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Reviewed, UniProtKB/Swiss-Prot Q9H461 (FZD8_HUMAN)

Last modified January 19, 2010. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Frizzled-8
      Short name=Fz-8
      Short name=hFz8
Gene names
Name: FZD8
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length694 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subunit structure

Interacts with GOPC. Interacts with RSPO1 and RSPO3 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.

Domain

The PDZ-binding motif mediates interaction with GOPC By similarity.

Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 694667Frizzled-8
PRO_0000013000

Regions

Topological domain28 – 275248Extracellular Potential
Transmembrane276 – 296211 Potential
Topological domain297 – 31216Cytoplasmic Potential
Transmembrane313 – 333212 Potential
Topological domain334 – 39663Extracellular Potential
Transmembrane397 – 417213 Potential
Topological domain418 – 43922Cytoplasmic Potential
Transmembrane440 – 460214 Potential
Topological domain461 – 48323Extracellular Potential
Transmembrane484 – 504215 Potential
Topological domain505 – 53228Cytoplasmic Potential
Transmembrane533 – 553216 Potential
Topological domain554 – 58431Extracellular Potential
Transmembrane585 – 605217 Potential
Topological domain606 – 69489Cytoplasmic Potential
Domain30 – 151122FZ
Motif608 – 6136Lys-Thr-X-X-X-Trp motif
Motif692 – 6943PDZ-binding
Compositional bias168 – 1725Poly-Pro
Compositional bias194 – 2029Poly-Gly
Compositional bias211 – 2166Poly-Gly
Compositional bias639 – 66325Poly-Gly

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 96 By similarity
Disulfide bond43 ↔ 89 By similarity
Disulfide bond80 ↔ 118 By similarity
Disulfide bond107 ↔ 148 By similarity
Disulfide bond111 ↔ 135 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9H461-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: E740CBFDA2A233EF

FASTA69473,300
        10         20         30         40         50         60 
MEWGYLLEVT SLLAALALLQ RSSGAAAASA KELACQEITV PLCKGIGYNY TYMPNQFNHD 

        70         80         90        100        110        120 
TQDEAGLEVH QFWPLVEIQC SPDLKFFLCS MYTPICLEDY KKPLPPCRSV CERAKAGCAP 

       130        140        150        160        170        180 
LMRQYGFAWP DRMRCDRLPE QGNPDTLCMD YNRTDLTTAA PSPPRRLPPP PPGEQPPSGS 

       190        200        210        220        230        240 
GHGRPPGARP PHRGGGRGGG GGDAAAPPAR GGGGGGKARP PGGGAAPCEP GCQCRAPMVS 

       250        260        270        280        290        300 
VSSERHPLYN RVKTGQIANC ALPCHNPFFS QDERAFTVFW IGLWSVLCFV STFATVSTFL 

       310        320        330        340        350        360 
IDMERFKYPE RPIIFLSACY LFVSVGYLVR LVAGHEKVAC SGGAPGAGGA GGAGGAAAGA 

       370        380        390        400        410        420 
GAAGAGAGGP GGRGEYEELG AVEQHVRYET TGPALCTVVF LLVYFFGMAS SIWWVILSLT 

       430        440        450        460        470        480 
WFLAAGMKWG NEAIAGYSQY FHLAAWLVPS VKSIAVLALS SVDGDPVAGI CYVGNQSLDN 

       490        500        510        520        530        540 
LRGFVLAPLV IYLFIGTMFL LAGFVSLFRI RSVIKQQDGP TKTHKLEKLM IRLGLFTVLY 

       550        560        570        580        590        600 
TVPAAVVVAC LFYEQHNRPR WEATHNCPCL RDLQPDQARR PDYAVFMLKY FMCLVVGITS 

       610        620        630        640        650        660 
GVWVWSGKTL ESWRSLCTRC CWASKGAAVG GGAGATAAGG GGGPGGGGGG GPGGGGGPGG 

       670        680        690 
GGGSLYSDVS TGLTWRSGTA SSVSYPKQMP LSQV

« Hide

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References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2."
Saitoh T., Hirai M., Katoh M.
Int. J. Oncol. 18:991-996(2001) [PubMed: 11295046] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB043703 mRNA. Translation: BAB41064.1.
AL121749 Genomic DNA. Translation: CAC10185.1.
IPIIPI00010807.
RefSeqNP_114072.1.
UniGeneHs.302634

3D structure databases

SMRQ9H461. Positions 32-153.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9H461.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ9H461.

Genome annotation databases

EnsemblENST00000374694; ENSP00000363826; ENSG00000177283; Homo sapiens. [Genome view]
GeneID8325.
KEGGhsa:8325.
UCSCuc001iyz.1. human.

Organism-specific databases

CTD8325.
GeneCardsGC10M035967.
H-InvDBHIX0035305.
HGNCHGNC:4046. FZD8.
MIM606146. gene.
PharmGKBPA28463.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG04186.
HOGENOMHBG447413.
HOVERGENQ9H461.
InParanoidQ9H461.
OMAVWVWSGK.
OrthoDBEOG9RZ1K6.
PhylomeDBQ9H461.

Gene expression databases

ArrayExpressQ9H461.
BgeeQ9H461.
CleanExHS_FZD8.
GenevestigatorQ9H461.
GermOnlineENSG00000177283. Homo sapiens.

Family and domain databases

InterProIPR000539. Frizzled.
IPR020067. Frizzled-like_dom.
IPR000024. Frizzled_Cys-rich.
IPR020068. Frizzled_dom_subgr.
IPR015526. Frizzled_related.
IPR017981. GPCR_2-like.
[Graphical view]
Gene3DG3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHERPTHR11309. Fz_related. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio31175.
SOURCESearch...

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Entry information

Entry nameFZD8_HUMAN
AccessionPrimary (citable) accession number: Q9H461
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 1, 2001
Last modified: January 19, 2010
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents