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Q9H4I2

- ZHX3_HUMAN

UniProt

Q9H4I2 - ZHX3_HUMAN

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Protein

Zinc fingers and homeoboxes protein 3

Gene

ZHX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10024C2H2-type 1Add
BLAST
Zinc fingeri109 – 13224C2H2-type 2Add
BLAST
DNA bindingi304 – 36360Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi494 – 55360Homeobox 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi612 – 67160Homeobox 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi764 – 82360Homeobox 4PROSITE-ProRule annotationAdd
BLAST
DNA bindingi835 – 89460Homeobox 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein heterodimerization activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of osteoblast differentiation Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 3
Alternative name(s):
Triple homeobox protein 1
Zinc finger and homeodomain protein 3
Gene namesi
Name:ZHX3
Synonyms:KIAA0395, TIX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15935. ZHX3.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Zinc fingers and homeoboxes protein 3PRO_0000049395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei680 – 6801Phosphoserine1 Publication
Modified residuei708 – 7081PhosphoserineBy similarity
Modified residuei946 – 9461Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H4I2.
PaxDbiQ9H4I2.
PRIDEiQ9H4I2.

PTM databases

PhosphoSiteiQ9H4I2.

Expressioni

Tissue specificityi

Widely expressed. High expression in kidney. Expressed during osteogenic differentiation.2 Publications

Inductioni

Up-regulated during osteogenic differentiation of mesenchymal stem cells.1 Publication

Gene expression databases

BgeeiQ9H4I2.
CleanExiHS_ZHX3.
ExpressionAtlasiQ9H4I2. baseline and differential.
GenevestigatoriQ9H4I2.

Organism-specific databases

HPAiHPA006687.

Interactioni

Subunit structurei

Homodimer (via homeobox domain). Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.1 Publication

Protein-protein interaction databases

BioGridi116688. 6 interactions.
IntActiQ9H4I2. 4 interactions.
MINTiMINT-2870187.
STRINGi9606.ENSP00000312222.

Structurei

Secondary structure

1
956
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi503 – 51513
Beta strandi516 – 5183
Helixi522 – 53110
Helixi535 – 54814
Beta strandi549 – 5513
Beta strandi554 – 5563
Helixi621 – 63313
Helixi639 – 64911
Helixi653 – 66311
Helixi666 – 6694

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA5NMR-A613-674[»]
2DN0NMR-A494-556[»]
ProteinModelPortaliQ9H4I2.
SMRiQ9H4I2. Positions 77-159, 496-557, 613-675, 765-834.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4I2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 107107Required for nuclear localizationAdd
BLAST
Regioni242 – 488247Required for homodimerization and interaction with NFYAAdd
BLAST
Regioni303 – 502200Required for repressor activityAdd
BLAST
Regioni497 – 55559Required for nuclear localizationAdd
BLAST

Sequence similaritiesi

Belongs to the ZHX family.Curated
Contains 2 C2H2-type zinc fingers.Curated
Contains 5 homeobox DNA-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10024C2H2-type 1Add
BLAST
Zinc fingeri109 – 13224C2H2-type 2Add
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG39488.
GeneTreeiENSGT00530000063149.
HOVERGENiHBG007920.
InParanoidiQ9H4I2.
OMAiMKGKAEA.
PhylomeDBiQ9H4I2.
TreeFamiTF333363.

