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Q9H3Z7

- ABHGB_HUMAN

UniProt

Q9H3Z7 - ABHGB_HUMAN

Protein

Abhydrolase domain-containing protein 16B

Gene

ABHD16B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei247 – 2471Charge relay systemBy similarity
    Active sitei322 – 3221Charge relay systemBy similarity
    Active sitei418 – 4181Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    SignaLinkiQ9H3Z7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 16B (EC:3.-.-.-)
    Gene namesi
    Name:ABHD16B
    Synonyms:C20orf135
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16128. ABHD16B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25677.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Abhydrolase domain-containing protein 16BPRO_0000079463Add
    BLAST

    Proteomic databases

    PaxDbiQ9H3Z7.
    PRIDEiQ9H3Z7.

    PTM databases

    PhosphoSiteiQ9H3Z7.

    Expressioni

    Gene expression databases

    BgeeiQ9H3Z7.
    CleanExiHS_C20orf135.
    GenevestigatoriQ9H3Z7.

    Organism-specific databases

    HPAiHPA059272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3Z7.
    SMRiQ9H3Z7. Positions 169-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi53 – 575Poly-Ala
    Compositional biasi433 – 4375Poly-Arg

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. ABHD16 family.Curated

    Phylogenomic databases

    eggNOGiNOG325331.
    HOVERGENiHBG050666.
    InParanoidiQ9H3Z7.
    OMAiNAGFYEM.
    OrthoDBiEOG7N37CD.
    PhylomeDBiQ9H3Z7.
    TreeFamiTF314267.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view]
    PfamiPF12695. Abhydrolase_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H3Z7-1 [UniParc]FASTAAdd to Basket

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    MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL    50
    TCAAAAAGVW LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY 100
    ALAHSLGRWL VYPGSVSLMT RALLPLLQQG QERLVERYHG RRAKLVACDG 150
    NEIDTMFMDR RQHPGSHVHG PRLVICCEGN AGFYEMGCLS APLEAGYSVL 200
    GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH LVVYGWSVGG 250
    FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN 300
    LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR 350
    LLEHRYPVVM AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS 400
    YRARCEEELE GEEALGPHGP AFPWLVGQGL SSRRRRRLAL FLARKHLKNV 450
    EATHFSPLEP EEFQLPWRL 469
    Length:469
    Mass (Da):52,555
    Last modified:March 1, 2001 - v1
    Checksum:i85C72E84CCFFC9A1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101L → Q.
    Corresponds to variant rs2281534 [ dbSNP | Ensembl ].
    VAR_050920

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL118506 Genomic DNA. Translation: CAC15491.1.
    CCDSiCCDS13539.1.
    RefSeqiNP_542189.1. NM_080622.3.
    UniGeneiHs.266774.
    Hs.675171.

    Genome annotation databases

    EnsembliENST00000369916; ENSP00000358932; ENSG00000183260.
    GeneIDi140701.
    KEGGihsa:140701.
    UCSCiuc002ygx.1. human.

    Polymorphism databases

    DMDMi23813959.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL118506 Genomic DNA. Translation: CAC15491.1 .
    CCDSi CCDS13539.1.
    RefSeqi NP_542189.1. NM_080622.3.
    UniGenei Hs.266774.
    Hs.675171.

    3D structure databases

    ProteinModelPortali Q9H3Z7.
    SMRi Q9H3Z7. Positions 169-274.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9H3Z7.

    Polymorphism databases

    DMDMi 23813959.

    Proteomic databases

    PaxDbi Q9H3Z7.
    PRIDEi Q9H3Z7.

    Protocols and materials databases

    DNASUi 140701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369916 ; ENSP00000358932 ; ENSG00000183260 .
    GeneIDi 140701.
    KEGGi hsa:140701.
    UCSCi uc002ygx.1. human.

    Organism-specific databases

    CTDi 140701.
    GeneCardsi GC20P062493.
    HGNCi HGNC:16128. ABHD16B.
    HPAi HPA059272.
    neXtProti NX_Q9H3Z7.
    PharmGKBi PA25677.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325331.
    HOVERGENi HBG050666.
    InParanoidi Q9H3Z7.
    OMAi NAGFYEM.
    OrthoDBi EOG7N37CD.
    PhylomeDBi Q9H3Z7.
    TreeFami TF314267.

    Enzyme and pathway databases

    SignaLinki Q9H3Z7.

    Miscellaneous databases

    GenomeRNAii 140701.
    NextBioi 84271.
    PROi Q9H3Z7.

    Gene expression databases

    Bgeei Q9H3Z7.
    CleanExi HS_C20orf135.
    Genevestigatori Q9H3Z7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view ]
    Pfami PF12695. Abhydrolase_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiABHGB_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3Z7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3