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Protein
Submitted name:

Protein kinase

Gene

dik

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

SignaLinkiQ9H4D1.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinaseImported
Gene namesi
Name:dikImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24805.

PTM / Processingi

Proteomic databases

PaxDbiQ9H4D1.
PeptideAtlasiQ9H4D1.

PTM databases

iPTMnetiQ9H4D1.

Expressioni

Gene expression databases

GenevisibleiQ9H4D1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332454.

Structurei

3D structure databases

ProteinModelPortaliQ9H4D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 286265Protein kinaseInterPro annotationAdd
BLAST
Domaini437 – 766330ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 9 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
KOG0504. Eukaryota.
COG0515. LUCA.
COG0666. LUCA.
HOVERGENiHBG061582.
KOiK08848.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H4D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDGGTPWA LALLRTFDAG EFTGWEKVGS GGFGQVYKVR HVHWKTWLAI
60 70 80 90 100
KCSPSLHVDD RERMELLEEA KKMEMAKFRY ILPVYGICRE PVGLVMEYME
110 120 130 140 150
TGSLEKLLAS EPLPWDLRFR IIHETAVGMN FLHCMAPPLL HLDLKPANIL
160 170 180 190 200
LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG LFGTIAYLPP ERIREKSRLF
210 220 230 240 250
DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMVKVVKGH RPELPPVCRA
260 270 280 290 300
RPRACSHLIR LMQRCWQGDP RVRPTFQEIT SETEDLCEKP DDEVKETAHD
310 320 330 340 350
LDVKSPPEPR SEVVPARLKR ASAPTFDNDY SLSELLSQLD SGVSQAVEGP
360 370 380 390 400
EELSRSSSES KLPSSGSGKR LSGVSSVDSA FSSRGSLSLS FEREPSTSDL
410 420 430 440 450
GTTDVQKKKL VDAIVSGDTS KLMKILQPQD VDLALDSGAS LLHLAVEAGQ
460 470 480 490 500
EECAKWLLLN NANPNLSNRR GSTPLHMAVE RRVRGVVELL LARKISVNAK
510 520 530 540 550
DEDQWTALHF AAQNGDESST RLLLEKNASV NEVDFEGRTP MHVACQHGQE
560 570 580 590 600
NIVRILLRRG VDVSLQGKDA WLPLHYAAWQ GHLPIVKLLA KQPGVSVNAQ
610 620 630 640 650
TLDGRTPLHL AAQRGHYRVA RILIDLCSDV NVCSLLAQTP LHVAAETGHT
660 670 680 690 700
STARLLLHRG AGKKAVTSDG YTALHLAARN GHLATVKLLV EEKADVLARG
710 720 730 740 750
PLNQTALHLA AAHGHSEVVE ELVSADVIDL FDEQGLSALH LAAQGRHAQT
760 770 780
VETLLRHGAH INLQSLKFQG GHGPAATLLR RSKT
Length:784
Mass (Da):86,408
Last modified:March 1, 2001 - v1
Checksum:iF3C7D5D52A35AF91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278016 mRNA. Translation: CAC04247.1.
RefSeqiNP_065690.2. NM_020639.2.
UniGeneiHs.517310.

Genome annotation databases

GeneIDi54101.
KEGGihsa:54101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278016 mRNA. Translation: CAC04247.1.
RefSeqiNP_065690.2. NM_020639.2.
UniGeneiHs.517310.

3D structure databases

ProteinModelPortaliQ9H4D1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332454.

PTM databases

iPTMnetiQ9H4D1.

Proteomic databases

PaxDbiQ9H4D1.
PeptideAtlasiQ9H4D1.

Protocols and materials databases

DNASUi54101.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54101.
KEGGihsa:54101.

Organism-specific databases

CTDi54101.
PharmGKBiPA24805.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
KOG0504. Eukaryota.
COG0515. LUCA.
COG0666. LUCA.
HOVERGENiHBG061582.
KOiK08848.

Enzyme and pathway databases

SignaLinkiQ9H4D1.

Miscellaneous databases

GenomeRNAii54101.

Gene expression databases

GenevisibleiQ9H4D1. HS.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9H4D1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4D1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.