Family and domain databases

Gene3Di1.10.10.60. 5 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 3 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 5 hits.
PROSITEiPS50071. HOMEOBOX_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H4I2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKRKSTTP CMIPVKTVVL QDASMEAQPA ETLPEGPQQD LPPEASAASS
60 70 80 90 100
EAAQNPSSTD GSTLANGHRS TLDGYLYSCK YCDFRSHDMT QFVGHMNSEH
110 120 130 140 150
TDFNKDPTFV CSGCSFLAKT PEGLSLHNAT CHSGEASFVW NVAKPDNHVV
160 170 180 190 200
VEQSIPESTS TPDLAGEPSA EGADGQAEII ITKTPIMKIM KGKAEAKKIH
210 220 230 240 250
TLKENVPSQP VGEALPKLST GEMEVREGDH SFINGAVPVS QASASSAKNP
260 270 280 290 300
HAANGPLIGT VPVLPAGIAQ FLSLQQQPPV HAQHHVHQPL PTAKALPKVM
310 320 330 340 350
IPLSSIPTYN AAMDSNSFLK NSFHKFPYPT KAELCYLTVV TKYPEEQLKI
360 370 380 390 400
WFTAQRLKQG ISWSPEEIED ARKKMFNTVI QSVPQPTITV LNTPLVASAG
410 420 430 440 450
NVQHLIQAAL PGHVVGQPEG TGGGLLVTQP LMANGLQATS SPLPLTVTSV
460 470 480 490 500
PKQPGVAPIN TVCSNTTSAV KVVNAAQSLL TACPSITSQA FLDASIYKNK
510 520 530 540 550
KSHEQLSALK GSFCRNQFPG QSEVEHLTKV TGLSTREVRK WFSDRRYHCR
560 570 580 590 600
NLKGSRAMIP GDHSSIIIDS VPEVSFSPSS KVPEVTCIPT TATLATHPSA
610 620 630 640 650
KRQSWHQTPD FTPTKYKERA PEQLRALESS FAQNPLPLDE ELDRLRSETK
660 670 680 690 700
MTRREIDSWF SERRKKVNAE ETKKAEENAS QEEEEAAEDE GGEEDLASEL
710 720 730 740 750
RVSGENGSLE MPSSHILAER KVSPIKINLK NLRVTEANGR NEIPGLGACD
760 770 780 790 800
PEDDESNKLA EQLPGKVSCK KTAQQRHLLR QLFVQTQWPS NQDYDSIMAQ
810 820 830 840 850
TGLPRPEVVR WFGDSRYALK NGQLKWYEDY KRGNFPPGLL VIAPGNRELL
860 870 880 890 900
QDYYMTHKML YEEDLQNLCD KTQMSSQQVK QWFAEKMGEE TRAVADTGSE
910 920 930 940 950
DQGPGTGELT AVHKGMGDTY SEVSENSESW EPRVPEASSE PFDTSSPQAG

RQLETD
Length:956
Mass (Da):104,658
Last modified:March 1, 2004 - v3
Checksum:iB3DB35CFC1781A3A
GO
Isoform 2 (identifier: Q9H4I2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     879-956: VKQWFAEKMG...PQAGRQLETD → KQTEFDLINV...CRTFPLPSNG

Note: No experimental confirmation available.

Show »
Length:969
Mass (Da):106,318
Checksum:i22010A170A8BC89E
GO

Sequence cautioni

The sequence BAA23691.3 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti642 – 6421L → M in AAH68569. (PubMed:15489334)Curated
Sequence conflicti907 – 9071G → T in BAA23691. (PubMed:9455477)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101N → S.
Corresponds to variant rs17265513 [ dbSNP | Ensembl ].
VAR_049597

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei879 – 95678VKQWF…QLETD → KQTEFDLINVKDWPVWETAC HVEEPNPTLCCHMPFPCPAA GHLGELPESSQTAQSLPLPS ACPPPSKQQARWGSHQFFLP QCRTFPLPSNG in isoform 2. 1 PublicationVSP_054307Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081948 mRNA. Translation: BAC65211.1.
AB007855 mRNA. Translation: BAA23691.3. Different initiation.
AL022394 Genomic DNA. Translation: CAA18538.1.
AL031257 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75987.1.
CH471077 Genomic DNA. Translation: EAW75988.1.
BC068569 mRNA. Translation: AAH68569.1.
CCDSiCCDS13315.1. [Q9H4I2-1]
RefSeqiNP_055850.1. NM_015035.3. [Q9H4I2-1]
XP_005260398.1. XM_005260341.2. [Q9H4I2-2]
UniGeneiHs.380133.

Genome annotation databases

EnsembliENST00000309060; ENSP00000312222; ENSG00000174306. [Q9H4I2-1]
ENST00000432768; ENSP00000415498; ENSG00000174306. [Q9H4I2-1]
ENST00000540170; ENSP00000442290; ENSG00000174306. [Q9H4I2-1]
ENST00000544979; ENSP00000443783; ENSG00000174306. [Q9H4I2-2]
ENST00000559234; ENSP00000452965; ENSG00000174306. [Q9H4I2-1]
ENST00000560361; ENSP00000454006; ENSG00000174306. [Q9H4I2-1]
GeneIDi23051.
KEGGihsa:23051.
UCSCiuc002xjs.1. human. [Q9H4I2-1]

