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Protein

Homeodomain-interacting protein kinase 3

Gene

HIPK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261ATPPROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi203 – 2119ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mRNA transcription Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of JUN kinase activity Source: UniProtKB
  • peptidyl-serine phosphorylation Source: UniProtKB
  • peptidyl-threonine phosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9H422.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 3 (EC:2.7.11.1)
Alternative name(s):
Androgen receptor-interacting nuclear protein kinase
Short name:
ANPK
Fas-interacting serine/threonine-protein kinase
Short name:
FIST
Homolog of protein kinase YAK1
Gene namesi
Name:HIPK3
Synonyms:DYRK6, FIST3, PKY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4915. HIPK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi226 – 2261K → R: Loss of kinase activity and impaired activation of SF1. 1 Publication

Organism-specific databases

PharmGKBiPA29292.

Polymorphism and mutation databases

DMDMi61213741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12151215Homeodomain-interacting protein kinase 3PRO_0000085998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei359 – 3591PhosphotyrosineBy similarity
Cross-linki1208 – 1208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Autophosphorylated, but autophosphorylation is not required for catalytic activity.By similarity
May be sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9H422.
PaxDbiQ9H422.
PRIDEiQ9H422.

PTM databases

PhosphoSiteiQ9H422.

Expressioni

Tissue specificityi

Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.3 Publications

Gene expression databases

BgeeiQ9H422.
CleanExiHS_HIPK3.
ExpressionAtlasiQ9H422. baseline and differential.
GenevisibleiQ9H422. HS.

Organism-specific databases

HPAiHPA028069.

Interactioni

Subunit structurei

Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1. Binds to NR5A1/SF1, SPEN/MINT and RUNX2.By similarity2 Publications

Protein-protein interaction databases

BioGridi115420. 31 interactions.
IntActiQ9H422. 22 interactions.
MINTiMINT-1183373.
STRINGi9606.ENSP00000304226.

Structurei

3D structure databases

ProteinModelPortaliQ9H422.
SMRiQ9H422. Positions 189-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 525329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni767 – 944178Interaction with ARBy similarityAdd
BLAST
Regioni796 – 89196Interaction with FASBy similarityAdd
BLAST
Regioni855 – 1011157Required for localization to nuclear specklesBy similarityAdd
BLAST
Regioni866 – 91853SUMO interaction motifs (SIM); required for nuclear localization and kinase activityBy similarityAdd
BLAST
Regioni870 – 88011Interaction with UBL1CuratedAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi910 – 96253Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000231785.
HOVERGENiHBG051908.
InParanoidiQ9H422.
KOiK08826.
OMAiPAMLQTN.
OrthoDBiEOG7034GK.
PhylomeDBiQ9H422.
TreeFamiTF105417.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H422-1) [UniParc]FASTAAdd to basket

