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Q9H3Z7 (ABHGB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein 16B

EC=3.-.-.-
Gene names
Name:ABHD16B
Synonyms:C20orf135
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily. ABHD16 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Abhydrolase domain-containing protein 16B
PRO_0000079463

Regions

Compositional bias53 – 575Poly-Ala
Compositional bias433 – 4375Poly-Arg

Sites

Active site2471Charge relay system By similarity
Active site3221Charge relay system By similarity
Active site4181Charge relay system By similarity

Natural variations

Natural variant101L → Q.
Corresponds to variant rs2281534 [ dbSNP | Ensembl ].
VAR_050920

Sequences

Sequence LengthMass (Da)Tools
Q9H3Z7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 85C72E84CCFFC9A1

FASTA46952,555
        10         20         30         40         50         60 
MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL TCAAAAAGVW 

        70         80         90        100        110        120 
LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY ALAHSLGRWL VYPGSVSLMT 

       130        140        150        160        170        180 
RALLPLLQQG QERLVERYHG RRAKLVACDG NEIDTMFMDR RQHPGSHVHG PRLVICCEGN 

       190        200        210        220        230        240 
AGFYEMGCLS APLEAGYSVL GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH 

       250        260        270        280        290        300 
LVVYGWSVGG FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN 

       310        320        330        340        350        360 
LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR LLEHRYPVVM 

       370        380        390        400        410        420 
AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS YRARCEEELE GEEALGPHGP 

       430        440        450        460 
AFPWLVGQGL SSRRRRRLAL FLARKHLKNV EATHFSPLEP EEFQLPWRL 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL118506 Genomic DNA. Translation: CAC15491.1.
CCDSCCDS13539.1.
RefSeqNP_542189.1. NM_080622.3.
UniGeneHs.266774.
Hs.675171.

3D structure databases

ProteinModelPortalQ9H3Z7.
SMRQ9H3Z7. Positions 169-274.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9H3Z7.

Polymorphism databases

DMDM23813959.

Proteomic databases

PaxDbQ9H3Z7.
PRIDEQ9H3Z7.

Protocols and materials databases

DNASU140701.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369916; ENSP00000358932; ENSG00000183260.
GeneID140701.
KEGGhsa:140701.
UCSCuc002ygx.1. human.

Organism-specific databases

CTD140701.
GeneCardsGC20P062493.
HGNCHGNC:16128. ABHD16B.
HPAHPA059272.
neXtProtNX_Q9H3Z7.
PharmGKBPA25677.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325331.
HOVERGENHBG050666.
InParanoidQ9H3Z7.
OMANAGFYEM.
OrthoDBEOG7N37CD.
PhylomeDBQ9H3Z7.
TreeFamTF314267.

Enzyme and pathway databases

SignaLinkQ9H3Z7.

Gene expression databases

BgeeQ9H3Z7.
CleanExHS_C20orf135.
GenevestigatorQ9H3Z7.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi140701.
NextBio84271.
PROQ9H3Z7.

Entry information

Entry nameABHGB_HUMAN
AccessionPrimary (citable) accession number: Q9H3Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM