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Protein

Oxysterol-binding protein-related protein 3

Gene

OSBPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).4 Publications

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070882-MONOMER.
ReactomeiR-HSA-192105. Synthesis of bile acids and bile salts.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 3
Short name:
ORP-3
Short name:
OSBP-related protein 3
Gene namesi
Name:OSBPL3
Synonyms:KIAA0704, ORP3, OSBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16370. OSBPL3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • filopodium tip Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nuclear membrane Source: BHF-UCL
  • perinuclear endoplasmic reticulum Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60K → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi61K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi71K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi72R → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi97G → E: Decreases plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi162 – 167FFSGST → AAAAAA: No effect on interaction with VAPA. 1 Publication6
Mutagenesisi451 – 453FFD → VVV: Reduces VAPA binding. Abolishes association with endoplasmic reticulum. 2 Publications3

Organism-specific databases

DisGeNETi26031.
OpenTargetsiENSG00000070882.
PharmGKBiPA32828.

Polymorphism and mutation databases

BioMutaiOSBPL3.
DMDMi20139176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003711 – 887Oxysterol-binding protein-related protein 3Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1 Publication1
Modified residuei304PhosphoserineCombined sources1 Publication1
Modified residuei309PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1 Publication1
Modified residuei323Phosphoserine1 Publication1
Modified residuei371Phosphoserine1 Publication1
Modified residuei372PhosphoserineCombined sources1 Publication1
Modified residuei410PhosphoserineCombined sources1 Publication1
Modified residuei425PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1 Publication1
Modified residuei440PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204). Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H4L5.
MaxQBiQ9H4L5.
PaxDbiQ9H4L5.
PeptideAtlasiQ9H4L5.
PRIDEiQ9H4L5.

PTM databases

iPTMnetiQ9H4L5.
PhosphoSitePlusiQ9H4L5.

Expressioni

Tissue specificityi

Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732).2 Publications

Developmental stagei

Expressed in several fetal tissues including kidney, thymus, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000070882.
ExpressionAtlasiQ9H4L5. baseline and differential.
GenevisibleiQ9H4L5. HS.

Organism-specific databases

HPAiHPA000691.
HPA048401.

Interactioni

Subunit structurei

Homodimer (PubMed:16143324). Interacts with RRAS (PubMed:18270267). Interacts (phosphorylated form) with VAPA (PubMed:16143324, PubMed:25447204).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G45EBI-1051317,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi117497. 31 interactors.
IntActiQ9H4L5. 33 interactors.
MINTiMINT-1631853.
STRINGi9606.ENSP00000315410.

Structurei

3D structure databases

ProteinModelPortaliQ9H4L5.
SMRiQ9H4L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 146PHPROSITE-ProRule annotationAdd BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 167FFAT 11 Publication7
Motifi450 – 454FFAT 21 Publication5

Domaini

The FFAT 2 motif is required for interaction with VAPA and regulation of the endoplasmic reticulum targeting of ORP3. The FFAT 1 motif may contribute to VAPA binding.2 Publications
The PH domain binds phosphoinositides, with a preference for PI(3,4)P2 and PI(3,4,5)P3. The PH domain mediates targeting to the plasma membrane (PubMed:18270267).2 Publications

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOVERGENiHBG058934.
InParanoidiQ9H4L5.
KOiK20463.
OMAiEIAMFPR.
OrthoDBiEOG091G0DJB.
PhylomeDBiQ9H4L5.
TreeFamiTF320922.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1a (identifier: Q9H4L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE
60 70 80 90 100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID
110 120 130 140 150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN
160 170 180 190 200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS
210 220 230 240 250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY
260 270 280 290 300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR
310 320 330 340 350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA
360 370 380 390 400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR
410 420 430 440 450
IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE
460 470 480 490 500
FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP
510 520 530 540 550
VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN
560 570 580 590 600
EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA
610 620 630 640 650
GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD
660 670 680 690 700
VRWKNKFWGK SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI
710 720 730 740 750
EHYGEIVIKN LHDDSCYCKV NFIKAKYWST NAHEIEGTVF DRSGKAVHRL
760 770 780 790 800
FGKWHESIYC GGGSSSACVW RANPMPKGYE QYYSFTQFAL ELNEMDPSSK
810 820 830 840 850
SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR RVLEENHVEH
860 870 880
QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW
Length:887
Mass (Da):101,224
Last modified:March 1, 2001 - v1
Checksum:i12E16912BD3F2E99
GO
Isoform 1b (identifier: Q9H4L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.

Show »
Length:856
Mass (Da):97,687
Checksum:i1D56185E3FB98744
GO
Isoform 1c (identifier: Q9H4L5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.

Show »
Length:851
Mass (Da):97,325
Checksum:iDA08C319F2BAEDCE
GO
Isoform 1d (identifier: Q9H4L5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.

