ID MTG2_HUMAN Reviewed; 406 AA. AC Q9H4K7; A6NDR3; B4DR85; Q96I17; Q9NVG9; Q9UFR4; DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 170. DE RecName: Full=Mitochondrial ribosome-associated GTPase 2; DE AltName: Full=GTP-binding protein 5; DE AltName: Full=Protein obg homolog 1; DE Short=ObgH1; GN Name=MTG2; Synonyms=GTPBP5, OBGH1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain, and Small intestine; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-406 (ISOFORM 1/2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [6] RP FUNCTION, SUBCELLULAR LOCATION, AND REGION. RX PubMed=17054726; DOI=10.1111/j.1365-2443.2006.01017.x; RA Hirano Y., Ohniwa R.L., Wada C., Yoshimura S.H., Takeyasu K.; RT "Human small G proteins, ObgH1, and ObgH2, participate in the maintenance RT of mitochondria and nucleolar architectures."; RL Genes Cells 11:1295-1304(2006). RN [7] RP FUNCTION, ASSOCIATION WITH MITOCHONDRIAL RIBOSOME LARGE SUBUNIT, AND RP SUBCELLULAR LOCATION. RX PubMed=23396448; DOI=10.1093/nar/gkt079; RA Kotani T., Akabane S., Takeyasu K., Ueda T., Takeuchi N.; RT "Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial RT ribosome subunit and are involved in translation and assembly of RT respiratory complexes."; RL Nucleic Acids Res. 41:3713-3722(2013). CC -!- FUNCTION: Plays a role in the regulation of the mitochondrial ribosome CC assembly and of translational activity. Displays GTPase activity. CC Involved in the ribosome maturation process. CC {ECO:0000269|PubMed:17054726, ECO:0000269|PubMed:23396448}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; CC -!- SUBUNIT: Associates with the mitochondrial ribosome large subunit; the CC association occurs in a GTP-dependent manner. CC -!- SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane; CC Peripheral membrane protein; Matrix side. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9H4K7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H4K7-2; Sequence=VSP_056672; CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase CC superfamily. OBG GTPase family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA91783.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001603; BAA91783.1; ALT_TERM; mRNA. DR EMBL; AK299147; BAG61197.1; -; mRNA. DR EMBL; AK316027; BAH14398.1; -; mRNA. DR EMBL; AK316325; BAH14696.1; -; mRNA. DR EMBL; AL078633; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471077; EAW75386.1; -; Genomic_DNA. DR EMBL; BC007885; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC036716; AAH36716.1; -; mRNA. DR EMBL; AL117498; CAB55963.1; -; mRNA. DR CCDS; CCDS13492.1; -. [Q9H4K7-1] DR PIR; T17273; T17273. DR RefSeq; NP_056481.1; NM_015666.3. [Q9H4K7-1] DR RefSeq; XP_005260450.1; XM_005260393.1. DR RefSeq; XP_011527078.1; XM_011528776.1. DR RefSeq; XP_016883295.1; XM_017027806.1. DR PDB; 7O9K; EM; 3.10 A; G=1-406. DR PDB; 7ODT; EM; 3.10 A; t=1-406. DR PDB; 7OF5; EM; 2.90 A; x=1-406. DR PDB; 7OF7; EM; 2.50 A; x=1-406. DR PDBsum; 7O9K; -. DR PDBsum; 7ODT; -. DR PDBsum; 7OF5; -. DR PDBsum; 7OF7; -. DR AlphaFoldDB; Q9H4K7; -. DR EMDB; EMD-12763; -. DR EMDB; EMD-12847; -. DR EMDB; EMD-12870; -. DR EMDB; EMD-12872; -. DR SMR; Q9H4K7; -. DR BioGRID; 117590; 283. DR IntAct; Q9H4K7; 22. DR MINT; Q9H4K7; -. DR STRING; 9606.ENSP00000359859; -. DR iPTMnet; Q9H4K7; -. DR PhosphoSitePlus; Q9H4K7; -. DR SwissPalm; Q9H4K7; -. DR BioMuta; MTG2; -. DR DMDM; 32469779; -. DR EPD; Q9H4K7; -. DR jPOST; Q9H4K7; -. DR MassIVE; Q9H4K7; -. DR MaxQB; Q9H4K7; -. DR PaxDb; 9606-ENSP00000359859; -. DR PeptideAtlas; Q9H4K7; -. DR ProteomicsDB; 4933; -. DR ProteomicsDB; 80850; -. [Q9H4K7-1] DR Pumba; Q9H4K7; -. DR Antibodypedia; 29445; 162 antibodies from 26 providers. DR DNASU; 26164; -. DR Ensembl; ENST00000370823.8; ENSP00000359859.3; ENSG00000101181.18. [Q9H4K7-1] DR GeneID; 26164; -. DR KEGG; hsa:26164; -. DR MANE-Select; ENST00000370823.8; ENSP00000359859.3; NM_015666.4; NP_056481.1. DR UCSC; uc002yce.5; human. [Q9H4K7-1] DR AGR; HGNC:16239; -. DR CTD; 26164; -. DR DisGeNET; 26164; -. DR GeneCards; MTG2; -. DR HGNC; HGNC:16239; MTG2. DR HPA; ENSG00000101181; Low tissue specificity. DR MIM; 610919; gene. DR