ID CA198_HUMAN Reviewed; 327 AA. AC Q9H425; A8K8R8; B3KTW1; G5EA08; DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 141. DE RecName: Full=Uncharacterized protein C1orf198; GN Name=C1orf198; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Mesangial cell, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PROTEIN SEQUENCE OF 2-12, AND ACETYLATION AT ALA-2. RX PubMed=12665801; DOI=10.1038/nbt810; RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., RA Vandekerckhove J.; RT "Exploring proteomes and analyzing protein processing by mass spectrometric RT identification of sorted N-terminal peptides."; RL Nat. Biotechnol. 21:566-569(2003). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18220336; DOI=10.1021/pr0705441; RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III; RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient RT phosphoproteomic analysis."; RL J. Proteome Res. 7:1346-1351(2008). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [8] RP SUBCELLULAR LOCATION. RX PubMed=22361696; DOI=10.1016/j.jprot.2012.01.030; RA Stadler C., Hjelmare M., Neumann B., Jonasson K., Pepperkok R., Uhlen M., RA Lundberg E.; RT "Systematic validation of antibody binding and protein subcellular RT localization using siRNA and confocal microscopy."; RL J. Proteomics 75:2236-2251(2012). RN [9] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-175, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-289, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22361696}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9H425-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H425-2; Sequence=VSP_044252; CC Name=3; CC IsoId=Q9H425-3; Sequence=VSP_046926; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK027431; BAB55105.1; -; mRNA. DR EMBL; AK096166; BAG53223.1; -; mRNA. DR EMBL; AK292433; BAF85122.1; -; mRNA. DR EMBL; AL118511; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471098; EAW69926.1; -; Genomic_DNA. DR EMBL; BC066649; AAH66649.1; -; mRNA. DR CCDS; CCDS1587.1; -. [Q9H425-1] DR CCDS; CCDS44330.1; -. [Q9H425-3] DR CCDS; CCDS44331.1; -. [Q9H425-2] DR RefSeq; NP_001129966.1; NM_001136494.1. [Q9H425-3] DR RefSeq; NP_001129967.1; NM_001136495.1. [Q9H425-2] DR RefSeq; NP_116189.1; NM_032800.2. [Q9H425-1] DR RefSeq; XP_016858088.1; XM_017002599.1. [Q9H425-2] DR AlphaFoldDB; Q9H425; -. DR BioGRID; 124327; 89. DR IntAct; Q9H425; 25. DR MINT; Q9H425; -. DR STRING; 9606.ENSP00000355623; -. DR GlyCosmos; Q9H425; 1 site, 1 glycan. DR GlyGen; Q9H425; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q9H425; -. DR PhosphoSitePlus; Q9H425; -. DR BioMuta; C1orf198; -. DR DMDM; 74752632; -. DR EPD; Q9H425; -. DR jPOST; Q9H425; -. DR MassIVE; Q9H425; -. DR MaxQB; Q9H425; -. DR PaxDb; 9606-ENSP00000355623; -. DR PeptideAtlas; Q9H425; -. DR ProteomicsDB; 1887; -. DR ProteomicsDB; 34104; -. DR ProteomicsDB; 80782; -. [Q9H425-1] DR Pumba; Q9H425; -. DR Antibodypedia; 1577; 70 antibodies from 15 providers. DR DNASU; 84886; -. DR Ensembl; ENST00000366663.10; ENSP00000355623.5; ENSG00000119280.17. [Q9H425-1] DR Ensembl; ENST00000470540.5; ENSP00000428172.1; ENSG00000119280.17. [Q9H425-3] DR Ensembl; ENST00000523410.1; ENSP00000430967.1; ENSG00000119280.17. [Q9H425-2] DR GeneID; 84886; -. DR KEGG; hsa:84886; -. DR MANE-Select; ENST00000366663.10; ENSP00000355623.5; NM_032800.3; NP_116189.1. DR UCSC; uc001hub.4; human. [Q9H425-1] DR AGR; HGNC:25900; -. DR CTD; 84886; -. DR DisGeNET; 84886; -. DR GeneCards; C1orf198; -. DR HGNC; HGNC:25900; C1orf198. DR HPA; ENSG00000119280; Tissue enhanced (brain). DR neXtProt; NX_Q9H425; -. DR OpenTargets; ENSG00000119280; -. DR PharmGKB; PA143485319; -. DR VEuPathDB; HostDB:ENSG00000119280; -. DR eggNOG; ENOG502R926; Eukaryota. DR GeneTree; ENSGT00390000018361; -. DR HOGENOM; CLU_069832_0_0_1; -. DR InParanoid; Q9H425; -. DR OMA; TKSQMDF; -. DR OrthoDB; 2918041at2759; -. DR PhylomeDB; Q9H425; -. DR TreeFam; TF334642; -. DR PathwayCommons; Q9H425; -. DR SignaLink; Q9H425; -. DR BioGRID-ORCS; 84886; 18 hits in 1159 CRISPR screens. DR ChiTaRS; C1orf198; human. DR GenomeRNAi; 84886; -. DR Pharos; Q9H425; Tdark. DR PRO; PR:Q9H425; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9H425; Protein. DR Bgee; ENSG00000119280; Expressed in cardiac muscle of right atrium and 187 other cell types or tissues. DR ExpressionAtlas; Q9H425; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR InterPro; IPR031600; DUF4706. DR PANTHER; PTHR34394; SIMILAR TO RIKEN CDNA 2310022B05; 1. DR PANTHER; PTHR34394:SF1; SIMILAR TO RIKEN CDNA 2310022B05; 1. DR Pfam; PF15797; DUF4706; 1. DR Genevisible; Q9H425; HS. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Cytoplasm; Direct protein sequencing; KW Phosphoprotein; Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:12665801, FT ECO:0007744|PubMed:22814378" FT CHAIN 2..327 FT /note="Uncharacterized protein C1orf198" FT /id="PRO_0000280342" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 76..113 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 134..299 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 134..178 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 179..203 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 232..248 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 2 FT /note="N-acetylalanine" FT /evidence="ECO:0000269|PubMed:12665801, FT ECO:0007744|PubMed:22814378" FT MOD_RES 37 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:23186163" FT MOD_RES 129 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8C3W1" FT MOD_RES 175 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 289 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT VAR_SEQ 1..130 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044252" FT VAR_SEQ 1..38 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046926" FT VARIANT 274 FT /note="A -> S (in dbSNP:rs34864456)" FT /id="VAR_050707" FT VARIANT 306 FT /note="K -> R (in dbSNP:rs35115679)" FT /id="VAR_050708" FT CONFLICT 163 FT /note="Q -> L (in Ref. 1; BAG53223)" FT /evidence="ECO:0000305" SQ SEQUENCE 327 AA; 36346 MW; 769AFAB47FE287C4 CRC64; MASMAAAIAA SRSAVMSGNR PLDDRERKRF TYFSSLSPMA RKIMQDKEKI REKYGPEWAR LPPAQQDEII DRCLVGPRAP APRDPGDSEE LTRFPGLRGP TGQKVVRFGD EDLTWQDEHS APFSWETKSQ MEFSISALSI QEPSNGTAAS EPRPLSKASQ GSQALKSSQG SRSSSLDALG PTRKEEEASF WKINAERSRG EGPEAEFQSL TPSQIKSMEK GEKVLPPCYR QEPAPKDREA KVERPSTLRQ EQRPLPNVST ERERPQPVQA FSSALHEAAP SQLEGKLPSP DVRQDDGEDT LFSEPKFAQV SSSNVVLKTG FDFLDNW //