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Protein

Calsyntenin-2

Gene

CLSTN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate calcium-mediated postsynaptic signals.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Calsyntenin-2
Alternative name(s):
Alcadein-gamma
Short name:
Alc-gamma
Gene namesi
Name:CLSTN2
Synonyms:CS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17448. CLSTN2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 831ExtracellularSequence analysisAdd BLAST811
Transmembranei832 – 852HelicalSequence analysisAdd BLAST21
Topological domaini853 – 955CytoplasmicSequence analysisAdd BLAST103

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64084.
OpenTargetsiENSG00000158258.
PharmGKBiPA38239.

Polymorphism and mutation databases

BioMutaiCLSTN2.
DMDMi296434469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000402321 – 955Calsyntenin-2Add BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi716N-linked (GlcNAc...)Sequence analysis1
Glycosylationi729N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9H4D0.
PaxDbiQ9H4D0.
PeptideAtlasiQ9H4D0.
PRIDEiQ9H4D0.

PTM databases

iPTMnetiQ9H4D0.
PhosphoSitePlusiQ9H4D0.

Expressioni

Tissue specificityi

Restricted to the brain.1 Publication

Gene expression databases

BgeeiENSG00000158258.
CleanExiHS_CLSTN2.
GenevisibleiQ9H4D0. HS.

Organism-specific databases

HPAiHPA031342.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000402460.

Structurei

3D structure databases

ProteinModelPortaliQ9H4D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST117
Domaini161 – 280Cadherin 2PROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi889 – 929Glu-rich (highly acidic)Add BLAST41

Domaini

Binds synaptic Ca2+ with its cytoplasmic domain.By similarity

Sequence similaritiesi

Contains 2 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOVERGENiHBG051146.
InParanoidiQ9H4D0.
OMAiWQDWTKR.
OrthoDBiEOG091G05I8.
PhylomeDBiQ9H4D0.
TreeFamiTF315946.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 1 hit.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGRLCWVP LLLALGVGSG SGGGGDSRQR RLLAAKVNKH KPWIETSYHG
60 70 80 90 100
VITENNDTVI LDPPLVALDK DAPVPFAGEI CAFKIHGQEL PFEAVVLNKT
110 120 130 140 150
SGEGRLRAKS PIDCELQKEY TFIIQAYDCG AGPHETAWKK SHKAVVHIQV
160 170 180 190 200
KDVNEFAPTF KEPAYKAVVT EGKIYDSILQ VEAIDEDCSP QYSQICNYEI
210 220 230 240 250
VTTDVPFAID RNGNIRNTEK LSYDKQHQYE ILVTAYDCGQ KPAAQDTLVQ
260 270 280 290 300
VDVKPVCKPG WQDWTKRIEY QPGSGSMPLF PSIHLETCDG AVSSLQIVTE
310 320 330 340 350
LQTNYIGKGC DRETYSEKSL QKLCGASSGI IDLLPSPSAA TNWTAGLLVD
360 370 380 390 400
SSEMIFKFDG RQGAKVPDGI VPKNLTDQFT ITMWMKHGPS PGVRAEKETI
410 420 430 440 450
LCNSDKTEMN RHHYALYVHN CRLVFLLRKD FDQADTFRPA EFHWKLDQIC
460 470 480 490 500
DKEWHYYVIN VEFPVVTLYM DGATYEPYLV TNDWPIHPSH IAMQLTVGAC
510 520 530 540 550
WQGGEVTKPQ FAQFFHGSLA SLTIRPGKME SQKVISCLQA CKEGLDINSL
560 570 580 590 600
ESLGQGIKYH FNPSQSILVM EGDDIGNINR ALQKVSYINS RQFPTAGVRR
610 620 630 640 650
LKVSSKVQCF GEDVCISIPE VDAYVMVLQA IEPRITLRGT DHFWRPAAQF
660 670 680 690 700
ESARGVTLFP DIKIVSTFAK TEAPGDVKTT DPKSEVLEEM LHNLDFCDIL
710 720 730 740 750
VIGGDLDPRQ ECLELNHSEL HQRHLDATNS TAGYSIYGVG SMSRYEQVLH
760 770 780 790 800
HIRYRNWRPA SLEARRFRIK CSELNGRYTS NEFNLEVSIL HEDQVSDKEH
810 820 830 840 850
VNHLIVQPPF LQSVHHPESR SSIQHSSVVP SIATVVIIIS VCMLVFVVAM
860 870 880 890 900
GVYRVRIAHQ HFIQETEAAK ESEMDWDDSA LTITVNPMEK HEGPGHGEDE
910 920 930 940 950
TEGEEEEEAE EEMSSSSGSD DSEEEEEEEG MGRGRHGQNG ARQAQLEWDD