neXtProt; NX_Q9H4K7; -. DR OpenTargets; ENSG00000101181; -. DR PharmGKB; PA29059; -. DR VEuPathDB; HostDB:ENSG00000101181; -. DR eggNOG; KOG1489; Eukaryota. DR GeneTree; ENSGT00940000157379; -. DR HOGENOM; CLU_011747_2_3_1; -. DR InParanoid; Q9H4K7; -. DR OMA; VVFDWEP; -. DR OrthoDB; 232786at2759; -. DR PhylomeDB; Q9H4K7; -. DR TreeFam; TF314774; -. DR PathwayCommons; Q9H4K7; -. DR SignaLink; Q9H4K7; -. DR BioGRID-ORCS; 26164; 354 hits in 1132 CRISPR screens. DR ChiTaRS; MTG2; human. DR GenomeRNAi; 26164; -. DR Pharos; Q9H4K7; Tbio. DR PRO; PR:Q9H4K7; -. DR Proteomes; UP000005640; Chromosome 20. DR RNAct; Q9H4K7; Protein. DR Bgee; ENSG00000101181; Expressed in cerebellar hemisphere and 157 other cell types or tissues. DR ExpressionAtlas; Q9H4K7; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB. DR GO; GO:0005759; C:mitochondrial matrix; IDA:UniProtKB. DR GO; GO:0005761; C:mitochondrial ribosome; IDA:UniProtKB. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IBA:GO_Central. DR GO; GO:0003924; F:GTPase activity; IDA:UniProtKB. DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro. DR GO; GO:0070129; P:regulation of mitochondrial translation; IMP:UniProtKB. DR GO; GO:0044065; P:regulation of respiratory system process; IMP:UniProtKB. DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. DR CDD; cd01898; Obg; 1. DR Gene3D; 2.70.210.12; GTP1/OBG domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR HAMAP; MF_01454; GTPase_Obg; 1. DR InterPro; IPR031167; G_OBG. DR InterPro; IPR006073; GTP-bd. DR InterPro; IPR014100; GTP-bd_Obg/CgtA. DR InterPro; IPR006169; GTP1_OBG_dom. DR InterPro; IPR036726; GTP1_OBG_dom_sf. DR InterPro; IPR045086; OBG_GTPase. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR NCBIfam; TIGR02729; Obg_CgtA; 1. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR11702; DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED; 1. DR PANTHER; PTHR11702:SF31; MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2; 1. DR Pfam; PF01018; GTP1_OBG; 1. DR Pfam; PF01926; MMR_HSR1; 1. DR PIRSF; PIRSF002401; GTP_bd_Obg/CgtA; 1. DR PRINTS; PR00326; GTP1OBG. DR SUPFAM; SSF82051; Obg GTP-binding protein N-terminal domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51710; G_OBG; 1. DR PROSITE; PS51883; OBG; 1. DR Genevisible; Q9H4K7; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; GTP-binding; Magnesium; Membrane; KW Metal-binding; Mitochondrion; Mitochondrion inner membrane; KW Nucleotide-binding; Reference proteome; Ribosome biogenesis; KW Translation regulation. FT CHAIN 1..406 FT /note="Mitochondrial ribosome-associated GTPase 2" FT /id="PRO_0000205429" FT DOMAIN 70..224 FT /note="Obg" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01231" FT DOMAIN 225..390 FT /note="OBG-type G" FT REGION 15..406 FT /note="Localized in the mitochondria" FT REGION 30..406 FT /note="Not localized in the mitochondria" FT BINDING 231..238 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 238 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000250" FT BINDING 256..260 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 258 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000250" FT BINDING 278..281 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 345..348 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 371..373 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT VAR_SEQ 1..228 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056672" FT VARIANT 47 FT /note="G -> S (in dbSNP:rs6062133)" FT /id="VAR_033983" FT VARIANT 93 FT /note="H -> R (in dbSNP:rs11700220)" FT /id="VAR_049299" FT VARIANT 337 FT /note="A -> V (in dbSNP:rs35693261)" FT /id="VAR_049300" SQ SEQUENCE 406 AA; 43955 MW; 08756F661F79DDBB CRC64; MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD LAKHQELPGK KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF GGPDGGDGGN GGHVILRVDQ QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY IAALGGAGGK GNRFFLANNN RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL LRAISNARPA VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP EAQANLSQLR DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG RQPLRW //