NX_Q9H4L5.
PharmGKBi PA32828.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281324.
HOVERGENi HBG058934.
InParanoidi Q9H4L5.
OMAi PLERMVY.
OrthoDBi EOG780RKR.
PhylomeDBi Q9H4L5.
TreeFami TF320922.

Miscellaneous databases

ChiTaRSi OSBPL3. human.
GeneWikii OSBPL3.
GenomeRNAii 26031.
NextBioi 47824.
PROi Q9H4L5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H4L5.
Bgeei Q9H4L5.
Genevestigatori Q9H4L5.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR10972. PTHR10972. 1 hit.
Pfami PF01237. Oxysterol_BP. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells."
    Gregorio-King C.C., Collier G.R., McMillan J.S., Waugh C.M., McLeod J.L., Collier F.M., Kirkland M.A.
    Blood 98:2279-2281(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
  2. "A family of 12 human genes containing oxysterol-binding domains."
    Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
    Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
  3. "ORP3 splice variants and their expression in human tissues and hematopoietic cells."
    Collier F.M., Gregorio-King C.C., Apostolopoulos J., Walder K., Kirkland M.A.
    DNA Cell Biol. 22:1-9(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 1D; 2A; 2B; 2C AND 2D).
  4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
    Tissue: Brain.
  5. Ohara O., Suyama M., Nagase T., Ishikawa K.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
    Tissue: Uterus.
  10. "The OSBP-related protein family in humans."
    Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
    J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-245 (ISOFORM 1A).
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410 AND SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-251; SER-304; SER-372 AND SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-410 AND SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304; SER-372 AND SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSBL3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4L5
Secondary accession number(s): A4D167
, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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