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Q9H427

- KCNKF_HUMAN

UniProt

Q9H427 - KCNKF_HUMAN

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Protein

Potassium channel subfamily K member 15

Gene

KCNK15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

  1. potassium channel activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of ion transmembrane transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

SignaLinkiQ9H427.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
TWIK-related acid-sensitive K(+) channel 5
Two pore potassium channel KT3.3
Short name:
Two pore K(+) channel KT3.3
Gene namesi
Name:KCNK15
Synonyms:TASK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13814. KCNK15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Intramembranei80 – 10122Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Intramembranei189 – 20921Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence AnalysisAdd
BLAST
Topological domaini244 – 33087CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi138 – 1381R → Y: No effect on lack of functional expression. 1 Publication
Mutagenesisi141 – 1455LAAKC → HRAKK: No effect on lack of functional expression. 1 Publication
Mutagenesisi151 – 1511W → R: No effect on lack of functional expression. 1 Publication
Mutagenesisi153 – 1531C → D: No effect on lack of functional expression. 1 Publication

Organism-specific databases

PharmGKBiPA30056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Potassium channel subfamily K member 15PRO_0000101765Add
BLAST

Proteomic databases

PaxDbiQ9H427.
PRIDEiQ9H427.

Expressioni

Tissue specificityi

Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.2 Publications

Gene expression databases

BgeeiQ9H427.
CleanExiHS_KCNK15.
GenevestigatoriQ9H427.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000361952.

Structurei

3D structure databases

ProteinModelPortaliQ9H427.
SMRiQ9H427. Positions 11-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259548.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9H427.
KOiK04923.
OrthoDBiEOG7B05DC.
PhylomeDBiQ9H427.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR008073. TASK5.
[Graphical view]
PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9H427-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR
60 70 80 90 100
KFGFSAEDYR ELERLALQAE PHRAGRQWKF PGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNAVVRRLL LAAKCCLGLR
160 170 180 190 200
WTCVSTENLV VAGLLACAAT LALGAVAFSH FEGWTFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN LVVLRFLVAS
260 270 280 290 300
ADWPERAARP PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA
310 320 330
RDNLGFSPPS SPGVVRGGQA PRPGARWKSI
Length:330
Mass (Da):36,130
Last modified:November 1, 2002 - v2
Checksum:iAA2A54D0615BC53C
GO

Polymorphismi

Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951G → E in TASK-5B. 4 Publications
Corresponds to variant rs1111032 [ dbSNP | Ensembl ].
VAR_014211
Natural varianti260 – 2601P → T in TASK-5B. 3 Publications
Corresponds to variant rs6073538 [ dbSNP | Ensembl ].
VAR_014212
Natural varianti261 – 2611P → H in TASK-5A. 2 Publications
Corresponds to variant rs13037900 [ dbSNP | Ensembl ].
VAR_014213
Natural varianti323 – 3231P → L in TASK-5B. 2 Publications
Corresponds to variant rs13042905 [ dbSNP | Ensembl ].
VAR_014214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257081 mRNA. Translation: AAG33127.1.
AF294350 mRNA. Translation: AAK97091.1.
AF294351 mRNA. Translation: AAK97092.1.
AF294352 Genomic DNA. Translation: AAK97093.1.
AF336342 mRNA. Translation: AAK37518.1.
AL118522 Genomic DNA. Translation: CAC14068.1.
BC093874 mRNA. Translation: AAH93874.1.
BC143282 mRNA. Translation: AAI43283.1.
CCDSiCCDS13337.1.
PIRiJC7703.
RefSeqiNP_071753.2. NM_022358.3.
UniGeneiHs.528664.

Genome annotation databases

EnsembliENST00000372861; ENSP00000361952; ENSG00000124249.
GeneIDi60598.
KEGGihsa:60598.
UCSCiuc002xmr.3. human.

Polymorphism databases

DMDMi24636282.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257081 mRNA. Translation: AAG33127.1 .
AF294350 mRNA. Translation: AAK97091.1 .
AF294351 mRNA. Translation: AAK97092.1 .
AF294352 Genomic DNA. Translation: AAK97093.1 .
AF336342 mRNA. Translation: AAK37518.1 .
AL118522 Genomic DNA. Translation: CAC14068.1 .
BC093874 mRNA. Translation: AAH93874.1 .
BC143282 mRNA. Translation: AAI43283.1 .
CCDSi CCDS13337.1.
PIRi JC7703.
RefSeqi NP_071753.2. NM_022358.3.
UniGenei Hs.528664.

3D structure databases

ProteinModelPortali Q9H427.
SMRi Q9H427. Positions 11-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000361952.

Chemistry

GuidetoPHARMACOLOGYi 524.

Polymorphism databases

DMDMi 24636282.

Proteomic databases

PaxDbi Q9H427.
PRIDEi Q9H427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372861 ; ENSP00000361952 ; ENSG00000124249 .
GeneIDi 60598.
KEGGi hsa:60598.
UCSCi uc002xmr.3. human.

Organism-specific databases

CTDi 60598.
GeneCardsi GC20P043374.
H-InvDB HIX0040517.
HGNCi HGNC:13814. KCNK15.
MIMi 607368. gene.
neXtProti NX_Q9H427.
PharmGKBi PA30056.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259548.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000231463.
HOVERGENi HBG052239.
InParanoidi Q9H427.
KOi K04923.
OrthoDBi EOG7B05DC.
PhylomeDBi Q9H427.
TreeFami TF313947.

Enzyme and pathway databases

SignaLinki Q9H427.

Miscellaneous databases

ChiTaRSi KCNK15. human.
GeneWikii KCNK15.
GenomeRNAii 60598.
NextBioi 65457.
PROi Q9H427.
SOURCEi Search...

Gene expression databases

Bgeei Q9H427.
CleanExi HS_KCNK15.
Genevestigatori Q9H427.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR008073. TASK5.
[Graphical view ]
PANTHERi PTHR11003:SF18. PTHR11003:SF18. 1 hit.
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TASK-5, a new member of the tandem-pore K(+) channel family."
    Kim D., Gnatenco C.
    Biochem. Biophys. Res. Commun. 284:923-930(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLU-95.
  2. "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1."
    Vega-Saenz de Miera E., Lau D.H.P., Zhadina M., Pountney D., Coetzee W.A., Rudy B.
    J. Neurophysiol. 86:130-142(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system."
    Karschin C., Wischmeyer E., Preisig-Mueller R., Rajan S., Derst C., Grzeschik K.-H., Daut J., Karschin A.
    Mol. Cell. Neurosci. 18:632-648(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM, VARIANTS GLU-95; THR-260; HIS-261 AND LEU-323, MUTAGENESIS OF ARG-138; 141-LEU--CYS-145; TRP-151 AND CYS-153.
    Tissue: Brain, Colon and Ovarian carcinoma.
  4. "TASK-5, a novel member of the tandem pore K+ channel family."
    Ashmole I., Goodwin P.A., Stanfield P.R.
    Pflugers Arch. 442:828-833(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-95; THR-260 AND LEU-323.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-95; THR-260 AND HIS-261.
    Tissue: Brain.

Entry informationi

Entry nameiKCNKF_HUMAN
AccessioniPrimary (citable) accession number: Q9H427
Secondary accession number(s): Q52LL3, Q9HBC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3