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Q9H422

- HIPK3_HUMAN

UniProt

Q9H422 - HIPK3_HUMAN

Protein

Homeodomain-interacting protein kinase 3

Gene

HIPK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi203 – 2119ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. mRNA transcription Source: UniProtKB
    3. negative regulation of apoptotic process Source: UniProtKB
    4. negative regulation of JUN kinase activity Source: UniProtKB
    5. peptidyl-serine phosphorylation Source: UniProtKB
    6. peptidyl-threonine phosphorylation Source: UniProtKB
    7. protein phosphorylation Source: UniProtKB
    8. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9H422.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeodomain-interacting protein kinase 3 (EC:2.7.11.1)
    Alternative name(s):
    Androgen receptor-interacting nuclear protein kinase
    Short name:
    ANPK
    Fas-interacting serine/threonine-protein kinase
    Short name:
    FIST
    Homolog of protein kinase YAK1
    Gene namesi
    Name:HIPK3
    Synonyms:DYRK6, FIST3, PKY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:4915. HIPK3.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. PML body Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi226 – 2261K → R: Loss of kinase activity and impaired activation of SF1. 1 Publication

    Organism-specific databases

    PharmGKBiPA29292.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12151215Homeodomain-interacting protein kinase 3PRO_0000085998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei359 – 3591PhosphotyrosineBy similarity
    Cross-linki1208 – 1208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Autophosphorylated, but autophosphorylation is not required for catalytic activity.By similarity
    May be sumoylated.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9H422.
    PRIDEiQ9H422.

    PTM databases

    PhosphoSiteiQ9H422.

    Expressioni

    Tissue specificityi

    Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.3 Publications

    Gene expression databases

    ArrayExpressiQ9H422.
    BgeeiQ9H422.
    CleanExiHS_HIPK3.
    GenevestigatoriQ9H422.

    Organism-specific databases

    HPAiHPA028069.

    Interactioni

    Subunit structurei

    Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) By similarity. Interacts with UBL1/SUMO-1. Binds to NR5A1/SF1, SPEN/MINT and RUNX2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi115420. 32 interactions.
    IntActiQ9H422. 22 interactions.
    MINTiMINT-1183373.
    STRINGi9606.ENSP00000304226.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H422.
    SMRiQ9H422. Positions 189-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini197 – 525329Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni767 – 944178Interaction with ARBy similarityAdd
    BLAST
    Regioni796 – 89196Interaction with FASBy similarityAdd
    BLAST
    Regioni855 – 1011157Required for localization to nuclear specklesBy similarityAdd
    BLAST
    Regioni866 – 91853SUMO interaction motifs (SIM); required for nuclear localization and kinase activityBy similarityAdd
    BLAST
    Regioni870 – 88011Interaction with UBL1CuratedAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi910 – 96253Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231785.
    HOVERGENiHBG051908.
    InParanoidiQ9H422.
    KOiK08826.
    OMAiPAMLQTN.
    OrthoDBiEOG7034GK.
    PhylomeDBiQ9H422.
    TreeFamiTF105417.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H422-1) [UniParc]FASTAAdd to Basket

    Also known as: HIPK3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCVFQERNY PRTYVNGRNF     50
    GNSHPPTKGS AFQTKIPFNR PRGHNFSLQT SAVVLKNTAG ATKVIAAQAQ 100
    QAHVQAPQIG AWRNRLHFLE GPQRCGLKRK SEELDNHSSA MQIVDELSIL 150
    PAMLQTNMGN PVTVVTATTG SKQNCTTGEG DYQLVQHEVL CSMKNTYEVL 200
    DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI EVSILARLST 250
    ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR 300
    PILQQVATAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH 350
    VSKTVCSTYL QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP 400
    GALEYDQIRY ISQTQGLPGE QLLNVGTKST RFFCKETDMS HSGWRLKTLE 450
    EHEAETGMKS KEARKYIFNS LDDVAHVNTV MDLEGSDLLA EKADRREFVS 500
    LLKKMLLIDA DLRITPAETL NHPFVNMKHL LDFPHSNHVK SCFHIMDICK 550
    SHLNSCDTNN HNKTSLLRPV ASSSTATLTA NFTKIGTLRS QALTTSAHSV 600
    VHHGIPLQAG TAQFGCGDAF QQTLIICPPA IQGIPATHGK PTSYSIRVDN 650
    TVPLVTQAPA VQPLQIRPGV LSQTWSGRTQ QMLVPAWQQV TPLAPATTTL 700
    TSESVAGSHR LGDWGKMISC SNHYNSVMPQ PLLTNQITLS APQPVSVGIA 750
    HVVWPQPATT KKNKQCQNRG ILVKLMEWEP GREEINAFSW SNSLQNTNIP 800
    HSAFISPKII NGKDVEEVSC IETQDNQNSE GEARNCCETS IRQDSDSSVS 850
    DKQRQTIIIA DSPSPAVSVI TISSDTDEEE TSQRHSLREC KGSLDCEACQ 900
    STLNIDRMCS LSSPDSTLST SSSGQSSPSP CKRPNSMSDE EQESSCDTVD 950
    GSPTSDSSGH DSPFAESTFV EDTHENTELV SSADTETKPA VCSVVVPPVE 1000
    LENGLNADEH MANTDSICQP LIKGRSAPGR LNQPSAVGTR QQKLTSAFQQ 1050
    QHLNFSQVQH FGSGHQEWNG NFGHRRQQAY IPTSVTSNPF TLSHGSPNHT 1100
    AVHAHLAGNT HLGGQPTLLP YPSSATLSSA APVAHLLASP CTSRPMLQHP 1150
    TYNISHPSGI VHQVPVGLNP RLLPSPTIHQ TQYKPIFPPH SYIAASPAYT 1200
    GFPLSPTKLS QYPYM 1215
    Length:1,215
    Mass (Da):133,743
    Last modified:March 1, 2001 - v1
    Checksum:iE952D04786955721
    GO
    Isoform 2 (identifier: Q9H422-2) [UniParc]FASTAAdd to Basket

    Also known as: FIST

    The sequence of this isoform differs from the canonical sequence as follows:
         770-790: Missing.

    Show »
    Length:1,194
    Mass (Da):131,256
    Checksum:i9F7C34FB1110F10B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691N → K in AAG25990. (PubMed:11034606)Curated
    Sequence conflicti111 – 1111A → V in AAC64294. (PubMed:9373137)Curated
    Sequence conflicti1148 – 11481Q → K in AAG25990. (PubMed:11034606)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti142 – 1421Q → R.1 Publication
    Corresponds to variant rs34193811 [ dbSNP | Ensembl ].
    VAR_040549
    Natural varianti170 – 1701G → E.1 Publication
    Corresponds to variant rs34698015 [ dbSNP | Ensembl ].
    VAR_040550
    Natural varianti191 – 1911C → R.1 Publication
    Corresponds to variant rs35689361 [ dbSNP | Ensembl ].
    VAR_040551
    Natural varianti474 – 4741V → I.
    Corresponds to variant rs266472 [ dbSNP | Ensembl ].
    VAR_051627
    Natural varianti500 – 5001S → N.1 Publication
    Corresponds to variant rs11032229 [ dbSNP | Ensembl ].
    VAR_040552
    Natural varianti729 – 7291P → L.1 Publication
    Corresponds to variant rs55807239 [ dbSNP | Ensembl ].
    VAR_040553

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei770 – 79021Missing in isoform 2. 1 PublicationVSP_013140Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004849 mRNA. Translation: AAC64294.1.
    AF305239 mRNA. Translation: AAG25990.1.
    AL122015 Genomic DNA. Translation: CAC13164.1.
    AL122015 Genomic DNA. Translation: CAJ55828.1.
    Y09306 mRNA. Translation: CAA70489.1. Different termination.
    CCDSiCCDS41634.1. [Q9H422-2]
    CCDS7884.1. [Q9H422-1]
    RefSeqiNP_001041665.1. NM_001048200.2. [Q9H422-2]
    NP_001265092.1. NM_001278163.1. [Q9H422-2]
    NP_005725.3. NM_005734.4. [Q9H422-1]
    XP_005252786.1. XM_005252729.2. [Q9H422-1]
    XP_006718183.1. XM_006718120.1. [Q9H422-1]
    UniGeneiHs.201918.
    Hs.709696.

