Q9H4B4 (PLK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 111.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serine/threonine-protein kinase PLK3 EC=2.7.11.21 Alternative name(s): Cytokine-inducible serine/threonine-protein kinase FGF-inducible kinase Polo-like kinase 3 Short name=PLK-3 Proliferation-related kinase | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 646 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.25 Ref.26 Ref.27 Ref.28 Ref.30 Ref.31 Ref.32 Ref.33 |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subunit structure | Interacts (via the POLO-box domain) with CIB1; leading to ihnibit PLK3 kinase activity. Interacts with GOLGB1. Ref.15 Ref.29 Ref.33 |
| Subcellular location | Cytoplasm. Nucleus. Nucleus › nucleolus. Golgi apparatus. Cytoplasm › cytoskeleton › centrosome. Note: Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (Ref.21). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. Ref.15 Ref.18 Ref.21 Ref.23 Ref.25 Ref.30 |
| Tissue specificity | Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. |
| Developmental stage | Expression is cell cycle regulated with a peak in G1 phase. Ref.21 |
| Induction | Cytokine and cellular adhesion trigger induction. Down-regulated in a majority of lung carcinoma samples. Ref.7 |
| Domain | The POLO box domains act as phosphopeptide-binding module that recongnize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them By similarity. The POLO box domains mediates localization to the centrosome. |
| Post-translational modification | Phosphorylated in an ATM-dependent manner following DNA damage. Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Ref.8 Ref.12 Ref.13 Ref.16 Ref.19 Ref.20 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.30 Ref.31 Ref.32 |
| Sequence similarities | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Contains 2 POLO box domains. Contains 1 protein kinase domain. |
| Sequence caution | The sequence AAC50637.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PRNP | P04156 | 4 | EBI-751877,EBI-977302 | |
| VRK1 | Q99986 | 12 | EBI-751877,EBI-1769146 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 646 | 646 | Serine/threonine-protein kinase PLK3 | PRO_0000086564 | |||||
Regions | |||||||||
| Domain | 62 – 314 | 253 | Protein kinase | ||||||
| Domain | 470 – 537 | 68 | POLO box 1 | ||||||
| Domain | 567 – 637 | 71 | POLO box 2 | ||||||
| Nucleotide binding | 68 – 76 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 185 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 91 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 219 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 348 | 1 | Phosphothreonine Ref.24 | ||||||
Natural variations | |||||||||
| Natural variant | 61 | 1 | T → S. Ref.2 Corresponds to variant rs17884581 [ dbSNP | Ensembl ]. | VAR_021091 | |||||
| Natural variant | 68 | 1 | L → F. Ref.2 Corresponds to variant rs17884316 [ dbSNP | Ensembl ]. | VAR_021092 | |||||
| Natural variant | 283 | 1 | L → F. Ref.2 Corresponds to variant rs17880471 [ dbSNP | Ensembl ]. | VAR_021093 | |||||
| Natural variant | 483 | 1 | R → C. Ref.2 Corresponds to variant rs17884653 [ dbSNP | Ensembl ]. | VAR_021094 | |||||
| Natural variant | 491 | 1 | D → N. Ref.5 Corresponds to variant rs17855444 [ dbSNP | Ensembl ]. | VAR_062384 | |||||
| Natural variant | 498 | 1 | S → L. Ref.2 Corresponds to variant rs17880829 [ dbSNP | Ensembl ]. | VAR_021095 | |||||
| Natural variant | 618 | 1 | S → P. Ref.2 Corresponds to variant rs17881786 [ dbSNP | Ensembl ]. | VAR_021096 | |||||
Experimental info | |||||||||
| Mutagenesis | 91 | 1 | K → R: Kinase defective mutant, abolishes activity. Ref.12 Ref.15 Ref.20 Ref.25 Ref.26 Ref.27 Ref.28 | ||||||
| Mutagenesis | 203 | 1 | D → A: Kinase defective mutant, abolishes activity. Ref.11 | ||||||
| Mutagenesis | 219 | 1 | T → E: Kinase-defective mutant. Ref.18 | ||||||
| Mutagenesis | 467 – 468 | 2 | WV → FA: Abolishes localization to the centrosome and ability to induce the G2/M arrest. | ||||||
| Sequence conflict | 16 | 1 | A → T in CAC10659. Ref.1 | ||||||
| Sequence conflict | 20 | 1 | P → T in CAC10659. Ref.1 | ||||||
| Sequence conflict | 99 | 1 | A → V in CAC10659. Ref.1 | ||||||
| Sequence conflict | 353 | 1 | G → V in CAC10659. Ref.1 | ||||||
| Sequence conflict | 419 | 1 | D → H in CAC10659. Ref.1 | ||||||
| Sequence conflict | 464 – 470 | 7 | VSKWVDY → FSEWVGF in CAC10659. Ref.1 | ||||||
| Sequence conflict | 522 | 1 | P → R in CAC10659. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages." Holtrich U., Wolf G., Yuan J., Bereiter-Hahn J., Karn T., Weiler M., Kauselmann G., Rehli M., Andreesen R., Kaufmann M., Kuhl D., Strebhardt K. Oncogene 19:4832-4839(2000) [PubMed: 11039900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo. |
