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Protein

Serine hydrolase-like protein 2

Gene

SERHL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Sequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-SERHL. AlphaBeta_hydrolase.
MEROPSiS33.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydrolase-like protein 2 (EC:3.1.-.-)
Gene namesi
Name:SERHL2
Synonyms:SERHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:29446. SERHL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670935.

Polymorphism and mutation databases

BioMutaiSERHL2.
DMDMi21362935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Serine hydrolase-like protein 2PRO_0000097692Add
BLAST

Proteomic databases

PaxDbiQ9H4I8.
PRIDEiQ9H4I8.

PTM databases

iPTMnetiQ9H4I8.
PhosphoSiteiQ9H4I8.

Expressioni

Gene expression databases

BgeeiQ9H4I8.
CleanExiHS_SERHL.
HS_SERHL2.
ExpressionAtlasiQ9H4I8. baseline and differential.
GenevisibleiQ9H4I8. HS.

Organism-specific databases

HPAiHPA047904.

Interactioni

Protein-protein interaction databases

BioGridi128960. 6 interactions.
STRINGi9606.ENSP00000331376.

Structurei

3D structure databases

ProteinModelPortaliQ9H4I8.
SMRiQ9H4I8. Positions 9-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG1454. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00530000063960.
HOVERGENiHBG023947.
InParanoidiQ9H4I8.
OMAiSFLQCTH.
PhylomeDBiQ9H4I8.
TreeFamiTF326547.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9H4I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENAAPGLI SELKLAVPWG HIAAKAWGSL QGPPVLCLHG WLDNASSFDR
60 70 80 90 100
LIPLLPQDFY YVAMDFGGHG LSSHYSPGVP YYLQTFVSEI RRVVAALKWN
110 120 130 140 150
RFSILGHSFG GVVGGMFFCT FPEMVDKLIL LDTPLFLLES DEMENLLTYK
160 170 180 190 200
RRAIEHVLQV EASQEPSHVF SLKQLLQRLL KSNSHLSEEC GELLLQRGTT
210 220 230 240 250
KVATGLVLNR DQRLAWAENS IDFISRELCA HSIRKLQAHV LLIKAVHGYF
260 270 280 290 300
DSRQNYSEKE SLSFMIDTMK STLKEQFQFV EVPGNHCVHM SEPQHVASII
310
SSFLQCTHML PAQL
Length:314
Mass (Da):35,369
Last modified:March 1, 2001 - v1
Checksum:i2572F470136E4427
GO
Isoform 2 (identifier: Q9H4I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-57: Missing.
     96-109: Missing.

Show »
Length:250
Mass (Da):28,342
Checksum:i2C2C27F6BF7021F9
GO
Isoform 3 (identifier: Q9H4I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-191: Missing.

Show »
Length:134
Mass (Da):15,110
Checksum:i550C4794CD7E2A34
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31E → K.
Corresponds to variant rs3213549 [ dbSNP | Ensembl ].
VAR_051334
Natural varianti46 – 461S → N.
Corresponds to variant rs926333 [ dbSNP | Ensembl ].
VAR_021962
Natural varianti306 – 3061C → R.
Corresponds to variant rs137055 [ dbSNP | Ensembl ].
VAR_051335

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei8 – 5750Missing in isoform 2. 1 PublicationVSP_003968Add
BLAST
Alternative sequencei12 – 191180Missing in isoform 3. 1 PublicationVSP_003970Add
BLAST
Alternative sequencei96 – 10914Missing in isoform 2. 1 PublicationVSP_003969Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450314 mRNA. Translation: CAC16804.1.
AL590120 mRNA. Translation: CAC34873.1.
AL590118 mRNA. Translation: CAC34871.1.
AL589866 mRNA. Translation: CAC34477.1.
Z93241 Genomic DNA. Translation: CAI19834.1.
Z93241 Genomic DNA. Translation: CAQ08411.1.
Z93241 Genomic DNA. Translation: CAQ08412.1.
BC119650 mRNA. Translation: AAI19651.1.
BC127635 mRNA. Translation: AAI27636.1.
BC127636 mRNA. Translation: AAI27637.1.
CCDSiCCDS14037.1. [Q9H4I8-1]
CCDS63498.1. [Q9H4I8-2]
RefSeqiNP_001271263.1. NM_001284334.1. [Q9H4I8-2]
NP_055324.2. NM_014509.4. [Q9H4I8-1]
UniGeneiHs.728878.

Genome annotation databases

EnsembliENST00000327678; ENSP00000331376; ENSG00000183569. [Q9H4I8-1]
ENST00000335879; ENSP00000336578; ENSG00000183569. [Q9H4I8-2]
ENST00000407614; ENSP00000385691; ENSG00000183569. [Q9H4I8-3]
GeneIDi253190.
KEGGihsa:253190.
UCSCiuc003bcr.5. human. [Q9H4I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450314 mRNA. Translation: CAC16804.1.
AL590120 mRNA. Translation: CAC34873.1.
AL590118 mRNA. Translation: CAC34871.1.
AL589866 mRNA. Translation: CAC34477.1.
Z93241 Genomic DNA. Translation: CAI19834.1.
Z93241 Genomic DNA. Translation: CAQ08411.1.
Z93241 Genomic DNA. Translation: CAQ08412.1.
BC119650 mRNA. Translation: AAI19651.1.
BC127635 mRNA. Translation: AAI27636.1.
BC127636 mRNA. Translation: AAI27637.1.
CCDSiCCDS14037.1. [Q9H4I8-1]
CCDS63498.1. [Q9H4I8-2]
RefSeqiNP_001271263.1. NM_001284334.1. [Q9H4I8-2]
NP_055324.2. NM_014509.4. [Q9H4I8-1]
UniGeneiHs.728878.

3D structure databases

ProteinModelPortaliQ9H4I8.
SMRiQ9H4I8. Positions 9-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128960. 6 interactions.
STRINGi9606.ENSP00000331376.

Protein family/group databases

ESTHERihuman-SERHL. AlphaBeta_hydrolase.
MEROPSiS33.012.

PTM databases

iPTMnetiQ9H4I8.
PhosphoSiteiQ9H4I8.

Polymorphism and mutation databases

BioMutaiSERHL2.
DMDMi21362935.

Proteomic databases

PaxDbiQ9H4I8.
PRIDEiQ9H4I8.

Protocols and materials databases

DNASUi253190.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327678; ENSP00000331376; ENSG00000183569. [Q9H4I8-1]
ENST00000335879; ENSP00000336578; ENSG00000183569. [Q9H4I8-2]
ENST00000407614; ENSP00000385691; ENSG00000183569. [Q9H4I8-3]
GeneIDi253190.
KEGGihsa:253190.
UCSCiuc003bcr.5. human. [Q9H4I8-1]

Organism-specific databases

CTDi253190.
GeneCardsiSERHL2.
HGNCiHGNC:29446. SERHL2.
HPAiHPA047904.
MIMi607979. gene.
neXtProtiNX_Q9H4I8.
PharmGKBiPA142670935.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1454. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00530000063960.
HOVERGENiHBG023947.
InParanoidiQ9H4I8.
OMAiSFLQCTH.
PhylomeDBiQ9H4I8.
TreeFamiTF326547.

Miscellaneous databases

GenomeRNAii253190.
NextBioi92077.
PROiQ9H4I8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H4I8.
CleanExiHS_SERHL.
HS_SERHL2.
ExpressionAtlasiQ9H4I8. baseline and differential.
GenevisibleiQ9H4I8. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Kidney and Testis.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiSEHL2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4I8
Secondary accession number(s): B1AHE9
, B1AHF0, Q0VDJ1, Q5H973, Q9BR29, Q9BR30, Q9Y3I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene may have been partially duplicated (see SERHL).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.