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Protein

CUE domain-containing protein 2

Gene

CUEDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.2 Publications

GO - Biological processi

  • negative regulation of cytokine production involved in inflammatory response Source: MGI
  • negative regulation of macrophage cytokine production Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein 2
Gene namesi
Name:CUEDC2
Synonyms:C10orf66
ORF Names:HOYS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28352. CUEDC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Organism-specific databases

PharmGKBiPA134871975.

Polymorphism and mutation databases

BioMutaiCUEDC2.
DMDMi74752634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287CUE domain-containing protein 2PRO_0000282992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H467.
MaxQBiQ9H467.
PaxDbiQ9H467.
PeptideAtlasiQ9H467.
PRIDEiQ9H467.

PTM databases

iPTMnetiQ9H467.
PhosphoSiteiQ9H467.

Expressioni

Tissue specificityi

Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Gene expression databases

BgeeiENSG00000107874.
CleanExiHS_CUEDC2.
GenevisibleiQ9H467. HS.

Organism-specific databases

HPAiHPA036544.
HPA041829.

Interactioni

Subunit structurei

Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-1248228,EBI-78473
PGRP064019EBI-1248228,EBI-78539

Protein-protein interaction databases

BioGridi122475. 21 interactions.
IntActiQ9H467. 3 interactions.
MINTiMINT-4787857.
STRINGi9606.ENSP00000358953.

Structurei

3D structure databases

ProteinModelPortaliQ9H467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 18744CUEPROSITE-ProRule annotationAdd
BLAST

Domaini

The CUE domain mediates interaction with PGR and ESR1.

Sequence similaritiesi

Belongs to the CUEDC2 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJTC. Eukaryota.
ENOG4111GK5. LUCA.
GeneTreeiENSGT00390000014513.
HOGENOMiHOG000044753.
HOVERGENiHBG106839.
InParanoidiQ9H467.
OMAiTEMEKNQ.
OrthoDBiEOG091G0FYA.
PhylomeDBiQ9H467.
TreeFamiTF324328.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE
60 70 80 90 100
NFDMEAFTEM MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS
110 120 130 140 150
SGVQGQVPIS PEPLQRPEML KEETRSSAAA AADTQDEATG AEEELLPGVD
160 170 180 190 200
VLLEVFPTCS VEQAQWVLAK ARGDLEEAVQ MLVEGKEEGP AAWEGPNQDL
210 220 230 240 250
PRRLRGPQKD ELKSFILQKY MMVDSAEDQK IHRPMAPKEA PKKLIRYIDN
260 270 280
QVVSTKGERF KDVRNPEAEE MKATYINLKP ARKYRFH
Length:287
Mass (Da):32,009
Last modified:March 1, 2001 - v1
Checksum:iD092D9A6168E9C15
GO

Sequence cautioni

The sequence AAH00262 differs from that shown. Reason: Erroneous termination at position 227. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281D → Y in AAH00262 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025425 mRNA. Translation: BAB87809.1.
AB232358 mRNA. Translation: BAE19942.1.
AL121928 Genomic DNA. Translation: CAC08403.1.
CH471066 Genomic DNA. Translation: EAW49696.1.
CH471066 Genomic DNA. Translation: EAW49697.1.
BC000262 mRNA. Translation: AAH00262.1. Sequence problems.
CCDSiCCDS41566.1.
RefSeqiNP_076945.2. NM_024040.2.
UniGeneiHs.500874.

Genome annotation databases

EnsembliENST00000369937; ENSP00000358953; ENSG00000107874.
GeneIDi79004.
KEGGihsa:79004.
UCSCiuc001kvn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025425 mRNA. Translation: BAB87809.1.
AB232358 mRNA. Translation: BAE19942.1.
AL121928 Genomic DNA. Translation: CAC08403.1.
CH471066 Genomic DNA. Translation: EAW49696.1.
CH471066 Genomic DNA. Translation: EAW49697.1.
BC000262 mRNA. Translation: AAH00262.1. Sequence problems.
CCDSiCCDS41566.1.
RefSeqiNP_076945.2. NM_024040.2.
UniGeneiHs.500874.

3D structure databases

ProteinModelPortaliQ9H467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122475. 21 interactions.
IntActiQ9H467. 3 interactions.
MINTiMINT-4787857.
STRINGi9606.ENSP00000358953.

PTM databases

iPTMnetiQ9H467.
PhosphoSiteiQ9H467.

Polymorphism and mutation databases

BioMutaiCUEDC2.
DMDMi74752634.

Proteomic databases

EPDiQ9H467.
MaxQBiQ9H467.
PaxDbiQ9H467.
PeptideAtlasiQ9H467.
PRIDEiQ9H467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369937; ENSP00000358953; ENSG00000107874.
GeneIDi79004.
KEGGihsa:79004.
UCSCiuc001kvn.3. human.

Organism-specific databases

CTDi79004.
GeneCardsiCUEDC2.
HGNCiHGNC:28352. CUEDC2.
HPAiHPA036544.
HPA041829.
MIMi614142. gene.
neXtProtiNX_Q9H467.
PharmGKBiPA134871975.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTC. Eukaryota.
ENOG4111GK5. LUCA.
GeneTreeiENSGT00390000014513.
HOGENOMiHOG000044753.
HOVERGENiHBG106839.
InParanoidiQ9H467.
OMAiTEMEKNQ.
OrthoDBiEOG091G0FYA.
PhylomeDBiQ9H467.
TreeFamiTF324328.

Miscellaneous databases

ChiTaRSiCUEDC2. human.
GenomeRNAii79004.
PROiQ9H467.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107874.
CleanExiHS_CUEDC2.
GenevisibleiQ9H467. HS.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUED2_HUMAN
AccessioniPrimary (citable) accession number: Q9H467
Secondary accession number(s): D3DR88, Q9BWG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.