Q9H4K7 (GTPB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP-binding protein 5

Alternative name(s):
Protein obg homolog 1
Short name=ObgH1

Gene names

Name:	GTPBP5
Synonyms:	OBGH1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the ribosome maturation process. Plays a role of GTPase in vitro. When missing, mitochondria elongation and abnormal nuclear morphology are observed. Ref.5
Subcellular location	Mitochondrion Ref.5.
Sequence similarities	Belongs to the GTP1/OBG family. Contains 1 G (guanine nucleotide-binding) domain.
Sequence caution	The sequence BAA91783.1 differs from that shown. Reason: Erroneous termination at position 402. Translated as Gln.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	GTP-binding protein 5		PRO_0000205429
Regions
	Domain	236 – 346	111	G
	Nucleotide binding	231 – 238	8	GTP Potential
	Nucleotide binding	278 – 282	5	GTP Potential
	Nucleotide binding	345 – 348	4	GTP Potential
	Region	15 – 406	392	Localized in the mitochondria
	Region	30 – 406	377	Not localized in the mitochondria
Natural variations
	Natural variant	47	1	G → S. Corresponds to variant rs6062133 [ dbSNP | Ensembl ].		VAR_033983
	Natural variant	93	1	H → R. Corresponds to variant rs11700220 [ dbSNP | Ensembl ].		VAR_049299
	Natural variant	337	1	A → V. Corresponds to variant rs35693261 [ dbSNP | Ensembl ].		VAR_049300

Sequences

	Sequence		Length	Mass (Da)
	Q9H4K7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 08756F661F79DDBB	FASTA	406	43,955
	10 20 30 40 50 60 MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD LAKHQELPGK 70 80 90 100 110 120 KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF GGPDGGDGGN GGHVILRVDQ 130 140 150 160 170 180 QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY 190 200 210 220 230 240 IAALGGAGGK GNRFFLANNN RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL 250 260 270 280 290 300 LRAISNARPA VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI 310 320 330 340 350 360 ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP EAQANLSQLR 370 380 390 400 DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG RQPLRW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-406. Tissue: Testis.
[5]	"Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures." Hirano Y., Ohniwa R.L., Wada C., Yoshimura S.H., Takeyasu K. Genes Cells 11:1295-1304(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001603 mRNA. Translation: BAA91783.1. Different termination. AL078633 Genomic DNA. Translation: CAC04015.1. BC007885 mRNA. No translation available. BC036716 mRNA. Translation: AAH36716.1. AL117498 mRNA. Translation: CAB55963.1.
IPI	IPI00878209.
PIR	T17273.
RefSeq	NP_056481.1. NM_015666.3.
UniGene	Hs.340636.
3D structure databases
ProteinModelPortal	Q9H4K7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359859.
PTM databases
PhosphoSite	Q9H4K7.
Polymorphism databases
DMDM	32469779.
Proteomic databases
PaxDb	Q9H4K7.
PRIDE	Q9H4K7.
Protocols and materials databases
DNASU	26164.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370823; ENSP00000359859; ENSG00000101181.
GeneID	26164.
KEGG	hsa:26164.
UCSC	uc002yce.4. human.
Organism-specific databases
CTD	26164.
GeneCards	GC20P060758.
HGNC	HGNC:16239. GTPBP5.
HPA	HPA047379.
MIM	610919. gene.
neXtProt	NX_Q9H4K7.
PharmGKB	PA29059.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0536.
HOGENOM	HOG000019084.
HOVERGEN	HBG051857.
InParanoid	Q9H4K7.
KO	K03979.
OMA	SCVGDEY.
OrthoDB	EOG4BZN33.
PhylomeDB	Q9H4K7.
Gene expression databases
ArrayExpress	Q9H4K7.
Bgee	Q9H4K7.
CleanEx	HS_GTPBP5.
Genevestigator	Q9H4K7.
GermOnline	ENSG00000101181. Homo sapiens.
Family and domain databases
Gene3D	2.70.210.12. 1 hit.
InterPro	IPR014100. GTP-bd_Obg/CgtA. IPR006169. GTP1_OBG_dom. IPR006073. GTP_binding_domain. IPR005225. Small_GTP-bd_dom. [Graphical view]
PANTHER	PTHR11702:SF3. PTHR11702:SF3. 1 hit.
Pfam	PF01018. GTP1_OBG. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
PIRSF	PIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SUPFAM	SSF82051. GTP1_OBG_sub. 1 hit.
TIGRFAMs	TIGR02729. Obg_CgtA. 1 hit. TIGR00231. small_GTP. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	26164.
NextBio	48263.
SOURCE	Search...

Entry information

Entry name

GTPB5_HUMAN

Accession

Primary (citable) accession number: Q9H4K7
Secondary accession number(s): A6NDR3 , Q96I17, Q9NVG9, Q9UFR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.