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Q9H4G1

- CST9L_HUMAN

UniProt

Q9H4G1 - CST9L_HUMAN

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Protein

Cystatin-9-like

Gene

CST9L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9-like
Gene namesi
Name:CST9L
ORF Names:UNQ1835/PRO3543
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16233. CST9L.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 147119Cystatin-9-likePRO_0000006656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi98 ↔ 108By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi122 ↔ 142By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H4G1.
PRIDEiQ9H4G1.

Expressioni

Gene expression databases

BgeeiQ9H4G1.
CleanExiHS_CST9L.
GenevestigatoriQ9H4G1.

Interactioni

Protein-protein interaction databases

BioGridi126159. 3 interactions.
IntActiQ9H4G1. 3 interactions.
STRINGi9606.ENSP00000366178.

Structurei

3D structure databases

ProteinModelPortaliQ9H4G1.
SMRiQ9H4G1. Positions 53-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43835.
GeneTreeiENSGT00430000031103.
HOGENOMiHOG000231754.
HOVERGENiHBG096568.
InParanoidiQ9H4G1.
KOiK13905.
OMAiTCLEGFH.
OrthoDBiEOG74J9B3.
PhylomeDBiQ9H4G1.

Family and domain databases

InterProiIPR027213. CST9_like.
IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGLPWKGGL SWALLLLLLG SQILLIYAWH FHEQRDCDEH NVMARYLPAT
60 70 80 90 100
VEFAVHTFNQ QSKDYYAYRL GHILNSWKEQ VESKTVFSME LLLGRTRCGK
110 120 130 140
FEDDIDNCHF QESTELNNTF TCFFTISTRP WMTQFSLLNK TCLEGFH
Length:147
Mass (Da):17,276
Last modified:March 1, 2001 - v1
Checksum:i3A3286FFADCA4FD6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091H → P.
Corresponds to variant rs2295564 [ dbSNP | Ensembl ].
VAR_022079

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358615 mRNA. Translation: AAQ88978.1.
AK312112 mRNA. Translation: BAG35048.1.
AL121894 Genomic DNA. Translation: CAC05421.1.
CH471133 Genomic DNA. Translation: EAX10140.1.
BC029656 mRNA. Translation: AAH29656.1.
CCDSiCCDS13157.1.
RefSeqiNP_542177.1. NM_080610.2.
UniGeneiHs.121554.

Genome annotation databases

EnsembliENST00000376979; ENSP00000366178; ENSG00000101435.
GeneIDi128821.
KEGGihsa:128821.
UCSCiuc002wtk.4. human.

Polymorphism databases

DMDMi20137970.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358615 mRNA. Translation: AAQ88978.1 .
AK312112 mRNA. Translation: BAG35048.1 .
AL121894 Genomic DNA. Translation: CAC05421.1 .
CH471133 Genomic DNA. Translation: EAX10140.1 .
BC029656 mRNA. Translation: AAH29656.1 .
CCDSi CCDS13157.1.
RefSeqi NP_542177.1. NM_080610.2.
UniGenei Hs.121554.

3D structure databases

ProteinModelPortali Q9H4G1.
SMRi Q9H4G1. Positions 53-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126159. 3 interactions.
IntActi Q9H4G1. 3 interactions.
STRINGi 9606.ENSP00000366178.

Polymorphism databases

DMDMi 20137970.

Proteomic databases

PaxDbi Q9H4G1.
PRIDEi Q9H4G1.

Protocols and materials databases

DNASUi 128821.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376979 ; ENSP00000366178 ; ENSG00000101435 .
GeneIDi 128821.
KEGGi hsa:128821.
UCSCi uc002wtk.4. human.

Organism-specific databases

CTDi 128821.
GeneCardsi GC20M023545.
HGNCi HGNC:16233. CST9L.
neXtProti NX_Q9H4G1.
PharmGKBi PA26982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43835.
GeneTreei ENSGT00430000031103.
HOGENOMi HOG000231754.
HOVERGENi HBG096568.
InParanoidi Q9H4G1.
KOi K13905.
OMAi TCLEGFH.
OrthoDBi EOG74J9B3.
PhylomeDBi Q9H4G1.

Miscellaneous databases

GeneWikii CST9L.
GenomeRNAii 128821.
NextBioi 82459.
PROi Q9H4G1.

Gene expression databases

Bgeei Q9H4G1.
CleanExi HS_CST9L.
Genevestigatori Q9H4G1.

Family and domain databases

InterProi IPR027213. CST9_like.
IPR027214. Cystatin.
IPR000010. Prot_inh_cystat.
[Graphical view ]
PANTHERi PTHR11413. PTHR11413. 1 hit.
PTHR11413:SF22. PTHR11413:SF22. 1 hit.
Pfami PF00031. Cystatin. 1 hit.
[Graphical view ]
SMARTi SM00043. CY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.

Entry informationi

Entry nameiCST9L_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G1
Secondary accession number(s): B2R5A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3