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Protein

Serine hydrolase-like protein 2

Gene

SERHL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Miscellaneous

This gene may have been partially duplicated (see SERHL).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-SERHL AlphaBeta_hydrolase
MEROPSiS33.012

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydrolase-like protein 2 (EC:3.1.-.-)
Gene namesi
Name:SERHL2
Synonyms:SERHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000183569.17
HGNCiHGNC:29446 SERHL2
MIMi607979 gene
neXtProtiNX_Q9H4I8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183569
PharmGKBiPA142670935

Polymorphism and mutation databases

BioMutaiSERHL2
DMDMi21362935

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976921 – 314Serine hydrolase-like protein 2Add BLAST314

Proteomic databases

PaxDbiQ9H4I8
PeptideAtlasiQ9H4I8
PRIDEiQ9H4I8

PTM databases

iPTMnetiQ9H4I8
PhosphoSitePlusiQ9H4I8

Expressioni

Gene expression databases

BgeeiENSG00000183569
CleanExiHS_SERHL
HS_SERHL2
ExpressionAtlasiQ9H4I8 baseline and differential
GenevisibleiQ9H4I8 HS

Interactioni

Protein-protein interaction databases

BioGridi128960, 8 interactors
IntActiQ9H4I8, 2 interactors
STRINGi9606.ENSP00000331376

Structurei

3D structure databases

ProteinModelPortaliQ9H4I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 293AB hydrolase-1Sequence analysisAdd BLAST261

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG1454 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00530000063960
HOVERGENiHBG023947
InParanoidiQ9H4I8
OMAiLFEFHEV
OrthoDBiEOG091G0D40
PhylomeDBiQ9H4I8
TreeFamiTF326547

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9H4I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENAAPGLI SELKLAVPWG HIAAKAWGSL QGPPVLCLHG WLDNASSFDR
60 70 80 90 100
LIPLLPQDFY YVAMDFGGHG LSSHYSPGVP YYLQTFVSEI RRVVAALKWN
110 120 130 140 150
RFSILGHSFG GVVGGMFFCT FPEMVDKLIL LDTPLFLLES DEMENLLTYK
160 170 180 190 200
RRAIEHVLQV EASQEPSHVF SLKQLLQRLL KSNSHLSEEC GELLLQRGTT
210 220 230 240 250
KVATGLVLNR DQRLAWAENS IDFISRELCA HSIRKLQAHV LLIKAVHGYF
260 270 280 290 300
DSRQNYSEKE SLSFMIDTMK STLKEQFQFV EVPGNHCVHM SEPQHVASII
310
SSFLQCTHML PAQL
Length:314
Mass (Da):35,369
Last modified:March 1, 2001 - v1
Checksum:i2572F470136E4427
GO
Isoform 2 (identifier: Q9H4I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-57: Missing.
     96-109: Missing.

Show »
Length:250
Mass (Da):28,342
Checksum:i2C2C27F6BF7021F9
GO
Isoform 3 (identifier: Q9H4I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-191: Missing.

Show »
Length:134
Mass (Da):15,110
Checksum:i550C4794CD7E2A34
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0513343E → K. Corresponds to variant dbSNP:rs3213549Ensembl.1
Natural variantiVAR_02196246S → N. Corresponds to variant dbSNP:rs926333Ensembl.1
Natural variantiVAR_051335306C → R. Corresponds to variant dbSNP:rs137055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039688 – 57Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_00397012 – 191Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_00396996 – 109Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450314 mRNA Translation: CAC16804.1
AL590120 mRNA Translation: CAC34873.1
AL590118 mRNA Translation: CAC34871.1
AL589866 mRNA Translation: CAC34477.1
Z93241 Genomic DNA No translation available.
BC119650 mRNA Translation: AAI19651.1
BC127635 mRNA Translation: AAI27636.1
BC127636 mRNA Translation: AAI27637.1
CCDSiCCDS14037.1 [Q9H4I8-1]
CCDS63498.1 [Q9H4I8-2]
RefSeqiNP_001271263.1, NM_001284334.1 [Q9H4I8-2]
NP_055324.2, NM_014509.4 [Q9H4I8-1]
UniGeneiHs.728878

Genome annotation databases

EnsembliENST00000327678; ENSP00000331376; ENSG00000183569 [Q9H4I8-1]
ENST00000335879; ENSP00000336578; ENSG00000183569 [Q9H4I8-2]
ENST00000407614; ENSP00000385691; ENSG00000183569 [Q9H4I8-3]
GeneIDi253190
KEGGihsa:253190
UCSCiuc003bcr.5 human [Q9H4I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEHL2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4I8
Secondary accession number(s): B1AHE9
, B1AHF0, Q0VDJ1, Q5H973, Q9BR29, Q9BR30, Q9Y3I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health