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Q9H4K7

- MTG2_HUMAN

UniProt

Q9H4K7 - MTG2_HUMAN

Protein

Mitochondrial ribosome-associated GTPase 2

Gene

MTG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.2 Publications

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi238 – 2381MagnesiumBy similarity
    Metal bindingi258 – 2581MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi231 – 2388GTPBy similarity
    Nucleotide bindingi256 – 2605GTPBy similarity
    Nucleotide bindingi278 – 2814GTPBy similarity
    Nucleotide bindingi345 – 3484GTPBy similarity
    Nucleotide bindingi371 – 3733GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. GTP catabolic process Source: UniProtKB
    2. regulation of mitochondrial translation Source: UniProtKB
    3. regulation of respiratory system process Source: UniProtKB
    4. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis, Translation regulation

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial ribosome-associated GTPase 2
    Alternative name(s):
    GTP-binding protein 5
    Protein obg homolog 1
    Short name:
    ObgH1
    Gene namesi
    Name:MTG2
    Synonyms:GTPBP5, OBGH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16239. MTG2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial matrix Source: UniProtKB
    3. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29059.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Mitochondrial ribosome-associated GTPase 2PRO_0000205429Add
    BLAST

    Proteomic databases

    MaxQBiQ9H4K7.
    PaxDbiQ9H4K7.
    PRIDEiQ9H4K7.

    PTM databases

    PhosphoSiteiQ9H4K7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H4K7.
    BgeeiQ9H4K7.
    CleanExiHS_GTPBP5.
    GenevestigatoriQ9H4K7.

    Organism-specific databases

    HPAiHPA047379.

    Interactioni

    Subunit structurei

    Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.

    Protein-protein interaction databases

    BioGridi117590. 4 interactions.
    IntActiQ9H4K7. 2 interactions.
    MINTiMINT-3067906.
    STRINGi9606.ENSP00000359859.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4K7.
    SMRiQ9H4K7. Positions 72-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini225 – 390166OBG-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 406392Localized in the mitochondriaAdd
    BLAST
    Regioni30 – 406377Not localized in the mitochondriaAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0536.
    HOGENOMiHOG000019084.
    HOVERGENiHBG051857.
    InParanoidiQ9H4K7.
    KOiK03979.
    OMAiHYEGHLQ.
    PhylomeDBiQ9H4K7.
    TreeFamiTF314774.

    Family and domain databases

    Gene3Di2.70.210.12. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01454. GTPase_Obg.
    InterProiIPR014100. GTP-bd_Obg/CgtA.
    IPR006169. GTP1_OBG_dom.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view]
    PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
    PfamiPF01018. GTP1_OBG. 1 hit.
    PF01926. MMR_HSR1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF82051. SSF82051. 1 hit.
    TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H4K7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD    50
    LAKHQELPGK KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF 100
    GGPDGGDGGN GGHVILRVDQ QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG 150
    AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY IAALGGAGGK GNRFFLANNN 200
    RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL LRAISNARPA 250
    VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI 300
    ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP 350
    EAQANLSQLR DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG 400
    RQPLRW 406
    Length:406
    Mass (Da):43,955
    Last modified:March 1, 2001 - v1
    Checksum:i08756F661F79DDBB
    GO
    Isoform 2 (identifier: Q9H4K7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-228: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:178
    Mass (Da):19,820
    Checksum:iFB5A91C4B58FB5C5
    GO

    Sequence cautioni

    The sequence BAA91783.1 differs from that shown. Reason: Erroneous termination at position 402. Translated as Gln.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471G → S.
    Corresponds to variant rs6062133 [ dbSNP | Ensembl ].
    VAR_033983
    Natural varianti93 – 931H → R.
    Corresponds to variant rs11700220 [ dbSNP | Ensembl ].
    VAR_049299
    Natural varianti337 – 3371A → V.
    Corresponds to variant rs35693261 [ dbSNP | Ensembl ].
    VAR_049300

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 228228Missing in isoform 2. 1 PublicationVSP_056672Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001603 mRNA. Translation: BAA91783.1. Different termination.
    AK299147 mRNA. Translation: BAG61197.1.
    AK316027 mRNA. Translation: BAH14398.1.
    AK316325 mRNA. Translation: BAH14696.1.
    AL078633 Genomic DNA. Translation: CAC04015.1.
    CH471077 Genomic DNA. Translation: EAW75386.1.
    BC007885 mRNA. No translation available.
    BC036716 mRNA. Translation: AAH36716.1.
    AL117498 mRNA. Translation: CAB55963.1.
    CCDSiCCDS13492.1.
    PIRiT17273.
    RefSeqiNP_056481.1. NM_015666.3.
    XP_005260450.1. XM_005260393.1.
    XP_006723838.1. XM_006723775.1.
    UniGeneiHs.340636.

