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Q9H4A5

- GLP3L_HUMAN

UniProt

Q9H4A5 - GLP3L_HUMAN

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Protein

Golgi phosphoprotein 3-like

Gene
GOLPH3L, GPP34R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671PtdIns4P By similarity
Binding sitei76 – 761PtdIns4P By similarity
Binding sitei157 – 1571PtdIns4P By similarity
Binding sitei160 – 1601PtdIns4P By similarity

GO - Molecular functioni

  1. phosphatidylinositol-4-phosphate binding Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. Golgi organization Source: UniProtKB
  2. positive regulation of protein secretion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi phosphoprotein 3-like
Alternative name(s):
GPP34-related protein
Gene namesi
Name:GOLPH3L
Synonyms:GPP34R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24882. GOLPH3L.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatustrans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side
Note: Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.1 Publication

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. Golgi membrane Source: UniProtKB
  3. trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi7 – 104RARR → AAAA: Loss of binding to coatomer. 1 Publication

Organism-specific databases

PharmGKBiPA134922683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Golgi phosphoprotein 3-likePRO_0000324135Add
BLAST

Proteomic databases

MaxQBiQ9H4A5.
PaxDbiQ9H4A5.
PeptideAtlasiQ9H4A5.
PRIDEiQ9H4A5.

PTM databases

PhosphoSiteiQ9H4A5.

Expressioni

Gene expression databases

ArrayExpressiQ9H4A5.
BgeeiQ9H4A5.
CleanExiHS_GOLPH3L.
GenevestigatoriQ9H4A5.

Organism-specific databases

HPAiHPA028558.

Interactioni

Subunit structurei

Homooligomer By similarity. Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428582EBI-4403434,EBI-466029
ZDHHC17Q8IUH52EBI-4403434,EBI-524753

Protein-protein interaction databases

BioGridi120500. 4 interactions.
IntActiQ9H4A5. 3 interactions.
STRINGi9606.ENSP00000271732.

Structurei

3D structure databases

ProteinModelPortaliQ9H4A5.
SMRiQ9H4A5. Positions 45-282.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 18712Beta-hairpin required for oligomerization By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the GOLPH3/VPS74 family.

Phylogenomic databases

eggNOGiNOG79916.
HOGENOMiHOG000209848.
HOVERGENiHBG059607.
KOiK15620.
OMAiDKYDMAM.
OrthoDBiEOG7ZKSBV.
PhylomeDBiQ9H4A5.
TreeFamiTF314360.

Family and domain databases

InterProiIPR008628. GPP34.
[Graphical view]
PANTHERiPTHR12704. PTHR12704. 1 hit.
PfamiPF05719. GPP34. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H4A5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTTLTHRARR TEISKNSEKK MESEEDSNWE KSPDNEDSGD SKDIRLTLME    50
EVLLLGLKDK EGYTSFWNDC ISSGLRGGIL IELAMRGRIY LEPPTMRKKR 100
LLDRKVLLKS DSPTGDVLLD ETLKHIKATE PTETVQTWIE LLTGETWNPF 150
KLQYQLRNVR ERIAKNLVEK GILTTEKQNF LLFDMTTHPV TNTTEKQRLV 200
KKLQDSVLER WVNDPQRMDK RTLALLVLAH SSDVLENVFS SLTDDKYDVA 250
MNRAKDLVEL DPEVEGTKPS ATEMIWAVLA AFNKS 285
Length:285
Mass (Da):32,767
Last modified:March 1, 2001 - v1
Checksum:iE618915FD86F3772
GO
Isoform 2 (identifier: Q9H4A5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-105: Missing.

Note: No experimental confirmation available.

Show »
Length:241
Mass (Da):27,672
Checksum:iEB4C9E1203CEEAEA
GO

Sequence cautioni

The sequence BAA91750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei62 – 10544Missing in isoform 2. VSP_055229Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121S → G in BAH13319. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296153 mRNA. Translation: CAC13125.1.
AK001549 mRNA. Translation: BAA91750.1. Different initiation.
AK300635 mRNA. Translation: BAH13319.1.
AK315594 mRNA. Translation: BAG37966.1.
AL356292, AL356356 Genomic DNA. Translation: CAI13650.1.
AL356356, AL356292 Genomic DNA. Translation: CAI15495.1.
CH471121 Genomic DNA. Translation: EAW53526.1.
BC013870 mRNA. Translation: AAH13870.1.
CCDSiCCDS966.1. [Q9H4A5-1]
RefSeqiNP_060648.2. NM_018178.5.
UniGeneiHs.203699.

Genome annotation databases

EnsembliENST00000271732; ENSP00000271732; ENSG00000143457.
GeneIDi55204.
KEGGihsa:55204.
UCSCiuc001evj.2. human. [Q9H4A5-1]

Polymorphism databases

DMDMi74752638.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296153 mRNA. Translation: CAC13125.1 .
AK001549 mRNA. Translation: BAA91750.1 . Different initiation.
AK300635 mRNA. Translation: BAH13319.1 .
AK315594 mRNA. Translation: BAG37966.1 .
AL356292 , AL356356 Genomic DNA. Translation: CAI13650.1 .
AL356356 , AL356292 Genomic DNA. Translation: CAI15495.1 .
CH471121 Genomic DNA. Translation: EAW53526.1 .
BC013870 mRNA. Translation: AAH13870.1 .
CCDSi CCDS966.1. [Q9H4A5-1 ]
RefSeqi NP_060648.2. NM_018178.5.
UniGenei Hs.203699.

3D structure databases

ProteinModelPortali Q9H4A5.
SMRi Q9H4A5. Positions 45-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120500. 4 interactions.
IntActi Q9H4A5. 3 interactions.
STRINGi 9606.ENSP00000271732.

PTM databases

PhosphoSitei Q9H4A5.

Polymorphism databases

DMDMi 74752638.

Proteomic databases

MaxQBi Q9H4A5.
PaxDbi Q9H4A5.
PeptideAtlasi Q9H4A5.
PRIDEi Q9H4A5.

Protocols and materials databases

DNASUi 55204.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271732 ; ENSP00000271732 ; ENSG00000143457 .
GeneIDi 55204.
KEGGi hsa:55204.
UCSCi uc001evj.2. human. [Q9H4A5-1 ]

Organism-specific databases

CTDi 55204.
GeneCardsi GC01M150618.
HGNCi HGNC:24882. GOLPH3L.
HPAi HPA028558.
MIMi 612208. gene.
neXtProti NX_Q9H4A5.
PharmGKBi PA134922683.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79916.
HOGENOMi HOG000209848.
HOVERGENi HBG059607.
KOi K15620.
OMAi DKYDMAM.
OrthoDBi EOG7ZKSBV.
PhylomeDBi Q9H4A5.
TreeFami TF314360.

Miscellaneous databases

ChiTaRSi GOLPH3L. human.
GenomeRNAii 55204.
NextBioi 35480017.
PROi Q9H4A5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H4A5.
Bgeei Q9H4A5.
CleanExi HS_GOLPH3L.
Genevestigatori Q9H4A5.

Family and domain databases

InterProi IPR008628. GPP34.
[Graphical view ]
PANTHERi PTHR12704. PTHR12704. 1 hit.
Pfami PF05719. GPP34. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer."
    Tu L., Chen L., Banfield D.K.
    Traffic 13:1496-1507(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF 7-ARG--ARG-10, COATOMER-BINDING, INTERACTION WITH ARF1.
  8. "GOLPH3L antagonizes GOLPH3 to determine Golgi morphology."
    Ng M.M., Dippold H.C., Buschman M.D., Noakes C.J., Field S.J.
    Mol. Biol. Cell 24:796-808(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, LIPID-BINDING, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGLP3L_HUMAN
AccessioniPrimary (citable) accession number: Q9H4A5
Secondary accession number(s): B1AN09, B7Z6N3, Q9NVK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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