Q9H4L3 (Q9H4L3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Breast and ovarian cancer susceptibility protein 2 EMBL ABJ90481.1

Submitted name:
Breast cancer 2 tumor suppressor EMBL AAG32681.1

Gene names

Name:

BRCA2 EMBL AAG32681.1

Organism

Homo sapiens (Human) EMBL AAG32681.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	56 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Inferred from electronic annotation. Source: Compara brain development Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara chromosome organization Inferred from electronic annotation. Source: Compara double-strand break repair via homologous recombination Inferred from electronic annotation. Source: Compara female gonad development Inferred from electronic annotation. Source: Compara hemopoiesis Inferred from electronic annotation. Source: Compara inner cell mass cell proliferation Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Inferred from electronic annotation. Source: Compara male meiosis I Inferred from electronic annotation. Source: Compara oocyte maturation Inferred from electronic annotation. Source: Compara positive regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara regulation of S phase of mitotic cell cycle Inferred from electronic annotation. Source: InterPro regulation of cytokinesis Inferred from electronic annotation. Source: Compara replication fork protection Inferred from electronic annotation. Source: Compara response to UV-C Inferred from electronic annotation. Source: Compara response to X-ray Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	single-stranded DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAG32681.1
	Non-terminal residue	56	1	EMBL AAG32681.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H4L3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 72A1D919AC358716	FASTA	56	6,668
	10 20 30 40 50 ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV LLQLKY

References

[1]	"Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer." Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A., Hornby D.P., Dalton A. Breast Cancer Res. 4:R6-R6(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"A novel BRCA2 mutation in a Chinese family." Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY008850 Genomic DNA. Translation: AAG32681.1. DQ889340 Genomic DNA. Translation: ABJ90481.1.
IPI	IPI00412408.
UniGene	Hs.34012.
3D structure databases
HSSP	HSSP built from PDB template 1MIU based on UniProtKB P97929.
ProteinModelPortal	Q9H4L3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H4L3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q9H4L3.
Bgee	Q9H4L3.
Family and domain databases
InterPro	IPR015525. BRCA2. IPR015252. DNA_recomb/repair_BRCA2_hlx. [Graphical view]
PANTHER	PTHR11289. PTHR11289. 1 hit.
Pfam	PF09169. BRCA-2_helical. 1 hit. [Graphical view]
SUPFAM	SSF81872. BRCA2_helical. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q9H4L3_HUMAN

Accession

Primary (citable) accession number: Q9H4L3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.