STLPY
Length:955
Mass (Da):107,006
Last modified:May 18, 2010 - v2
Checksum:i6059F3277F152E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti847V → D in AAI03507 (PubMed:15489334).Curated1
Sequence conflicti946L → P in AAI03507 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036112193S → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055615331I → T.Corresponds to variant rs17348572dbSNPEnsembl.1
Natural variantiVAR_039557366V → I.3 PublicationsCorresponds to variant rs7632885dbSNPEnsembl.1
Natural variantiVAR_036113765R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs766718816dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278018 mRNA. Translation: CAC14924.1.
AY753303 mRNA. Translation: AAV30553.1.
AK315308 mRNA. Translation: BAG37712.1.
AC010181 Genomic DNA. No translation available.
AC048346 Genomic DNA. No translation available.
AC092988 Genomic DNA. No translation available.
AC108744 Genomic DNA. No translation available.
AC117390 Genomic DNA. No translation available.
AC117396 Genomic DNA. No translation available.
AC117449 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79018.1.
BC004871 mRNA. Translation: AAH04871.2.
BC007943 mRNA. Translation: AAH07943.2.
BC103496 mRNA. Translation: AAI03497.1.
BC103506 mRNA. Translation: AAI03507.1.
BC104485 mRNA. Translation: AAI04486.1.
CCDSiCCDS3112.1.
RefSeqiNP_071414.2. NM_022131.2.
UniGeneiHs.158529.

Genome annotation databases

EnsembliENST00000458420; ENSP00000402460; ENSG00000158258.
GeneIDi64084.
KEGGihsa:64084.
UCSCiuc003etn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278018 mRNA. Translation: CAC14924.1.
AY753303 mRNA. Translation: AAV30553.1.
AK315308 mRNA. Translation: BAG37712.1.
AC010181 Genomic DNA. No translation available.
AC048346 Genomic DNA. No translation available.
AC092988 Genomic DNA. No translation available.
AC108744 Genomic DNA. No translation available.
AC117390 Genomic DNA. No translation available.
AC117396 Genomic DNA. No translation available.
AC117449 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79018.1.
BC004871 mRNA. Translation: AAH04871.2.
BC007943 mRNA. Translation: AAH07943.2.
BC103496 mRNA. Translation: AAI03497.1.
BC103506 mRNA. Translation: AAI03507.1.
BC104485 mRNA. Translation: AAI04486.1.
CCDSiCCDS3112.1.
RefSeqiNP_071414.2. NM_022131.2.
UniGeneiHs.158529.

3D structure databases

ProteinModelPortaliQ9H4D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402460.

PTM databases

iPTMnetiQ9H4D0.
PhosphoSitePlusiQ9H4D0.

Polymorphism and mutation databases

BioMutaiCLSTN2.
DMDMi296434469.

Proteomic databases

EPDiQ9H4D0.
PaxDbiQ9H4D0.
PeptideAtlasiQ9H4D0.
PRIDEiQ9H4D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458420; ENSP00000402460; ENSG00000158258.
GeneIDi64084.
KEGGihsa:64084.
UCSCiuc003etn.4. human.

Organism-specific databases

CTDi64084.
DisGeNETi64084.
GeneCardsiCLSTN2.
H-InvDBHIX0003719.
HGNCiHGNC:17448. CLSTN2.
HPAiHPA031342.
MIMi611323. gene.
neXtProtiNX_Q9H4D0.
OpenTargetsiENSG00000158258.
PharmGKBiPA38239.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOVERGENiHBG051146.
InParanoidiQ9H4D0.
OMAiWQDWTKR.
OrthoDBiEOG091G05I8.
PhylomeDBiQ9H4D0.
TreeFamiTF315946.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158258-MONOMER.

Miscellaneous databases

ChiTaRSiCLSTN2. human.
GenomeRNAii64084.
PROiQ9H4D0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158258.
CleanExiHS_CLSTN2.
GenevisibleiQ9H4D0. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 1 hit.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSTN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4D0
Secondary accession number(s): B2RCW5
, D3DNF4, Q3SX54, Q3ZB76, Q5UE56, Q96HZ2, Q9BSS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.