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Protein

Tyrosine-protein kinase Srms

Gene

SRMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPPROSITE-ProRule annotation1
Active sitei350Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi236 – 244ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8849472 PTK6 Down-Regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ9H3Y6

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Srms (EC:2.7.10.22 Publications)
Gene namesi
Name:SRMS
Synonyms:C20orf148
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125508.3
HGNCiHGNC:11298 SRMS
MIMi617797 gene
neXtProtiNX_Q9H3Y6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi223W → A: Loss of kinase activity. 1 Publication1
Mutagenesisi258K → M: Loss of kinase activity. Exhibits a diffused cytoplasmic localization. No effect on interaction with KHDRBS1 or VIM but abolishes tyrosine phosphorylation of both substrates. 2 Publications1
Mutagenesisi380Y → F: Significant reduction in phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi6725
OpenTargetsiENSG00000125508
PharmGKBiPA36122

Chemistry databases

ChEMBLiCHEMBL5703
GuidetoPHARMACOLOGYi2207

Polymorphism and mutation databases

BioMutaiSRMS
DMDMi27805732

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881601 – 488Tyrosine-protein kinase SrmsAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei380Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H3Y6
PaxDbiQ9H3Y6
PeptideAtlasiQ9H3Y6
PRIDEiQ9H3Y6

PTM databases

iPTMnetiQ9H3Y6
PhosphoSitePlusiQ9H3Y6

Expressioni

Tissue specificityi

Highly expressed in most breast cancers (at protein level).

Gene expression databases

BgeeiENSG00000125508
CleanExiHS_SRMS
GenevisibleiQ9H3Y6 HS

Organism-specific databases

HPAiCAB044668
CAB044669
HPA073987

Interactioni

Subunit structurei

Interacts (via the SH2 and SH3 domains) with DOK1 (PubMed:23822091). Interacts with KHDRBS1/SAM68 and VIM (PubMed:29496907).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DOK1Q997047EBI-8541270,EBI-1384360

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112603, 3 interactors
IntActiQ9H3Y6, 2 interactors
MINTiQ9H3Y6
STRINGi9606.ENSP00000217188

Chemistry databases

BindingDBiQ9H3Y6

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y6
SMRiQ9H3Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 112SH3PROSITE-ProRule annotationAdd BLAST62
Domaini120 – 212SH2PROSITE-ProRule annotationAdd BLAST93
Domaini230 – 488Protein kinasePROSITE-ProRule annotationAdd BLAST259

Domaini

The N-terminal region regulates its kinase activity.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
HOGENOMiHOG000233858
HOVERGENiHBG008761
InParanoidiQ9H3Y6
KOiK08895
OMAiLYEVFTY
OrthoDBiEOG091G0D46
PhylomeDBiQ9H3Y6
TreeFamiTF351634

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H3Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS
60 70 80 90 100
PFPQLFLALY DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG
110 120 130 140 150
LVPITHVAKA SPETLSDQPW YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE
160 170 180 190 200
SSLGGYSLSV RAQAKVCHYR VSMAADGSLY LQKGRLFPGL EELLTYYKAN
210 220 230 240 250
WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY FGEVWEGLWL
260 270 280 290 300
GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI
310 320 330 340 350
VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD
360 370 380 390 400
LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY
410 420 430 440 450
RVFSQKSDVW SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA
460 470 480
CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP
Length:488
Mass (Da):54,507
Last modified:March 1, 2001 - v1
Checksum:i83193AD26C5F6F68
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04183173R → C1 PublicationCorresponds to variant dbSNP:rs56053583Ensembl.1
Natural variantiVAR_04183275G → R1 PublicationCorresponds to variant dbSNP:rs55863722Ensembl.1
Natural variantiVAR_04183388I → V1 PublicationCorresponds to variant dbSNP:rs35558836Ensembl.1
Natural variantiVAR_051700218P → L. Corresponds to variant dbSNP:rs378483Ensembl.1
Natural variantiVAR_051701255V → M. Corresponds to variant dbSNP:rs34969822Ensembl.1
Natural variantiVAR_041834301V → L1 PublicationCorresponds to variant dbSNP:rs310657Ensembl.1
Natural variantiVAR_051702325P → L. Corresponds to variant dbSNP:rs8122355Ensembl.1
Natural variantiVAR_041835377D → E1 PublicationCorresponds to variant dbSNP:rs55838540Ensembl.1
Natural variantiVAR_041836397A → V1 PublicationCorresponds to variant dbSNP:rs6011889Ensembl.1
Natural variantiVAR_041837452P → L1 PublicationCorresponds to variant dbSNP:rs8120713Ensembl.1
Natural variantiVAR_041838453A → T1 PublicationCorresponds to variant dbSNP:rs310655Ensembl.1
Natural variantiVAR_041839457V → L1 PublicationCorresponds to variant dbSNP:rs310654Ensembl.1
Natural variantiVAR_041840465S → T1 PublicationCorresponds to variant dbSNP:rs33933649Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121829 Genomic DNA No translation available.
CCDSiCCDS13525.1
RefSeqiNP_543013.1, NM_080823.3

Genome annotation databases

EnsembliENST00000217188; ENSP00000217188; ENSG00000125508
GeneIDi6725
KEGGihsa:6725
UCSCiuc002yfi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSRMS_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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