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Protein

Golgi-associated plant pathogenesis-related protein 1

Gene

GLIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of epithelial cell migration Source: UniProtKB
  2. positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  3. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi-associated plant pathogenesis-related protein 1
Short name:
GAPR-1
Short name:
Golgi-associated PR-1 protein
Alternative name(s):
Glioma pathogenesis-related protein 2
Short name:
GliPR 2
Gene namesi
Name:GLIPR2
Synonyms:C9orf19, GAPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18007. GLIPR2.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
Note: Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 154153Golgi-associated plant pathogenesis-related protein 1PRO_0000211524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9H4G4.
PaxDbiQ9H4G4.
PeptideAtlasiQ9H4G4.
PRIDEiQ9H4G4.

PTM databases

PhosphoSiteiQ9H4G4.

Expressioni

Tissue specificityi

Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.1 Publication

Gene expression databases

BgeeiQ9H4G4.
CleanExiHS_GLIPR2.
ExpressionAtlasiQ9H4G4. baseline and differential.
GenevestigatoriQ9H4G4.

Organism-specific databases

HPAiHPA029478.

Interactioni

Subunit structurei

Homodimer. Interacts with CAV1.1 Publication

Protein-protein interaction databases

BioGridi127417. 8 interactions.
DIPiDIP-60127N.
IntActiQ9H4G4. 1 interaction.
STRINGi9606.ENSP00000367196.

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2319Combined sources
Helixi33 – 4917Combined sources
Helixi56 – 594Combined sources
Beta strandi62 – 7211Combined sources
Helixi76 – 849Combined sources
Helixi85 – 895Combined sources
Turni99 – 1013Combined sources
Helixi102 – 1087Combined sources
Beta strandi114 – 1218Combined sources
Beta strandi127 – 1359Combined sources
Helixi144 – 1485Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
ProteinModelPortaliQ9H4G4.
SMRiQ9H4G4. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4G4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 132119SCPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 988Interaction with CAV1

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili30 – 5324Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2340.
GeneTreeiENSGT00390000020276.
HOVERGENiHBG051701.
InParanoidiQ9H4G4.
OMAiRKQHGVP.
PhylomeDBiQ9H4G4.
TreeFamiTF313138.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4G4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR
60 70 80 90 100
ILKHSPESSR GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG
110 120 130 140 150
TGHFTAMVWK NTKKMGVGKA SASDGSSFVV ARYFPAGNVV NEGFFEENVL

PPKK
Length:154
Mass (Da):17,218
Last modified:January 23, 2007 - v3
Checksum:i5AA9B26A21EF1039
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371R → Q AA sequence (PubMed:11865038)Curated
Sequence conflicti87 – 904IKNY → VHFM in AAH17918. (PubMed:15489334)Curated
Sequence conflicti101 – 15454TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019. (PubMed:14702039)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011129 mRNA. Translation: CAC12812.1.
AY039756 mRNA. Translation: AAK83460.1.
AK074488 mRNA. Translation: BAC11019.1.
AK075091 mRNA. Translation: BAC11395.1.
AL158830 Genomic DNA. Translation: CAH73678.1.
BC017918 mRNA. Translation: AAH17918.1.
CCDSiCCDS6598.1.
RefSeqiNP_071738.1. NM_022343.3.
UniGeneiHs.493819.

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694.
GeneIDi152007.
KEGGihsa:152007.
UCSCiuc003zyy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011129 mRNA. Translation: CAC12812.1.
AY039756 mRNA. Translation: AAK83460.1.
AK074488 mRNA. Translation: BAC11019.1.
AK075091 mRNA. Translation: BAC11395.1.
AL158830 Genomic DNA. Translation: CAH73678.1.
BC017918 mRNA. Translation: AAH17918.1.
CCDSiCCDS6598.1.
RefSeqiNP_071738.1. NM_022343.3.
UniGeneiHs.493819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
ProteinModelPortaliQ9H4G4.
SMRiQ9H4G4. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127417. 8 interactions.
DIPiDIP-60127N.
IntActiQ9H4G4. 1 interaction.
STRINGi9606.ENSP00000367196.

PTM databases

PhosphoSiteiQ9H4G4.

Proteomic databases

MaxQBiQ9H4G4.
PaxDbiQ9H4G4.
PeptideAtlasiQ9H4G4.
PRIDEiQ9H4G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694.
GeneIDi152007.
KEGGihsa:152007.
UCSCiuc003zyy.1. human.

Organism-specific databases

CTDi152007.
GeneCardsiGC09P036127.
HGNCiHGNC:18007. GLIPR2.
HPAiHPA029478.
MIMi607141. gene.
neXtProtiNX_Q9H4G4.
PharmGKBiPA164720283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2340.
GeneTreeiENSGT00390000020276.
HOVERGENiHBG051701.
InParanoidiQ9H4G4.
OMAiRKQHGVP.
PhylomeDBiQ9H4G4.
TreeFamiTF313138.

Miscellaneous databases

ChiTaRSiGLIPR2. human.
EvolutionaryTraceiQ9H4G4.
GenomeRNAii152007.
NextBioi86851.
PROiQ9H4G4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H4G4.
CleanExiHS_GLIPR2.
ExpressionAtlasiQ9H4G4. baseline and differential.
GenevestigatoriQ9H4G4.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
    Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
    J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68, SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, INTERACTION WITH CAV1.
    Tissue: Brain.
  2. "Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain."
    Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.
    Gene 293:141-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Placenta.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
    Tissue: Prostate.
  6. "Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism."
    Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I., Groves M.R.
    J. Mol. Biol. 339:173-183(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), HOMODIMERIZATION.

Entry informationi

Entry nameiGAPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G4
Secondary accession number(s): Q5VZR1
, Q8N2S6, Q8WWC9, Q8WX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.