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Q9H4L5

- OSBL3_HUMAN

UniProt

Q9H4L5 - OSBL3_HUMAN

Protein

Oxysterol-binding protein-related protein 3

Gene

OSBPL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL
    2. protein binding Source: IntAct

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterol-binding protein-related protein 3
    Short name:
    ORP-3
    Short name:
    OSBP-related protein 3
    Gene namesi
    Name:OSBPL3
    Synonyms:KIAA0704, ORP3, OSBP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16370. OSBPL3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: BHF-UCL
    2. membrane Source: UniProtKB
    3. nuclear membrane Source: BHF-UCL
    4. perinuclear endoplasmic reticulum Source: BHF-UCL
    5. plasma membrane Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32828.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Oxysterol-binding protein-related protein 3PRO_0000100371Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine1 Publication
    Modified residuei34 – 341Phosphoserine1 Publication
    Modified residuei251 – 2511Phosphoserine1 Publication
    Modified residuei304 – 3041Phosphoserine3 Publications
    Modified residuei372 – 3721Phosphoserine2 Publications
    Modified residuei410 – 4101Phosphoserine4 Publications
    Modified residuei437 – 4371Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H4L5.
    PaxDbiQ9H4L5.
    PRIDEiQ9H4L5.

    PTM databases

    PhosphoSiteiQ9H4L5.

    Expressioni

    Tissue specificityi

    Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung.

    Gene expression databases

    ArrayExpressiQ9H4L5.
    BgeeiQ9H4L5.
    GenevestigatoriQ9H4L5.

    Organism-specific databases

    HPAiHPA000691.
    HPA048401.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORFQ9Q2G45EBI-1051317,EBI-6248094From a different organism.

    Protein-protein interaction databases

    BioGridi117497. 9 interactions.
    IntActiQ9H4L5. 5 interactions.
    MINTiMINT-1631853.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4L5.
    SMRiQ9H4L5. Positions 49-146, 519-887.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 14696PHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the OSBP family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG281324.
    HOVERGENiHBG058934.
    InParanoidiQ9H4L5.
    OMAiPLERMVY.
    OrthoDBiEOG780RKR.
    PhylomeDBiQ9H4L5.
    TreeFamiTF320922.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR10972. PTHR10972. 1 hit.
    PfamiPF01237. Oxysterol_BP. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS01013. OSBP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1a (identifier: Q9H4L5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE    50
    PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 100
    VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 150
    EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 200
    FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 250
    SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 300
    LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 350
    FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR 400
    IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE 450
    FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP 500
    VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN 550
    EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 600
    GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD 650
    VRWKNKFWGK SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI 700
    EHYGEIVIKN LHDDSCYCKV NFIKAKYWST NAHEIEGTVF DRSGKAVHRL 750
    FGKWHESIYC GGGSSSACVW RANPMPKGYE QYYSFTQFAL ELNEMDPSSK 800
    SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR RVLEENHVEH 850
    QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW 887
    Length:887
    Mass (Da):101,224
    Last modified:March 1, 2001 - v1
    Checksum:i12E16912BD3F2E99
    GO
    Isoform 1b (identifier: Q9H4L5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-289: Missing.

    Show »
    Length:856
    Mass (Da):97,687
    Checksum:i1D56185E3FB98744
    GO
    Isoform 1c (identifier: Q9H4L5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         387-422: Missing.

    Show »
    Length:851
    Mass (Da):97,325
    Checksum:iDA08C319F2BAEDCE
    GO
    Isoform 1d (identifier: Q9H4L5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-289: Missing.
         387-422: Missing.

