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Protein

Golgi-associated plant pathogenesis-related protein 1

Gene

GLIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi-associated plant pathogenesis-related protein 1
Short name:
GAPR-1
Short name:
Golgi-associated PR-1 protein
Alternative name(s):
Glioma pathogenesis-related protein 2
Short name:
GliPR 2
Gene namesi
Name:GLIPR2
Synonyms:C9orf19, GAPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122694.15.
HGNCiHGNC:18007. GLIPR2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152007.
OpenTargetsiENSG00000122694.
PharmGKBiPA164720283.

Chemistry databases

DrugBankiDB03661. Cysteinesulfonic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002115242 – 154Golgi-associated plant pathogenesis-related protein 1Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9H4G4.
MaxQBiQ9H4G4.
PaxDbiQ9H4G4.
PeptideAtlasiQ9H4G4.
PRIDEiQ9H4G4.
TopDownProteomicsiQ9H4G4.

PTM databases

iPTMnetiQ9H4G4.
PhosphoSitePlusiQ9H4G4.
SwissPalmiQ9H4G4.

Expressioni

Tissue specificityi

Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000122694.
CleanExiHS_GLIPR2.
ExpressionAtlasiQ9H4G4. baseline and differential.
GenevisibleiQ9H4G4. HS.

Organism-specific databases

HPAiHPA029478.

Interactioni

Subunit structurei

Homodimer. Interacts with CAV1.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi127417. 7 interactors.
DIPiDIP-60127N.
IntActiQ9H4G4. 5 interactors.
STRINGi9606.ENSP00000367196.

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 23Combined sources19
Helixi33 – 49Combined sources17
Helixi56 – 59Combined sources4
Beta strandi62 – 72Combined sources11
Helixi76 – 84Combined sources9
Helixi85 – 89Combined sources5
Turni99 – 101Combined sources3
Helixi102 – 108Combined sources7
Beta strandi114 – 121Combined sources8
Beta strandi127 – 135Combined sources9
Helixi144 – 148Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
5VHGX-ray1.27A4-153[»]
ProteinModelPortaliQ9H4G4.
SMRiQ9H4G4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4G4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 132SCPAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 98Interaction with CAV11 Publication8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 53Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00390000020276.
HOVERGENiHBG051701.
InParanoidiQ9H4G4.
OMAiWYDEVKQ.
OrthoDBiEOG091G0QVD.
PhylomeDBiQ9H4G4.
TreeFamiTF313138.

Family and domain databases

CDDicd05382. SCP_GAPR-1_like. 1 hit.
Gene3Di3.40.33.10. 1 hit.
InterProiView protein in InterPro
IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR035940. CAP_sf.
IPR034113. SCP_GAPR1-like.
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiView protein in Pfam
PF00188. CAP. 1 hit.
PRINTSiPR00837. V5TPXLIKE.
SMARTiView protein in SMART
SM00198. SCP. 1 hit.
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiView protein in PROSITE
PS01009. CRISP_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR
60 70 80 90 100
ILKHSPESSR GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG
110 120 130 140 150
TGHFTAMVWK NTKKMGVGKA SASDGSSFVV ARYFPAGNVV NEGFFEENVL

PPKK
Length:154
Mass (Da):17,218
Last modified:January 23, 2007 - v3
Checksum:i5AA9B26A21EF1039
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37R → Q AA sequence (PubMed:11865038).Curated1
Sequence conflicti87 – 90IKNY → VHFM in AAH17918 (PubMed:15489334).Curated4
Sequence conflicti101 – 154TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019 (PubMed:14702039).CuratedAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011129 mRNA. Translation: CAC12812.1.
AY039756 mRNA. Translation: AAK83460.1.
AK074488 mRNA. Translation: BAC11019.1.
AK075091 mRNA. Translation: BAC11395.1.
AL158830 Genomic DNA. No translation available.
BC017918 mRNA. Translation: AAH17918.1.
CCDSiCCDS6598.1.
RefSeqiNP_071738.1. NM_022343.3.
UniGeneiHs.493819.

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694.
GeneIDi152007.
KEGGihsa:152007.
UCSCiuc003zyz.5. human.

Similar proteinsi

Entry informationi

Entry nameiGAPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G4
Secondary accession number(s): Q5VZR1
, Q8N2S6, Q8WWC9, Q8WX36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families