Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H427 (KCNKF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
TWIK-related acid-sensitive K(+) channel 5
Two pore potassium channel KT3.3
Short name=Two pore K(+) channel KT3.3
Gene names
Name:KCNK15
Synonyms:TASK5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Subunit structure

Heterodimer Potential.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland. Ref.1 Ref.4

Polymorphism

Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of ion transmembrane transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpotassium channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Potassium channel subfamily K member 15
PRO_0000101765

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Potential
Intramembrane80 – 10122Pore-forming; Name=Pore-forming 1; Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 15830Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Intramembrane189 – 20921Pore-forming; Name=Pore-forming 2; Potential
Transmembrane223 – 24321Helical; Potential
Topological domain244 – 33087Cytoplasmic Potential

Natural variations

Natural variant951G → E in TASK-5B. Ref.1 Ref.3 Ref.5 Ref.6
Corresponds to variant rs1111032 [ dbSNP | Ensembl ].
VAR_014211
Natural variant2601P → T in TASK-5B. Ref.3 Ref.5 Ref.6
Corresponds to variant rs6073538 [ dbSNP | Ensembl ].
VAR_014212
Natural variant2611P → H in TASK-5A. Ref.3 Ref.6
Corresponds to variant rs13037900 [ dbSNP | Ensembl ].
VAR_014213
Natural variant3231P → L in TASK-5B. Ref.3 Ref.5
Corresponds to variant rs13042905 [ dbSNP | Ensembl ].
VAR_014214

Experimental info

Mutagenesis1381R → Y: No effect on lack of functional expression. Ref.3
Mutagenesis141 – 1455LAAKC → HRAKK: No effect on lack of functional expression. Ref.3
Mutagenesis1511W → R: No effect on lack of functional expression. Ref.3
Mutagenesis1531C → D: No effect on lack of functional expression. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9H427 [UniParc].

Last modified November 1, 2002. Version 2.
Checksum: AA2A54D0615BC53C

FASTA33036,130
        10         20         30         40         50         60 
MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR KFGFSAEDYR 

        70         80         90        100        110        120 
ELERLALQAE PHRAGRQWKF PGSFYFAITV ITTIGYGHAA PGTDSGKVFC MFYALLGIPL 

       130        140        150        160        170        180 
TLVTFQSLGE RLNAVVRRLL LAAKCCLGLR WTCVSTENLV VAGLLACAAT LALGAVAFSH 

       190        200        210        220        230        240 
FEGWTFFHAY YYCFITLTTI GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN 

       250        260        270        280        290        300 
LVVLRFLVAS ADWPERAARP PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA 

       310        320        330 
RDNLGFSPPS SPGVVRGGQA PRPGARWKSI 

« Hide

References

« Hide 'large scale' references
[1]"TASK-5, a new member of the tandem-pore K(+) channel family."
Kim D., Gnatenco C.
Biochem. Biophys. Res. Commun. 284:923-930(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLU-95.
[2]"KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1."
Vega-Saenz de Miera E., Lau D.H.P., Zhadina M., Pountney D., Coetzee W.A., Rudy B.
J. Neurophysiol. 86:130-142(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system."
Karschin C., Wischmeyer E., Preisig-Mueller R., Rajan S., Derst C., Grzeschik K.-H., Daut J., Karschin A.
Mol. Cell. Neurosci. 18:632-648(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM, VARIANTS GLU-95; THR-260; HIS-261 AND LEU-323, MUTAGENESIS OF ARG-138; 141-LEU--CYS-145; TRP-151 AND CYS-153.
Tissue: Brain, Colon and Ovarian carcinoma.
[4]"TASK-5, a novel member of the tandem pore K+ channel family."
Ashmole I., Goodwin P.A., Stanfield P.R.
Pflugers Arch. 442:828-833(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-95; THR-260 AND LEU-323.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-95; THR-260 AND HIS-261.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF257081 mRNA. Translation: AAG33127.1.
AF294350 mRNA. Translation: AAK97091.1.
AF294351 mRNA. Translation: AAK97092.1.
AF294352 Genomic DNA. Translation: AAK97093.1.
AF336342 mRNA. Translation: AAK37518.1.
AL118522 Genomic DNA. Translation: CAC14068.1.
BC093874 mRNA. Translation: AAH93874.1.
BC143282 mRNA. Translation: AAI43283.1.
PIRJC7703.
RefSeqNP_071753.2. NM_022358.3.
UniGeneHs.528664.

3D structure databases

ProteinModelPortalQ9H427.
SMRQ9H427. Positions 18-242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000361952.

Chemistry

GuidetoPHARMACOLOGY524.

Polymorphism databases

DMDM24636282.

Proteomic databases

PaxDbQ9H427.
PRIDEQ9H427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372861; ENSP00000361952; ENSG00000124249.
GeneID60598.
KEGGhsa:60598.
UCSCuc002xmr.3. human.

Organism-specific databases

CTD60598.
GeneCardsGC20P043374.
H-InvDBHIX0040517.
HGNCHGNC:13814. KCNK15.
MIM607368. gene.
neXtProtNX_Q9H427.
PharmGKBPA30056.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259548.
HOGENOMHOG000231463.
HOVERGENHBG052239.
InParanoidQ9H427.
KOK04923.
OrthoDBEOG7B05DC.
PhylomeDBQ9H427.
TreeFamTF313947.

Enzyme and pathway databases

SignaLinkQ9H427.

Gene expression databases

BgeeQ9H427.
CleanExHS_KCNK15.
GenevestigatorQ9H427.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR008073. TASK5.
[Graphical view]
PANTHERPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetSearch...

Other

GeneWikiKCNK15.
GenomeRNAi60598.
NextBio65457.
PROQ9H427.
SOURCESearch...

Entry information

Entry nameKCNKF_HUMAN
AccessionPrimary (citable) accession number: Q9H427
Secondary accession number(s): Q52LL3, Q9HBC8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM