ID   Q9H4L3_HUMAN            Unreviewed;        56 AA.
AC   Q9H4L3;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Breast and ovarian cancer susceptibility protein 2 {ECO:0000313|EMBL:ABJ90481.1};
DE   SubName: Full=Breast cancer 2 tumor suppressor {ECO:0000313|EMBL:AAG32681.1};
DE   Flags: Fragment;
GN   Name=BRCA2 {ECO:0000313|EMBL:AAG32681.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG32681.1};
RN   [1] {ECO:0000313|EMBL:AAG32681.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12100744; DOI=10.1186/bcr443;
RA   Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A.,
RA   Hornby D.P., Dalton A.;
RT   "Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-
RT   onset breast cancer.";
RL   Breast Cancer Res. 4:R6-R6(2002).
RN   [2] {ECO:0000313|EMBL:ABJ90481.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J.;
RT   "A novel BRCA2 mutation in a Chinese family.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY008850; AAG32681.1; -; Genomic_DNA.
DR   EMBL; DQ889340; ABJ90481.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9H4L3; -.
DR   PeptideAtlas; Q9H4L3; -.
DR   ChiTaRS; BRCA2; human.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
PE   4: Predicted;
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172}.
FT   DOMAIN          1..56
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAG32681.1"
FT   NON_TER         56
FT                   /evidence="ECO:0000313|EMBL:AAG32681.1"
SQ   SEQUENCE   56 AA;  6668 MW;  72A1D919AC358716 CRC64;
     ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV LLQLKY
//