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Q9H4G4

- GAPR1_HUMAN

UniProt

Q9H4G4 - GAPR1_HUMAN

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Protein
Golgi-associated plant pathogenesis-related protein 1
Gene
GLIPR2, C9orf19, GAPR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. positive regulation of ERK1 and ERK2 cascade Source: UniProt
  2. positive regulation of epithelial cell migration Source: UniProt
  3. positive regulation of epithelial to mesenchymal transition Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi-associated plant pathogenesis-related protein 1
Short name:
GAPR-1
Short name:
Golgi-associated PR-1 protein
Alternative name(s):
Glioma pathogenesis-related protein 2
Short name:
GliPR 2
Gene namesi
Name:GLIPR2
Synonyms:C9orf19, GAPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18007. GLIPR2.

Subcellular locationi

Golgi apparatus membrane; Lipid-anchor
Note: Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.1 Publication

GO - Cellular componenti

  1. Golgi membrane Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 154153Golgi-associated plant pathogenesis-related protein 1
PRO_0000211524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9H4G4.
PaxDbiQ9H4G4.
PeptideAtlasiQ9H4G4.
PRIDEiQ9H4G4.

PTM databases

PhosphoSiteiQ9H4G4.

Expressioni

Tissue specificityi

Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.1 Publication

Gene expression databases

ArrayExpressiQ9H4G4.
BgeeiQ9H4G4.
CleanExiHS_GLIPR2.
GenevestigatoriQ9H4G4.

Organism-specific databases

HPAiHPA029478.

Interactioni

Subunit structurei

Homodimer. Interacts with CAV1.2 Publications

Protein-protein interaction databases

BioGridi127417. 5 interactions.
DIPiDIP-60127N.
IntActiQ9H4G4. 1 interaction.
STRINGi9606.ENSP00000367196.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2319
Helixi33 – 4917
Helixi56 – 594
Beta strandi62 – 7211
Helixi76 – 849
Helixi85 – 895
Turni99 – 1013
Helixi102 – 1087
Beta strandi114 – 1218
Beta strandi127 – 1359
Helixi144 – 1485

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
ProteinModelPortaliQ9H4G4.
SMRiQ9H4G4. Positions 4-154.

Miscellaneous databases

EvolutionaryTraceiQ9H4G4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 132119SCP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 988Interaction with CAV1

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili30 – 5324 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CRISP family.
Contains 1 SCP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2340.
HOVERGENiHBG051701.
OMAiKHSVESS.
PhylomeDBiQ9H4G4.
TreeFamiTF313138.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4G4-1 [UniParc]FASTAAdd to Basket

« Hide

MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR    50
ILKHSPESSR GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG 100
TGHFTAMVWK NTKKMGVGKA SASDGSSFVV ARYFPAGNVV NEGFFEENVL 150
PPKK 154
Length:154
Mass (Da):17,218
Last modified:January 23, 2007 - v3
Checksum:i5AA9B26A21EF1039
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371R → Q AA sequence 1 Publication
Sequence conflicti87 – 904IKNY → VHFM in AAH17918. 1 Publication
Sequence conflicti101 – 15454TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011129 mRNA. Translation: CAC12812.1.
AY039756 mRNA. Translation: AAK83460.1.
AK074488 mRNA. Translation: BAC11019.1.
AK075091 mRNA. Translation: BAC11395.1.
AL158830 Genomic DNA. Translation: CAH73678.1.
BC017918 mRNA. Translation: AAH17918.1.
CCDSiCCDS6598.1.
RefSeqiNP_071738.1. NM_022343.3.
UniGeneiHs.493819.

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694.
GeneIDi152007.
KEGGihsa:152007.
UCSCiuc003zyy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011129 mRNA. Translation: CAC12812.1 .
AY039756 mRNA. Translation: AAK83460.1 .
AK074488 mRNA. Translation: BAC11019.1 .
AK075091 mRNA. Translation: BAC11395.1 .
AL158830 Genomic DNA. Translation: CAH73678.1 .
BC017918 mRNA. Translation: AAH17918.1 .
CCDSi CCDS6598.1.
RefSeqi NP_071738.1. NM_022343.3.
UniGenei Hs.493819.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SMB X-ray 1.55 A 1-154 [» ]
4AIW X-ray 1.50 A 1-154 [» ]
ProteinModelPortali Q9H4G4.
SMRi Q9H4G4. Positions 4-154.
ModBasei Search...

Protein-protein interaction databases

BioGridi 127417. 5 interactions.
DIPi DIP-60127N.
IntActi Q9H4G4. 1 interaction.
STRINGi 9606.ENSP00000367196.

PTM databases

PhosphoSitei Q9H4G4.

Proteomic databases

MaxQBi Q9H4G4.
PaxDbi Q9H4G4.
PeptideAtlasi Q9H4G4.
PRIDEi Q9H4G4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377960 ; ENSP00000367196 ; ENSG00000122694 .
GeneIDi 152007.
KEGGi hsa:152007.
UCSCi uc003zyy.1. human.

Organism-specific databases

CTDi 152007.
GeneCardsi GC09P036127.
HGNCi HGNC:18007. GLIPR2.
HPAi HPA029478.
MIMi 607141. gene.
neXtProti NX_Q9H4G4.
PharmGKBi PA164720283.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2340.
HOVERGENi HBG051701.
OMAi KHSVESS.
PhylomeDBi Q9H4G4.
TreeFami TF313138.

Miscellaneous databases

ChiTaRSi GLIPR2. human.
EvolutionaryTracei Q9H4G4.
GenomeRNAii 152007.
NextBioi 86851.
PROi Q9H4G4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H4G4.
Bgeei Q9H4G4.
CleanExi HS_GLIPR2.
Genevestigatori Q9H4G4.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
    Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
    J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68, SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, INTERACTION WITH CAV1.
    Tissue: Brain.
  2. "Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain."
    Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.
    Gene 293:141-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Placenta.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
    Tissue: Prostate.
  6. "Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism."
    Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I., Groves M.R.
    J. Mol. Biol. 339:173-183(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), HOMODIMERIZATION.

Entry informationi

Entry nameiGAPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G4
Secondary accession number(s): Q5VZR1
, Q8N2S6, Q8WWC9, Q8WX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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