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Q9H427

- KCNKF_HUMAN

UniProt

Q9H427 - KCNKF_HUMAN

Protein

Potassium channel subfamily K member 15

Gene

KCNK15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Nov 2002)
      Previous versions | rss
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    Functioni

    Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of ion transmembrane transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    SignaLinkiQ9H427.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 15
    Alternative name(s):
    Acid-sensitive potassium channel protein TASK-5
    TWIK-related acid-sensitive K(+) channel 5
    Two pore potassium channel KT3.3
    Short name:
    Two pore K(+) channel KT3.3
    Gene namesi
    Name:KCNK15
    Synonyms:TASK5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13814. KCNK15.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi138 – 1381R → Y: No effect on lack of functional expression. 1 Publication
    Mutagenesisi141 – 1455LAAKC → HRAKK: No effect on lack of functional expression.
    Mutagenesisi151 – 1511W → R: No effect on lack of functional expression. 1 Publication
    Mutagenesisi153 – 1531C → D: No effect on lack of functional expression. 1 Publication

    Organism-specific databases

    PharmGKBiPA30056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Potassium channel subfamily K member 15PRO_0000101765Add
    BLAST

    Proteomic databases

    PaxDbiQ9H427.
    PRIDEiQ9H427.

    Expressioni

    Tissue specificityi

    Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.2 Publications

    Gene expression databases

    BgeeiQ9H427.
    CleanExiHS_KCNK15.
    GenevestigatoriQ9H427.

    Interactioni

    Subunit structurei

    Heterodimer.Curated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H427.
    SMRiQ9H427. Positions 18-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 33087CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei80 – 10122Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei189 – 20921Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259548.
    HOGENOMiHOG000231463.
    HOVERGENiHBG052239.
    InParanoidiQ9H427.
    KOiK04923.
    OrthoDBiEOG7B05DC.
    PhylomeDBiQ9H427.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR008073. TASK5.
    [Graphical view]
    PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01690. TASK5CHANNEL.
    PR01095. TASKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9H427-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR    50
    KFGFSAEDYR ELERLALQAE PHRAGRQWKF PGSFYFAITV ITTIGYGHAA 100
    PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNAVVRRLL LAAKCCLGLR 150
    WTCVSTENLV VAGLLACAAT LALGAVAFSH FEGWTFFHAY YYCFITLTTI 200
    GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN LVVLRFLVAS 250
    ADWPERAARP PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA 300
    RDNLGFSPPS SPGVVRGGQA PRPGARWKSI 330
    Length:330
    Mass (Da):36,130
    Last modified:November 1, 2002 - v2
    Checksum:iAA2A54D0615BC53C
    GO

    Polymorphismi

    Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951G → E in TASK-5B. 4 Publications
    Corresponds to variant rs1111032 [ dbSNP | Ensembl ].
    VAR_014211
    Natural varianti260 – 2601P → T in TASK-5B. 3 Publications
    Corresponds to variant rs6073538 [ dbSNP | Ensembl ].
    VAR_014212
    Natural varianti261 – 2611P → H in TASK-5A. 2 Publications
    Corresponds to variant rs13037900 [ dbSNP | Ensembl ].
    VAR_014213
    Natural varianti323 – 3231P → L in TASK-5B. 2 Publications
    Corresponds to variant rs13042905 [ dbSNP | Ensembl ].
    VAR_014214

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257081 mRNA. Translation: AAG33127.1.
    AF294350 mRNA. Translation: AAK97091.1.
    AF294351 mRNA. Translation: AAK97092.1.
    AF294352 Genomic DNA. Translation: AAK97093.1.
    AF336342 mRNA. Translation: AAK37518.1.
    AL118522 Genomic DNA. Translation: CAC14068.1.
    BC093874 mRNA. Translation: AAH93874.1.
    BC143282 mRNA. Translation: AAI43283.1.
    CCDSiCCDS13337.1.
    PIRiJC7703.
    RefSeqiNP_071753.2. NM_022358.3.
    UniGeneiHs.528664.

    Genome annotation databases

    EnsembliENST00000372861; ENSP00000361952; ENSG00000124249.
    GeneIDi60598.
    KEGGihsa:60598.
    UCSCiuc002xmr.3. human.

    Polymorphism databases

    DMDMi24636282.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257081 mRNA. Translation: AAG33127.1 .
    AF294350 mRNA. Translation: AAK97091.1 .
    AF294351 mRNA. Translation: AAK97092.1 .
    AF294352 Genomic DNA. Translation: AAK97093.1 .
    AF336342 mRNA. Translation: AAK37518.1 .
    AL118522 Genomic DNA. Translation: CAC14068.1 .
    BC093874 mRNA. Translation: AAH93874.1 .
    BC143282 mRNA. Translation: AAI43283.1 .
    CCDSi CCDS13337.1.
    PIRi JC7703.
    RefSeqi NP_071753.2. NM_022358.3.
    UniGenei Hs.528664.

    3D structure databases

    ProteinModelPortali Q9H427.
    SMRi Q9H427. Positions 18-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361952.

    Chemistry

    GuidetoPHARMACOLOGYi 524.

    Polymorphism databases

    DMDMi 24636282.

    Proteomic databases

    PaxDbi Q9H427.
    PRIDEi Q9H427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372861 ; ENSP00000361952 ; ENSG00000124249 .
    GeneIDi 60598.
    KEGGi hsa:60598.
    UCSCi uc002xmr.3. human.

    Organism-specific databases

    CTDi 60598.
    GeneCardsi GC20P043374.
    H-InvDB HIX0040517.
    HGNCi HGNC:13814. KCNK15.
    MIMi 607368. gene.
    neXtProti NX_Q9H427.
    PharmGKBi PA30056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259548.
    HOGENOMi HOG000231463.
    HOVERGENi HBG052239.
    InParanoidi Q9H427.
    KOi K04923.
    OrthoDBi EOG7B05DC.
    PhylomeDBi Q9H427.
    TreeFami TF313947.

    Enzyme and pathway databases

    SignaLinki Q9H427.

    Miscellaneous databases

    GeneWikii KCNK15.
    GenomeRNAii 60598.
    NextBioi 65457.
    PROi Q9H427.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H427.
    CleanExi HS_KCNK15.
    Genevestigatori Q9H427.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR008073. TASK5.
    [Graphical view ]
    PANTHERi PTHR11003:SF18. PTHR11003:SF18. 1 hit.
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01690. TASK5CHANNEL.
    PR01095. TASKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "TASK-5, a new member of the tandem-pore K(+) channel family."
      Kim D., Gnatenco C.
      Biochem. Biophys. Res. Commun. 284:923-930(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLU-95.
    2. "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1."
      Vega-Saenz de Miera E., Lau D.H.P., Zhadina M., Pountney D., Coetzee W.A., Rudy B.
      J. Neurophysiol. 86:130-142(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system."
      Karschin C., Wischmeyer E., Preisig-Mueller R., Rajan S., Derst C., Grzeschik K.-H., Daut J., Karschin A.
      Mol. Cell. Neurosci. 18:632-648(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM, VARIANTS GLU-95; THR-260; HIS-261 AND LEU-323, MUTAGENESIS OF ARG-138; 141-LEU--CYS-145; TRP-151 AND CYS-153.
      Tissue: Brain, Colon and Ovarian carcinoma.
    4. "TASK-5, a novel member of the tandem pore K+ channel family."
      Ashmole I., Goodwin P.A., Stanfield P.R.
      Pflugers Arch. 442:828-833(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-95; THR-260 AND LEU-323.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-95; THR-260 AND HIS-261.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNKF_HUMAN
    AccessioniPrimary (citable) accession number: Q9H427
    Secondary accession number(s): Q52LL3, Q9HBC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: November 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3