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Protein

Torsin-1A-interacting protein 2, isoform IFRG15

Gene

TOR1AIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-1A-interacting protein 2, isoform IFRG15
Alternative name(s):
15 kDa interferon-responsive protein
Short name:
IFRG15
Gene namesi
Name:TOR1AIP2
Synonyms:IFRG15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24055. TOR1AIP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Torsin-1A-interacting protein 2, isoform IFRG15PRO_0000421071Add
BLAST

Proteomic databases

EPDiQ9H496.
MaxQBiQ9H496.
PaxDbiQ9H496.
PeptideAtlasiQ9H496.
PRIDEiQ9H496.

PTM databases

iPTMnetiQ9H496.

Expressioni

Inductioni

Induced by interferon alpha.1 Publication

Gene expression databases

ExpressionAtlasiQ9H496. baseline and differential.
GenevisibleiQ9H496. HS.

Organism-specific databases

HPAiHPA058348.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-2510146,EBI-740322

Protein-protein interaction databases

BioGridi127870. 66 interactions.
IntActiQ9H496. 6 interactions.
STRINGi9606.ENSP00000452581.

Structurei

3D structure databases

ProteinModelPortaliQ9H496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWR7. Eukaryota.
ENOG41116VC. LUCA.
GeneTreeiENSGT00390000012166.
HOVERGENiHBG057391.
InParanoidiQ9H496.
PhylomeDBiQ9H496.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IFRG15 (identifier: Q9H496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSDNSHCPD CGQQWFPSLE LGHWLYQTEL VENECYQVFL DRINRADYCP
60 70 80 90 100
ECYPDNPANR SLVLPWSFPL EWAPQNLTRW TFEKACHPFL LGPPLVRKRI
110 120 130
HDSRVAGFNP ALQLILTRTD KTLNKKLGQN K
Note: No experimental confirmation available. Dubious isoform.
Length:131
Mass (Da):15,348
Last modified:March 1, 2001 - v1
Checksum:i858F0B2886A3D61A
GO
Isoform TOR1AIP2 (identifier: Q8NFQ8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q8NFQ8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:470
Mass (Da):51,263
GO

Sequence cautioni

The sequence AAH32790.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299406 mRNA. Translation: CAC13974.1.
AK289793 mRNA. Translation: BAF82482.1.
AL359853 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91065.1.
BC032790 mRNA. Translation: AAH32790.1. Sequence problems.
BC096704 mRNA. Translation: AAH96704.1.
BC098170 mRNA. Translation: AAH98170.1.
BC098309 mRNA. Translation: AAH98309.1.
BC098348 mRNA. Translation: AAH98348.1.
CCDSiCCDS53439.1. [Q9H496-1]
RefSeqiNP_071742.1. NM_022347.3. [Q9H496-1]
UniGeneiHs.571797.
Hs.723247.

Genome annotation databases

EnsembliENST00000482587; ENSP00000485355; ENSG00000169905. [Q9H496-1]
GeneIDi163590.
UCSCiuc001gnn.4. human. [Q9H496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299406 mRNA. Translation: CAC13974.1.
AK289793 mRNA. Translation: BAF82482.1.
AL359853 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91065.1.
BC032790 mRNA. Translation: AAH32790.1. Sequence problems.
BC096704 mRNA. Translation: AAH96704.1.
BC098170 mRNA. Translation: AAH98170.1.
BC098309 mRNA. Translation: AAH98309.1.
BC098348 mRNA. Translation: AAH98348.1.
CCDSiCCDS53439.1. [Q9H496-1]
RefSeqiNP_071742.1. NM_022347.3. [Q9H496-1]
UniGeneiHs.571797.
Hs.723247.

3D structure databases

ProteinModelPortaliQ9H496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127870. 66 interactions.
IntActiQ9H496. 6 interactions.
STRINGi9606.ENSP00000452581.

PTM databases

iPTMnetiQ9H496.

Proteomic databases

EPDiQ9H496.
MaxQBiQ9H496.
PaxDbiQ9H496.
PeptideAtlasiQ9H496.
PRIDEiQ9H496.

Protocols and materials databases

DNASUi163590.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000482587; ENSP00000485355; ENSG00000169905. [Q9H496-1]
GeneIDi163590.
UCSCiuc001gnn.4. human. [Q9H496-1]

Organism-specific databases

CTDi163590.
GeneCardsiTOR1AIP2.
HGNCiHGNC:24055. TOR1AIP2.
HPAiHPA058348.
MIMi614513. gene.
neXtProtiNX_Q9H496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWR7. Eukaryota.
ENOG41116VC. LUCA.
GeneTreeiENSGT00390000012166.
HOVERGENiHBG057391.
InParanoidiQ9H496.
PhylomeDBiQ9H496.

Miscellaneous databases

ChiTaRSiTOR1AIP2. human.
GenomeRNAii163590.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9H496. baseline and differential.
GenevisibleiQ9H496. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of novel interferon responsive genes."
    Dron M., Meritet J.F., Tovey M.G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY INTERFERON.
    Tissue: Lymphoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiIFG15_HUMAN
AccessioniPrimary (citable) accession number: Q9H496
Secondary accession number(s): Q05BU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.