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Protein

Mitochondrial ribosome-associated GTPase 2

Gene

MTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.2 Publications

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi238MagnesiumBy similarity1
Metal bindingi258MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi231 – 238GTPBy similarity8
Nucleotide bindingi256 – 260GTPBy similarity5
Nucleotide bindingi278 – 281GTPBy similarity4
Nucleotide bindingi345 – 348GTPBy similarity4
Nucleotide bindingi371 – 373GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • regulation of mitochondrial translation Source: UniProtKB
  • regulation of respiratory system process Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Translation regulation

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribosome-associated GTPase 2
Alternative name(s):
GTP-binding protein 5
Protein obg homolog 1
Short name:
ObgH1
Gene namesi
Name:MTG2
Synonyms:GTPBP5, OBGH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16239. MTG2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial matrix Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101181.
PharmGKBiPA29059.

Polymorphism and mutation databases

BioMutaiMTG2.
DMDMi32469779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054291 – 406Mitochondrial ribosome-associated GTPase 2Add BLAST406

Proteomic databases

EPDiQ9H4K7.
MaxQBiQ9H4K7.
PaxDbiQ9H4K7.
PeptideAtlasiQ9H4K7.
PRIDEiQ9H4K7.

PTM databases

iPTMnetiQ9H4K7.
PhosphoSitePlusiQ9H4K7.

Expressioni

Gene expression databases

BgeeiENSG00000101181.
CleanExiHS_GTPBP5.
ExpressionAtlasiQ9H4K7. baseline and differential.
GenevisibleiQ9H4K7. HS.

Organism-specific databases

HPAiHPA047379.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.

Protein-protein interaction databases

BioGridi117590. 19 interactors.
IntActiQ9H4K7. 2 interactors.
MINTiMINT-3067906.
STRINGi9606.ENSP00000359859.

Structurei

3D structure databases

ProteinModelPortaliQ9H4K7.
SMRiQ9H4K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 390OBG-type GAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 406Localized in the mitochondriaAdd BLAST392
Regioni30 – 406Not localized in the mitochondriaAdd BLAST377

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG051857.
InParanoidiQ9H4K7.
KOiK03979.
OMAiGHWALST.
OrthoDBiEOG091G0BY6.
PhylomeDBiQ9H4K7.
TreeFamiTF314774.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD
60 70 80 90 100
LAKHQELPGK KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF
110 120 130 140 150
GGPDGGDGGN GGHVILRVDQ QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG
160 170 180 190 200
AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY IAALGGAGGK GNRFFLANNN
210 220 230 240 250
RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL LRAISNARPA
260 270 280 290 300
VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI
310 320 330 340 350
ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP
360 370 380 390 400
EAQANLSQLR DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG

RQPLRW
Length:406
Mass (Da):43,955
Last modified:March 1, 2001 - v1
Checksum:i08756F661F79DDBB
GO
Isoform 2 (identifier: Q9H4K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,820
Checksum:iFB5A91C4B58FB5C5
GO

Sequence cautioni

The sequence BAA91783 differs from that shown. Reason: Erroneous termination at position 402. Translated as Gln.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03398347G → S.Corresponds to variant rs6062133dbSNPEnsembl.1
Natural variantiVAR_04929993H → R.Corresponds to variant rs11700220dbSNPEnsembl.1
Natural variantiVAR_049300337A → V.Corresponds to variant rs35693261dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566721 – 228Missing in isoform 2. 1 PublicationAdd BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001603 mRNA. Translation: BAA91783.1. Different termination.
AK299147 mRNA. Translation: BAG61197.1.
AK316027 mRNA. Translation: BAH14398.1.
AK316325 mRNA. Translation: BAH14696.1.
AL078633 Genomic DNA. Translation: CAC04015.1.
CH471077 Genomic DNA. Translation: EAW75386.1.
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1.
AL117498 mRNA. Translation: CAB55963.1.
CCDSiCCDS13492.1. [Q9H4K7-1]
PIRiT17273.
RefSeqiNP_056481.1. NM_015666.3. [Q9H4K7-1]
XP_005260450.1. XM_005260393.1. [Q9H4K7-1]
XP_011527078.1. XM_011528776.1. [Q9H4K7-1]
XP_016883295.1. XM_017027806.1. [Q9H4K7-1]
UniGeneiHs.340636.

Genome annotation databases

EnsembliENST00000370823; ENSP00000359859; ENSG00000101181. [Q9H4K7-1]
GeneIDi26164.
KEGGihsa:26164.
UCSCiuc002yce.5. human. [Q9H4K7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001603 mRNA. Translation: BAA91783.1. Different termination.
AK299147 mRNA. Translation: BAG61197.1.
AK316027 mRNA. Translation: BAH14398.1.
AK316325 mRNA. Translation: BAH14696.1.
AL078633 Genomic DNA. Translation: CAC04015.1.
CH471077 Genomic DNA. Translation: EAW75386.1.
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1.
AL117498 mRNA. Translation: CAB55963.1.
CCDSiCCDS13492.1. [Q9H4K7-1]
PIRiT17273.
RefSeqiNP_056481.1. NM_015666.3. [Q9H4K7-1]
XP_005260450.1. XM_005260393.1. [Q9H4K7-1]
XP_011527078.1. XM_011528776.1. [Q9H4K7-1]
XP_016883295.1. XM_017027806.1. [Q9H4K7-1]
UniGeneiHs.340636.

3D structure databases

ProteinModelPortaliQ9H4K7.
SMRiQ9H4K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117590. 19 interactors.
IntActiQ9H4K7. 2 interactors.
MINTiMINT-3067906.
STRINGi9606.ENSP00000359859.

PTM databases

iPTMnetiQ9H4K7.
PhosphoSitePlusiQ9H4K7.

Polymorphism and mutation databases

BioMutaiMTG2.
DMDMi32469779.

Proteomic databases

EPDiQ9H4K7.
MaxQBiQ9H4K7.
PaxDbiQ9H4K7.
PeptideAtlasiQ9H4K7.
PRIDEiQ9H4K7.

Protocols and materials databases

DNASUi26164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370823; ENSP00000359859; ENSG00000101181. [Q9H4K7-1]
GeneIDi26164.
KEGGihsa:26164.
UCSCiuc002yce.5. human. [Q9H4K7-1]

Organism-specific databases

CTDi26164.
GeneCardsiMTG2.
HGNCiHGNC:16239. MTG2.
HPAiHPA047379.
MIMi610919. gene.
neXtProtiNX_Q9H4K7.
OpenTargetsiENSG00000101181.
PharmGKBiPA29059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG051857.
InParanoidiQ9H4K7.
KOiK03979.
OMAiGHWALST.
OrthoDBiEOG091G0BY6.
PhylomeDBiQ9H4K7.
TreeFamiTF314774.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101181-MONOMER.

Miscellaneous databases

GenomeRNAii26164.
PROiQ9H4K7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101181.
CleanExiHS_GTPBP5.
ExpressionAtlasiQ9H4K7. baseline and differential.
GenevisibleiQ9H4K7. HS.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4K7
Secondary accession number(s): A6NDR3
, B4DR85, Q96I17, Q9NVG9, Q9UFR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.