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Q9H4I2

- ZHX3_HUMAN

UniProt

Q9H4I2 - ZHX3_HUMAN

Protein

Zinc fingers and homeoboxes protein 3

Gene

ZHX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri77 – 10024C2H2-type 1Add
    BLAST
    Zinc fingeri109 – 13224C2H2-type 2Add
    BLAST
    DNA bindingi304 – 36360Homeobox 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi494 – 55360Homeobox 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi612 – 67160Homeobox 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi764 – 82360Homeobox 4PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi835 – 89460Homeobox 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    7. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. positive regulation of osteoblast differentiation Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc fingers and homeoboxes protein 3
    Alternative name(s):
    Triple homeobox protein 1
    Zinc finger and homeodomain protein 3
    Gene namesi
    Name:ZHX3
    Synonyms:KIAA0395, TIX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15935. ZHX3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956Zinc fingers and homeoboxes protein 3PRO_0000049395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei680 – 6801Phosphoserine1 Publication
    Modified residuei708 – 7081PhosphoserineBy similarity
    Modified residuei946 – 9461Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H4I2.
    PaxDbiQ9H4I2.
    PRIDEiQ9H4I2.

    PTM databases

    PhosphoSiteiQ9H4I2.

    Expressioni

    Tissue specificityi

    Widely expressed. High expression in kidney. Expressed during osteogenic differentiation.2 Publications

    Inductioni

    Up-regulated during osteogenic differentiation of mesenchymal stem cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9H4I2.
    BgeeiQ9H4I2.
    CleanExiHS_ZHX3.
    GenevestigatoriQ9H4I2.

    Organism-specific databases

    HPAiHPA006687.

    Interactioni

    Subunit structurei

    Homodimer (via homeobox domain). Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.1 Publication

    Protein-protein interaction databases

    BioGridi116688. 5 interactions.
    IntActiQ9H4I2. 4 interactions.
    MINTiMINT-2870187.
    STRINGi9606.ENSP00000312222.

    Structurei

    Secondary structure

    1
    956
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi503 – 51513
    Beta strandi516 – 5183
    Helixi522 – 53110
    Helixi535 – 54814
    Beta strandi549 – 5513
    Beta strandi554 – 5563
    Helixi621 – 63313
    Helixi639 – 64911
    Helixi653 – 66311
    Helixi666 – 6694

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DA5NMR-A613-674[»]
    2DN0NMR-A494-556[»]
    ProteinModelPortaliQ9H4I2.
    SMRiQ9H4I2. Positions 77-159, 316-358, 496-557, 613-675, 765-834.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H4I2.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 107107Required for nuclear localizationAdd
    BLAST
    Regioni242 – 488247Required for homodimerization and interaction with NFYAAdd
    BLAST
    Regioni303 – 502200Required for repressor activityAdd
    BLAST
    Regioni497 – 55559Required for nuclear localizationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ZHX family.Curated
    Contains 2 C2H2-type zinc fingers.Curated
    Contains 5 homeobox DNA-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri77 – 10024C2H2-type 1Add
    BLAST
    Zinc fingeri109 – 13224C2H2-type 2Add
    BLAST

    Keywords - Domaini

    Homeobox, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG39488.
    HOVERGENiHBG007920.
    InParanoidiQ9H4I2.
    OMAiMKGKAEA.
    PhylomeDBiQ9H4I2.
    TreeFamiTF333363.

    Family and domain databases

    Gene3Di1.10.10.60. 5 hits.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 3 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 5 hits.
    PROSITEiPS50071. HOMEOBOX_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H4I2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASKRKSTTP CMIPVKTVVL QDASMEAQPA ETLPEGPQQD LPPEASAASS    50
    EAAQNPSSTD GSTLANGHRS TLDGYLYSCK YCDFRSHDMT QFVGHMNSEH 100
    TDFNKDPTFV CSGCSFLAKT PEGLSLHNAT CHSGEASFVW NVAKPDNHVV 150
    VEQSIPESTS TPDLAGEPSA EGADGQAEII ITKTPIMKIM KGKAEAKKIH 200
    TLKENVPSQP VGEALPKLST GEMEVREGDH SFINGAVPVS QASASSAKNP 250
    HAANGPLIGT VPVLPAGIAQ FLSLQQQPPV HAQHHVHQPL PTAKALPKVM 300
    IPLSSIPTYN AAMDSNSFLK NSFHKFPYPT KAELCYLTVV TKYPEEQLKI 350
    WFTAQRLKQG ISWSPEEIED ARKKMFNTVI QSVPQPTITV LNTPLVASAG 400
    NVQHLIQAAL PGHVVGQPEG TGGGLLVTQP LMANGLQATS SPLPLTVTSV 450
    PKQPGVAPIN TVCSNTTSAV KVVNAAQSLL TACPSITSQA FLDASIYKNK 500
    KSHEQLSALK GSFCRNQFPG QSEVEHLTKV TGLSTREVRK WFSDRRYHCR 550
    NLKGSRAMIP GDHSSIIIDS VPEVSFSPSS KVPEVTCIPT TATLATHPSA 600
    KRQSWHQTPD FTPTKYKERA PEQLRALESS FAQNPLPLDE ELDRLRSETK 650
    MTRREIDSWF SERRKKVNAE ETKKAEENAS QEEEEAAEDE GGEEDLASEL 700
    RVSGENGSLE MPSSHILAER KVSPIKINLK NLRVTEANGR NEIPGLGACD 750
    PEDDESNKLA EQLPGKVSCK KTAQQRHLLR QLFVQTQWPS NQDYDSIMAQ 800
    TGLPRPEVVR WFGDSRYALK NGQLKWYEDY KRGNFPPGLL VIAPGNRELL 850
    QDYYMTHKML YEEDLQNLCD KTQMSSQQVK QWFAEKMGEE TRAVADTGSE 900
    DQGPGTGELT AVHKGMGDTY SEVSENSESW EPRVPEASSE PFDTSSPQAG 950
    RQLETD 956
    Length:956
    Mass (Da):104,658
    Last modified:March 1, 2004 - v3
    Checksum:iB3DB35CFC1781A3A
    GO
    Isoform 2 (identifier: Q9H4I2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         879-956: VKQWFAEKMG...PQAGRQLETD → KQTEFDLINV...CRTFPLPSNG

    Note: No experimental confirmation available.

    Show »
    Length:969
    Mass (Da):106,318
    Checksum:i22010A170A8BC89E
    GO

    Sequence cautioni

    The sequence BAA23691.3 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti642 – 6421L → M in AAH68569. (PubMed:15489334)Curated
    Sequence conflicti907 – 9071G → T in BAA23691. (PubMed:9455477)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti310 – 3101N → S.
    Corresponds to variant rs17265513 [ dbSNP | Ensembl ].
    VAR_049597

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei879 – 95678VKQWF…QLETD → KQTEFDLINVKDWPVWETAC HVEEPNPTLCCHMPFPCPAA GHLGELPESSQTAQSLPLPS ACPPPSKQQARWGSHQFFLP QCRTFPLPSNG in isoform 2. 1 PublicationVSP_054307Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081948 mRNA. Translation: BAC65211.1.
    AB007855 mRNA. Translation: BAA23691.3. Different initiation.
    AL022394 Genomic DNA. Translation: CAA18538.1.
    AL031257 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75987.1.
    CH471077 Genomic DNA. Translation: EAW75988.1.
    BC068569 mRNA. Translation: AAH68569.1.
    CCDSiCCDS13315.1. [Q9H4I2-1]
    RefSeqiNP_055850.1. NM_015035.3. [Q9H4I2-1]
    XP_005260398.1. XM_005260341.2. [Q9H4I2-2]
    UniGeneiHs.380133.

    Genome annotation databases

    EnsembliENST00000309060; ENSP00000312222; ENSG00000174306. [Q9H4I2-1]
    ENST00000432768; ENSP00000415498; ENSG00000174306. [Q9H4I2-1]
    ENST00000540170; ENSP00000442290; ENSG00000174306. [Q9H4I2-1]
    ENST00000544979; ENSP00000443783; ENSG00000174306. [Q9H4I2-2]
    ENST00000559234; ENSP00000452965; ENSG00000174306. [Q9H4I2-1]
    ENST00000560361; ENSP00000454006; ENSG00000174306. [Q9H4I2-1]
    GeneIDi23051.
    KEGGihsa:23051.
    UCSCiuc002xjs.1. human. [Q9H4I2-1]

