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Q9H4L3

- Q9H4L3_HUMAN

UniProt

Q9H4L3 - Q9H4L3_HUMAN

Protein
Submitted name:

Breast and ovarian cancer susceptibility protein 2

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell aging Source: Ensembl
    3. chromosome organization Source: Ensembl
    4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
    5. double-strand break repair via homologous recombination Source: Ensembl
    6. female gonad development Source: Ensembl
    7. hemopoiesis Source: Ensembl
    8. inner cell mass cell proliferation Source: Ensembl
    9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    10. male meiosis I Source: Ensembl
    11. oocyte maturation Source: Ensembl
    12. positive regulation of mitotic cell cycle Source: Ensembl
    13. regulation of cytokinesis Source: Ensembl
    14. replication fork protection Source: Ensembl
    15. response to gamma radiation Source: Ensembl
    16. response to UV-C Source: Ensembl
    17. response to X-ray Source: Ensembl
    18. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Breast and ovarian cancer susceptibility protein 2Imported
    Submitted name:
    Breast cancer 2 tumor suppressorImported
    Gene namesi
    Name:BRCA2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H4L3.
    BgeeiQ9H4L3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4L3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR015525. BRCA2.
    IPR015252. BRCA2_hlx.
    [Graphical view]
    PANTHERiPTHR11289. PTHR11289. 1 hit.
    PfamiPF09169. BRCA-2_helical. 1 hit.
    [Graphical view]
    SUPFAMiSSF81872. SSF81872. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q9H4L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV   50
    LLQLKY 56
    Length:56
    Mass (Da):6,668
    Last modified:March 1, 2001 - v1
    Checksum:i72A1D919AC358716
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei56 – 561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008850 Genomic DNA. Translation: AAG32681.1.
    DQ889340 Genomic DNA. Translation: ABJ90481.1.
    UniGeneiHs.34012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY008850 Genomic DNA. Translation: AAG32681.1 .
    DQ889340 Genomic DNA. Translation: ABJ90481.1 .
    UniGenei Hs.34012.

    3D structure databases

    ProteinModelPortali Q9H4L3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q9H4L3.
    Bgeei Q9H4L3.

    Family and domain databases

    InterProi IPR015525. BRCA2.
    IPR015252. BRCA2_hlx.
    [Graphical view ]
    PANTHERi PTHR11289. PTHR11289. 1 hit.
    Pfami PF09169. BRCA-2_helical. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81872. SSF81872. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer."
      Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A., Hornby D.P., Dalton A.
      Breast Cancer Res. 4:R6-R6(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "A novel BRCA2 mutation in a Chinese family."
      Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9H4L3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4L3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.