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Q9H4L3

- Q9H4L3_HUMAN

UniProt

Q9H4L3 - Q9H4L3_HUMAN

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Protein
Submitted name:

Breast and ovarian cancer susceptibility protein 2

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell aging Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  5. double-strand break repair via homologous recombination Source: Ensembl
  6. female gonad development Source: Ensembl
  7. hemopoiesis Source: Ensembl
  8. inner cell mass cell proliferation Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. male meiosis I Source: Ensembl
  11. oocyte maturation Source: Ensembl
  12. positive regulation of mitotic cell cycle Source: Ensembl
  13. regulation of cytokinesis Source: Ensembl
  14. replication fork protection Source: Ensembl
  15. response to gamma radiation Source: Ensembl
  16. response to UV-C Source: Ensembl
  17. response to X-ray Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility protein 2Imported
Submitted name:
Breast cancer 2 tumor suppressorImported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9H4L3.
ExpressionAtlasiQ9H4L3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ9H4L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
[Graphical view]
SUPFAMiSSF81872. SSF81872. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9H4L3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV

LLQLKY
Length:56
Mass (Da):6,668
Last modified:March 1, 2001 - v1
Checksum:i72A1D919AC358716
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei56 – 561Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008850 Genomic DNA. Translation: AAG32681.1.
DQ889340 Genomic DNA. Translation: ABJ90481.1.
UniGeneiHs.34012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY008850 Genomic DNA. Translation: AAG32681.1 .
DQ889340 Genomic DNA. Translation: ABJ90481.1 .
UniGenei Hs.34012.

3D structure databases

ProteinModelPortali Q9H4L3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q9H4L3.
ExpressionAtlasi Q9H4L3. baseline and differential.

Family and domain databases

InterProi IPR015525. BRCA2.
IPR015252. BRCA2_hlx.
[Graphical view ]
PANTHERi PTHR11289. PTHR11289. 1 hit.
Pfami PF09169. BRCA-2_helical. 1 hit.
[Graphical view ]
SUPFAMi SSF81872. SSF81872. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer."
    Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A., Hornby D.P., Dalton A.
    Breast Cancer Res. 4:R6-R6(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A novel BRCA2 mutation in a Chinese family."
    Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9H4L3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4L3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.