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Protein

RWD domain-containing protein 1

Gene

RWDD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects DRG2 from proteolytic degradation.By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111832-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 1
Alternative name(s):
DRG family-regulatory protein 2
Gene namesi
Name:RWDD1
Synonyms:DFRP2
ORF Names:CGI-24, PTD013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20993. RWDD1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111832.
PharmGKBiPA134967923.

Polymorphism and mutation databases

DMDMi34098713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000975402 – 243RWD domain-containing protein 1Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei144PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H446.
MaxQBiQ9H446.
PaxDbiQ9H446.
PeptideAtlasiQ9H446.
PRIDEiQ9H446.

PTM databases

iPTMnetiQ9H446.
PhosphoSitePlusiQ9H446.

Expressioni

Gene expression databases

BgeeiENSG00000111832.
CleanExiHS_RWDD1.
ExpressionAtlasiQ9H446. baseline and differential.
GenevisibleiQ9H446. HS.

Organism-specific databases

HPAiHPA028712.
HPA028713.

Interactioni

Subunit structurei

Interacts with DRG2. Interacts with androgen receptor (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DRG1Q9Y2957EBI-748952,EBI-719554
DRG2P550396EBI-748952,EBI-750565

Protein-protein interaction databases

BioGridi119518. 4 interactors.
DIPiDIP-34520N.
IntActiQ9H446. 5 interactors.
MINTiMINT-1436573.
STRINGi9606.ENSP00000420357.

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 18Combined sources15
Beta strandi20 – 25Combined sources6
Beta strandi28 – 30Combined sources3
Beta strandi32 – 35Combined sources4
Beta strandi49 – 55Combined sources7
Turni60 – 62Combined sources3
Beta strandi66 – 74Combined sources9
Helixi77 – 94Combined sources18
Helixi100 – 117Combined sources18
Helixi118 – 120Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBMNMR-A1-121[»]
ProteinModelPortaliQ9H446.
SMRiQ9H446.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H446.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 114RWDPROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 197Interaction with DRG2By similarityAdd BLAST56

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOGENOMiHOG000237961.
HOVERGENiHBG060864.
InParanoidiQ9H446.
OMAiPPLWEIY.
OrthoDBiEOG091G0ODA.
PhylomeDBiQ9H446.
TreeFamiTF313662.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H446-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT
60 70 80 90 100
TLKFTYSEKY PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI
110 120 130 140 150
FTLVTAVQEK LNEIVDQIKT RREEEKKQKE KEAEEAEKQL FHGTPVTIEN
160 170 180 190 200
FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK LSGKQLFETD HNLDTSDIQF
210 220 230 240
LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD SAD
Length:243
Mass (Da):27,940
Last modified:March 1, 2001 - v1
Checksum:iA7AABD457136B4DA
GO
Isoform 2 (identifier: Q9H446-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:147
Mass (Da):17,082
Checksum:iA2927D314AE84CE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 130TRREEEKKQKE → LEERRKNKR in AAD27733 (PubMed:10810093).CuratedAdd BLAST11
Sequence conflicti139Q → R in AAD40376 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445001 – 96Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132958 mRNA. Translation: AAD27733.1.
AF092134 mRNA. Translation: AAD40376.1.
AK290727 mRNA. Translation: BAF83416.1.
AK301089 mRNA. Translation: BAG62691.1.
AL121953 Genomic DNA. Translation: CAC14427.1.
CH471051 Genomic DNA. Translation: EAW48221.1.
CH471051 Genomic DNA. Translation: EAW48222.1.
BC015802 mRNA. Translation: AAH15802.1.
CCDSiCCDS34520.1. [Q9H446-1]
CCDS43496.1. [Q9H446-2]
RefSeqiNP_001007465.1. NM_001007464.2. [Q9H446-2]
NP_057036.2. NM_015952.3. [Q9H446-1]
NP_057188.2. NM_016104.3. [Q9H446-2]
UniGeneiHs.532164.

Genome annotation databases

EnsembliENST00000466444; ENSP00000420357; ENSG00000111832. [Q9H446-1]
ENST00000487832; ENSP00000428778; ENSG00000111832. [Q9H446-2]
GeneIDi51389.
KEGGihsa:51389.
UCSCiuc003pxc.5. human. [Q9H446-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132958 mRNA. Translation: AAD27733.1.
AF092134 mRNA. Translation: AAD40376.1.
AK290727 mRNA. Translation: BAF83416.1.
AK301089 mRNA. Translation: BAG62691.1.
AL121953 Genomic DNA. Translation: CAC14427.1.
CH471051 Genomic DNA. Translation: EAW48221.1.
CH471051 Genomic DNA. Translation: EAW48222.1.
BC015802 mRNA. Translation: AAH15802.1.
CCDSiCCDS34520.1. [Q9H446-1]
CCDS43496.1. [Q9H446-2]
RefSeqiNP_001007465.1. NM_001007464.2. [Q9H446-2]
NP_057036.2. NM_015952.3. [Q9H446-1]
NP_057188.2. NM_016104.3. [Q9H446-2]
UniGeneiHs.532164.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBMNMR-A1-121[»]
ProteinModelPortaliQ9H446.
SMRiQ9H446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119518. 4 interactors.
DIPiDIP-34520N.
IntActiQ9H446. 5 interactors.
MINTiMINT-1436573.
STRINGi9606.ENSP00000420357.

PTM databases

iPTMnetiQ9H446.
PhosphoSitePlusiQ9H446.

Polymorphism and mutation databases

DMDMi34098713.

Proteomic databases

EPDiQ9H446.
MaxQBiQ9H446.
PaxDbiQ9H446.
PeptideAtlasiQ9H446.
PRIDEiQ9H446.

Protocols and materials databases

DNASUi51389.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466444; ENSP00000420357; ENSG00000111832. [Q9H446-1]
ENST00000487832; ENSP00000428778; ENSG00000111832. [Q9H446-2]
GeneIDi51389.
KEGGihsa:51389.
UCSCiuc003pxc.5. human. [Q9H446-1]

Organism-specific databases

CTDi51389.
GeneCardsiRWDD1.
HGNCiHGNC:20993. RWDD1.
HPAiHPA028712.
HPA028713.
neXtProtiNX_Q9H446.
OpenTargetsiENSG00000111832.
PharmGKBiPA134967923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOGENOMiHOG000237961.
HOVERGENiHBG060864.
InParanoidiQ9H446.
OMAiPPLWEIY.
OrthoDBiEOG091G0ODA.
PhylomeDBiQ9H446.
TreeFamiTF313662.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111832-MONOMER.

Miscellaneous databases

ChiTaRSiRWDD1. human.
EvolutionaryTraceiQ9H446.
GenomeRNAii51389.
PROiQ9H446.

Gene expression databases

BgeeiENSG00000111832.
CleanExiHS_RWDD1.
ExpressionAtlasiQ9H446. baseline and differential.
GenevisibleiQ9H446. HS.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRWDD1_HUMAN
AccessioniPrimary (citable) accession number: Q9H446
Secondary accession number(s): A8K3W2
, A8MT24, Q9Y313, Q9Y6B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.