| [2] | NIEHS SNPs program Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-61; PHE-68; PHE-283; CYS-483; LEU-498 AND PRO-618. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-491. Tissue: Brain. |
| [6] | "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas." Li B., Ouyang B., Pan H., Reissmann P.T., Slamon D.J., Arceci R., Lu L., Dai W. J. Biol. Chem. 271:19402-19408(1996) [PubMed: 8702627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-646. Tissue: Placenta. |
| [7] | "Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines." Wiest J., Clark A.M., Dai W. Genes Chromosomes Cancer 32:384-389(2001) [PubMed: 11746980] [Abstract] Cited for: INDUCTION. |
| [8] | "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways." Bahassi el M., Conn C.W., Myer D.L., Hennigan R.F., McGowan C.H., Sanchez Y., Stambrook P.J. Oncogene 21:6633-6640(2002) [PubMed: 12242661] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TP53 AND CHEK2, PHOSPHORYLATION. |
| [9] | "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions." Ouyang B., Pan H., Lu L., Li J., Stambrook P., Li B., Dai W. J. Biol. Chem. 272:28646-28651(1997) [PubMed: 9353331] [Abstract] Cited for: FUNCTION. |
| [10] | "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk." Ouyang B., Li W., Pan H., Meadows J., Hoffmann I., Dai W. Oncogene 18:6029-6036(1999) [PubMed: 10557092] [Abstract] Cited for: FUNCTION. |
| [11] | "Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3." Conn C.W., Hennigan R.F., Dai W., Sanchez Y., Stambrook P.J. Cancer Res. 60:6826-6831(2000) [PubMed: 11156373] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF ASP-203. |
| [12] | "Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3." Xie S., Wang Q., Wu H., Cogswell J., Lu L., Jhanwar-Uniyal M., Dai W. J. Biol. Chem. 276:36194-36199(2001) [PubMed: 11447225] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TP53, MUTAGENESIS OF LYS-91. |
| [13] | "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway." Xie S., Wu H., Wang Q., Cogswell J.P., Husain I., Conn C., Stambrook P., Jhanwar-Uniyal M., Dai W. J. Biol. Chem. 276:43305-43312(2001) [PubMed: 11551930] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TP53. |
| [14] | "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity." Wang Q., Xie S., Chen J., Fukasawa K., Naik U., Traganos F., Darzynkiewicz Z., Jhanwar-Uniyal M., Dai W. Mol. Cell. Biol. 22:3450-3459(2002) [PubMed: 11971976] [Abstract] Cited for: FUNCTION. |
| [15] | "Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle." Ruan Q., Wang Q., Xie S., Fang Y., Darzynkiewicz Z., Guan K., Jhanwar-Uniyal M., Dai W. Exp. Cell Res. 294:51-59(2004) [PubMed: 14980500] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GOLGB1, MUTAGENESIS OF LYS-91. |
| [16] | "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation." Bahassi el M., Hennigan R.F., Myer D.L., Stambrook P.J. Oncogene 23:2658-2663(2004) [PubMed: 14968113] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25C. |
| [17] | "MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3." Xie S., Wang Q., Ruan Q., Liu T., Jhanwar-Uniyal M., Guan K., Dai W. Oncogene 23:3822-3829(2004) [PubMed: 15021912] [Abstract] Cited for: FUNCTION. |
| [18] | "Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis." Jiang N., Wang X., Jhanwar-Uniyal M., Darzynkiewicz Z., Dai W. J. Biol. Chem. 281:10577-10582(2006) [PubMed: 16478733] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-219 AND 467-TRP-VAL-468. |
| [19] | "Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage." Bahassi el M., Myer D.L., McKenney R.J., Hennigan R.F., Stambrook P.J. Mutat. Res. 596:166-176(2006) [PubMed: 16481012] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TP53 AND CHEK2. |
| [20] | "Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells." Wang L., Dai W., Lu L. J. Biol. Chem. 282:32121-32127(2007) [PubMed: 17804415] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF JUN, MUTAGENESIS OF LYS-91. |
| [21] | "Polo-like kinase 3 is required for entry into S phase." Zimmerman W.C., Erikson R.L. Proc. Natl. Acad. Sci. U.S.A. 104:1847-1852(2007) [PubMed: 17264206] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE. |
| [22] | "Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1." Iida M., Matsuda M., Komatani H. Biochem. J. 411:27-32(2008) [PubMed: 18062778] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TOP2A. |
| [23] | "Activation of Polo-like kinase 3 by hypoxic stresses." Wang L., Gao J., Dai W., Lu L. J. Biol. Chem. 283:25928-25935(2008) [PubMed: 18650425] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF JUN, SUBCELLULAR LOCATION. |
