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Protein
Submitted name:

Breast and ovarian cancer susceptibility protein 2

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility protein 2Imported
Submitted name:
Breast cancer 2 tumor suppressorImported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

BgeeiQ9H4L3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369497.

Structurei

3D structure databases

ProteinModelPortaliQ9H4L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
[Graphical view]
SUPFAMiSSF81872. SSF81872. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9H4L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALCDTPGVDP KLISRIWVYN HYRWIIWKLA AMECAFPKEF ANRCLSPERV

LLQLKY
Length:56
Mass (Da):6,668
Last modified:March 1, 2001 - v1
Checksum:i72A1D919AC358716
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei56 – 561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008850 Genomic DNA. Translation: AAG32681.1.
DQ889340 Genomic DNA. Translation: ABJ90481.1.
UniGeneiHs.34012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008850 Genomic DNA. Translation: AAG32681.1.
DQ889340 Genomic DNA. Translation: ABJ90481.1.
UniGeneiHs.34012.

3D structure databases

ProteinModelPortaliQ9H4L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ9H4L3.

Family and domain databases

InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
[Graphical view]
SUPFAMiSSF81872. SSF81872. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer."
    Yassaee V.R., Zeinali S., Harirchi I., Jarvandi S., Mohagheghi M.A., Hornby D.P., Dalton A.
    Breast Cancer Res. 4:R6-R6(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A novel BRCA2 mutation in a Chinese family."
    Kwong A., Wong C.L., Chan K.Y., Khoo U.S., Ma E.S., Ford J.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9H4L3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4L3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.