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Protein

Dipeptidase 3

Gene

DPEP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi99Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi196Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi196Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi269Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi290Zinc 2; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
Biological processMeiosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646 Aflatoxin activation and detoxification

Protein family/group databases

MEROPSiM19.011

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:DPEP3
ORF Names:UNQ834/PRO1772
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000141096.4
HGNCiHGNC:23029 DPEP3
MIMi609926 gene
neXtProtiNX_Q9H4B8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978786

Polymorphism and mutation databases

BioMutaiDPEP3
DMDMi91206587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023160936 – 463Dipeptidase 3Add BLAST428
PropeptideiPRO_0000231610464 – 488Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 225PROSITE-ProRule annotation
Disulfide bondi297 ↔ 329PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434InterchainPROSITE-ProRule annotation
Lipidationi463GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9H4B8
PaxDbiQ9H4B8
PeptideAtlasiQ9H4B8
PRIDEiQ9H4B8
ProteomicsDBi80820

PTM databases

iPTMnetiQ9H4B8
PhosphoSitePlusiQ9H4B8

Expressioni

Gene expression databases

BgeeiENSG00000141096
CleanExiHS_DPEP3
GenevisibleiQ9H4B8 HS

Organism-specific databases

HPAiHPA031870
HPA058607

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).PROSITE-ProRule annotationBy similarity

Protein-protein interaction databases

BioGridi122099, 5 interactors
STRINGi9606.ENSP00000268793

Structurei

3D structure databases

ProteinModelPortaliQ9H4B8
SMRiQ9H4B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127 Eukaryota
COG2355 LUCA
HOGENOMiHOG000072016
HOVERGENiHBG002339
InParanoidiQ9H4B8
KOiK01273
OrthoDBiEOG091G09CU
PhylomeDBiQ9H4B8
TreeFamiTF324523

Family and domain databases

CDDicd01301 rDP_like, 1 hit
InterProiView protein in InterPro
IPR000180 Dipep_AS
IPR032466 Metal_Hydrolase
IPR008257 Pept_M19
PANTHERiPTHR10443 PTHR10443, 1 hit
PfamiView protein in Pfam
PF01244 Peptidase_M19, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
PROSITEiView protein in PROSITE
PS00869 RENAL_DIPEPTIDASE_1, 1 hit
PS51365 RENAL_DIPEPTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTGREGSR ALSRRYLRRL LLLLLLLLLR QPVTRAETTP GAPRALSTLG
60 70 80 90 100
SPSLFTTPGV PSALTTPGLT TPGTPKTLDL RGRAQALMRS FPLVDGHNDL
110 120 130 140 150
PQVLRQRYKN VLQDVNLRNF SHGQTSLDRL RDGLVGAQFW SASVSCQSQD
160 170 180 190 200
QTAVRLALEQ IDLIHRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS
210 220 230 240 250
LDSSLSVLRS FYVLGVRYLT LTFTCSTPWA ESSTKFRHHM YTNVSGLTSF
260 270 280 290 300
GEKVVEELNR LGMMIDLSYA SDTLIRRVLE VSQAPVIFSH SAARAVCDNL
310 320 330 340 350
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG
360 370 380 390 400
SEFIGIGGNY DGTGRFPQGL EDVSTYPVLI EELLSRSWSE EELQGVLRGN
410 420 430 440 450
LLRVFRQVEK VREESRAQSP VEAEFPYGQL STSCHSHLVP QNGHQATHLE
460 470 480
VTKQPTNRVP WRSSNASPYL VPGLVAAATI PTFTQWLC
Length:488
Mass (Da):53,687
Last modified:April 4, 2006 - v2
Checksum:iF14FEE5AFB3F4471
GO

Sequence cautioni

The sequence AAH57789 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG51910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC15385 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW83198 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48Missing in AAH57789 (PubMed:15489334).Curated1
Sequence conflicti312Missing in AAQ88756 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291679 mRNA Translation: CAC15385.1 Different initiation.
AY358390 mRNA Translation: AAQ88756.1
AK057401 mRNA Translation: BAG51910.1 Different initiation.
AC040162 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83198.1 Different initiation.
BC057789 mRNA Translation: AAH57789.1 Different initiation.
RefSeqiNP_001123230.1, NM_001129758.1
NP_071752.3, NM_022357.3
UniGeneiHs.302028

Genome annotation databases

EnsembliENST00000268793; ENSP00000268793; ENSG00000141096
GeneIDi64180
KEGGihsa:64180
UCSCiuc002evc.5 human

Similar proteinsi

Entry informationi

Entry nameiDPEP3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4B8
Secondary accession number(s): B3KQ48, Q6PEZ5, Q6UXE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: June 20, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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