    Show »
    Length:820
    Mass (Da):93,788
    Checksum:i3D0A8947F6EE4DC5
    GO
    Isoform 2a (identifier: Q9H4L5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
         632-887: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:642
    Mass (Da):72,211
    Checksum:i7AC19EA7AE07E5E4
    GO
    Isoform 2b (identifier: Q9H4L5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-289: Missing.
         584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
         632-887: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:611
    Mass (Da):68,674
    Checksum:i1A92347357A219CE
    GO
    Isoform 2c (identifier: Q9H4L5-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         387-422: Missing.
         584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
         632-887: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:606
    Mass (Da):68,313
    Checksum:iEA72B4600CF3C1B8
    GO
    Isoform 2d (identifier: Q9H4L5-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-289: Missing.
         387-422: Missing.
         584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
         632-887: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:575
    Mass (Da):64,776
    Checksum:iCD8F92033643E963
    GO

    Sequence cautioni

    The sequence BAA31679.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti354 – 3541M → V.
    Corresponds to variant rs11768296 [ dbSNP | Ensembl ].
    VAR_053548

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei259 – 28931Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d. 1 PublicationVSP_008219Add
    BLAST
    Alternative sequencei387 – 42236Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d. 1 PublicationVSP_008220Add
    BLAST
    Alternative sequencei584 – 63148YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationVSP_008221Add
    BLAST
    Alternative sequencei632 – 887256Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationVSP_008222Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008372 mRNA. Translation: AAG23400.1.
    AF392444 mRNA. Translation: AAL40657.1.
    AF491781 mRNA. Translation: AAM27386.1.
    AF491782 mRNA. Translation: AAM27387.1.
    AF491783 mRNA. Translation: AAM27388.1.
    AF491784 mRNA. Translation: AAM27389.1.
    AF491785 mRNA. Translation: AAM27390.1.
    AF491786 mRNA. Translation: AAM27391.1.
    AF515639 mRNA. Translation: AAM74165.1.
    AF515640 mRNA. Translation: AAM74166.1.
    AB014604 mRNA. Translation: BAA31679.2. Different initiation.
    AC003093 Genomic DNA. Translation: AAB83939.1.
    AC004008 Genomic DNA. No translation available.
    AC004016 Genomic DNA. Translation: AAC26986.2.
    AC004239 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24240.1.
    CH236948 Genomic DNA. Translation: EAL24241.1.
    CH236948 Genomic DNA. Translation: EAL24242.1.
    CH236948 Genomic DNA. Translation: EAL24243.1.
    CH236948 Genomic DNA. Translation: EAL24244.1.
    CH236948 Genomic DNA. Translation: EAL24245.1.
    CH471073 Genomic DNA. Translation: EAW93816.1.
    CH471073 Genomic DNA. Translation: EAW93817.1.
    CH471073 Genomic DNA. Translation: EAW93818.1.
    CH471073 Genomic DNA. Translation: EAW93819.1.
    CH471073 Genomic DNA. Translation: EAW93820.1.
    CH471073 Genomic DNA. Translation: EAW93821.1.
    BC017731 mRNA. Translation: AAH17731.1.
    AF323727 mRNA. Translation: AAG53408.1.
    CCDSiCCDS47564.1. [Q9H4L5-4]
    CCDS5390.1. [Q9H4L5-1]
    CCDS5391.1. [Q9H4L5-2]
    CCDS5392.1. [Q9H4L5-3]
    RefSeqiNP_056365.1. NM_015550.3. [Q9H4L5-1]
    NP_663160.1. NM_145320.2. [Q9H4L5-2]
    NP_663161.1. NM_145321.2. [Q9H4L5-3]
    NP_663162.1. NM_145322.2. [Q9H4L5-4]
    XP_005249755.1. XM_005249698.1. [Q9H4L5-1]
    XP_006715744.1. XM_006715681.1. [Q9H4L5-2]
    XP_006715745.1. XM_006715682.1. [Q9H4L5-3]
    XP_006715746.1. XM_006715683.1. [Q9H4L5-4]
    UniGeneiHs.520259.

