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Q9H3Y6

- SRMS_HUMAN

UniProt

Q9H3Y6 - SRMS_HUMAN

Protein

Tyrosine-protein kinase Srms

Gene

SRMS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei258 – 2581ATP
    Active sitei350 – 3501Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi236 – 2449ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. protein binding Source: UniProtKB
    4. protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine autophosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    SignaLinkiQ9H3Y6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Srms (EC:2.7.10.2)
    Gene namesi
    Name:SRMS
    Synonyms:C20orf148
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11298. SRMS.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localizes to punctate cytoplasmic structures.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi223 – 2231W → A: Loss of kinase activity. 1 Publication
    Mutagenesisi258 – 2581K → M: Loss of kinase activity. Exhibits a diffused cytoplasmic localization. 1 Publication
    Mutagenesisi380 – 3801Y → F: Significant reduction in phosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA36122.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Tyrosine-protein kinase SrmsPRO_0000088160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei380 – 3801Phosphotyrosine; by autocatalysis1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H3Y6.
    PaxDbiQ9H3Y6.
    PRIDEiQ9H3Y6.

    PTM databases

    PhosphoSiteiQ9H3Y6.

    Expressioni

    Tissue specificityi

    Highly expressed in most breast cancers (at protein level).

    Gene expression databases

    BgeeiQ9H3Y6.
    CleanExiHS_SRMS.
    GenevestigatoriQ9H3Y6.

    Organism-specific databases

    HPAiCAB044668.
    CAB044669.

    Interactioni

    Subunit structurei

    Interacts (via the SH2 and SH3 domains) with DOK1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DOK1Q997047EBI-8541270,EBI-1384360

    Protein-protein interaction databases

    BioGridi112603. 2 interactions.
    IntActiQ9H3Y6. 1 interaction.
    STRINGi9606.ENSP00000217188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3Y6.
    SMRiQ9H3Y6. Positions 56-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11262SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini120 – 21293SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 488259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5151N-terminalAdd
    BLAST

    Domaini

    The N-terminal region regulates its kinase activity.1 Publication

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    InParanoidiQ9H3Y6.
    KOiK08895.
    OMAiLYEVFTY.
    OrthoDBiEOG7KM5SC.
    PhylomeDBiQ9H3Y6.
    TreeFamiTF351634.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H3Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS    50
    PFPQLFLALY DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG 100
    LVPITHVAKA SPETLSDQPW YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE 150
    SSLGGYSLSV RAQAKVCHYR VSMAADGSLY LQKGRLFPGL EELLTYYKAN 200
    WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY FGEVWEGLWL 250
    GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI 300
    VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD 350
    LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY 400
    RVFSQKSDVW SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA 450
    CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP 488
    Length:488
    Mass (Da):54,507
    Last modified:March 1, 2001 - v1
    Checksum:i83193AD26C5F6F68
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731R → C.1 Publication
    Corresponds to variant rs56053583 [ dbSNP | Ensembl ].
    VAR_041831
    Natural varianti75 – 751G → R.1 Publication
    Corresponds to variant rs55863722 [ dbSNP | Ensembl ].
    VAR_041832
    Natural varianti88 – 881I → V.1 Publication
    Corresponds to variant rs35558836 [ dbSNP | Ensembl ].
    VAR_041833
    Natural varianti218 – 2181P → L.
    Corresponds to variant rs378483 [ dbSNP | Ensembl ].
    VAR_051700
    Natural varianti255 – 2551V → M.
    Corresponds to variant rs34969822 [ dbSNP | Ensembl ].
    VAR_051701
    Natural varianti301 – 3011V → L.1 Publication
    Corresponds to variant rs310657 [ dbSNP | Ensembl ].
    VAR_041834
    Natural varianti325 – 3251P → L.
    Corresponds to variant rs8122355 [ dbSNP | Ensembl ].
    VAR_051702
    Natural varianti377 – 3771D → E.1 Publication
    Corresponds to variant rs55838540 [ dbSNP | Ensembl ].
    VAR_041835
    Natural varianti397 – 3971A → V.1 Publication
    Corresponds to variant rs6011889 [ dbSNP | Ensembl ].
    VAR_041836
    Natural varianti452 – 4521P → L.1 Publication
    Corresponds to variant rs8120713 [ dbSNP | Ensembl ].
    VAR_041837
    Natural varianti453 – 4531A → T.1 Publication
    Corresponds to variant rs310655 [ dbSNP | Ensembl ].
    VAR_041838
    Natural varianti457 – 4571V → L.1 Publication
    Corresponds to variant rs310654 [ dbSNP | Ensembl ].
    VAR_041839
    Natural varianti465 – 4651S → T.1 Publication
    Corresponds to variant rs33933649 [ dbSNP | Ensembl ].
    VAR_041840

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121829 Genomic DNA. Translation: CAC15526.1.
    CCDSiCCDS13525.1.
    RefSeqiNP_543013.1. NM_080823.3.

    Genome annotation databases

    EnsembliENST00000217188; ENSP00000217188; ENSG00000125508.
    GeneIDi6725.
    KEGGihsa:6725.
    UCSCiuc002yfi.1. human.

    Polymorphism databases

    DMDMi27805732.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121829 Genomic DNA. Translation: CAC15526.1 .
    CCDSi CCDS13525.1.
    RefSeqi NP_543013.1. NM_080823.3.

    3D structure databases

    ProteinModelPortali Q9H3Y6.
    SMRi Q9H3Y6. Positions 56-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112603. 2 interactions.
    IntActi Q9H3Y6. 1 interaction.
    STRINGi 9606.ENSP00000217188.

    Chemistry

    BindingDBi Q9H3Y6.
    ChEMBLi CHEMBL5703.
    GuidetoPHARMACOLOGYi 2207.

    PTM databases

    PhosphoSitei Q9H3Y6.

    Polymorphism databases

    DMDMi 27805732.

    Proteomic databases

    MaxQBi Q9H3Y6.
    PaxDbi Q9H3Y6.
    PRIDEi Q9H3Y6.

    Protocols and materials databases

    DNASUi 6725.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217188 ; ENSP00000217188 ; ENSG00000125508 .
    GeneIDi 6725.
    KEGGi hsa:6725.
    UCSCi uc002yfi.1. human.

    Organism-specific databases

    CTDi 6725.
    GeneCardsi GC20M062172.
    HGNCi HGNC:11298. SRMS.
    HPAi CAB044668.
    CAB044669.
    neXtProti NX_Q9H3Y6.
    PharmGKBi PA36122.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    InParanoidi Q9H3Y6.
    KOi K08895.
    OMAi LYEVFTY.
    OrthoDBi EOG7KM5SC.
    PhylomeDBi Q9H3Y6.
    TreeFami TF351634.

    Enzyme and pathway databases

    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    SignaLinki Q9H3Y6.

    Miscellaneous databases

    GenomeRNAii 6725.
    NextBioi 26232.
    PROi Q9H3Y6.

    Gene expression databases

    Bgeei Q9H3Y6.
    CleanExi HS_SRMS.
    Genevestigatori Q9H3Y6.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1."
      Goel R.K., Miah S., Black K., Kalra N., Dai C., Lukong K.E.
      FEBS J. 280:4539-4559(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DOK1, N-TERMINAL REGION, PHOSPHORYLATION AT TYR-380, MUTAGENESIS OF TRP-223; LYS-258 AND TYR-380.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-73; ARG-75; VAL-88; LEU-301; GLU-377; VAL-397; LEU-452; THR-453; LEU-457 AND THR-465.

    Entry informationi

    Entry nameiSRMS_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3