Also known as: HIPK3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCVFQERNY PRTYVNGRNF
60 70 80 90 100
GNSHPPTKGS AFQTKIPFNR PRGHNFSLQT SAVVLKNTAG ATKVIAAQAQ
110 120 130 140 150
QAHVQAPQIG AWRNRLHFLE GPQRCGLKRK SEELDNHSSA MQIVDELSIL
160 170 180 190 200
PAMLQTNMGN PVTVVTATTG SKQNCTTGEG DYQLVQHEVL CSMKNTYEVL
210 220 230 240 250
DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI EVSILARLST
260 270 280 290 300
ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR
310 320 330 340 350
PILQQVATAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH
360 370 380 390 400
VSKTVCSTYL QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP
410 420 430 440 450
GALEYDQIRY ISQTQGLPGE QLLNVGTKST RFFCKETDMS HSGWRLKTLE
460 470 480 490 500
EHEAETGMKS KEARKYIFNS LDDVAHVNTV MDLEGSDLLA EKADRREFVS
510 520 530 540 550
LLKKMLLIDA DLRITPAETL NHPFVNMKHL LDFPHSNHVK SCFHIMDICK
560 570 580 590 600
SHLNSCDTNN HNKTSLLRPV ASSSTATLTA NFTKIGTLRS QALTTSAHSV
610 620 630 640 650
VHHGIPLQAG TAQFGCGDAF QQTLIICPPA IQGIPATHGK PTSYSIRVDN
660 670 680 690 700
TVPLVTQAPA VQPLQIRPGV LSQTWSGRTQ QMLVPAWQQV TPLAPATTTL
710 720 730 740 750
TSESVAGSHR LGDWGKMISC SNHYNSVMPQ PLLTNQITLS APQPVSVGIA
760 770 780 790 800
HVVWPQPATT KKNKQCQNRG ILVKLMEWEP GREEINAFSW SNSLQNTNIP
810 820 830 840 850
HSAFISPKII NGKDVEEVSC IETQDNQNSE GEARNCCETS IRQDSDSSVS
860 870 880 890 900
DKQRQTIIIA DSPSPAVSVI TISSDTDEEE TSQRHSLREC KGSLDCEACQ
910 920 930 940 950
STLNIDRMCS LSSPDSTLST SSSGQSSPSP CKRPNSMSDE EQESSCDTVD
960 970 980 990 1000
GSPTSDSSGH DSPFAESTFV EDTHENTELV SSADTETKPA VCSVVVPPVE
1010 1020 1030 1040 1050
LENGLNADEH MANTDSICQP LIKGRSAPGR LNQPSAVGTR QQKLTSAFQQ
1060 1070 1080 1090 1100
QHLNFSQVQH FGSGHQEWNG NFGHRRQQAY IPTSVTSNPF TLSHGSPNHT
1110 1120 1130 1140 1150
AVHAHLAGNT HLGGQPTLLP YPSSATLSSA APVAHLLASP CTSRPMLQHP
1160 1170 1180 1190 1200
TYNISHPSGI VHQVPVGLNP RLLPSPTIHQ TQYKPIFPPH SYIAASPAYT
1210
GFPLSPTKLS QYPYM
Length:1,215
Mass (Da):133,743
Last modified:March 1, 2001 - v1
Checksum:iE952D04786955721
GO
Isoform 2 (identifier: Q9H422-2) [UniParc]FASTAAdd to basket

Also known as: FIST

The sequence of this isoform differs from the canonical sequence as follows:
     770-790: Missing.

Show »
Length:1,194
Mass (Da):131,256
Checksum:i9F7C34FB1110F10B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691N → K in AAG25990 (PubMed:11034606).Curated
Sequence conflicti111 – 1111A → V in AAC64294 (PubMed:9373137).Curated
Sequence conflicti1148 – 11481Q → K in AAG25990 (PubMed:11034606).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421Q → R.1 Publication
Corresponds to variant rs34193811 [ dbSNP | Ensembl ].
VAR_040549
Natural varianti170 – 1701G → E.1 Publication
Corresponds to variant rs34698015 [ dbSNP | Ensembl ].
VAR_040550
Natural varianti191 – 1911C → R.1 Publication
Corresponds to variant rs35689361 [ dbSNP | Ensembl ].
VAR_040551
Natural varianti474 – 4741V → I.
Corresponds to variant rs266472 [ dbSNP | Ensembl ].
VAR_051627
Natural varianti500 – 5001S → N.1 Publication
Corresponds to variant rs11032229 [ dbSNP | Ensembl ].
VAR_040552
Natural varianti729 – 7291P → L.1 Publication
Corresponds to variant rs55807239 [ dbSNP | Ensembl ].
VAR_040553

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei770 – 79021Missing in isoform 2. 1 PublicationVSP_013140Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004849 mRNA. Translation: AAC64294.1.
AF305239 mRNA. Translation: AAG25990.1.
AL122015 Genomic DNA. Translation: CAC13164.1.
AL122015 Genomic DNA. Translation: CAJ55828.1.
Y09306 mRNA. Translation: CAA70489.1. Different termination.
CCDSiCCDS41634.1. [Q9H422-2]
CCDS7884.1. [Q9H422-1]
RefSeqiNP_001041665.1. NM_001048200.2. [Q9H422-2]
NP_001265092.1. NM_001278163.1. [Q9H422-2]
NP_005725.3. NM_005734.4. [Q9H422-1]
XP_005252786.1. XM_005252729.2. [Q9H422-1]
XP_011518137.1. XM_011519835.1. [Q9H422-1]
UniGeneiHs.201918.
Hs.709696.

