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Q9H4B8

- DPEP3_HUMAN

UniProt

Q9H4B8 - DPEP3_HUMAN

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Protein

Dipeptidase 3

Gene
DPEP3, UNQ834/PRO1772
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Enzyme regulationi

Inhibited by L-penicillamine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1; catalytic By similarity
Metal bindingi99 – 991Zinc 1; catalytic By similarity
Metal bindingi196 – 1961Zinc 1; catalytic By similarity
Metal bindingi196 – 1961Zinc 2; catalytic By similarity
Metal bindingi269 – 2691Zinc 2; catalytic By similarity
Metal bindingi290 – 2901Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro

GO - Biological processi

  1. male meiosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:DPEP3
ORF Names:UNQ834/PRO1772
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:23029. DPEP3.

Subcellular locationi

Membrane; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Chaini36 – 463428Dipeptidase 3PRO_0000231609Add
BLAST
Propeptidei464 – 48825Removed in mature form Reviewed predictionPRO_0000231610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 225 By similarity
Disulfide bondi297 ↔ 329 By similarity
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi434 – 434Interchain By similarity
Lipidationi463 – 4631GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9H4B8.
PRIDEiQ9H4B8.

PTM databases

PhosphoSiteiQ9H4B8.

Expressioni

Gene expression databases

BgeeiQ9H4B8.
CleanExiHS_DPEP3.
GenevestigatoriQ9H4B8.

Organism-specific databases

HPAiHPA031870.
HPA058607.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

BioGridi122099. 1 interaction.
STRINGi9606.ENSP00000268793.

Structurei

3D structure databases

ProteinModelPortaliQ9H4B8.
SMRiQ9H4B8. Positions 80-437.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ9H4B8.
OrthoDBiEOG7SJD4N.
PhylomeDBiQ9H4B8.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4B8-1 [UniParc]FASTAAdd to Basket

« Hide

MQPTGREGSR ALSRRYLRRL LLLLLLLLLR QPVTRAETTP GAPRALSTLG    50
SPSLFTTPGV PSALTTPGLT TPGTPKTLDL RGRAQALMRS FPLVDGHNDL 100
PQVLRQRYKN VLQDVNLRNF SHGQTSLDRL RDGLVGAQFW SASVSCQSQD 150
QTAVRLALEQ IDLIHRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS 200
LDSSLSVLRS FYVLGVRYLT LTFTCSTPWA ESSTKFRHHM YTNVSGLTSF 250
GEKVVEELNR LGMMIDLSYA SDTLIRRVLE VSQAPVIFSH SAARAVCDNL 300
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG 350
SEFIGIGGNY DGTGRFPQGL EDVSTYPVLI EELLSRSWSE EELQGVLRGN 400
LLRVFRQVEK VREESRAQSP VEAEFPYGQL STSCHSHLVP QNGHQATHLE 450
VTKQPTNRVP WRSSNASPYL VPGLVAAATI PTFTQWLC 488
Length:488
Mass (Da):53,687
Last modified:April 4, 2006 - v2
Checksum:iF14FEE5AFB3F4471
GO

Sequence cautioni

The sequence AAH57789.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG51910.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC15385.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAW83198.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481Missing in AAH57789. 1 Publication
Sequence conflicti312 – 3121Missing in AAQ88756. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291679 mRNA. Translation: CAC15385.1. Different initiation.
AY358390 mRNA. Translation: AAQ88756.1.
AK057401 mRNA. Translation: BAG51910.1. Different initiation.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83198.1. Different initiation.
BC057789 mRNA. Translation: AAH57789.1. Different initiation.
RefSeqiNP_001123230.1. NM_001129758.1.
NP_071752.3. NM_022357.3.
UniGeneiHs.302028.

Genome annotation databases

EnsembliENST00000268793; ENSP00000268793; ENSG00000141096.
GeneIDi64180.
KEGGihsa:64180.
UCSCiuc002evc.4. human.

Polymorphism databases

DMDMi91206587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291679 mRNA. Translation: CAC15385.1 . Different initiation.
AY358390 mRNA. Translation: AAQ88756.1 .
AK057401 mRNA. Translation: BAG51910.1 . Different initiation.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83198.1 . Different initiation.
BC057789 mRNA. Translation: AAH57789.1 . Different initiation.
RefSeqi NP_001123230.1. NM_001129758.1.
NP_071752.3. NM_022357.3.
UniGenei Hs.302028.

3D structure databases

ProteinModelPortali Q9H4B8.
SMRi Q9H4B8. Positions 80-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122099. 1 interaction.
STRINGi 9606.ENSP00000268793.

Protein family/group databases

MEROPSi M19.004.

PTM databases

PhosphoSitei Q9H4B8.

Polymorphism databases

DMDMi 91206587.

Proteomic databases

PaxDbi Q9H4B8.
PRIDEi Q9H4B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268793 ; ENSP00000268793 ; ENSG00000141096 .
GeneIDi 64180.
KEGGi hsa:64180.
UCSCi uc002evc.4. human.

Organism-specific databases

CTDi 64180.
GeneCardsi GC16M068009.
HGNCi HGNC:23029. DPEP3.
HPAi HPA031870.
HPA058607.
MIMi 609926. gene.
neXtProti NX_Q9H4B8.
PharmGKBi PA134978786.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2355.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q9H4B8.
OrthoDBi EOG7SJD4N.
PhylomeDBi Q9H4B8.
TreeFami TF324523.

Miscellaneous databases

GeneWikii DPEP3.
GenomeRNAii 64180.
NextBioi 66099.
PROi Q9H4B8.
SOURCEi Search...

Gene expression databases

Bgeei Q9H4B8.
CleanExi HS_DPEP3.
Genevestigatori Q9H4B8.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a second human homologue of renal membrane dipeptidase."
    Chen J.M., Fortunato M., Barrett A.J.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDPEP3_HUMAN
AccessioniPrimary (citable) accession number: Q9H4B8
Secondary accession number(s): B3KQ48, Q6PEZ5, Q6UXE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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