Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H4G4 (GAPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi-associated plant pathogenesis-related protein 1

Short name=GAPR-1
Short name=Golgi-associated PR-1 protein
Alternative name(s):
Glioma pathogenesis-related protein 2
Short name=GliPR 2
Gene names
Name:GLIPR2
Synonyms:C9orf19, GAPR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer. Interacts with CAV1. Ref.1 Ref.6

Subcellular location

Golgi apparatus membrane; Lipid-anchor. Note: Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate. Ref.1

Tissue specificity

Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney. Ref.2

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 154153Golgi-associated plant pathogenesis-related protein 1
PRO_0000211524

Regions

Domain14 – 132119SCP
Region91 – 988Interaction with CAV1
Coiled coil30 – 5324 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine Ref.1

Experimental info

Sequence conflict371R → Q AA sequence Ref.1
Sequence conflict87 – 904IKNY → VHFM in AAH17918. Ref.5
Sequence conflict101 – 15454TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019. Ref.3

Secondary structure

..................... 154
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9H4G4 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5AA9B26A21EF1039

FASTA15417,218
        10         20         30         40         50         60 
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR ILKHSPESSR 

        70         80         90        100        110        120 
GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG TGHFTAMVWK NTKKMGVGKA 

       130        140        150 
SASDGSSFVV ARYFPAGNVV NEGFFEENVL PPKK 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68, SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, INTERACTION WITH CAV1.
Tissue: Brain.
[2]"Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain."
Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.
Gene 293:141-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Placenta.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Placenta.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
Tissue: Prostate.
[6]"Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism."
Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I., Groves M.R.
J. Mol. Biol. 339:173-183(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), HOMODIMERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011129 mRNA. Translation: CAC12812.1.
AY039756 mRNA. Translation: AAK83460.1.
AK074488 mRNA. Translation: BAC11019.1.
AK075091 mRNA. Translation: BAC11395.1.
AL158830 Genomic DNA. Translation: CAH73678.1.
BC017918 mRNA. Translation: AAH17918.1.
CCDSCCDS6598.1.
RefSeqNP_071738.1. NM_022343.3.
UniGeneHs.493819.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
ProteinModelPortalQ9H4G4.
SMRQ9H4G4. Positions 4-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127417. 5 interactions.
DIPDIP-60127N.
IntActQ9H4G4. 1 interaction.
STRING9606.ENSP00000367196.

PTM databases

PhosphoSiteQ9H4G4.

Proteomic databases

MaxQBQ9H4G4.
PaxDbQ9H4G4.
PeptideAtlasQ9H4G4.
PRIDEQ9H4G4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377960; ENSP00000367196; ENSG00000122694.
GeneID152007.
KEGGhsa:152007.
UCSCuc003zyy.1. human.

Organism-specific databases

CTD152007.
GeneCardsGC09P036127.
HGNCHGNC:18007. GLIPR2.
HPAHPA029478.
MIM607141. gene.
neXtProtNX_Q9H4G4.
PharmGKBPA164720283.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2340.
HOVERGENHBG051701.
OMAKHSVESS.
PhylomeDBQ9H4G4.
TreeFamTF313138.

Gene expression databases

ArrayExpressQ9H4G4.
BgeeQ9H4G4.
CleanExHS_GLIPR2.
GenevestigatorQ9H4G4.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGLIPR2. human.
EvolutionaryTraceQ9H4G4.
GenomeRNAi152007.
NextBio86851.
PROQ9H4G4.
SOURCESearch...

Entry information

Entry nameGAPR1_HUMAN
AccessionPrimary (citable) accession number: Q9H4G4
Secondary accession number(s): Q5VZR1 expand/collapse secondary AC list , Q8N2S6, Q8WWC9, Q8WX36
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM