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Protein

Mitochondrial ribosome-associated GTPase 2

Gene

MTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.2 Publications

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi238 – 2381MagnesiumBy similarity
Metal bindingi258 – 2581MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi231 – 2388GTPBy similarity
Nucleotide bindingi256 – 2605GTPBy similarity
Nucleotide bindingi278 – 2814GTPBy similarity
Nucleotide bindingi345 – 3484GTPBy similarity
Nucleotide bindingi371 – 3733GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • metabolic process Source: GOC
  • regulation of mitochondrial translation Source: UniProtKB
  • regulation of respiratory system process Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Translation regulation

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribosome-associated GTPase 2
Alternative name(s):
GTP-binding protein 5
Protein obg homolog 1
Short name:
ObgH1
Gene namesi
Name:MTG2
Synonyms:GTPBP5, OBGH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16239. MTG2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial matrix Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29059.

Polymorphism and mutation databases

BioMutaiMTG2.
DMDMi32469779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Mitochondrial ribosome-associated GTPase 2PRO_0000205429Add
BLAST

Proteomic databases

MaxQBiQ9H4K7.
PaxDbiQ9H4K7.
PRIDEiQ9H4K7.

PTM databases

PhosphoSiteiQ9H4K7.

Expressioni

Gene expression databases

BgeeiQ9H4K7.
CleanExiHS_GTPBP5.
ExpressionAtlasiQ9H4K7. baseline and differential.
GenevestigatoriQ9H4K7.

Organism-specific databases

HPAiHPA047379.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner.

Protein-protein interaction databases

BioGridi117590. 5 interactions.
IntActiQ9H4K7. 2 interactions.
MINTiMINT-3067906.
STRINGi9606.ENSP00000359859.

Structurei

3D structure databases

ProteinModelPortaliQ9H4K7.
SMRiQ9H4K7. Positions 72-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 390166OBG-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 406392Localized in the mitochondriaAdd
BLAST
Regioni30 – 406377Not localized in the mitochondriaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0536.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG051857.
InParanoidiQ9H4K7.
KOiK03979.
OMAiAYPFTTR.
PhylomeDBiQ9H4K7.
TreeFamiTF314774.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD
60 70 80 90 100
LAKHQELPGK KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF
110 120 130 140 150
GGPDGGDGGN GGHVILRVDQ QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG
160 170 180 190 200
AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY IAALGGAGGK GNRFFLANNN
210 220 230 240 250
RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL LRAISNARPA
260 270 280 290 300
VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI
310 320 330 340 350
ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP
360 370 380 390 400
EAQANLSQLR DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG

RQPLRW
Length:406
Mass (Da):43,955
Last modified:March 1, 2001 - v1
Checksum:i08756F661F79DDBB
GO
Isoform 2 (identifier: Q9H4K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):19,820
Checksum:iFB5A91C4B58FB5C5
GO

Sequence cautioni

The sequence BAA91783.1 differs from that shown. Reason: Erroneous termination at position 402. Translated as Gln.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471G → S.
Corresponds to variant rs6062133 [ dbSNP | Ensembl ].
VAR_033983
Natural varianti93 – 931H → R.
Corresponds to variant rs11700220 [ dbSNP | Ensembl ].
VAR_049299
Natural varianti337 – 3371A → V.
Corresponds to variant rs35693261 [ dbSNP | Ensembl ].
VAR_049300

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 228228Missing in isoform 2. 1 PublicationVSP_056672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001603 mRNA. Translation: BAA91783.1. Different termination.
AK299147 mRNA. Translation: BAG61197.1.
AK316027 mRNA. Translation: BAH14398.1.
AK316325 mRNA. Translation: BAH14696.1.
AL078633 Genomic DNA. Translation: CAC04015.1.
CH471077 Genomic DNA. Translation: EAW75386.1.
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1.
AL117498 mRNA. Translation: CAB55963.1.
CCDSiCCDS13492.1. [Q9H4K7-1]
PIRiT17273.
RefSeqiNP_056481.1. NM_015666.3. [Q9H4K7-1]
XP_005260450.1. XM_005260393.1. [Q9H4K7-1]
UniGeneiHs.340636.

Genome annotation databases

EnsembliENST00000370823; ENSP00000359859; ENSG00000101181. [Q9H4K7-1]
GeneIDi26164.
KEGGihsa:26164.
UCSCiuc002yce.4. human. [Q9H4K7-1]
uc011aab.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001603 mRNA. Translation: BAA91783.1. Different termination.
AK299147 mRNA. Translation: BAG61197.1.
AK316027 mRNA. Translation: BAH14398.1.
AK316325 mRNA. Translation: BAH14696.1.
AL078633 Genomic DNA. Translation: CAC04015.1.
CH471077 Genomic DNA. Translation: EAW75386.1.
BC007885 mRNA. No translation available.
BC036716 mRNA. Translation: AAH36716.1.
AL117498 mRNA. Translation: CAB55963.1.
CCDSiCCDS13492.1. [Q9H4K7-1]
PIRiT17273.
RefSeqiNP_056481.1. NM_015666.3. [Q9H4K7-1]
XP_005260450.1. XM_005260393.1. [Q9H4K7-1]
UniGeneiHs.340636.

3D structure databases

ProteinModelPortaliQ9H4K7.
SMRiQ9H4K7. Positions 72-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117590. 5 interactions.
IntActiQ9H4K7. 2 interactions.
MINTiMINT-3067906.
STRINGi9606.ENSP00000359859.

PTM databases

PhosphoSiteiQ9H4K7.

Polymorphism and mutation databases

BioMutaiMTG2.
DMDMi32469779.

Proteomic databases

MaxQBiQ9H4K7.
PaxDbiQ9H4K7.
PRIDEiQ9H4K7.

Protocols and materials databases

DNASUi26164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370823; ENSP00000359859; ENSG00000101181. [Q9H4K7-1]
GeneIDi26164.
KEGGihsa:26164.
UCSCiuc002yce.4. human. [Q9H4K7-1]
uc011aab.2. human.

Organism-specific databases

CTDi26164.
GeneCardsiGC20P060759.
HGNCiHGNC:16239. MTG2.
HPAiHPA047379.
MIMi610919. gene.
neXtProtiNX_Q9H4K7.
PharmGKBiPA29059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0536.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG051857.
InParanoidiQ9H4K7.
KOiK03979.
OMAiAYPFTTR.
PhylomeDBiQ9H4K7.
TreeFamiTF314774.

Miscellaneous databases

GenomeRNAii26164.
NextBioi35474323.
PROiQ9H4K7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H4K7.
CleanExiHS_GTPBP5.
ExpressionAtlasiQ9H4K7. baseline and differential.
GenevestigatoriQ9H4K7.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-406 (ISOFORM 1/2).
    Tissue: Testis.
  6. "Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures."
    Hirano Y., Ohniwa R.L., Wada C., Yoshimura S.H., Takeyasu K.
    Genes Cells 11:1295-1304(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION.
  7. "Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes."
    Kotani T., Akabane S., Takeyasu K., Ueda T., Takeuchi N.
    Nucleic Acids Res. 41:3713-3722(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH MITOCHONDRIAL RIBOSOME LARGE SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4K7
Secondary accession number(s): A6NDR3
, B4DR85, Q96I17, Q9NVG9, Q9UFR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.