    Genome annotation databases

    EnsembliENST00000370823; ENSP00000359859; ENSG00000101181.
    ENST00000536470; ENSP00000445056; ENSG00000101181.
    GeneIDi26164.
    KEGGihsa:26164.
    UCSCiuc002yce.4. human.

    Polymorphism databases

    DMDMi32469779.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001603 mRNA. Translation: BAA91783.1 . Different termination.
    AK299147 mRNA. Translation: BAG61197.1 .
    AK316027 mRNA. Translation: BAH14398.1 .
    AK316325 mRNA. Translation: BAH14696.1 .
    AL078633 Genomic DNA. Translation: CAC04015.1 .
    CH471077 Genomic DNA. Translation: EAW75386.1 .
    BC007885 mRNA. No translation available.
    BC036716 mRNA. Translation: AAH36716.1 .
    AL117498 mRNA. Translation: CAB55963.1 .
    CCDSi CCDS13492.1.
    PIRi T17273.
    RefSeqi NP_056481.1. NM_015666.3.
    XP_005260450.1. XM_005260393.1.
    XP_006723838.1. XM_006723775.1.
    UniGenei Hs.340636.

    3D structure databases

    ProteinModelPortali Q9H4K7.
    SMRi Q9H4K7. Positions 72-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117590. 4 interactions.
    IntActi Q9H4K7. 2 interactions.
    MINTi MINT-3067906.
    STRINGi 9606.ENSP00000359859.

    PTM databases

    PhosphoSitei Q9H4K7.

    Polymorphism databases

    DMDMi 32469779.

    Proteomic databases

    MaxQBi Q9H4K7.
    PaxDbi Q9H4K7.
    PRIDEi Q9H4K7.

    Protocols and materials databases

    DNASUi 26164.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370823 ; ENSP00000359859 ; ENSG00000101181 .
    ENST00000536470 ; ENSP00000445056 ; ENSG00000101181 .
    GeneIDi 26164.
    KEGGi hsa:26164.
    UCSCi uc002yce.4. human.

    Organism-specific databases

    CTDi 26164.
    GeneCardsi GC20P060759.
    HGNCi HGNC:16239. MTG2.
    HPAi HPA047379.
    MIMi 610919. gene.
    neXtProti NX_Q9H4K7.
    PharmGKBi PA29059.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0536.
    HOGENOMi HOG000019084.
    HOVERGENi HBG051857.
    InParanoidi Q9H4K7.
    KOi K03979.
    OMAi HYEGHLQ.
    PhylomeDBi Q9H4K7.
    TreeFami TF314774.

    Miscellaneous databases

    GenomeRNAii 26164.
    NextBioi 48263.
    PROi Q9H4K7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H4K7.
    Bgeei Q9H4K7.
    CleanExi HS_GTPBP5.
    Genevestigatori Q9H4K7.

    Family and domain databases

    Gene3Di 2.70.210.12. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01454. GTPase_Obg.
    InterProi IPR014100. GTP-bd_Obg/CgtA.
    IPR006169. GTP1_OBG_dom.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11702:SF3. PTHR11702:SF3. 1 hit.
    Pfami PF01018. GTP1_OBG. 1 hit.
    PF01926. MMR_HSR1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF82051. SSF82051. 1 hit.
    TIGRFAMsi TIGR02729. Obg_CgtA. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Small intestine.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-406 (ISOFORM 1/2).
      Tissue: Testis.
    6. "Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures."
      Hirano Y., Ohniwa R.L., Wada C., Yoshimura S.H., Takeyasu K.
      Genes Cells 11:1295-1304(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION.
    7. "Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes."
      Kotani T., Akabane S., Takeyasu K., Ueda T., Takeuchi N.
      Nucleic Acids Res. 41:3713-3722(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH MITOCHONDRIAL RIBOSOME LARGE SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMTG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4K7
    Secondary accession number(s): A6NDR3
    , B4DR85, Q96I17, Q9NVG9, Q9UFR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3