    Genome annotation databases

    EnsembliENST00000313367; ENSP00000315410; ENSG00000070882. [Q9H4L5-1]
    ENST00000396429; ENSP00000379706; ENSG00000070882. [Q9H4L5-3]
    ENST00000396431; ENSP00000379708; ENSG00000070882. [Q9H4L5-2]
    ENST00000409069; ENSP00000386953; ENSG00000070882. [Q9H4L5-4]
    ENST00000409452; ENSP00000386801; ENSG00000070882. [Q9H4L5-5]
    ENST00000409555; ENSP00000386990; ENSG00000070882. [Q9H4L5-8]
    ENST00000409759; ENSP00000386325; ENSG00000070882. [Q9H4L5-7]
    ENST00000409863; ENSP00000386429; ENSG00000070882. [Q9H4L5-6]
    GeneIDi26031.
    KEGGihsa:26031.
    UCSCiuc003sxf.3. human. [Q9H4L5-1]
    uc003sxg.3. human. [Q9H4L5-3]
    uc003sxh.3. human. [Q9H4L5-2]
    uc003sxi.3. human. [Q9H4L5-4]
    uc003sxj.1. human. [Q9H4L5-7]
    uc003sxk.1. human. [Q9H4L5-8]

    Polymorphism databases

    DMDMi20139176.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008372 mRNA. Translation: AAG23400.1 .
    AF392444 mRNA. Translation: AAL40657.1 .
    AF491781 mRNA. Translation: AAM27386.1 .
    AF491782 mRNA. Translation: AAM27387.1 .
    AF491783 mRNA. Translation: AAM27388.1 .
    AF491784 mRNA. Translation: AAM27389.1 .
    AF491785 mRNA. Translation: AAM27390.1 .
    AF491786 mRNA. Translation: AAM27391.1 .
    AF515639 mRNA. Translation: AAM74165.1 .
    AF515640 mRNA. Translation: AAM74166.1 .
    AB014604 mRNA. Translation: BAA31679.2 . Different initiation.
    AC003093 Genomic DNA. Translation: AAB83939.1 .
    AC004008 Genomic DNA. No translation available.
    AC004016 Genomic DNA. Translation: AAC26986.2 .
    AC004239 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24240.1 .
    CH236948 Genomic DNA. Translation: EAL24241.1 .
    CH236948 Genomic DNA. Translation: EAL24242.1 .
    CH236948 Genomic DNA. Translation: EAL24243.1 .
    CH236948 Genomic DNA. Translation: EAL24244.1 .
    CH236948 Genomic DNA. Translation: EAL24245.1 .
    CH471073 Genomic DNA. Translation: EAW93816.1 .
    CH471073 Genomic DNA. Translation: EAW93817.1 .
    CH471073 Genomic DNA. Translation: EAW93818.1 .
    CH471073 Genomic DNA. Translation: EAW93819.1 .
    CH471073 Genomic DNA. Translation: EAW93820.1 .
    CH471073 Genomic DNA. Translation: EAW93821.1 .
    BC017731 mRNA. Translation: AAH17731.1 .
    AF323727 mRNA. Translation: AAG53408.1 .
    CCDSi CCDS47564.1. [Q9H4L5-4 ]
    CCDS5390.1. [Q9H4L5-1 ]
    CCDS5391.1. [Q9H4L5-2 ]
    CCDS5392.1. [Q9H4L5-3 ]
    RefSeqi NP_056365.1. NM_015550.3. [Q9H4L5-1 ]
    NP_663160.1. NM_145320.2. [Q9H4L5-2 ]
    NP_663161.1. NM_145321.2. [Q9H4L5-3 ]
    NP_663162.1. NM_145322.2. [Q9H4L5-4 ]
    XP_005249755.1. XM_005249698.1. [Q9H4L5-1 ]
    XP_006715744.1. XM_006715681.1. [Q9H4L5-2 ]
    XP_006715745.1. XM_006715682.1. [Q9H4L5-3 ]
    XP_006715746.1. XM_006715683.1. [Q9H4L5-4 ]
    UniGenei Hs.520259.

