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Protein

Regulating synaptic membrane exocytosis protein 4

Gene

RIMS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101098-MONOMER.
SignaLinkiQ9H426.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 4
Alternative name(s):
RIM4 gamma
Rab3-interacting molecule 4
Short name:
RIM 4
Gene namesi
Name:RIMS4
Synonyms:C20orf190
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16183. RIMS4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • presynaptic active zone Source: ParkinsonsUK-UCL
  • synaptic membrane Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi140730.
OpenTargetsiENSG00000101098.
PharmGKBiPA25733.

Polymorphism and mutation databases

BioMutaiRIMS4.
DMDMi41017798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902071 – 269Regulating synaptic membrane exocytosis protein 4Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H426.
PeptideAtlasiQ9H426.
PRIDEiQ9H426.

PTM databases

iPTMnetiQ9H426.
PhosphoSitePlusiQ9H426.

Expressioni

Gene expression databases

BgeeiENSG00000101098.
CleanExiHS_RIMS4.
GenevisibleiQ9H426. HS.

Organism-specific databases

HPAiHPA060928.

Interactioni

Subunit structurei

Binds PPFIA3 (By similarity). Does not bind RAB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126676. 4 interactors.
IntActiQ9H426. 1 interactor.
STRINGi9606.ENSP00000439287.

Structurei

3D structure databases

ProteinModelPortaliQ9H426.
SMRiQ9H426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 217C2PROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISKP. Eukaryota.
ENOG410YDA1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiQ9H426.
KOiK15299.
OMAiSTVGPCC.
OrthoDBiEOG091G0IYY.
PhylomeDBiQ9H426.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H426-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAGDSRRLKG AIQRSTETGL
60 70 80 90 100
AVEMPSRTLR QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM
110 120 130 140 150
GPAQFVGRQT LATTPMGDVE IGLQERNGQL EVDIIQARGL TAKPGSKTLP
160 170 180 190 200
AAYIKAYLLE NGICIAKKKT KVARKSLDPL YNQVLLFPES PQGKVLQVIV
210 220 230 240 250
WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS MVDPATGPLL
260
RQASQLSLES TVGPCGERS
Length:269
Mass (Da):29,329
Last modified:January 16, 2004 - v3
Checksum:iA0199FD06A3986FA
GO
Isoform 2 (identifier: Q9H426-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-32: A → AE

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):29,459
Checksum:i16789FF9BFB12D42
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04488132A → AE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326954 mRNA. Translation: AAQ01681.1.
AL118522 Genomic DNA. Translation: CAI22760.1.
CH471077 Genomic DNA. Translation: EAW75897.1.
CH471077 Genomic DNA. Translation: EAW75898.1.
BC104190 mRNA. Translation: AAI04191.1.
BC112985 mRNA. Translation: AAI12986.1.
CCDSiCCDS13338.1. [Q9H426-1]
CCDS56191.1. [Q9H426-2]
RefSeqiNP_001192246.1. NM_001205317.1. [Q9H426-2]
NP_892015.1. NM_182970.3. [Q9H426-1]
UniGeneiHs.517065.

Genome annotation databases

EnsembliENST00000372851; ENSP00000361942; ENSG00000101098. [Q9H426-1]
ENST00000541604; ENSP00000439287; ENSG00000101098. [Q9H426-2]
GeneIDi140730.
KEGGihsa:140730.
UCSCiuc002xms.4. human. [Q9H426-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326954 mRNA. Translation: AAQ01681.1.
AL118522 Genomic DNA. Translation: CAI22760.1.
CH471077 Genomic DNA. Translation: EAW75897.1.
CH471077 Genomic DNA. Translation: EAW75898.1.
BC104190 mRNA. Translation: AAI04191.1.
BC112985 mRNA. Translation: AAI12986.1.
CCDSiCCDS13338.1. [Q9H426-1]
CCDS56191.1. [Q9H426-2]
RefSeqiNP_001192246.1. NM_001205317.1. [Q9H426-2]
NP_892015.1. NM_182970.3. [Q9H426-1]
UniGeneiHs.517065.

3D structure databases

ProteinModelPortaliQ9H426.
SMRiQ9H426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126676. 4 interactors.
IntActiQ9H426. 1 interactor.
STRINGi9606.ENSP00000439287.

PTM databases

iPTMnetiQ9H426.
PhosphoSitePlusiQ9H426.

Polymorphism and mutation databases

BioMutaiRIMS4.
DMDMi41017798.

Proteomic databases

PaxDbiQ9H426.
PeptideAtlasiQ9H426.
PRIDEiQ9H426.

Protocols and materials databases

DNASUi140730.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372851; ENSP00000361942; ENSG00000101098. [Q9H426-1]
ENST00000541604; ENSP00000439287; ENSG00000101098. [Q9H426-2]
GeneIDi140730.
KEGGihsa:140730.
UCSCiuc002xms.4. human. [Q9H426-1]

Organism-specific databases

CTDi140730.
DisGeNETi140730.
GeneCardsiRIMS4.
HGNCiHGNC:16183. RIMS4.
HPAiHPA060928.
MIMi611601. gene.
neXtProtiNX_Q9H426.
OpenTargetsiENSG00000101098.
PharmGKBiPA25733.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISKP. Eukaryota.
ENOG410YDA1. LUCA.
GeneTreeiENSGT00550000074588.
HOGENOMiHOG000231017.
HOVERGENiHBG056381.
InParanoidiQ9H426.
KOiK15299.
OMAiSTVGPCC.
OrthoDBiEOG091G0IYY.
PhylomeDBiQ9H426.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101098-MONOMER.
SignaLinkiQ9H426.

Miscellaneous databases

GenomeRNAii140730.
PROiQ9H426.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101098.
CleanExiHS_RIMS4.
GenevisibleiQ9H426. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIMS4_HUMAN
AccessioniPrimary (citable) accession number: Q9H426
Secondary accession number(s): A4FU94
, E1P613, Q3MI44, Q5JWT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.