| [24] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-348, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [25] | "Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation." Sang M., Ando K., Okoshi R., Koida N., Li Y., Zhu Y., Shimozato O., Geng C., Shan B., Nakagawara A., Ozaki T. Genes Cells 14:775-788(2009) [PubMed: 19490146] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF TP73, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-91. |
| [26] | "Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation." Lopez-Sanchez I., Sanz-Garcia M., Lazo P.A. Mol. Cell. Biol. 29:1189-1201(2009) [PubMed: 19103756] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF VRK1, MUTAGENESIS OF LYS-91. |
| [27] | "Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha." Xu D., Yao Y., Lu L., Costa M., Dai W. J. Biol. Chem. 285:38944-38950(2010) [PubMed: 20889502] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF HIF1A, MUTAGENESIS OF LYS-91. |
| [28] | "Regulation of PTEN stability and activity by Plk3." Xu D., Yao Y., Jiang X., Lu L., Dai W. J. Biol. Chem. 285:39935-39942(2010) [PubMed: 20940307] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF PTEN, MUTAGENESIS OF LYS-91. |
| [29] | "Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells." Naik M.U., Pham N.T., Beebe K., Dai W., Naik U.P. Int. J. Cancer 128:587-596(2011) [PubMed: 20473878] [Abstract] Cited for: INTERACTION WITH CIB1. |
| [30] | "Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells." Wang L., Payton R., Dai W., Lu L. J. Biol. Chem. 286:1951-1958(2011) [PubMed: 21098032] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF ATF2, SUBCELLULAR LOCATION. |
| [31] | "Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints." Wang J., Beauchemin M., Bertrand R. Cell. Signal. 23:2030-2038(2011) [PubMed: 21840391] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF BCL2L1. |
| [32] | "Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors." Myer D.L., Robbins S.B., Yin M., Boivin G.P., Liu Y., Greis K.D., Bahassi el M., Stambrook P.J. Mutat. Res. 714:1-10(2011) [PubMed: 21376736] [Abstract] Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25A. |
| [33] | "Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells." Kostyak J.C., Naik U.P. PLoS ONE 6:E14513-E14513(2011) [PubMed: 21264284] [Abstract] Cited for: FUNCTION, INTERACTION WITH CIB1. |
| [34] | "Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy." Strebhardt K. Nat. Rev. Drug Discov. 9:643-660(2010) [PubMed: 20671765] [Abstract] Cited for: REVIEW ON FUNCTION. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ293866 mRNA. Translation: CAC10659.1. AY764184 Genomic DNA. Translation: AAU88146.1. AL592166 Genomic DNA. Translation: CAI13006.1. CH471059 Genomic DNA. Translation: EAX07021.1. BC013899 mRNA. Translation: AAH13899.1. U56998 mRNA. Translation: AAC50637.1. Different initiation. |
| IPI | IPI00304186. |
| RefSeq | NP_004064.2. NM_004073.2. |
| UniGene | Hs.632415. |
3D structure databases | |
| ProteinModelPortal | Q9H4B4. |
| SMR | Q9H4B4. Positions 48-335, 455-643. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9H4B4. 3 interactions. |
| MINT | MINT-110679. |
| STRING | Q9H4B4. |
Polymorphism databases | |
| DMDM | 51338822. |
Proteomic databases | |
| PRIDE | Q9H4B4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000372201; ENSP00000361275; ENSG00000173846. |
| GeneID | 1263. |
| KEGG | hsa:1263. |
| UCSC | uc001cmn.1. human. |
Organism-specific databases | |
| CTD | 1263. |
| GeneCards | GC01P045265. |
| H-InvDB | HIX0199969. |
| HGNC | HGNC:2154. PLK3. |
| MIM | 602913. gene. |
| neXtProt | NX_Q9H4B4. |
| PharmGKB | PA26664. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG10409. |
| GeneTree | ENSGT00530000062954. |
| HOGENOM | HBG738952. |
| HOVERGEN | HBG001843. |
| InParanoid | Q9H4B4. |
| OMA | PRSGRTY. |
| OrthoDB | EOG4GHZNR. |
| PhylomeDB | Q9H4B4. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.21. 2681. |
Gene expression databases | |
| ArrayExpress | Q9H4B4. |
| Bgee | Q9H4B4. |
| CleanEx | HS_PLK3. |
| Genevestigator | Q9H4B4. |
| GermOnline | ENSG00000173846. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000959. POLO_box_duplicated_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view] |
| KO | K08862. |
| Pfam | PF00069. Pkinase. 1 hit. PF00659. POLO_box. 2 hits. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS50078. POLO_BOX. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 5111. |
| SOURCE | Search... |
Entry information
| Entry name | PLK3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H4B4 Secondary accession number(s): Q15767, Q5JR99, Q96CV1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with