Reviewed, UniProtKB/Swiss-Prot Q9H467 (CUED2_HUMAN)

Names and origin

Protein names

Recommended name:
    CUE domain-containing protein 2

Gene names

Name:	CUEDC2
Synonyms:	C10orf66
ORF Names:	HOYS6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Ref.5
Subunit structure	Interacts with PGR and ESR1. Ref.5
Subcellular location	Cytoplasm. Nucleus. Ref.5
Domain	The CUE domain mediates interaction with PGR and ESR1.
Sequence similarities	Belongs to the CUEDC2 family. Contains 1 CUE domain.
Sequence caution	The sequence AAH00262.1 differs from that shown. Reason: Erroneous termination at position 227. Translated as Glu.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.5 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ESR1	P03372	2	EBI-1248228,EBI-78473
PGR	P06401	5	EBI-1248228,EBI-78539

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	CUE domain-containing protein 2		PRO_0000282992
Regions
	Domain	144 – 187	44	CUE
Experimental info
	Sequence conflict	228	1	D → Y in AAH00262. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9H467-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: D092D9A6168E9C15	FASTA	287	32,009
	10 20 30 40 50 60 MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM 70 80 90 100 110 120 MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS SGVQGQVPIS PEPLQRPEML 130 140 150 160 170 180 KEETRSSAAA AADTQDEATG AEEELLPGVD VLLEVFPTCS VEQAQWVLAK ARGDLEEAVQ 190 200 210 220 230 240 MLVEGKEEGP AAWEGPNQDL PRRLRGPQKD ELKSFILQKY MMVDSAEDQK IHRPMAPKEA 250 260 270 280 PKKLIRYIDN QVVSTKGERF KDVRNPEAEE MKATYINLKP ARKYRFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of an osteocyte derived gene." Ikeda A., Turitani K. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Osteocyte.
[2]	"Nucleotide sequence of human CUEDC2 mRNA." Matsumoto K., Abiko S., Ariga H. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retinoblastoma.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome." Zhang P.-J., Zhao J., Li H.-Y., Man J.-H., He K., Zhou T., Pan X., Li A.-L., Gong W.-L., Jin B.-F., Xia Q., Yu M., Shen B.-F., Zhang X.-M. EMBO J. 26:1831-1842(2007) [PubMed: 17347654] [Abstract] Cited for: FUNCTION, INTERACTION WITH PGR AND ESR1, SUBCELLULAR LOCATION.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB025425 mRNA. Translation: BAB87809.1. AB232358 mRNA. Translation: BAE19942.1. AL121928 Genomic DNA. Translation: CAC08403.1. BC000262 mRNA. Translation: AAH00262.1. Sequence problems.
IPI	IPI00100463.
RefSeq	NP_076945.2.
UniGene	Hs.500874
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H467. 3 interactions.
STRING	Q9H467.
Proteomic databases
PRIDE	Q9H467.
Genome annotation databases
Ensembl	ENST00000369937; ENSP00000358953; ENSG00000107874; Homo sapiens. [Genome view]
GeneID	79004.
KEGG	hsa:79004.
UCSC	uc001kvn.2. human.
Organism-specific databases
CTD	79004.
GeneCards	GC10M104172.
HGNC	HGNC:28352. CUEDC2.
PharmGKB	PA134871975.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H467.
OMA	VEENFDV.
Gene expression databases
ArrayExpress	Q9H467.
Bgee	Q9H467.
CleanEx	HS_CUEDC2.
Genevestigator	Q9H467.
Family and domain databases
InterPro	IPR003892. CUE. [Graphical view]
PROSITE	PS51140. CUE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	67629.

Entry information

Entry name

CUED2_HUMAN

Accession

Primary (citable) accession number: Q9H467
Secondary accession number(s): Q9BWG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.