Q9H4A5 (GLP3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Golgi phosphoprotein 3-like

Alternative name(s):
GPP34-related protein

Gene names

Name:	GOLPH3L
Synonyms:	GPP34R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity. Golgi apparatus › Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi localization By similarity.
Sequence similarities	Belongs to the GOLPH3/VPS74 family.
Sequence caution	The sequence BAA91750.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus Membrane
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HTT	P42858	2	EBI-4403434,EBI-466029

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Golgi phosphoprotein 3-like		PRO_0000324135
Regions
	Region	176 – 187	12	Beta-hairpin required for oligomerization By similarity
Sites
	Binding site	67	1	PtdIns4P By similarity
	Binding site	76	1	PtdIns4P By similarity
	Binding site	157	1	PtdIns4P By similarity
	Binding site	160	1	PtdIns4P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9H4A5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: E618915FD86F3772	FASTA	285	32,767
	10 20 30 40 50 60 MTTLTHRARR TEISKNSEKK MESEEDSNWE KSPDNEDSGD SKDIRLTLME EVLLLGLKDK 70 80 90 100 110 120 EGYTSFWNDC ISSGLRGGIL IELAMRGRIY LEPPTMRKKR LLDRKVLLKS DSPTGDVLLD 130 140 150 160 170 180 ETLKHIKATE PTETVQTWIE LLTGETWNPF KLQYQLRNVR ERIAKNLVEK GILTTEKQNF 190 200 210 220 230 240 LLFDMTTHPV TNTTEKQRLV KKLQDSVLER WVNDPQRMDK RTLALLVLAH SSDVLENVFS 250 260 270 280 SLTDDKYDVA MNRAKDLVEL DPEVEGTKPS ATEMIWAVLA AFNKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proteomics characterization of abundant Golgi membrane proteins." Bell A.W., Ward M.A., Blackstock W.P., Freeman H.N.M., Choudhary J.S., Lewis A.P., Chotai D., Fazel A., Gushue J.N., Paiement J., Palcy S., Chevet E., Lafreniere-Roula M., Solari R., Thomas D.Y., Rowley A., Bergeron J.J.M. J. Biol. Chem. 276:5152-5165(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ296153 mRNA. Translation: CAC13125.1. AK001549 mRNA. Translation: BAA91750.1. Different initiation. AK315594 mRNA. Translation: BAG37966.1. AL356292, AL356356 Genomic DNA. Translation: CAI13650.1. AL356356, AL356292 Genomic DNA. Translation: CAI15495.1. CH471121 Genomic DNA. Translation: EAW53526.1. BC013870 mRNA. Translation: AAH13870.1.
IPI	IPI00012313.
RefSeq	NP_060648.2. NM_018178.5.
UniGene	Hs.740573.
3D structure databases
ProteinModelPortal	Q9H4A5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H4A5. 1 interaction.
STRING	9606.ENSP00000271732.
PTM databases
PhosphoSite	Q9H4A5.
Polymorphism databases
DMDM	74752638.
Proteomic databases
PaxDb	Q9H4A5.
PeptideAtlas	Q9H4A5.
PRIDE	Q9H4A5.
Protocols and materials databases
DNASU	55204.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000271732; ENSP00000271732; ENSG00000143457.
GeneID	55204.
KEGG	hsa:55204.
UCSC	uc001evj.2. human.
Organism-specific databases
CTD	55204.
GeneCards	GC01M150618.
HGNC	HGNC:24882. GOLPH3L.
HPA	HPA028558.
MIM	612208. gene.
neXtProt	NX_Q9H4A5.
PharmGKB	PA134922683.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79916.
HOGENOM	HOG000209848.
HOVERGEN	HBG059607.
KO	K15620.
OrthoDB	EOG4XWFZG.
PhylomeDB	Q9H4A5.
Gene expression databases
ArrayExpress	Q9H4A5.
Bgee	Q9H4A5.
CleanEx	HS_GOLPH3L.
Genevestigator	Q9H4A5.
Family and domain databases
InterPro	IPR008628. GPP34. [Graphical view]
PANTHER	PTHR12704. PTHR12704. 1 hit.
Pfam	PF05719. GPP34. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GOLPH3L. human.
GenomeRNAi	55204.
NextBio	59098.
SOURCE	Search...

Entry information

Entry name

GLP3L_HUMAN

Accession

Primary (citable) accession number: Q9H4A5
Secondary accession number(s): B1AN09, Q9NVK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.