Show »
Length:820
Mass (Da):93,788
Checksum:i3D0A8947F6EE4DC5
GO
Isoform 2a (identifier: Q9H4L5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:642
Mass (Da):72,211
Checksum:i7AC19EA7AE07E5E4
GO
Isoform 2b (identifier: Q9H4L5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:611
Mass (Da):68,674
Checksum:i1A92347357A219CE
GO
Isoform 2c (identifier: Q9H4L5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:606
Mass (Da):68,313
Checksum:iEA72B4600CF3C1B8
GO
Isoform 2d (identifier: Q9H4L5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:575
Mass (Da):64,776
Checksum:iCD8F92033643E963
GO

Sequence cautioni

The sequence BAA31679 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053548354M → V.Corresponds to variant rs11768296dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008219259 – 289Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_008220387 – 422Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_008221584 – 631YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_008222632 – 887Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST256

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008372 mRNA. Translation: AAG23400.1.
AF392444 mRNA. Translation: AAL40657.1.
AF491781 mRNA. Translation: AAM27386.1.
AF491782 mRNA. Translation: AAM27387.1.
AF491783 mRNA. Translation: AAM27388.1.
AF491784 mRNA. Translation: AAM27389.1.
AF491785 mRNA. Translation: AAM27390.1.
AF491786 mRNA. Translation: AAM27391.1.
AF515639 mRNA. Translation: AAM74165.1.
AF515640 mRNA. Translation: AAM74166.1.
AB014604 mRNA. Translation: BAA31679.2. Different initiation.
AC003093 Genomic DNA. Translation: AAB83939.1.
AC004008 Genomic DNA. No translation available.
AC004016 Genomic DNA. Translation: AAC26986.2.
AC004239 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24240.1.
CH236948 Genomic DNA. Translation: EAL24241.1.
CH236948 Genomic DNA. Translation: EAL24242.1.
CH236948 Genomic DNA. Translation: EAL24243.1.
CH236948 Genomic DNA. Translation: EAL24244.1.
CH236948 Genomic DNA. Translation: EAL24245.1.
CH471073 Genomic DNA. Translation: EAW93816.1.
CH471073 Genomic DNA. Translation: EAW93817.1.
CH471073 Genomic DNA. Translation: EAW93818.1.
CH471073 Genomic DNA. Translation: EAW93819.1.
CH471073 Genomic DNA. Translation: EAW93820.1.
CH471073 Genomic DNA. Translation: EAW93821.1.
BC017731 mRNA. Translation: AAH17731.1.
AF323727 mRNA. Translation: AAG53408.1.
CCDSiCCDS47564.1. [Q9H4L5-4]
CCDS5390.1. [Q9H4L5-1]
CCDS5391.1. [Q9H4L5-2]
CCDS5392.1. [Q9H4L5-3]
RefSeqiNP_056365.1. NM_015550.3. [Q9H4L5-1]
NP_663160.1. NM_145320.2. [Q9H4L5-2]
NP_663161.1. NM_145321.2. [Q9H4L5-3]
NP_663162.1. NM_145322.2. [Q9H4L5-4]
XP_005249755.1. XM_005249698.3. [Q9H4L5-1]
XP_006715744.1. XM_006715681.3. [Q9H4L5-2]
XP_006715745.1. XM_006715682.3. [Q9H4L5-3]
XP_006715746.1. XM_006715683.3. [Q9H4L5-4]
XP_011513560.1. XM_011515258.2. [Q9H4L5-1]
UniGeneiHs.520259.