    Polymorphism databases

    DMDMi44889075.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081948 mRNA. Translation: BAC65211.1 .
    AB007855 mRNA. Translation: BAA23691.3 . Different initiation.
    AL022394 Genomic DNA. Translation: CAA18538.1 .
    AL031257 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75987.1 .
    CH471077 Genomic DNA. Translation: EAW75988.1 .
    BC068569 mRNA. Translation: AAH68569.1 .
    CCDSi CCDS13315.1. [Q9H4I2-1 ]
    RefSeqi NP_055850.1. NM_015035.3. [Q9H4I2-1 ]
    XP_005260398.1. XM_005260341.2. [Q9H4I2-2 ]
    UniGenei Hs.380133.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DA5 NMR - A 613-674 [» ]
    2DN0 NMR - A 494-556 [» ]
    ProteinModelPortali Q9H4I2.
    SMRi Q9H4I2. Positions 77-159, 316-358, 496-557, 613-675, 765-834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116688. 5 interactions.
    IntActi Q9H4I2. 4 interactions.
    MINTi MINT-2870187.
    STRINGi 9606.ENSP00000312222.

    PTM databases

    PhosphoSitei Q9H4I2.

    Polymorphism databases

    DMDMi 44889075.

    Proteomic databases

    MaxQBi Q9H4I2.
    PaxDbi Q9H4I2.
    PRIDEi Q9H4I2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309060 ; ENSP00000312222 ; ENSG00000174306 . [Q9H4I2-1 ]
    ENST00000432768 ; ENSP00000415498 ; ENSG00000174306 . [Q9H4I2-1 ]
    ENST00000540170 ; ENSP00000442290 ; ENSG00000174306 . [Q9H4I2-1 ]
    ENST00000544979 ; ENSP00000443783 ; ENSG00000174306 . [Q9H4I2-2 ]
    ENST00000559234 ; ENSP00000452965 ; ENSG00000174306 . [Q9H4I2-1 ]
    ENST00000560361 ; ENSP00000454006 ; ENSG00000174306 . [Q9H4I2-1 ]
    GeneIDi 23051.
    KEGGi hsa:23051.
    UCSCi uc002xjs.1. human. [Q9H4I2-1 ]

    Organism-specific databases

    CTDi 23051.
    GeneCardsi GC20M039807.
    H-InvDB HIX0015822.
    HGNCi HGNC:15935. ZHX3.
    HPAi HPA006687.
    MIMi 609598. gene.
    neXtProti NX_Q9H4I2.
    PharmGKBi PA38056.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39488.
    HOVERGENi HBG007920.
    InParanoidi Q9H4I2.
    OMAi MKGKAEA.
    PhylomeDBi Q9H4I2.
    TreeFami TF333363.

    Miscellaneous databases

    ChiTaRSi ZHX3. human.
    EvolutionaryTracei Q9H4I2.
    GeneWikii ZHX3.
    GenomeRNAii 23051.
    NextBioi 35509490.
    PROi Q9H4I2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H4I2.
    Bgeei Q9H4I2.
    CleanExi HS_ZHX3.
    Genevestigatori Q9H4I2.

    Family and domain databases

    Gene3Di 1.10.10.60. 5 hits.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 3 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 5 hits.
    PROSITEi PS50071. HOMEOBOX_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3."
      Yamada K., Kawata H., Shou Z., Hirano S., Mizutani T., Yazawa T., Sekiguchi T., Yoshino M., Kajitani T., Miyamoto K.
      Biochem. J. 373:167-178(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, HOMODIMERIZATION, HETERODIMERIZATION WITH ZFX1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NFYA.
      Tissue: Testis.
    2. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Ohara O., Nagase T., Kikuno R.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-946, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation."
      Suehiro F., Nishimura M., Kawamoto T., Kanawa M., Yoshizawa Y., Murata H., Kato Y.
      Stem Cells Dev. 20:1539-1547(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    13. "Solution structure of the homeobox domain of zinc fingers and homeoboxes protein 3 (triple homeobox 1 protein)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 494-675.
    14. "Solution structure of the second homeobox domain of human zinc fingers and homeoboxes protein 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 494-556.

    Entry informationi

    Entry nameiZHX3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4I2
    Secondary accession number(s): E1P5W5
    , F5H820, O43145, Q6NUJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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