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Q9H4G4

- GAPR1_HUMAN

UniProt

Q9H4G4 - GAPR1_HUMAN

Protein

Golgi-associated plant pathogenesis-related protein 1

Gene

GLIPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein homodimerization activity Source: UniProt

    GO - Biological processi

    1. positive regulation of epithelial cell migration Source: UniProt
    2. positive regulation of epithelial to mesenchymal transition Source: UniProt
    3. positive regulation of ERK1 and ERK2 cascade Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi-associated plant pathogenesis-related protein 1
    Short name:
    GAPR-1
    Short name:
    Golgi-associated PR-1 protein
    Alternative name(s):
    Glioma pathogenesis-related protein 2
    Short name:
    GliPR 2
    Gene namesi
    Name:GLIPR2
    Synonyms:C9orf19, GAPR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18007. GLIPR2.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
    Note: Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi membrane Source: UniProt

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164720283.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 154153Golgi-associated plant pathogenesis-related protein 1PRO_0000211524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiQ9H4G4.
    PaxDbiQ9H4G4.
    PeptideAtlasiQ9H4G4.
    PRIDEiQ9H4G4.

    PTM databases

    PhosphoSiteiQ9H4G4.

    Expressioni

    Tissue specificityi

    Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9H4G4.
    BgeeiQ9H4G4.
    CleanExiHS_GLIPR2.
    GenevestigatoriQ9H4G4.

    Organism-specific databases

    HPAiHPA029478.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CAV1.1 Publication

    Protein-protein interaction databases

    BioGridi127417. 5 interactions.
    DIPiDIP-60127N.
    IntActiQ9H4G4. 1 interaction.
    STRINGi9606.ENSP00000367196.

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2319
    Helixi33 – 4917
    Helixi56 – 594
    Beta strandi62 – 7211
    Helixi76 – 849
    Helixi85 – 895
    Turni99 – 1013
    Helixi102 – 1087
    Beta strandi114 – 1218
    Beta strandi127 – 1359
    Helixi144 – 1485

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SMBX-ray1.55A1-154[»]
    4AIWX-ray1.50A1-154[»]
    ProteinModelPortaliQ9H4G4.
    SMRiQ9H4G4. Positions 4-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H4G4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 132119SCPAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni91 – 988Interaction with CAV1

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili30 – 5324Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2340.
    HOVERGENiHBG051701.
    OMAiKHSVESS.
    PhylomeDBiQ9H4G4.
    TreeFamiTF313138.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H4G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR    50
    ILKHSPESSR GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG 100
    TGHFTAMVWK NTKKMGVGKA SASDGSSFVV ARYFPAGNVV NEGFFEENVL 150
    PPKK 154
    Length:154
    Mass (Da):17,218
    Last modified:January 23, 2007 - v3
    Checksum:i5AA9B26A21EF1039
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371R → Q AA sequence (PubMed:11865038)Curated
    Sequence conflicti87 – 904IKNY → VHFM in AAH17918. (PubMed:15489334)Curated
    Sequence conflicti101 – 15454TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019. (PubMed:14702039)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011129 mRNA. Translation: CAC12812.1.
    AY039756 mRNA. Translation: AAK83460.1.
    AK074488 mRNA. Translation: BAC11019.1.
    AK075091 mRNA. Translation: BAC11395.1.
    AL158830 Genomic DNA. Translation: CAH73678.1.
    BC017918 mRNA. Translation: AAH17918.1.
    CCDSiCCDS6598.1.
    RefSeqiNP_071738.1. NM_022343.3.
    UniGeneiHs.493819.

    Genome annotation databases

    EnsembliENST00000377960; ENSP00000367196; ENSG00000122694.
    GeneIDi152007.
    KEGGihsa:152007.
    UCSCiuc003zyy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011129 mRNA. Translation: CAC12812.1 .
    AY039756 mRNA. Translation: AAK83460.1 .
    AK074488 mRNA. Translation: BAC11019.1 .
    AK075091 mRNA. Translation: BAC11395.1 .
    AL158830 Genomic DNA. Translation: CAH73678.1 .
    BC017918 mRNA. Translation: AAH17918.1 .
    CCDSi CCDS6598.1.
    RefSeqi NP_071738.1. NM_022343.3.
    UniGenei Hs.493819.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SMB X-ray 1.55 A 1-154 [» ]
    4AIW X-ray 1.50 A 1-154 [» ]
    ProteinModelPortali Q9H4G4.
    SMRi Q9H4G4. Positions 4-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127417. 5 interactions.
    DIPi DIP-60127N.
    IntActi Q9H4G4. 1 interaction.
    STRINGi 9606.ENSP00000367196.

    PTM databases

    PhosphoSitei Q9H4G4.

    Proteomic databases

    MaxQBi Q9H4G4.
    PaxDbi Q9H4G4.
    PeptideAtlasi Q9H4G4.
    PRIDEi Q9H4G4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377960 ; ENSP00000367196 ; ENSG00000122694 .
    GeneIDi 152007.
    KEGGi hsa:152007.
    UCSCi uc003zyy.1. human.

    Organism-specific databases

    CTDi 152007.
    GeneCardsi GC09P036127.
    HGNCi HGNC:18007. GLIPR2.
    HPAi HPA029478.
    MIMi 607141. gene.
    neXtProti NX_Q9H4G4.
    PharmGKBi PA164720283.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2340.
    HOVERGENi HBG051701.
    OMAi KHSVESS.
    PhylomeDBi Q9H4G4.
    TreeFami TF313138.

    Miscellaneous databases

    ChiTaRSi GLIPR2. human.
    EvolutionaryTracei Q9H4G4.
    GenomeRNAii 152007.
    NextBioi 86851.
    PROi Q9H4G4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H4G4.
    Bgeei Q9H4G4.
    CleanExi HS_GLIPR2.
    Genevestigatori Q9H4G4.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
      Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
      J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68, SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, INTERACTION WITH CAV1.
      Tissue: Brain.
    2. "Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain."
      Eisenberg I., Barash M., Kahan T., Mitrani-Rosenbaum S.
      Gene 293:141-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Placenta.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-90.
      Tissue: Prostate.
    6. "Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism."
      Serrano R.L., Kuhn A., Hendricks A., Helms J.B., Sinning I., Groves M.R.
      J. Mol. Biol. 339:173-183(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), HOMODIMERIZATION.

    Entry informationi

    Entry nameiGAPR1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4G4
    Secondary accession number(s): Q5VZR1
    , Q8N2S6, Q8WWC9, Q8WX36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3