Q9H4L5 (OSBL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxysterol-binding protein-related protein 3
Short name=ORP-3
Short name=OSBP-related protein 3

Gene names

Name:	OSBPL3
Synonyms:	KIAA0704, ORP3, OSBP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	887 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung.
Sequence similarities	Belongs to the OSBP family. Contains 1 PH domain.
Sequence caution	The sequence BAA31679.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from direct assay PubMed 14593528. Source: BHF-UCL nuclear membrane Inferred from direct assay PubMed 14593528. Source: BHF-UCL perinuclear endoplasmic reticulum Inferred from direct assay PubMed 14593528. Source: BHF-UCL plasma membrane Inferred from direct assay PubMed 14593528. Source: BHF-UCL
Molecular_function	cholesterol binding Inferred from direct assay PubMed 17428193. Source: BHF-UCL phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ORF	Q9Q2G4	5	EBI-1051317,EBI-6248094	From a different organism.

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1a (identifier: Q9H4L5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1b (identifier: Q9H4L5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.

Isoform 1c (identifier: Q9H4L5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.

Isoform 1d (identifier: Q9H4L5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.

Isoform 2a (identifier: Q9H4L5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2b (identifier: Q9H4L5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2c (identifier: Q9H4L5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2d (identifier: Q9H4L5-8)

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 887	887	Oxysterol-binding protein-related protein 3		PRO_0000100371
Regions
	Domain	51 – 146	96	PH
Amino acid modifications
	Modified residue	16	1	Phosphoserine Ref.13
	Modified residue	34	1	Phosphoserine Ref.14
	Modified residue	251	1	Phosphoserine Ref.13
	Modified residue	304	1	Phosphoserine Ref.13 Ref.15 Ref.16
	Modified residue	372	1	Phosphoserine Ref.13 Ref.16
	Modified residue	410	1	Phosphoserine Ref.12 Ref.13 Ref.14 Ref.16
	Modified residue	437	1	Phosphoserine Ref.11 Ref.12 Ref.14
Natural variations
	Alternative sequence	259 – 289	31	Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d.		VSP_008219
	Alternative sequence	387 – 422	36	Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d.		VSP_008220
	Alternative sequence	584 – 631	48	YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d.		VSP_008221
	Alternative sequence	632 – 887	256	Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d.		VSP_008222
	Natural variant	354	1	M → V. Corresponds to variant rs11768296 [ dbSNP | Ensembl ].		VAR_053548