Genome annotation databases

EnsembliENST00000303296; ENSP00000304226; ENSG00000110422.
ENST00000379016; ENSP00000368301; ENSG00000110422. [Q9H422-2]
ENST00000456517; ENSP00000398241; ENSG00000110422. [Q9H422-2]
ENST00000525975; ENSP00000431710; ENSG00000110422. [Q9H422-2]
GeneIDi10114.
KEGGihsa:10114.
UCSCiuc001mul.2. human. [Q9H422-1]
uc001mum.2. human. [Q9H422-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004849 mRNA. Translation: AAC64294.1.
AF305239 mRNA. Translation: AAG25990.1.
AL122015 Genomic DNA. Translation: CAC13164.1.
AL122015 Genomic DNA. Translation: CAJ55828.1.
Y09306 mRNA. Translation: CAA70489.1. Different termination.
CCDSiCCDS41634.1. [Q9H422-2]
CCDS7884.1. [Q9H422-1]
RefSeqiNP_001041665.1. NM_001048200.2. [Q9H422-2]
NP_001265092.1. NM_001278163.1. [Q9H422-2]
NP_005725.3. NM_005734.4. [Q9H422-1]
XP_005252786.1. XM_005252729.2. [Q9H422-1]
XP_011518137.1. XM_011519835.1. [Q9H422-1]
UniGeneiHs.201918.
Hs.709696.

3D structure databases

ProteinModelPortaliQ9H422.
SMRiQ9H422. Positions 189-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115420. 31 interactions.
IntActiQ9H422. 22 interactions.
MINTiMINT-1183373.
STRINGi9606.ENSP00000304226.

Chemistry

BindingDBiQ9H422.
ChEMBLiCHEMBL4577.
GuidetoPHARMACOLOGYi2035.

PTM databases

PhosphoSiteiQ9H422.

Polymorphism and mutation databases

DMDMi61213741.

Proteomic databases

MaxQBiQ9H422.
PaxDbiQ9H422.
PRIDEiQ9H422.

Protocols and materials databases

DNASUi10114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303296; ENSP00000304226; ENSG00000110422.
ENST00000379016; ENSP00000368301; ENSG00000110422. [Q9H422-2]
ENST00000456517; ENSP00000398241; ENSG00000110422. [Q9H422-2]
ENST00000525975; ENSP00000431710; ENSG00000110422. [Q9H422-2]
GeneIDi10114.
KEGGihsa:10114.
UCSCiuc001mul.2. human. [Q9H422-1]
uc001mum.2. human. [Q9H422-2]

Organism-specific databases

CTDi10114.
GeneCardsiGC11P033278.
HGNCiHGNC:4915. HIPK3.
HPAiHPA028069.
MIMi604424. gene.
neXtProtiNX_Q9H422.
PharmGKBiPA29292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000231785.
HOVERGENiHBG051908.
InParanoidiQ9H422.
KOiK08826.
OMAiPAMLQTN.
OrthoDBiEOG7034GK.
PhylomeDBiQ9H422.
TreeFamiTF105417.

Enzyme and pathway databases

SignaLinkiQ9H422.

Miscellaneous databases

ChiTaRSiHIPK3. human.
GeneWikiiHIPK3.
GenomeRNAii10114.
NextBioi38263.
PROiQ9H422.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H422.
CleanExiHS_HIPK3.
ExpressionAtlasiQ9H422. baseline and differential.
GenevisibleiQ9H422. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1."
    Begley D.A., Berkenpas M.B., Sampson K.E., Abraham I.
    Gene 200:35-43(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation."
    Rochat-Steiner V., Becker K., Micheau O., Schneider P., Burns K., Tschopp J.
    J. Exp. Med. 192:1165-1174(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Becker W., Joost H.G.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-295 (ISOFORMS 1/2).
  5. "Activation of androgen receptor function by a novel nuclear protein kinase."
    Moilanen A.-M., Karvonen U., Poukka H., Jaenne O.A., Palvimo J.J.
    Mol. Biol. Cell 9:2527-2543(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif."
    Minty A., Dumont X., Kaghad M., Caput D.
    J. Biol. Chem. 275:36316-36323(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBL1.
  7. "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells."
    Curtin J.F., Cotter T.G.
    J. Biol. Chem. 279:17090-17100(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
    Lan H.-C., Li H.-J., Lin G., Lai P.-Y., Chung B.-C.
    Mol. Cell. Biol. 27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS KINASE AND IN CAMP SIGNALING PATHWAY, INTERACTION WITH NR5A1/SF1, MUTAGENESIS OF LYS-226.
  9. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-142; GLU-170; ARG-191; ASN-500 AND LEU-729.

Entry informationi

Entry nameiHIPK3_HUMAN
AccessioniPrimary (citable) accession number: Q9H422
Secondary accession number(s): O14632
, Q2PBG4, Q2PBG5, Q92632, Q9HAS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.