    3D structure databases

    ProteinModelPortali Q9H4L5.
    SMRi Q9H4L5. Positions 49-146, 519-887.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117497. 9 interactions.
    IntActi Q9H4L5. 5 interactions.
    MINTi MINT-1631853.

    PTM databases

    PhosphoSitei Q9H4L5.

    Polymorphism databases

    DMDMi 20139176.

    Proteomic databases

    MaxQBi Q9H4L5.
    PaxDbi Q9H4L5.
    PRIDEi Q9H4L5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313367 ; ENSP00000315410 ; ENSG00000070882 . [Q9H4L5-1 ]
    ENST00000396429 ; ENSP00000379706 ; ENSG00000070882 . [Q9H4L5-3 ]
    ENST00000396431 ; ENSP00000379708 ; ENSG00000070882 . [Q9H4L5-2 ]
    ENST00000409069 ; ENSP00000386953 ; ENSG00000070882 . [Q9H4L5-4 ]
    ENST00000409452 ; ENSP00000386801 ; ENSG00000070882 . [Q9H4L5-5 ]
    ENST00000409555 ; ENSP00000386990 ; ENSG00000070882 . [Q9H4L5-8 ]
    ENST00000409759 ; ENSP00000386325 ; ENSG00000070882 . [Q9H4L5-7 ]
    ENST00000409863 ; ENSP00000386429 ; ENSG00000070882 . [Q9H4L5-6 ]
    GeneIDi 26031.
    KEGGi hsa:26031.
    UCSCi uc003sxf.3. human. [Q9H4L5-1 ]
    uc003sxg.3. human. [Q9H4L5-3 ]
    uc003sxh.3. human. [Q9H4L5-2 ]
    uc003sxi.3. human. [Q9H4L5-4 ]
    uc003sxj.1. human. [Q9H4L5-7 ]
    uc003sxk.1. human. [Q9H4L5-8 ]

    Organism-specific databases

    CTDi 26031.
    GeneCardsi GC07M024836.
    HGNCi HGNC:16370. OSBPL3.
    HPAi HPA000691.
    HPA048401.
    MIMi 606732. gene.
    neXtProti NX_Q9H4L5.
    PharmGKBi PA32828.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281324.
    HOVERGENi HBG058934.
    InParanoidi Q9H4L5.
    OMAi PLERMVY.
    OrthoDBi EOG780RKR.
    PhylomeDBi Q9H4L5.
    TreeFami TF320922.

    Miscellaneous databases

    ChiTaRSi OSBPL3. human.
    GeneWikii OSBPL3.
    GenomeRNAii 26031.
    NextBioi 47824.
    PROi Q9H4L5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H4L5.
    Bgeei Q9H4L5.
    Genevestigatori Q9H4L5.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR10972. PTHR10972. 1 hit.
    Pfami PF01237. Oxysterol_BP. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS01013. OSBP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells."
      Gregorio-King C.C., Collier G.R., McMillan J.S., Waugh C.M., McLeod J.L., Collier F.M., Kirkland M.A.
      Blood 98:2279-2281(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
    2. "A family of 12 human genes containing oxysterol-binding domains."
      Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
      Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
    3. "ORP3 splice variants and their expression in human tissues and hematopoietic cells."
      Collier F.M., Gregorio-King C.C., Apostolopoulos J., Walder K., Kirkland M.A.
      DNA Cell Biol. 22:1-9(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 1D; 2A; 2B; 2C AND 2D).
    4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
      Tissue: Brain.
    5. Ohara O., Suyama M., Nagase T., Ishikawa K.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
      Tissue: Uterus.
    10. "The OSBP-related protein family in humans."
      Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
      J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-245 (ISOFORM 1A).
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410 AND SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-251; SER-304; SER-372 AND SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-410 AND SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304; SER-372 AND SER-410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOSBL3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4L5
    Secondary accession number(s): A4D167
    , A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3