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Q9H3Z7

- ABHGB_HUMAN

UniProt

Q9H3Z7 - ABHGB_HUMAN

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Protein
Abhydrolase domain-containing protein 16B
Gene
ABHD16B, C20orf135
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei247 – 2471Charge relay system By similarity
Active sitei322 – 3221Charge relay system By similarity
Active sitei418 – 4181Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SignaLinkiQ9H3Z7.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 16B (EC:3.-.-.-)
Gene namesi
Name:ABHD16B
Synonyms:C20orf135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16128. ABHD16B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Abhydrolase domain-containing protein 16B
PRO_0000079463Add
BLAST

Proteomic databases

PaxDbiQ9H3Z7.
PRIDEiQ9H3Z7.

PTM databases

PhosphoSiteiQ9H3Z7.

Expressioni

Gene expression databases

BgeeiQ9H3Z7.
CleanExiHS_C20orf135.
GenevestigatoriQ9H3Z7.

Organism-specific databases

HPAiHPA059272.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Z7.
SMRiQ9H3Z7. Positions 169-274.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 575Poly-Ala
Compositional biasi433 – 4375Poly-Arg

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG325331.
HOVERGENiHBG050666.
InParanoidiQ9H3Z7.
OMAiNAGFYEM.
OrthoDBiEOG7N37CD.
PhylomeDBiQ9H3Z7.
TreeFamiTF314267.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H3Z7-1 [UniParc]FASTAAdd to Basket

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MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL    50
TCAAAAAGVW LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY 100
ALAHSLGRWL VYPGSVSLMT RALLPLLQQG QERLVERYHG RRAKLVACDG 150
NEIDTMFMDR RQHPGSHVHG PRLVICCEGN AGFYEMGCLS APLEAGYSVL 200
GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH LVVYGWSVGG 250
FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN 300
LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR 350
LLEHRYPVVM AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS 400
YRARCEEELE GEEALGPHGP AFPWLVGQGL SSRRRRRLAL FLARKHLKNV 450
EATHFSPLEP EEFQLPWRL 469
Length:469
Mass (Da):52,555
Last modified:March 1, 2001 - v1
Checksum:i85C72E84CCFFC9A1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → Q.
Corresponds to variant rs2281534 [ dbSNP | Ensembl ].
VAR_050920

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL118506 Genomic DNA. Translation: CAC15491.1.
CCDSiCCDS13539.1.
RefSeqiNP_542189.1. NM_080622.3.
UniGeneiHs.266774.
Hs.675171.

Genome annotation databases

EnsembliENST00000369916; ENSP00000358932; ENSG00000183260.
GeneIDi140701.
KEGGihsa:140701.
UCSCiuc002ygx.1. human.

Polymorphism databases

DMDMi23813959.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL118506 Genomic DNA. Translation: CAC15491.1 .
CCDSi CCDS13539.1.
RefSeqi NP_542189.1. NM_080622.3.
UniGenei Hs.266774.
Hs.675171.

3D structure databases

ProteinModelPortali Q9H3Z7.
SMRi Q9H3Z7. Positions 169-274.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9H3Z7.

Polymorphism databases

DMDMi 23813959.

Proteomic databases

PaxDbi Q9H3Z7.
PRIDEi Q9H3Z7.

Protocols and materials databases

DNASUi 140701.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369916 ; ENSP00000358932 ; ENSG00000183260 .
GeneIDi 140701.
KEGGi hsa:140701.
UCSCi uc002ygx.1. human.

Organism-specific databases

CTDi 140701.
GeneCardsi GC20P062493.
HGNCi HGNC:16128. ABHD16B.
HPAi HPA059272.
neXtProti NX_Q9H3Z7.
PharmGKBi PA25677.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325331.
HOVERGENi HBG050666.
InParanoidi Q9H3Z7.
OMAi NAGFYEM.
OrthoDBi EOG7N37CD.
PhylomeDBi Q9H3Z7.
TreeFami TF314267.

Enzyme and pathway databases

SignaLinki Q9H3Z7.

Miscellaneous databases

GenomeRNAii 140701.
NextBioi 84271.
PROi Q9H3Z7.

Gene expression databases

Bgeei Q9H3Z7.
CleanExi HS_C20orf135.
Genevestigatori Q9H3Z7.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view ]
Pfami PF12695. Abhydrolase_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiABHGB_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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