Polymorphism databases

DMDMi44889075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081948 mRNA. Translation: BAC65211.1 .
AB007855 mRNA. Translation: BAA23691.3 . Different initiation.
AL022394 Genomic DNA. Translation: CAA18538.1 .
AL031257 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75987.1 .
CH471077 Genomic DNA. Translation: EAW75988.1 .
BC068569 mRNA. Translation: AAH68569.1 .
CCDSi CCDS13315.1. [Q9H4I2-1 ]
RefSeqi NP_055850.1. NM_015035.3. [Q9H4I2-1 ]
XP_005260398.1. XM_005260341.2. [Q9H4I2-2 ]
UniGenei Hs.380133.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DA5 NMR - A 613-674 [» ]
2DN0 NMR - A 494-556 [» ]
ProteinModelPortali Q9H4I2.
SMRi Q9H4I2. Positions 77-159, 496-557, 613-675, 765-834.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116688. 6 interactions.
IntActi Q9H4I2. 4 interactions.
MINTi MINT-2870187.
STRINGi 9606.ENSP00000312222.

PTM databases

PhosphoSitei Q9H4I2.

Polymorphism databases

DMDMi 44889075.

Proteomic databases

MaxQBi Q9H4I2.
PaxDbi Q9H4I2.
PRIDEi Q9H4I2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309060 ; ENSP00000312222 ; ENSG00000174306 . [Q9H4I2-1 ]
ENST00000432768 ; ENSP00000415498 ; ENSG00000174306 . [Q9H4I2-1 ]
ENST00000540170 ; ENSP00000442290 ; ENSG00000174306 . [Q9H4I2-1 ]
ENST00000544979 ; ENSP00000443783 ; ENSG00000174306 . [Q9H4I2-2 ]
ENST00000559234 ; ENSP00000452965 ; ENSG00000174306 . [Q9H4I2-1 ]
ENST00000560361 ; ENSP00000454006 ; ENSG00000174306 . [Q9H4I2-1 ]
GeneIDi 23051.
KEGGi hsa:23051.
UCSCi uc002xjs.1. human. [Q9H4I2-1 ]

Organism-specific databases

CTDi 23051.
GeneCardsi GC20M039807.
H-InvDB HIX0015822.
HGNCi HGNC:15935. ZHX3.
HPAi HPA006687.
MIMi 609598. gene.
neXtProti NX_Q9H4I2.
PharmGKBi PA38056.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39488.
GeneTreei ENSGT00530000063149.
HOVERGENi HBG007920.
InParanoidi Q9H4I2.
OMAi MKGKAEA.
PhylomeDBi Q9H4I2.
TreeFami TF333363.

Miscellaneous databases

ChiTaRSi ZHX3. human.
EvolutionaryTracei Q9H4I2.
GeneWikii ZHX3.
GenomeRNAii 23051.
NextBioi 35509490.
PROi Q9H4I2.
SOURCEi Search...

Gene expression databases

Bgeei Q9H4I2.
CleanExi HS_ZHX3.
ExpressionAtlasi Q9H4I2. baseline and differential.
Genevestigatori Q9H4I2.

Family and domain databases

Gene3Di 1.10.10.60. 5 hits.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00046. Homeobox. 3 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 5 hits.
PROSITEi PS50071. HOMEOBOX_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."
    Yamada K., Kawata H., Shou Z., Hirano S., Mizutani T., Yazawa T., Sekiguchi T., Yoshino M., Kajitani T., Miyamoto K.
    Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, HOMODIMERIZATION, HETERODIMERIZATION WITH ZFX1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NFYA.
    Tissue: Testis.
  2. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-946, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation."
    Suehiro F., Nishimura M., Kawamoto T., Kanawa M., Yoshizawa Y., Murata H., Kato Y.
    Stem Cells Dev. 20:1539-1547(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  13. "Solution structure of the homeobox domain of zinc fingers and homeoboxes protein 3 (triple homeobox 1 protein)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 494-675.
  14. "Solution structure of the second homeobox domain of human zinc fingers and homeoboxes protein 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 494-556.

Entry informationi

Entry nameiZHX3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4I2
Secondary accession number(s): E1P5W5
, F5H820, O43145, Q6NUJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2004
Last modified: November 26, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3