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Protein

Potassium channel subfamily K member 15

Gene

KCNK15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124249-MONOMER.
ReactomeiR-HSA-5576886. Phase 4 - resting membrane potential.
SignaLinkiQ9H427.

Protein family/group databases

TCDBi1.A.1.9.12. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
TWIK-related acid-sensitive K(+) channel 5
Two pore potassium channel KT3.3
Short name:
Two pore K(+) channel KT3.3
Gene namesi
Name:KCNK15
Synonyms:TASK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13814. KCNK15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei80 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST22
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei189 – 209Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 330CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi138R → Y: No effect on lack of functional expression. 1 Publication1
Mutagenesisi141 – 145LAAKC → HRAKK: No effect on lack of functional expression. 1 Publication5
Mutagenesisi151W → R: No effect on lack of functional expression. 1 Publication1
Mutagenesisi153C → D: No effect on lack of functional expression. 1 Publication1

Organism-specific databases

PharmGKBiPA30056.

Polymorphism and mutation databases

BioMutaiKCNK15.
DMDMi24636282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017651 – 330Potassium channel subfamily K member 15Add BLAST330

Proteomic databases

MaxQBiQ9H427.
PaxDbiQ9H427.
PRIDEiQ9H427.

Expressioni

Tissue specificityi

Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.2 Publications

Gene expression databases

BgeeiENSG00000124249.
CleanExiHS_KCNK15.

Organism-specific databases

HPAiHPA064861.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000361952.

Structurei

3D structure databases

ProteinModelPortaliQ9H427.
SMRiQ9H427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9H427.
KOiK04923.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9H427.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR008073. TASK5.
[Graphical view]
PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9H427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR
60 70 80 90 100
KFGFSAEDYR ELERLALQAE PHRAGRQWKF PGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNAVVRRLL LAAKCCLGLR
160 170 180 190 200
WTCVSTENLV VAGLLACAAT LALGAVAFSH FEGWTFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN LVVLRFLVAS
260 270 280 290 300
ADWPERAARP PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA
310 320 330
RDNLGFSPPS SPGVVRGGQA PRPGARWKSI
Length:330
Mass (Da):36,130
Last modified:November 1, 2002 - v2
Checksum:iAA2A54D0615BC53C
GO

Polymorphismi

Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01421195G → E in TASK-5B. 4 PublicationsCorresponds to variant rs1111032dbSNPEnsembl.1
Natural variantiVAR_014212260P → T in TASK-5B. 3 PublicationsCorresponds to variant rs6073538dbSNPEnsembl.1
Natural variantiVAR_014213261P → H in TASK-5A. 2 PublicationsCorresponds to variant rs13037900dbSNPEnsembl.1
Natural variantiVAR_014214323P → L in TASK-5B. 2 PublicationsCorresponds to variant rs13042905dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257081 mRNA. Translation: AAG33127.1.
AF294350 mRNA. Translation: AAK97091.1.
AF294351 mRNA. Translation: AAK97092.1.
AF294352 Genomic DNA. Translation: AAK97093.1.
AF336342 mRNA. Translation: AAK37518.1.
AL118522 Genomic DNA. Translation: CAC14068.1.
BC093874 mRNA. Translation: AAH93874.1.
BC143282 mRNA. Translation: AAI43283.1.
CCDSiCCDS13337.1.
PIRiJC7703.
RefSeqiNP_071753.2. NM_022358.3.
UniGeneiHs.528664.

Genome annotation databases

EnsembliENST00000372861; ENSP00000361952; ENSG00000124249.
GeneIDi60598.
KEGGihsa:60598.
UCSCiuc002xmr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257081 mRNA. Translation: AAG33127.1.
AF294350 mRNA. Translation: AAK97091.1.
AF294351 mRNA. Translation: AAK97092.1.
AF294352 Genomic DNA. Translation: AAK97093.1.
AF336342 mRNA. Translation: AAK37518.1.
AL118522 Genomic DNA. Translation: CAC14068.1.
BC093874 mRNA. Translation: AAH93874.1.
BC143282 mRNA. Translation: AAI43283.1.
CCDSiCCDS13337.1.
PIRiJC7703.
RefSeqiNP_071753.2. NM_022358.3.
UniGeneiHs.528664.

3D structure databases

ProteinModelPortaliQ9H427.
SMRiQ9H427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361952.

Protein family/group databases

TCDBi1.A.1.9.12. the voltage-gated ion channel (vic) superfamily.

Polymorphism and mutation databases

BioMutaiKCNK15.
DMDMi24636282.

Proteomic databases

MaxQBiQ9H427.
PaxDbiQ9H427.
PRIDEiQ9H427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372861; ENSP00000361952; ENSG00000124249.
GeneIDi60598.
KEGGihsa:60598.
UCSCiuc002xmr.4. human.

Organism-specific databases

CTDi60598.
GeneCardsiKCNK15.
H-InvDBHIX0040517.
HGNCiHGNC:13814. KCNK15.
HPAiHPA064861.
MIMi607368. gene.
neXtProtiNX_Q9H427.
PharmGKBiPA30056.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9H427.
KOiK04923.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9H427.
TreeFamiTF313947.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124249-MONOMER.
ReactomeiR-HSA-5576886. Phase 4 - resting membrane potential.
SignaLinkiQ9H427.

Miscellaneous databases

ChiTaRSiKCNK15. human.
GeneWikiiKCNK15.
GenomeRNAii60598.
PROiQ9H427.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124249.
CleanExiHS_KCNK15.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR008073. TASK5.
[Graphical view]
PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNKF_HUMAN
AccessioniPrimary (citable) accession number: Q9H427
Secondary accession number(s): Q52LL3, Q9HBC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.