    Genome annotation databases

    EnsembliENST00000303296; ENSP00000304226; ENSG00000110422. [Q9H422-1]
    ENST00000379016; ENSP00000368301; ENSG00000110422. [Q9H422-2]
    ENST00000456517; ENSP00000398241; ENSG00000110422. [Q9H422-2]
    ENST00000525975; ENSP00000431710; ENSG00000110422. [Q9H422-2]
    GeneIDi10114.
    KEGGihsa:10114.
    UCSCiuc001mul.2. human. [Q9H422-1]
    uc001mum.2. human. [Q9H422-2]

    Polymorphism databases

    DMDMi61213741.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004849 mRNA. Translation: AAC64294.1 .
    AF305239 mRNA. Translation: AAG25990.1 .
    AL122015 Genomic DNA. Translation: CAC13164.1 .
    AL122015 Genomic DNA. Translation: CAJ55828.1 .
    Y09306 mRNA. Translation: CAA70489.1 . Different termination.
    CCDSi CCDS41634.1. [Q9H422-2 ]
    CCDS7884.1. [Q9H422-1 ]
    RefSeqi NP_001041665.1. NM_001048200.2. [Q9H422-2 ]
    NP_001265092.1. NM_001278163.1. [Q9H422-2 ]
    NP_005725.3. NM_005734.4. [Q9H422-1 ]
    XP_005252786.1. XM_005252729.2. [Q9H422-1 ]
    XP_006718183.1. XM_006718120.1. [Q9H422-1 ]
    UniGenei Hs.201918.
    Hs.709696.

    3D structure databases

    ProteinModelPortali Q9H422.
    SMRi Q9H422. Positions 189-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115420. 32 interactions.
    IntActi Q9H422. 22 interactions.
    MINTi MINT-1183373.
    STRINGi 9606.ENSP00000304226.

    Chemistry

    BindingDBi Q9H422.
    ChEMBLi CHEMBL4577.
    GuidetoPHARMACOLOGYi 2035.

    PTM databases

    PhosphoSitei Q9H422.

    Polymorphism databases

    DMDMi 61213741.

    Proteomic databases

    PaxDbi Q9H422.
    PRIDEi Q9H422.

    Protocols and materials databases

    DNASUi 10114.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303296 ; ENSP00000304226 ; ENSG00000110422 . [Q9H422-1 ]
    ENST00000379016 ; ENSP00000368301 ; ENSG00000110422 . [Q9H422-2 ]
    ENST00000456517 ; ENSP00000398241 ; ENSG00000110422 . [Q9H422-2 ]
    ENST00000525975 ; ENSP00000431710 ; ENSG00000110422 . [Q9H422-2 ]
    GeneIDi 10114.
    KEGGi hsa:10114.
    UCSCi uc001mul.2. human. [Q9H422-1 ]
    uc001mum.2. human. [Q9H422-2 ]

    Organism-specific databases

    CTDi 10114.
    GeneCardsi GC11P033235.
    HGNCi HGNC:4915. HIPK3.
    HPAi HPA028069.
    MIMi 604424. gene.
    neXtProti NX_Q9H422.
    PharmGKBi PA29292.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231785.
    HOVERGENi HBG051908.
    InParanoidi Q9H422.
    KOi K08826.
    OMAi PAMLQTN.
    OrthoDBi EOG7034GK.
    PhylomeDBi Q9H422.
    TreeFami TF105417.

    Enzyme and pathway databases

    SignaLinki Q9H422.

    Miscellaneous databases

    ChiTaRSi HIPK3. human.
    GeneWikii HIPK3.
    GenomeRNAii 10114.
    NextBioi 38263.
    PROi Q9H422.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H422.
    Bgeei Q9H422.
    CleanExi HS_HIPK3.
    Genevestigatori Q9H422.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1."
      Begley D.A., Berkenpas M.B., Sampson K.E., Abraham I.
      Gene 200:35-43(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation."
      Rochat-Steiner V., Becker K., Micheau O., Schneider P., Burns K., Tschopp J.
      J. Exp. Med. 192:1165-1174(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Becker W., Joost H.G.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-295 (ISOFORMS 1/2).
    5. "Activation of androgen receptor function by a novel nuclear protein kinase."
      Moilanen A.-M., Karvonen U., Poukka H., Jaenne O.A., Palvimo J.J.
      Mol. Biol. Cell 9:2527-2543(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif."
      Minty A., Dumont X., Kaghad M., Caput D.
      J. Biol. Chem. 275:36316-36323(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBL1.
    7. "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells."
      Curtin J.F., Cotter T.G.
      J. Biol. Chem. 279:17090-17100(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
      Lan H.-C., Li H.-J., Lin G., Lai P.-Y., Chung B.-C.
      Mol. Cell. Biol. 27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS KINASE AND IN CAMP SIGNALING PATHWAY, INTERACTION WITH NR5A1/SF1, MUTAGENESIS OF LYS-226.
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-142; GLU-170; ARG-191; ASN-500 AND LEU-729.

    Entry informationi

    Entry nameiHIPK3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H422
    Secondary accession number(s): O14632
    , Q2PBG4, Q2PBG5, Q92632, Q9HAS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3