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Protein

Abhydrolase domain-containing protein 16B

Gene

ABHD16B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei247 – 2471Charge relay systemBy similarity
Active sitei322 – 3221Charge relay systemBy similarity
Active sitei418 – 4181Charge relay systemBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SignaLinkiQ9H3Z7.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 16B (EC:3.-.-.-)
Gene namesi
Name:ABHD16B
Synonyms:C20orf135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16128. ABHD16B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Abhydrolase domain-containing protein 16BPRO_0000079463Add
BLAST

Proteomic databases

PaxDbiQ9H3Z7.
PRIDEiQ9H3Z7.

PTM databases

PhosphoSiteiQ9H3Z7.

Expressioni

Gene expression databases

BgeeiQ9H3Z7.
CleanExiHS_C20orf135.
GenevestigatoriQ9H3Z7.

Organism-specific databases

HPAiHPA059272.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 575Poly-Ala
Compositional biasi433 – 4375Poly-Arg

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD16 family.Curated

Phylogenomic databases

eggNOGiNOG325331.
GeneTreeiENSGT00390000017119.
HOVERGENiHBG050666.
InParanoidiQ9H3Z7.
OMAiNAGFYEM.
OrthoDBiEOG7N37CD.
PhylomeDBiQ9H3Z7.
TreeFamiTF314267.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H3Z7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL
60 70 80 90 100
TCAAAAAGVW LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY
110 120 130 140 150
ALAHSLGRWL VYPGSVSLMT RALLPLLQQG QERLVERYHG RRAKLVACDG
160 170 180 190 200
NEIDTMFMDR RQHPGSHVHG PRLVICCEGN AGFYEMGCLS APLEAGYSVL
210 220 230 240 250
GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH LVVYGWSVGG
260 270 280 290 300
FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN
310 320 330 340 350
LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR
360 370 380 390 400
LLEHRYPVVM AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS
410 420 430 440 450
YRARCEEELE GEEALGPHGP AFPWLVGQGL SSRRRRRLAL FLARKHLKNV
460
EATHFSPLEP EEFQLPWRL
Length:469
Mass (Da):52,555
Last modified:March 1, 2001 - v1
Checksum:i85C72E84CCFFC9A1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → Q.
Corresponds to variant rs2281534 [ dbSNP | Ensembl ].
VAR_050920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL118506 Genomic DNA. Translation: CAC15491.1.
CCDSiCCDS13539.1.
RefSeqiNP_542189.1. NM_080622.3.
UniGeneiHs.266774.
Hs.675171.

Genome annotation databases

EnsembliENST00000369916; ENSP00000358932; ENSG00000183260.
GeneIDi140701.
KEGGihsa:140701.
UCSCiuc002ygx.1. human.

Polymorphism databases

DMDMi23813959.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL118506 Genomic DNA. Translation: CAC15491.1.
CCDSiCCDS13539.1.
RefSeqiNP_542189.1. NM_080622.3.
UniGeneiHs.266774.
Hs.675171.

3D structure databases

ProteinModelPortaliQ9H3Z7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9H3Z7.

Polymorphism databases

DMDMi23813959.

Proteomic databases

PaxDbiQ9H3Z7.
PRIDEiQ9H3Z7.

Protocols and materials databases

DNASUi140701.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369916; ENSP00000358932; ENSG00000183260.
GeneIDi140701.
KEGGihsa:140701.
UCSCiuc002ygx.1. human.

Organism-specific databases

CTDi140701.
GeneCardsiGC20P062493.
HGNCiHGNC:16128. ABHD16B.
HPAiHPA059272.
neXtProtiNX_Q9H3Z7.
PharmGKBiPA25677.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325331.
GeneTreeiENSGT00390000017119.
HOVERGENiHBG050666.
InParanoidiQ9H3Z7.
OMAiNAGFYEM.
OrthoDBiEOG7N37CD.
PhylomeDBiQ9H3Z7.
TreeFamiTF314267.

Enzyme and pathway databases

SignaLinkiQ9H3Z7.

Miscellaneous databases

GenomeRNAii140701.
NextBioi84271.
PROiQ9H3Z7.

Gene expression databases

BgeeiQ9H3Z7.
CleanExiHS_C20orf135.
GenevestigatoriQ9H3Z7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiABHGB_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.