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Q9H4B8

- DPEP3_HUMAN

UniProt

Q9H4B8 - DPEP3_HUMAN

Protein

Dipeptidase 3

Gene

DPEP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by L-penicillamine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi99 – 991Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi196 – 1961Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi196 – 1961Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi269 – 2691Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi290 – 2901Zinc 2; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    GO - Biological processi

    1. male meiosis Source: UniProtKB

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM19.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidase 3 (EC:3.4.13.19)
    Gene namesi
    Name:DPEP3
    ORF Names:UNQ834/PRO1772
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:23029. DPEP3.

    Subcellular locationi

    Membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134978786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 463428Dipeptidase 3PRO_0000231609Add
    BLAST
    Propeptidei464 – 48825Removed in mature formSequence AnalysisPRO_0000231610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi146 ↔ 225PROSITE-ProRule annotation
    Disulfide bondi297 ↔ 329PROSITE-ProRule annotation
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi434 – 434InterchainPROSITE-ProRule annotation
    Lipidationi463 – 4631GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9H4B8.
    PRIDEiQ9H4B8.

    PTM databases

    PhosphoSiteiQ9H4B8.

    Expressioni

    Gene expression databases

    BgeeiQ9H4B8.
    CleanExiHS_DPEP3.
    GenevestigatoriQ9H4B8.

    Organism-specific databases

    HPAiHPA031870.
    HPA058607.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.PROSITE-ProRule annotation

    Protein-protein interaction databases

    BioGridi122099. 1 interaction.
    STRINGi9606.ENSP00000268793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H4B8.
    SMRiQ9H4B8. Positions 80-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2355.
    HOGENOMiHOG000072016.
    HOVERGENiHBG002339.
    InParanoidiQ9H4B8.
    OrthoDBiEOG7SJD4N.
    PhylomeDBiQ9H4B8.
    TreeFamiTF324523.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H4B8-1 [UniParc]FASTAAdd to Basket

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    MQPTGREGSR ALSRRYLRRL LLLLLLLLLR QPVTRAETTP GAPRALSTLG    50
    SPSLFTTPGV PSALTTPGLT TPGTPKTLDL RGRAQALMRS FPLVDGHNDL 100
    PQVLRQRYKN VLQDVNLRNF SHGQTSLDRL RDGLVGAQFW SASVSCQSQD 150
    QTAVRLALEQ IDLIHRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS 200
    LDSSLSVLRS FYVLGVRYLT LTFTCSTPWA ESSTKFRHHM YTNVSGLTSF 250
    GEKVVEELNR LGMMIDLSYA SDTLIRRVLE VSQAPVIFSH SAARAVCDNL 300
    LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG 350
    SEFIGIGGNY DGTGRFPQGL EDVSTYPVLI EELLSRSWSE EELQGVLRGN 400
    LLRVFRQVEK VREESRAQSP VEAEFPYGQL STSCHSHLVP QNGHQATHLE 450
    VTKQPTNRVP WRSSNASPYL VPGLVAAATI PTFTQWLC 488
    Length:488
    Mass (Da):53,687
    Last modified:April 4, 2006 - v2
    Checksum:iF14FEE5AFB3F4471
    GO

    Sequence cautioni

    The sequence AAH57789.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG51910.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC15385.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAW83198.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481Missing in AAH57789. (PubMed:15489334)Curated
    Sequence conflicti312 – 3121Missing in AAQ88756. (PubMed:12975309)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291679 mRNA. Translation: CAC15385.1. Different initiation.
    AY358390 mRNA. Translation: AAQ88756.1.
    AK057401 mRNA. Translation: BAG51910.1. Different initiation.
    AC040162 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83198.1. Different initiation.
    BC057789 mRNA. Translation: AAH57789.1. Different initiation.
    RefSeqiNP_001123230.1. NM_001129758.1.
    NP_071752.3. NM_022357.3.
    UniGeneiHs.302028.

    Genome annotation databases

    EnsembliENST00000268793; ENSP00000268793; ENSG00000141096.
    GeneIDi64180.
    KEGGihsa:64180.
    UCSCiuc002evc.4. human.

    Polymorphism databases

    DMDMi91206587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291679 mRNA. Translation: CAC15385.1 . Different initiation.
    AY358390 mRNA. Translation: AAQ88756.1 .
    AK057401 mRNA. Translation: BAG51910.1 . Different initiation.
    AC040162 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83198.1 . Different initiation.
    BC057789 mRNA. Translation: AAH57789.1 . Different initiation.
    RefSeqi NP_001123230.1. NM_001129758.1.
    NP_071752.3. NM_022357.3.
    UniGenei Hs.302028.

    3D structure databases

    ProteinModelPortali Q9H4B8.
    SMRi Q9H4B8. Positions 80-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122099. 1 interaction.
    STRINGi 9606.ENSP00000268793.

    Protein family/group databases

    MEROPSi M19.004.

    PTM databases

    PhosphoSitei Q9H4B8.

    Polymorphism databases

    DMDMi 91206587.

    Proteomic databases

    PaxDbi Q9H4B8.
    PRIDEi Q9H4B8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268793 ; ENSP00000268793 ; ENSG00000141096 .
    GeneIDi 64180.
    KEGGi hsa:64180.
    UCSCi uc002evc.4. human.

    Organism-specific databases

    CTDi 64180.
    GeneCardsi GC16M068009.
    HGNCi HGNC:23029. DPEP3.
    HPAi HPA031870.
    HPA058607.
    MIMi 609926. gene.
    neXtProti NX_Q9H4B8.
    PharmGKBi PA134978786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2355.
    HOGENOMi HOG000072016.
    HOVERGENi HBG002339.
    InParanoidi Q9H4B8.
    OrthoDBi EOG7SJD4N.
    PhylomeDBi Q9H4B8.
    TreeFami TF324523.

    Miscellaneous databases

    GeneWikii DPEP3.
    GenomeRNAii 64180.
    NextBioi 66099.
    PROi Q9H4B8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H4B8.
    CleanExi HS_DPEP3.
    Genevestigatori Q9H4B8.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a second human homologue of renal membrane dipeptidase."
      Chen J.M., Fortunato M., Barrett A.J.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiDPEP3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H4B8
    Secondary accession number(s): B3KQ48, Q6PEZ5, Q6UXE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3