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Q9H4G1

- CST9L_HUMAN

UniProt

Q9H4G1 - CST9L_HUMAN

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Protein
Cystatin-9-like
Gene
CST9L, UNQ1835/PRO3543
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystatin-9-like
    Gene namesi
    Name:CST9L
    ORF Names:UNQ1835/PRO3543
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16233. CST9L.

    Subcellular locationi

    Secreted Reviewed prediction

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 Publication
    Add
    BLAST
    Chaini29 – 147119Cystatin-9-like
    PRO_0000006656Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi98 ↔ 108 By similarity
    Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi122 ↔ 142 By similarity
    Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H4G1.
    PRIDEiQ9H4G1.

    Expressioni

    Gene expression databases

    BgeeiQ9H4G1.
    CleanExiHS_CST9L.
    GenevestigatoriQ9H4G1.

    Interactioni

    Protein-protein interaction databases

    BioGridi126159. 3 interactions.
    IntActiQ9H4G1. 3 interactions.
    STRINGi9606.ENSP00000366178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4G1.
    SMRiQ9H4G1. Positions 53-137.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cystatin family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43835.
    HOGENOMiHOG000231754.
    HOVERGENiHBG096568.
    InParanoidiQ9H4G1.
    KOiK13905.
    OMAiTCLEGFH.
    OrthoDBiEOG74J9B3.
    PhylomeDBiQ9H4G1.

    Family and domain databases

    InterProiIPR027213. CST9_like.
    IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view]
    PANTHERiPTHR11413. PTHR11413. 1 hit.
    PTHR11413:SF22. PTHR11413:SF22. 1 hit.
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    SMARTiSM00043. CY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H4G1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGLPWKGGL SWALLLLLLG SQILLIYAWH FHEQRDCDEH NVMARYLPAT    50
    VEFAVHTFNQ QSKDYYAYRL GHILNSWKEQ VESKTVFSME LLLGRTRCGK 100
    FEDDIDNCHF QESTELNNTF TCFFTISTRP WMTQFSLLNK TCLEGFH 147
    Length:147
    Mass (Da):17,276
    Last modified:March 1, 2001 - v1
    Checksum:i3A3286FFADCA4FD6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091H → P.
    Corresponds to variant rs2295564 [ dbSNP | Ensembl ].
    VAR_022079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358615 mRNA. Translation: AAQ88978.1.
    AK312112 mRNA. Translation: BAG35048.1.
    AL121894 Genomic DNA. Translation: CAC05421.1.
    CH471133 Genomic DNA. Translation: EAX10140.1.
    BC029656 mRNA. Translation: AAH29656.1.
    CCDSiCCDS13157.1.
    RefSeqiNP_542177.1. NM_080610.2.
    UniGeneiHs.121554.

    Genome annotation databases

    EnsembliENST00000376979; ENSP00000366178; ENSG00000101435.
    GeneIDi128821.
    KEGGihsa:128821.
    UCSCiuc002wtk.4. human.

    Polymorphism databases

    DMDMi20137970.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358615 mRNA. Translation: AAQ88978.1 .
    AK312112 mRNA. Translation: BAG35048.1 .
    AL121894 Genomic DNA. Translation: CAC05421.1 .
    CH471133 Genomic DNA. Translation: EAX10140.1 .
    BC029656 mRNA. Translation: AAH29656.1 .
    CCDSi CCDS13157.1.
    RefSeqi NP_542177.1. NM_080610.2.
    UniGenei Hs.121554.

    3D structure databases

    ProteinModelPortali Q9H4G1.
    SMRi Q9H4G1. Positions 53-137.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 126159. 3 interactions.
    IntActi Q9H4G1. 3 interactions.
    STRINGi 9606.ENSP00000366178.

    Polymorphism databases

    DMDMi 20137970.

    Proteomic databases

    PaxDbi Q9H4G1.
    PRIDEi Q9H4G1.

    Protocols and materials databases

    DNASUi 128821.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376979 ; ENSP00000366178 ; ENSG00000101435 .
    GeneIDi 128821.
    KEGGi hsa:128821.
    UCSCi uc002wtk.4. human.

    Organism-specific databases

    CTDi 128821.
    GeneCardsi GC20M023545.
    HGNCi HGNC:16233. CST9L.
    neXtProti NX_Q9H4G1.
    PharmGKBi PA26982.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43835.
    HOGENOMi HOG000231754.
    HOVERGENi HBG096568.
    InParanoidi Q9H4G1.
    KOi K13905.
    OMAi TCLEGFH.
    OrthoDBi EOG74J9B3.
    PhylomeDBi Q9H4G1.

    Miscellaneous databases

    GeneWikii CST9L.
    GenomeRNAii 128821.
    NextBioi 82459.
    PROi Q9H4G1.

    Gene expression databases

    Bgeei Q9H4G1.
    CleanExi HS_CST9L.
    Genevestigatori Q9H4G1.

    Family and domain databases

    InterProi IPR027213. CST9_like.
    IPR027214. Cystatin.
    IPR000010. Prot_inh_cystat.
    [Graphical view ]
    PANTHERi PTHR11413. PTHR11413. 1 hit.
    PTHR11413:SF22. PTHR11413:SF22. 1 hit.
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    SMARTi SM00043. CY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.

    Entry informationi

    Entry nameiCST9L_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4G1
    Secondary accession number(s): B2R5A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: July 9, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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