Genome annotation databases

EnsembliENST00000313367; ENSP00000315410; ENSG00000070882. [Q9H4L5-1]
ENST00000396429; ENSP00000379706; ENSG00000070882. [Q9H4L5-3]
ENST00000396431; ENSP00000379708; ENSG00000070882. [Q9H4L5-2]
ENST00000409069; ENSP00000386953; ENSG00000070882. [Q9H4L5-4]
ENST00000409452; ENSP00000386801; ENSG00000070882. [Q9H4L5-5]
ENST00000409555; ENSP00000386990; ENSG00000070882. [Q9H4L5-8]
ENST00000409759; ENSP00000386325; ENSG00000070882. [Q9H4L5-7]
ENST00000409863; ENSP00000386429; ENSG00000070882. [Q9H4L5-6]
GeneIDi26031.
KEGGihsa:26031.
UCSCiuc003sxf.5. human. [Q9H4L5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008372 mRNA. Translation: AAG23400.1.
AF392444 mRNA. Translation: AAL40657.1.
AF491781 mRNA. Translation: AAM27386.1.
AF491782 mRNA. Translation: AAM27387.1.
AF491783 mRNA. Translation: AAM27388.1.
AF491784 mRNA. Translation: AAM27389.1.
AF491785 mRNA. Translation: AAM27390.1.
AF491786 mRNA. Translation: AAM27391.1.
AF515639 mRNA. Translation: AAM74165.1.
AF515640 mRNA. Translation: AAM74166.1.
AB014604 mRNA. Translation: BAA31679.2. Different initiation.
AC003093 Genomic DNA. Translation: AAB83939.1.
AC004008 Genomic DNA. No translation available.
AC004016 Genomic DNA. Translation: AAC26986.2.
AC004239 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24240.1.
CH236948 Genomic DNA. Translation: EAL24241.1.
CH236948 Genomic DNA. Translation: EAL24242.1.
CH236948 Genomic DNA. Translation: EAL24243.1.
CH236948 Genomic DNA. Translation: EAL24244.1.
CH236948 Genomic DNA. Translation: EAL24245.1.
CH471073 Genomic DNA. Translation: EAW93816.1.
CH471073 Genomic DNA. Translation: EAW93817.1.
CH471073 Genomic DNA. Translation: EAW93818.1.
CH471073 Genomic DNA. Translation: EAW93819.1.
CH471073 Genomic DNA. Translation: EAW93820.1.
CH471073 Genomic DNA. Translation: EAW93821.1.
BC017731 mRNA. Translation: AAH17731.1.
AF323727 mRNA. Translation: AAG53408.1.
CCDSiCCDS47564.1. [Q9H4L5-4]
CCDS5390.1. [Q9H4L5-1]
CCDS5391.1. [Q9H4L5-2]
CCDS5392.1. [Q9H4L5-3]
RefSeqiNP_056365.1. NM_015550.3. [Q9H4L5-1]
NP_663160.1. NM_145320.2. [Q9H4L5-2]
NP_663161.1. NM_145321.2. [Q9H4L5-3]
NP_663162.1. NM_145322.2. [Q9H4L5-4]
XP_005249755.1. XM_005249698.3. [Q9H4L5-1]
XP_006715744.1. XM_006715681.3. [Q9H4L5-2]
XP_006715745.1. XM_006715682.3. [Q9H4L5-3]
XP_006715746.1. XM_006715683.3. [Q9H4L5-4]
XP_011513560.1. XM_011515258.2. [Q9H4L5-1]
UniGeneiHs.520259.

3D structure databases

ProteinModelPortaliQ9H4L5.
SMRiQ9H4L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117497. 31 interactors.
IntActiQ9H4L5. 33 interactors.
MINTiMINT-1631853.
STRINGi9606.ENSP00000315410.

PTM databases

iPTMnetiQ9H4L5.
PhosphoSitePlusiQ9H4L5.

Polymorphism and mutation databases

BioMutaiOSBPL3.
DMDMi20139176.

Proteomic databases

EPDiQ9H4L5.
MaxQBiQ9H4L5.
PaxDbiQ9H4L5.
PeptideAtlasiQ9H4L5.
PRIDEiQ9H4L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313367; ENSP00000315410; ENSG00000070882. [Q9H4L5-1]
ENST00000396429; ENSP00000379706; ENSG00000070882. [Q9H4L5-3]
ENST00000396431; ENSP00000379708; ENSG00000070882. [Q9H4L5-2]
ENST00000409069; ENSP00000386953; ENSG00000070882. [Q9H4L5-4]
ENST00000409452; ENSP00000386801; ENSG00000070882. [Q9H4L5-5]
ENST00000409555; ENSP00000386990; ENSG00000070882. [Q9H4L5-8]
ENST00000409759; ENSP00000386325; ENSG00000070882. [Q9H4L5-7]
ENST00000409863; ENSP00000386429; ENSG00000070882. [Q9H4L5-6]
GeneIDi26031.
KEGGihsa:26031.
UCSCiuc003sxf.5. human. [Q9H4L5-1]

Organism-specific databases

CTDi26031.
DisGeNETi26031.
GeneCardsiOSBPL3.
HGNCiHGNC:16370. OSBPL3.
HPAiHPA000691.
HPA048401.
MIMi606732. gene.
neXtProtiNX_Q9H4L5.
OpenTargetsiENSG00000070882.
PharmGKBiPA32828.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOVERGENiHBG058934.
InParanoidiQ9H4L5.
KOiK20463.
OMAiEIAMFPR.
OrthoDBiEOG091G0DJB.
PhylomeDBiQ9H4L5.
TreeFamiTF320922.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070882-MONOMER.
ReactomeiR-HSA-192105. Synthesis of bile acids and bile salts.

Miscellaneous databases

ChiTaRSiOSBPL3. human.
GeneWikiiOSBPL3.
GenomeRNAii26031.
PROiQ9H4L5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070882.
ExpressionAtlasiQ9H4L5. baseline and differential.
GenevisibleiQ9H4L5. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4L5
Secondary accession number(s): A4D167
, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.