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Q9H4K7

- MTG2_HUMAN

UniProt

Q9H4K7 - MTG2_HUMAN

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Protein
Mitochondrial ribosome-associated GTPase 2
Gene
MTG2, GTPBP5, OBGH1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.2 Publications

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi238 – 2381Magnesium By similarity
Metal bindingi258 – 2581Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi231 – 2388GTP By similarity
Nucleotide bindingi256 – 2605GTP By similarity
Nucleotide bindingi278 – 2814GTP By similarity
Nucleotide bindingi345 – 3484GTP By similarity
Nucleotide bindingi371 – 3733GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. GTP catabolic process Source: UniProtKB
  2. regulation of mitochondrial translation Source: UniProtKB
  3. regulation of respiratory system process Source: UniProtKB
  4. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Translation regulation

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribosome-associated GTPase 2
Alternative name(s):
GTP-binding protein 5
Protein obg homolog 1
Short name:
ObgH1
Gene namesi
Name:MTG2
Synonyms:GTPBP5, OBGH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16239. MTG2.

Subcellular locationi

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side 2 Publications

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial matrix Source: UniProtKB
  3. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Mitochondrial ribosome-associated GTPase 2UniRule annotation
PRO_0000205429Add
BLAST

Proteomic databases

MaxQBiQ9H4K7.
PaxDbiQ9H4K7.
PRIDEiQ9H4K7.

PTM databases

PhosphoSiteiQ9H4K7.

Expressioni

Gene expression databases

ArrayExpressiQ9H4K7.
BgeeiQ9H4K7.
CleanExiHS_GTPBP5.
GenevestigatoriQ9H4K7.

Organism-specific databases

HPAiHPA047379.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi117590. 4 interactions.
IntActiQ9H4K7. 2 interactions.
MINTiMINT-3067906.
STRINGi9606.ENSP00000359859.

Structurei

3D structure databases

ProteinModelPortaliQ9H4K7.
SMRiQ9H4K7. Positions 72-381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 390166OBG-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 406392Localized in the mitochondriaUniRule annotation
Add
BLAST
Regioni30 – 406377Not localized in the mitochondriaUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0536.
HOGENOMiHOG000019084.
HOVERGENiHBG051857.
InParanoidiQ9H4K7.
KOiK03979.
OMAiHYEGHLQ.
PhylomeDBiQ9H4K7.
TreeFamiTF314774.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H4K7-1 [UniParc]FASTAAdd to Basket

« Hide

MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD    50
LAKHQELPGK KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF 100
GGPDGGDGGN GGHVILRVDQ QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG 150
AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY IAALGGAGGK GNRFFLANNN 200
RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL LRAISNARPA 250
VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI 300
ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP 350
EAQANLSQLR DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG 400
RQPLRW 406
Length:406
Mass (Da):43,955
Last modified:March 1, 2001 - v1
Checksum:i08756F661F79DDBB
GO

Sequence cautioni

The sequence BAA91783.1 differs from that shown. Reason: Erroneous termination at position 402. Translated as Gln.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471G → S.
Corresponds to variant rs6062133 [ dbSNP | Ensembl ].
VAR_033983
Natural varianti93 – 931H → R.
Corresponds to variant rs11700220 [ dbSNP | Ensembl ].
VAR_049299
Natural varianti337 – 3371A → V.
Corresponds to variant rs35693261 [ dbSNP | Ensembl ].
VAR_049300

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001603 mRNA. Translation: BAA91783.1. Different termination.
AL078633 Genomic DNA. Translation: CAC04015.1.
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1.
AL117498 mRNA. Translation: CAB55963.1.
CCDSiCCDS13492.1.
PIRiT17273.
RefSeqiNP_056481.1. NM_015666.3.
XP_005260450.1. XM_005260393.1.
XP_006723838.1. XM_006723775.1.
UniGeneiHs.340636.

Genome annotation databases

EnsembliENST00000370823; ENSP00000359859; ENSG00000101181.
GeneIDi26164.
KEGGihsa:26164.
UCSCiuc002yce.4. human.

Polymorphism databases

DMDMi32469779.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001603 mRNA. Translation: BAA91783.1 . Different termination.
AL078633 Genomic DNA. Translation: CAC04015.1 .
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1 .
AL117498 mRNA. Translation: CAB55963.1 .
CCDSi CCDS13492.1.
PIRi T17273.
RefSeqi NP_056481.1. NM_015666.3.
XP_005260450.1. XM_005260393.1.
XP_006723838.1. XM_006723775.1.
UniGenei Hs.340636.

3D structure databases

ProteinModelPortali Q9H4K7.
SMRi Q9H4K7. Positions 72-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117590. 4 interactions.
IntActi Q9H4K7. 2 interactions.
MINTi MINT-3067906.
STRINGi 9606.ENSP00000359859.

PTM databases

PhosphoSitei Q9H4K7.

Polymorphism databases

DMDMi 32469779.

Proteomic databases

MaxQBi Q9H4K7.
PaxDbi Q9H4K7.
PRIDEi Q9H4K7.

Protocols and materials databases

DNASUi 26164.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370823 ; ENSP00000359859 ; ENSG00000101181 .
GeneIDi 26164.
KEGGi hsa:26164.
UCSCi uc002yce.4. human.

Organism-specific databases

CTDi 26164.
GeneCardsi GC20P060759.
HGNCi HGNC:16239. MTG2.
HPAi HPA047379.
MIMi 610919. gene.
neXtProti NX_Q9H4K7.
PharmGKBi PA29059.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0536.
HOGENOMi HOG000019084.
HOVERGENi HBG051857.
InParanoidi Q9H4K7.
KOi K03979.
OMAi HYEGHLQ.
PhylomeDBi Q9H4K7.
TreeFami TF314774.

Miscellaneous databases

GenomeRNAii 26164.
NextBioi 48263.
PROi Q9H4K7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H4K7.
Bgeei Q9H4K7.
CleanExi HS_GTPBP5.
Genevestigatori Q9H4K7.

Family and domain databases

Gene3Di 2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01454. GTPase_Obg.
InterProi IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view ]
PANTHERi PTHR11702:SF3. PTHR11702:SF3. 1 hit.
Pfami PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view ]
PIRSFi PIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsi TIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-406.
    Tissue: Testis.
  5. "Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures."
    Hirano Y., Ohniwa R.L., Wada C., Yoshimura S.H., Takeyasu K.
    Genes Cells 11:1295-1304(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION.
  6. "Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes."
    Kotani T., Akabane S., Takeyasu K., Ueda T., Takeuchi N.
    Nucleic Acids Res. 41:3713-3722(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH MITOCHONDRIAL RIBOSOME LARGE SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4K7
Secondary accession number(s): A6NDR3
, Q96I17, Q9NVG9, Q9UFR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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