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Q9H4L3 (Q9H4L3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Breast cancer 2 tumor suppressor EMBL AAG32681.1
Gene names
Name:BRCA2 EMBL AAG32681.1
OrganismHomo sapiens (Human) EMBL AAG32681.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length56 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

cell aging

Inferred from electronic annotation. Source: Ensembl

chromosome organization

Inferred from electronic annotation. Source: Ensembl

double-strand break repair via homologous recombination

Inferred from electronic annotation. Source: Ensembl

female gonad development

Inferred from electronic annotation. Source: Ensembl

hemopoiesis

Inferred from electronic annotation. Source: Ensembl

inner cell mass cell proliferation

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

male meiosis I

Inferred from electronic annotation. Source: Ensembl

oocyte maturation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

regulation of cytokinesis

Inferred from electronic annotation. Source: Ensembl

replication fork protection

Inferred from electronic annotation. Source: Ensembl

response to UV-C

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionsingle-stranded DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAG32681.1
Non-terminal residue561 EMBL AAG32681.1

Sequences

Sequence LengthMass (Da)Tools
Q9H4L3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 72A1D919AC358716

FASTA566,668
        10         20         30         40         50 
ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV LLQLKY 

« Hide

References

[1]"Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer."
Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A., Hornby D.P., Dalton A.
Breast Cancer Res. 4:R6-R6(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"A novel BRCA2 mutation in a Chinese family."
Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY008850 Genomic DNA. Translation: AAG32681.1.
DQ889340 Genomic DNA. Translation: ABJ90481.1.
UniGeneHs.34012.

3D structure databases

ProteinModelPortalQ9H4L3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ9H4L3.
BgeeQ9H4L3.

Family and domain databases

InterProIPR015525. BRCA2.
IPR015252. DNA_recomb/repair_BRCA2_hlx.
[Graphical view]
PANTHERPTHR11289. PTHR11289. 1 hit.
PfamPF09169. BRCA-2_helical. 1 hit.
[Graphical view]
SUPFAMSSF81872. SSF81872. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9H4L3_HUMAN
AccessionPrimary (citable) accession number: Q9H4L3
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.