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Protein

Dipeptidase 2

Gene

DPEP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi91Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi188Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi188Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei215SubstratePROSITE-ProRule annotation1
Metal bindingi261Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi282Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei293SubstratePROSITE-ProRule annotation1
Binding sitei351SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS09532-MONOMER
ReactomeiR-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646 Aflatoxin activation and detoxification

Protein family/group databases

MEROPSiM19.004

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 2 (EC:3.4.13.19)
Gene namesi
Name:DPEP2
ORF Names:UNQ284/PRO323
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167261.13
HGNCiHGNC:23028 DPEP2
MIMi609925 gene
neXtProtiNX_Q9H4A9

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167261
PharmGKBiPA134985997

Polymorphism and mutation databases

BioMutaiDPEP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000023160333 – 463Dipeptidase 2Add BLAST431
PropeptideiPRO_0000231604464 – 486Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi138 ↔ 217PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi289 ↔ 321PROSITE-ProRule annotation
Disulfide bondi426InterchainPROSITE-ProRule annotation
Lipidationi463GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9H4A9
PeptideAtlasiQ9H4A9
PRIDEiQ9H4A9

PTM databases

iPTMnetiQ9H4A9
PhosphoSitePlusiQ9H4A9

Expressioni

Gene expression databases

BgeeiENSG00000167261
CleanExiHS_DPEP2
ExpressionAtlasiQ9H4A9 baseline and differential
GenevisibleiQ9H4A9 HS

Organism-specific databases

HPAiHPA035644

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

BioGridi122097, 24 interactors
IntActiQ9H4A9, 2 interactors
STRINGi9606.ENSP00000377430

Structurei

3D structure databases

ProteinModelPortaliQ9H4A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127 Eukaryota
COG2355 LUCA
GeneTreeiENSGT00390000017920
HOGENOMiHOG000072016
HOVERGENiHBG002339
InParanoidiQ9H4A9
KOiK01273
OMAiVDGHNDM
OrthoDBiEOG091G09CU
PhylomeDBiQ9H4A9
TreeFamiTF324523

Family and domain databases

CDDicd01301 rDP_like, 1 hit
InterProiView protein in InterPro
IPR000180 Dipep_AS
IPR028531 Dpep2
IPR032466 Metal_Hydrolase
IPR008257 Pept_M19
PANTHERiPTHR10443 PTHR10443, 1 hit
PTHR10443:SF9 PTHR10443:SF9, 1 hit
PfamiView protein in Pfam
PF01244 Peptidase_M19, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
PROSITEiView protein in PROSITE
PS00869 RENAL_DIPEPTIDASE_1, 1 hit
PS51365 RENAL_DIPEPTIDASE_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPSGLEGPG TFGRWPLLSL LLLLLLLQPV TCAYTTPGPP RALTTLGAPR
60 70 80 90 100
AHTMPGTYAP STTLSSPSTQ GLQEQARALM RDFPLVDGHN DLPLVLRQVY
110 120 130 140 150
QKGLQDVNLR NFSYGQTSLD RLRDGLVGAQ FWSAYVPCQT QDRDALRLTL
160 170 180 190 200
EQIDLIRRMC ASYSELELVT SAKALNDTQK LACLIGVEGG HSLDNSLSIL
210 220 230 240 250
RTFYMLGVRY LTLTHTCNTP WAESSAKGVH SFYNNISGLT DFGEKVVAEM
260 270 280 290 300
NRLGMMVDLS HVSDAVARRA LEVSQAPVIF SHSAARGVCN SARNVPDDIL
310 320 330 340 350
QLLKKNGGVV MVSLSMGVIQ CNPSANVSTV ADHFDHIKAV IGSKFIGIGG
360 370 380 390 400
DYDGAGKFPQ GLEDVSTYPV LIEELLSRGW SEEELQGVLR GNLLRVFRQV
410 420 430 440 450
EKVQEENKWQ SPLEDKFPDE QLSSSCHSDL SRLRQRQSLT SGQELTEIPI
460 470 480
HWTAKLPAKW SVSESSPHMA PVLAVVATFP VLILWL
Length:486
Mass (Da):53,365
Last modified:March 28, 2018 - v3
Checksum:i8860C41CD9801FAC
GO
Isoform 2 (identifier: Q9H4A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-129: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):43,887
Checksum:i43570E38247DF936
GO
Isoform 3 (identifier: Q9H4A9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-258: KVVAEMNRLGMMVD → MLWHGGPWKCHRHL
     259-486: Missing.

Show »
Length:258
Mass (Da):28,559
Checksum:iE3ED60D75DDBC9F1
GO

Sequence cautioni

The sequence AAQ88819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060230201R → P. Corresponds to variant dbSNP:rs255051Ensembl.1
Natural variantiVAR_033894468H → D. Corresponds to variant dbSNP:rs1133090Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01785143 – 129Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_059428245 – 258KVVAE…GMMVD → MLWHGGPWKCHRHL in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_059429259 – 486Missing in isoform 3. Add BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295149 mRNA Translation: CAC14667.1
AK092884 mRNA Translation: BAG52621.1
AK315090 mRNA Translation: BAG37555.1
AC040162 Genomic DNA No translation available.
KC877614 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83200.1
CH471092 Genomic DNA Translation: EAW83201.1
CH471092 Genomic DNA Translation: EAW83202.1
BC024021 mRNA Translation: AAH24021.1
AY358454 mRNA Translation: AAQ88819.1 Different initiation.
CCDSiCCDS10857.1 [Q9H4A9-1]
RefSeqiNP_071750.1, NM_022355.3 [Q9H4A9-1]
UniGeneiHs.372633

Genome annotation databases

EnsembliENST00000393847; ENSP00000377430; ENSG00000167261 [Q9H4A9-1]
ENST00000572888; ENSP00000458977; ENSG00000167261 [Q9H4A9-1]
ENST00000575203; ENSP00000459375; ENSG00000167261 [Q9H4A9-3]
GeneIDi64174
KEGGihsa:64174
UCSCiuc002eve.5 human [Q9H4A9-1]
uc059wbx.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPEP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4A9
Secondary accession number(s): A0A024R6Y5
, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health