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Protein

Dipeptidase 2

Gene

DPEP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi91Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi188Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi188Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei215SubstratePROSITE-ProRule annotation1
Metal bindingi261Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi282Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei293SubstratePROSITE-ProRule annotation1
Binding sitei351SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS09532-MONOMER.
ZFISH:HS09532-MONOMER.
ReactomeiR-HSA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-HSA-5423646. Aflatoxin activation and detoxification.

Protein family/group databases

MEROPSiM19.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 2 (EC:3.4.13.19)
Gene namesi
Name:DPEP2
ORF Names:UNQ284/PRO323
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23028. DPEP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64174.
PharmGKBiPA134985997.

Polymorphism and mutation databases

BioMutaiDPEP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000023160333 – 463Dipeptidase 2Add BLAST431
PropeptideiPRO_0000231604464 – 486Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...)1 Publication1
Disulfide bondi138 ↔ 217PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi235N-linked (GlcNAc...)1 Publication1
Disulfide bondi289 ↔ 321PROSITE-ProRule annotation
Disulfide bondi426InterchainPROSITE-ProRule annotation
Lipidationi463GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9H4A9.
PaxDbiQ9H4A9.
PeptideAtlasiQ9H4A9.
PRIDEiQ9H4A9.

PTM databases

iPTMnetiQ9H4A9.
PhosphoSitePlusiQ9H4A9.

Expressioni

Gene expression databases

BgeeiENSG00000167261.
CleanExiHS_DPEP2.
ExpressionAtlasiQ9H4A9. baseline and differential.
GenevisibleiQ9H4A9. HS.

Organism-specific databases

HPAiHPA035644.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

BioGridi122097. 23 interactors.
IntActiQ9H4A9. 1 interactor.
STRINGi9606.ENSP00000377430.

Structurei

3D structure databases

ProteinModelPortaliQ9H4A9.
SMRiQ9H4A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ9H4A9.
KOiK01273.
OrthoDBiEOG091G09CU.
PhylomeDBiQ9H4A9.
TreeFamiTF324523.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPSGLEGPG TFGRWPLLSL LLLLLLLQPV TCAYTTPGPP RALTTLGAPR
60 70 80 90 100
AHTMPGTYAP STTLSSPSTQ GLQEQARALM RDFPLVDGHN DLPLVLRQVY
110 120 130 140 150
QKGLQDVNLR NFSYGQTSLD RLRDGLVGAQ FWSAYVPCQT QDRDALRLTL
160 170 180 190 200
EQIDLIRRMC ASYSELELVT SAKALNDTQK LACLIGVEGG HSLDNSLSIL
210 220 230 240 250
PTFYMLGVRY LTLTHTCNTP WAESSAKGVH SFYNNISGLT DFGEKVVAEM
260 270 280 290 300
NRLGMMVDLS HVSDAVARRA LEVSQAPVIF SHSAARGVCN SARNVPDDIL
310 320 330 340 350
QLLKKNGGVV MVSLSMGVIQ CNPSANVSTV ADHFDHIKAV IGSKFIGIGG
360 370 380 390 400
DYDGAGKFPQ GLEDVSTYPV LIEELLSRGW SEEELQGVLR GNLLRVFRQV
410 420 430 440 450
EKVQEENKWQ SPLEDKFPDE QLSSSCHSDL SRLRQRQSLT SGQELTEIPI
460 470 480
HWTAKLPAKW SVSESSPHMA PVLAVVATFP VLILWL
Length:486
Mass (Da):53,306
Last modified:May 18, 2010 - v2
Checksum:iB08130A393809D04
GO
Isoform 2 (identifier: Q9H4A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-129: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):43,828
Checksum:i7BB6FA876E7D7B9E
GO

Sequence cautioni

The sequence AAQ88819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060230201P → R.5 PublicationsCorresponds to variant rs255051dbSNPEnsembl.1
Natural variantiVAR_033894468H → D.Corresponds to variant rs1133090dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01785143 – 129Missing in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295149 mRNA. Translation: CAC14667.1.
AK315090 mRNA. Translation: BAG37555.1.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83200.1.
BC024021 mRNA. Translation: AAH24021.1.
AY358454 mRNA. Translation: AAQ88819.1. Different initiation.
CCDSiCCDS10857.1. [Q9H4A9-1]
RefSeqiNP_071750.1. NM_022355.3.
UniGeneiHs.372633.

Genome annotation databases

EnsembliENST00000393847; ENSP00000377430; ENSG00000167261.
ENST00000572888; ENSP00000458977; ENSG00000167261.
GeneIDi64174.
KEGGihsa:64174.
UCSCiuc002eve.5. human. [Q9H4A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295149 mRNA. Translation: CAC14667.1.
AK315090 mRNA. Translation: BAG37555.1.
AC040162 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83200.1.
BC024021 mRNA. Translation: AAH24021.1.
AY358454 mRNA. Translation: AAQ88819.1. Different initiation.
CCDSiCCDS10857.1. [Q9H4A9-1]
RefSeqiNP_071750.1. NM_022355.3.
UniGeneiHs.372633.

3D structure databases

ProteinModelPortaliQ9H4A9.
SMRiQ9H4A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122097. 23 interactors.
IntActiQ9H4A9. 1 interactor.
STRINGi9606.ENSP00000377430.

Protein family/group databases

MEROPSiM19.004.

PTM databases

iPTMnetiQ9H4A9.
PhosphoSitePlusiQ9H4A9.

Polymorphism and mutation databases

BioMutaiDPEP2.

Proteomic databases

EPDiQ9H4A9.
PaxDbiQ9H4A9.
PeptideAtlasiQ9H4A9.
PRIDEiQ9H4A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393847; ENSP00000377430; ENSG00000167261.
ENST00000572888; ENSP00000458977; ENSG00000167261.
GeneIDi64174.
KEGGihsa:64174.
UCSCiuc002eve.5. human. [Q9H4A9-1]

Organism-specific databases

CTDi64174.
DisGeNETi64174.
GeneCardsiDPEP2.
HGNCiHGNC:23028. DPEP2.
HPAiHPA035644.
MIMi609925. gene.
neXtProtiNX_Q9H4A9.
PharmGKBiPA134985997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ9H4A9.
KOiK01273.
OrthoDBiEOG091G09CU.
PhylomeDBiQ9H4A9.
TreeFamiTF324523.

Enzyme and pathway databases

BioCyciMetaCyc:HS09532-MONOMER.
ZFISH:HS09532-MONOMER.
ReactomeiR-HSA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-HSA-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

GenomeRNAii64174.
PROiQ9H4A9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167261.
CleanExiHS_DPEP2.
ExpressionAtlasiQ9H4A9. baseline and differential.
GenevisibleiQ9H4A9. HS.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR028531. Dpep2.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF9. PTHR10443:SF9. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4A9
Secondary accession number(s): B2RCF8, Q6UX92, Q8TC95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.