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Protein

Pancreatic progenitor cell differentiation and proliferation factor

Gene

PPDPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of exocrine pancreas development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic progenitor cell differentiation and proliferation factor
Alternative name(s):
Exocrine differentiation and proliferation factor
Gene namesi
Name:PPDPF
Synonyms:C20orf149, EXPDF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16142. PPDPF.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125534.
PharmGKBiPA25691.

Polymorphism and mutation databases

BioMutaiPPDPF.
DMDMi27734256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794681 – 114Pancreatic progenitor cell differentiation and proliferation factorAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H3Y8.
MaxQBiQ9H3Y8.
PaxDbiQ9H3Y8.
PeptideAtlasiQ9H3Y8.
PRIDEiQ9H3Y8.

PTM databases

iPTMnetiQ9H3Y8.
PhosphoSitePlusiQ9H3Y8.

Expressioni

Gene expression databases

BgeeiENSG00000125534.
CleanExiHS_C20orf149.
ExpressionAtlasiQ9H3Y8. baseline and differential.
GenevisibleiQ9H3Y8. HS.

Organism-specific databases

HPAiHPA040929.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPDPF family.Curated

Phylogenomic databases

eggNOGiENOG410IYFA. Eukaryota.
ENOG4111Z27. LUCA.
GeneTreeiENSGT00390000009113.
HOGENOMiHOG000112412.
InParanoidiQ9H3Y8.
PhylomeDBiQ9H3Y8.
TreeFamiTF333000.

Family and domain databases

InterProiIPR026754. PPDPF.
[Graphical view]
PANTHERiPTHR14572:SF0. PTHR14572:SF0. 1 hit.
PfamiPF15060. PPDFL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIPSSGSL VATHDYYRRR LGSTSSNSSC SSTECPGEAI PHPPGLPKAD
60 70 80 90 100
PGHWWASFFF GKSTLPFMAT VLESAEHSEP PQASSSMTAC GLARDAPRKQ
110
PGGQSSTASA GPPS
Length:114
Mass (Da):11,777
Last modified:March 1, 2001 - v1
Checksum:iCCFE0A5207C887FE
GO
Isoform 2 (identifier: Q9H3Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-70: FMAT → PPTL
     71-114: Missing.

Note: No experimental confirmation available.
Show »
Length:70
Mass (Da):7,416
Checksum:iEFFC83589ECEF0FD
GO

Sequence cautioni

The sequence CAI95747 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00382367 – 70FMAT → PPTL in isoform 2. Curated4
Alternative sequenceiVSP_00382471 – 114Missing in isoform 2. CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121829 Genomic DNA. Translation: CAC15523.1.
AL121829 Genomic DNA. Translation: CAC15524.1.
AL121829 Genomic DNA. Translation: CAI95747.1. Sequence problems.
CH471077 Genomic DNA. Translation: EAW75264.1.
CH471077 Genomic DNA. Translation: EAW75265.1.
BC002531 mRNA. Translation: AAH02531.1.
BC056416 mRNA. Translation: AAH56416.1.
CCDSiCCDS13523.1. [Q9H3Y8-1]
RefSeqiNP_077275.1. NM_024299.2. [Q9H3Y8-1]
UniGeneiHs.79625.

Genome annotation databases

EnsembliENST00000370179; ENSP00000359198; ENSG00000125534. [Q9H3Y8-1]
GeneIDi79144.
KEGGihsa:79144.
UCSCiuc002yff.4. human. [Q9H3Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121829 Genomic DNA. Translation: CAC15523.1.
AL121829 Genomic DNA. Translation: CAC15524.1.
AL121829 Genomic DNA. Translation: CAI95747.1. Sequence problems.
CH471077 Genomic DNA. Translation: EAW75264.1.
CH471077 Genomic DNA. Translation: EAW75265.1.
BC002531 mRNA. Translation: AAH02531.1.
BC056416 mRNA. Translation: AAH56416.1.
CCDSiCCDS13523.1. [Q9H3Y8-1]
RefSeqiNP_077275.1. NM_024299.2. [Q9H3Y8-1]
UniGeneiHs.79625.

3D structure databases

ProteinModelPortaliQ9H3Y8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9H3Y8.
PhosphoSitePlusiQ9H3Y8.

Polymorphism and mutation databases

BioMutaiPPDPF.
DMDMi27734256.

Proteomic databases

EPDiQ9H3Y8.
MaxQBiQ9H3Y8.
PaxDbiQ9H3Y8.
PeptideAtlasiQ9H3Y8.
PRIDEiQ9H3Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370179; ENSP00000359198; ENSG00000125534. [Q9H3Y8-1]
GeneIDi79144.
KEGGihsa:79144.
UCSCiuc002yff.4. human. [Q9H3Y8-1]

Organism-specific databases

CTDi79144.
GeneCardsiPPDPF.
HGNCiHGNC:16142. PPDPF.
HPAiHPA040929.
neXtProtiNX_Q9H3Y8.
OpenTargetsiENSG00000125534.
PharmGKBiPA25691.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYFA. Eukaryota.
ENOG4111Z27. LUCA.
GeneTreeiENSGT00390000009113.
HOGENOMiHOG000112412.
InParanoidiQ9H3Y8.
PhylomeDBiQ9H3Y8.
TreeFamiTF333000.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125534-MONOMER.

Miscellaneous databases

ChiTaRSiPPDPF. human.
GenomeRNAii79144.
PROiQ9H3Y8.

Gene expression databases

BgeeiENSG00000125534.
CleanExiHS_C20orf149.
ExpressionAtlasiQ9H3Y8. baseline and differential.
GenevisibleiQ9H3Y8. HS.

Family and domain databases

InterProiIPR026754. PPDPF.
[Graphical view]
PANTHERiPTHR14572:SF0. PTHR14572:SF0. 1 hit.
PfamiPF15060. PPDFL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPDPF_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y8
Secondary accession number(s): E1P5J2, Q4VXP1, Q9H3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.