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1a [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 12E16912BD3F2E99	FASTA	887	101,224
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 310 320 330 340 350 360 LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 370 380 390 400 410 420 LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR IHAESLLLDS PAVAKSGDNL 430 440 450 460 470 480 AEENSRDENR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISD DDSYVSDISD 490 500 510 520 530 540 NLSLDNLSND LDNERQTLGP VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL 550 560 570 580 590 600 SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 610 620 630 640 650 660 GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD VRWKNKFWGK 670 680 690 700 710 720 SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI EHYGEIVIKN LHDDSCYCKV 730 740 750 760 770 780 NFIKAKYWST NAHEIEGTVF DRSGKAVHRL FGKWHESIYC GGGSSSACVW RANPMPKGYE 790 800 810 820 830 840 QYYSFTQFAL ELNEMDPSSK SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR 850 860 870 880 RVLEENHVEH QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW
	Isoform 1b [UniParc]. Checksum: 1D56185E3FB98744	FASTA	856	97,687
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 310 320 330 340 350 360 MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK NALSSALAQN 370 380 390 400 410 420 TDLKERLRRI HAESLLLDSP AVAKSGDNLA EENSRDENRA LVHQLSNESR LSITDSLSEF 430 440 450 460 470 480 FDAQEVLLSP SSSENEISDD DSYVSDISDN LSLDNLSNDL DNERQTLGPV LDSGREAKSR 490 500 510 520 530 540 RRTCLPAPCP SSSNISLWNI LRNNIGKDLS KVAMPVELNE PLNTLQRLCE ELEYSELLDK 550 560 570 580 590 600 AAQIPSPLER MVYVAAFAIS AYASSYYRAG SKPFNPVLGE TYECIREDKG FQFFSEQVSH 610 620 630 640 650 660 HPPISACHAE SRNFVFWQDV RWKNKFWGKS MEIVPIGTTH VTLPVFGDHF EWNKVTSCIH 670 680 690 700 710 720 NILSGQRWIE HYGEIVIKNL HDDSCYCKVN FIKAKYWSTN AHEIEGTVFD RSGKAVHRLF 730 740 750 760 770 780 GKWHESIYCG GGSSSACVWR ANPMPKGYEQ YYSFTQFALE LNEMDPSSKS LLPPTDTRFR 790 800 810 820 830 840 PDQRFLEEGN LEEAEIQKQR IEQLQRERRR VLEENHVEHQ PRFFRKSDDD SWVSNGTYLE 850 LRKDLGFSKL DHPVLW
	Isoform 1c [UniParc]. Checksum: DA08C319F2BAEDCE	FASTA	851	97,325
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 310 320 330 340 350 360 LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 370 380 390 400 410 420 LKQLMEQDAS SSPSAQVIGL KNALSSENSR DENRALVHQL SNESRLSITD SLSEFFDAQE 430 440 450 460 470 480 VLLSPSSSEN EISDDDSYVS DISDNLSLDN LSNDLDNERQ TLGPVLDSGR EAKSRRRTCL 490 500 510 520 530 540 PAPCPSSSNI SLWNILRNNI GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAQIP 550 560 570 580 590 600 SPLERMVYVA AFAISAYASS YYRAGSKPFN PVLGETYECI REDKGFQFFS EQVSHHPPIS 610 620 630 640 650 660 ACHAESRNFV FWQDVRWKNK FWGKSMEIVP IGTTHVTLPV FGDHFEWNKV TSCIHNILSG 670 680 690 700 710 720 QRWIEHYGEI VIKNLHDDSC YCKVNFIKAK YWSTNAHEIE GTVFDRSGKA VHRLFGKWHE 730 740 750 760 770 780 SIYCGGGSSS ACVWRANPMP KGYEQYYSFT QFALELNEMD PSSKSLLPPT DTRFRPDQRF 790 800 810 820 830 840 LEEGNLEEAE IQKQRIEQLQ RERRRVLEEN HVEHQPRFFR KSDDDSWVSN GTYLELRKDL 850 GFSKLDHPVL W
	Isoform 1d [UniParc]. Checksum: 3D0A8947F6EE4DC5	FASTA	820	93,788
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 310 320 330 340 350 360 MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK NALSSENSRD 370 380 390 400 410 420 ENRALVHQLS NESRLSITDS LSEFFDAQEV LLSPSSSENE ISDDDSYVSD ISDNLSLDNL 430 440 450 460 470 480 SNDLDNERQT LGPVLDSGRE AKSRRRTCLP APCPSSSNIS LWNILRNNIG KDLSKVAMPV 490 500 510 520 530 540 ELNEPLNTLQ RLCEELEYSE LLDKAAQIPS PLERMVYVAA FAISAYASSY YRAGSKPFNP 550 560 570 580 590 600 VLGETYECIR EDKGFQFFSE QVSHHPPISA CHAESRNFVF WQDVRWKNKF WGKSMEIVPI 610 620 630 640 650 660 GTTHVTLPVF GDHFEWNKVT SCIHNILSGQ RWIEHYGEIV IKNLHDDSCY CKVNFIKAKY 670 680 690 700 710 720 WSTNAHEIEG TVFDRSGKAV HRLFGKWHES IYCGGGSSSA CVWRANPMPK GYEQYYSFTQ 730 740 750 760 770 780 FALELNEMDP SSKSLLPPTD TRFRPDQRFL EEGNLEEAEI QKQRIEQLQR ERRRVLEENH 790 800 810 820 VEHQPRFFRK SDDDSWVSNG TYLELRKDLG FSKLDHPVLW
	Isoform 2a [UniParc]. Checksum: 7AC19EA7AE07E5E4	FASTA	642	72,211
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 310 320 330 340 350 360 LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 370 380 390 400 410 420 LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR IHAESLLLDS PAVAKSGDNL 430 440 450 460 470 480 AEENSRDENR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISD DDSYVSDISD 490 500 510 520 530 540 NLSLDNLSND LDNERQTLGP VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL 550 560 570 580 590 600 SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVRSQPSLA TVQPRSPSHE 610 620 630 640 AIHGAHQRDS PCSLRFHFDC SVNRFITQSC LASSAWLFPV TL
	Isoform 2b [UniParc]. Checksum: 1A92347357A219CE	FASTA	611	68,674
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 310 320 330 340 350 360 MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK NALSSALAQN 370 380 390 400 410 420 TDLKERLRRI HAESLLLDSP AVAKSGDNLA EENSRDENRA LVHQLSNESR LSITDSLSEF 430 440 450 460 470 480 FDAQEVLLSP SSSENEISDD DSYVSDISDN LSLDNLSNDL DNERQTLGPV LDSGREAKSR 490 500 510 520 530 540 RRTCLPAPCP SSSNISLWNI LRNNIGKDLS KVAMPVELNE PLNTLQRLCE ELEYSELLDK 550 560 570 580 590 600 AAQIPSPLER MVRSQPSLAT VQPRSPSHEA IHGAHQRDSP CSLRFHFDCS VNRFITQSCL 610 ASSAWLFPVT L
	Isoform 2c [UniParc]. Checksum: EA72B4600CF3C1B8	FASTA	606	68,313
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 310 320 330 340 350 360 LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 370 380 390 400 410 420 LKQLMEQDAS SSPSAQVIGL KNALSSENSR DENRALVHQL SNESRLSITD SLSEFFDAQE 430 440 450 460 470 480 VLLSPSSSEN EISDDDSYVS DISDNLSLDN LSNDLDNERQ TLGPVLDSGR EAKSRRRTCL 490 500 510 520 530 540 PAPCPSSSNI SLWNILRNNI GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAQIP 550 560 570 580 590 600 SPLERMVRSQ PSLATVQPRS PSHEAIHGAH QRDSPCSLRF HFDCSVNRFI TQSCLASSAW LFPVTL
	Isoform 2d [UniParc]. Checksum: CD8F92033643E963	FASTA	575	64,776
	10 20 30 40 50 60 MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 70 80 90 100 110 120 KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 130 140 150 160 170 180 EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 190 200 210 220 230 240 SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 250 260 270 280 290 300 QSMDVLHRTY SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 310 320 330 340 350 360 MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK NALSSENSRD 370 380 390 400 410 420 ENRALVHQLS NESRLSITDS LSEFFDAQEV LLSPSSSENE ISDDDSYVSD ISDNLSLDNL 430 440 450 460 470 480 SNDLDNERQT LGPVLDSGRE AKSRRRTCLP APCPSSSNIS LWNILRNNIG KDLSKVAMPV 490 500 510 520 530 540 ELNEPLNTLQ RLCEELEYSE LLDKAAQIPS PLERMVRSQP SLATVQPRSP SHEAIHGAHQ 550 560 570 RDSPCSLRFH FDCSVNRFIT QSCLASSAWL FPVTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells." Gregorio-King C.C., Collier G.R., McMillan J.S., Waugh C.M., McLeod J.L., Collier F.M., Kirkland M.A. Blood 98:2279-2281(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
[2]	"A family of 12 human genes containing oxysterol-binding domains." Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R. Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
[3]	"ORP3 splice variants and their expression in human tissues and hematopoietic cells." Collier F.M., Gregorio-King C.C., Apostolopoulos J., Walder K., Kirkland M.A. DNA Cell Biol. 22:1-9(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 1D; 2A; 2B; 2C AND 2D).
[4]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A). Tissue: Brain.
[5]	Ohara O., Suyama M., Nagase T., Ishikawa K. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A). Tissue: Uterus.
[10]	"The OSBP-related protein family in humans." Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M. J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-245 (ISOFORM 1A).
[11]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410 AND SER-437, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-251; SER-304; SER-372 AND SER-410, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-410 AND SER-437, MASS SPECTROMETRY.
[15]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[16]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304; SER-372 AND SER-410, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY008372 mRNA. Translation: AAG23400.1. AF392444 mRNA. Translation: AAL40657.1. AF491781 mRNA. Translation: AAM27386.1. AF491782 mRNA. Translation: AAM27387.1. AF491783 mRNA. Translation: AAM27388.1. AF491784 mRNA. Translation: AAM27389.1. AF491785 mRNA. Translation: AAM27390.1. AF491786 mRNA. Translation: AAM27391.1. AF515639 mRNA. Translation: AAM74165.1. AF515640 mRNA. Translation: AAM74166.1. AB014604 mRNA. Translation: BAA31679.2. Different initiation. AC003093 Genomic DNA. Translation: AAB83939.1. AC004008 Genomic DNA. No translation available. AC004016 Genomic DNA. Translation: AAC26986.2. AC004239 Genomic DNA. No translation available. CH236948 Genomic DNA. Translation: EAL24240.1. CH236948 Genomic DNA. Translation: EAL24241.1. CH236948 Genomic DNA. Translation: EAL24242.1. CH236948 Genomic DNA. Translation: EAL24243.1. CH236948 Genomic DNA. Translation: EAL24244.1. CH236948 Genomic DNA. Translation: EAL24245.1. CH471073 Genomic DNA. Translation: EAW93816.1. CH471073 Genomic DNA. Translation: EAW93817.1. CH471073 Genomic DNA. Translation: EAW93818.1. CH471073 Genomic DNA. Translation: EAW93819.1. CH471073 Genomic DNA. Translation: EAW93820.1. CH471073 Genomic DNA. Translation: EAW93821.1. BC017731 mRNA. Translation: AAH17731.1. AF323727 mRNA. Translation: AAG53408.1.
IPI	IPI00023555. IPI00162669. IPI00162670. IPI00167053. IPI00169296. IPI00169299. IPI00375694. IPI00375695.
RefSeq	NP_056365.1. NM_015550.2. NP_663160.1. NM_145320.1. NP_663161.1. NM_145321.1. NP_663162.1. NM_145322.1.
UniGene	Hs.520259.
3D structure databases
ProteinModelPortal	Q9H4L5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H4L5. 3 interactions.
MINT	MINT-1631853.
PTM databases
PhosphoSite	Q9H4L5.
Polymorphism databases
DMDM	20139176.
Proteomic databases
PaxDb	Q9H4L5.
PRIDE	Q9H4L5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313367; ENSP00000315410; ENSG00000070882. ENST00000352860; ENSP00000315331; ENSG00000070882. ENST00000353930; ENSP00000315277; ENSG00000070882. ENST00000396429; ENSP00000379706; ENSG00000070882. ENST00000396431; ENSP00000379708; ENSG00000070882. ENST00000409069; ENSP00000386953; ENSG00000070882. ENST00000409452; ENSP00000386801; ENSG00000070882. ENST00000409555; ENSP00000386990; ENSG00000070882. ENST00000409759; ENSP00000386325; ENSG00000070882. ENST00000409863; ENSP00000386429; ENSG00000070882. ENST00000431825; ENSP00000389779; ENSG00000070882.
GeneID	26031.
KEGG	hsa:26031.
UCSC	uc003sxf.3. human. uc003sxg.3. human. uc003sxh.3. human. uc003sxi.3. human. uc003sxj.1. human. uc003sxk.1. human.
Organism-specific databases
CTD	26031.
GeneCards	GC07M024804.
HGNC	HGNC:16370. OSBPL3.
HPA	HPA000691.
MIM	606732. gene.
neXtProt	NX_Q9H4L5.
PharmGKB	PA32828.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281324.
HOVERGEN	HBG058934.
InParanoid	Q9H4L5.
OMA	PLERMVY.
OrthoDB	EOG4XPQFD.
PhylomeDB	Q9H4L5.
Gene expression databases
ArrayExpress	Q9H4L5.
Bgee	Q9H4L5.
Genevestigator	Q9H4L5.
GermOnline	ENSG00000070882. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000648. Oxysterol-bd. IPR018494. Oxysterol-bd_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR10972. PTHR10972. 1 hit.
Pfam	PF01237. Oxysterol_BP. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS01013. OSBP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OSBPL3. human.
GenomeRNAi	26031.
NextBio	47824.
SOURCE	Search...

Entry information

Entry name

OSBL3_HUMAN

Accession

Primary (citable) accession number: Q9H4L5
Secondary accession number(s): A4D167 , A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.