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Protein

Fructosamine-3-kinase

Gene

FN3K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme.

GO - Molecular functioni

  • fructosamine-3-kinase activity Source: UniProtKB
  • kinase activity Source: Reactome

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • fructosamine metabolic process Source: GO_Central
  • fructoselysine metabolic process Source: UniProtKB
  • post-translational protein modification Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000167363-MONOMER.
ZFISH:ENSG00000167363-MONOMER.
BRENDAi2.7.1.171. 2681.
ReactomeiR-HSA-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructosamine-3-kinase (EC:2.7.1.-)
Gene namesi
Name:FN3K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24822. FN3K.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi64122.
OpenTargetsiENSG00000167363.
PharmGKBiPA134870460.

Polymorphism and mutation databases

BioMutaiFN3K.
DMDMi13959371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002163371 – 309Fructosamine-3-kinaseAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H479.
MaxQBiQ9H479.
PaxDbiQ9H479.
PeptideAtlasiQ9H479.
PRIDEiQ9H479.

PTM databases

iPTMnetiQ9H479.
PhosphoSitePlusiQ9H479.

Expressioni

Tissue specificityi

Expressed in erythrocytes.

Gene expression databases

BgeeiENSG00000167363.
CleanExiHS_FN3K.
GenevisibleiQ9H479. HS.

Organism-specific databases

HPAiHPA059151.
HPA061358.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi122075. 1 interactor.
IntActiQ9H479. 1 interactor.
STRINGi9606.ENSP00000300784.

Structurei

3D structure databases

ProteinModelPortaliQ9H479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fructosamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ9H479.
KOiK15522.
OMAiYIPQVNE.
OrthoDBiEOG091G0KFO.
PhylomeDBiQ9H479.
TreeFamiTF313452.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLLRAELR TATLRAFGGP GAGCISEGRA YDTDAGPVFV KVNRRTQARQ
60 70 80 90 100
MFEGEVASLE ALRSTGLVRV PRPMKVIDLP GGGAAFVMEH LKMKSLSSQA
110 120 130 140 150
SKLGEQMADL HLYNQKLREK LKEEENTVGR RGEGAEPQYV DKFGFHTVTC
160 170 180 190 200
CGFIPQVNEW QDDWPTFFAR HRLQAQLDLI EKDYADREAR ELWSRLQVKI
210 220 230 240 250
PDLFCGLEIV PALLHGDLWS GNVAEDDVGP IIYDPASFYG HSEFELAIAL
260 270 280 290 300
MFGGFPRSFF TAYHRKIPKA PGFDQRLLLY QLFNYLNHWN HFGREYRSPS

LGTMRRLLK
Length:309
Mass (Da):35,171
Last modified:March 1, 2001 - v1
Checksum:iBA886A86655DE28F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404615 mRNA. Translation: CAC16393.1.
BC042680 mRNA. Translation: AAH42680.1.
CCDSiCCDS11818.1.
RefSeqiNP_071441.1. NM_022158.3.
UniGeneiHs.151135.

Genome annotation databases

EnsembliENST00000300784; ENSP00000300784; ENSG00000167363.
GeneIDi64122.
KEGGihsa:64122.
UCSCiuc010wvs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404615 mRNA. Translation: CAC16393.1.
BC042680 mRNA. Translation: AAH42680.1.
CCDSiCCDS11818.1.
RefSeqiNP_071441.1. NM_022158.3.
UniGeneiHs.151135.

3D structure databases

ProteinModelPortaliQ9H479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122075. 1 interactor.
IntActiQ9H479. 1 interactor.
STRINGi9606.ENSP00000300784.

PTM databases

iPTMnetiQ9H479.
PhosphoSitePlusiQ9H479.

Polymorphism and mutation databases

BioMutaiFN3K.
DMDMi13959371.

Proteomic databases

EPDiQ9H479.
MaxQBiQ9H479.
PaxDbiQ9H479.
PeptideAtlasiQ9H479.
PRIDEiQ9H479.

Protocols and materials databases

DNASUi64122.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300784; ENSP00000300784; ENSG00000167363.
GeneIDi64122.
KEGGihsa:64122.
UCSCiuc010wvs.2. human.

Organism-specific databases

CTDi64122.
DisGeNETi64122.
GeneCardsiFN3K.
HGNCiHGNC:24822. FN3K.
HPAiHPA059151.
HPA061358.
MIMi608425. gene.
neXtProtiNX_Q9H479.
OpenTargetsiENSG00000167363.
PharmGKBiPA134870460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ9H479.
KOiK15522.
OMAiYIPQVNE.
OrthoDBiEOG091G0KFO.
PhylomeDBiQ9H479.
TreeFamiTF313452.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000167363-MONOMER.
ZFISH:ENSG00000167363-MONOMER.
BRENDAi2.7.1.171. 2681.
ReactomeiR-HSA-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Miscellaneous databases

ChiTaRSiFN3K. human.
GeneWikiiFN3K.
Fructosamine-3-kinase.
GenomeRNAii64122.
PROiQ9H479.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167363.
CleanExiHS_FN3K.
GenevisibleiQ9H479. HS.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFN3K_HUMAN
AccessioniPrimary (citable) accession number: Q9H479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.