Q9H3Y6 (SRMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase Srms
EC=2.7.10.2

Gene names

Name:	SRMS
Synonyms:	C20orf148

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in proliferation or differentiation of keratinocytes in the skin By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	SH2 domain SH3 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Tyrosine-protein kinase Srms		PRO_0000088160
Regions
	Domain	51 – 112	62	SH3
	Domain	120 – 212	93	SH2
	Domain	230 – 488	259	Protein kinase
	Nucleotide binding	236 – 244	9	ATP By similarity
Sites
	Active site	350	1	Proton acceptor By similarity
	Binding site	258	1	ATP By similarity
Amino acid modifications
	Modified residue	261	1	N6-acetyllysine By similarity
	Modified residue	380	1	Phosphotyrosine; by autocatalysis By similarity
Natural variations
	Natural variant	73	1	R → C. Ref.2 Corresponds to variant rs56053583 [ dbSNP | Ensembl ].		VAR_041831
	Natural variant	75	1	G → R. Ref.2 Corresponds to variant rs55863722 [ dbSNP | Ensembl ].		VAR_041832
	Natural variant	88	1	I → V. Ref.2 Corresponds to variant rs35558836 [ dbSNP | Ensembl ].		VAR_041833
	Natural variant	218	1	P → L. Corresponds to variant rs378483 [ dbSNP | Ensembl ].		VAR_051700
	Natural variant	255	1	V → M. Corresponds to variant rs34969822 [ dbSNP | Ensembl ].		VAR_051701
	Natural variant	301	1	V → L. Ref.2 Corresponds to variant rs310657 [ dbSNP | Ensembl ].		VAR_041834
	Natural variant	325	1	P → L. Corresponds to variant rs8122355 [ dbSNP | Ensembl ].		VAR_051702
	Natural variant	377	1	D → E. Ref.2 Corresponds to variant rs55838540 [ dbSNP | Ensembl ].		VAR_041835
	Natural variant	397	1	A → V. Ref.2 Corresponds to variant rs6011889 [ dbSNP | Ensembl ].		VAR_041836
	Natural variant	452	1	P → L. Ref.2 Corresponds to variant rs8120713 [ dbSNP | Ensembl ].		VAR_041837
	Natural variant	453	1	A → T. Ref.2 Corresponds to variant rs310655 [ dbSNP | Ensembl ].		VAR_041838
	Natural variant	457	1	V → L. Ref.2 Corresponds to variant rs310654 [ dbSNP | Ensembl ].		VAR_041839
	Natural variant	465	1	S → T. Ref.2 Corresponds to variant rs33933649 [ dbSNP | Ensembl ].		VAR_041840

Sequences

	Sequence		Length	Mass (Da)
	Q9H3Y6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 83193AD26C5F6F68	FASTA	488	54,507
	10 20 30 40 50 60 MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS PFPQLFLALY 70 80 90 100 110 120 DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW 130 140 150 160 170 180 YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY 190 200 210 220 230 240 LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY 250 260 270 280 290 300 FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI 310 320 330 340 350 360 VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD LAARNVLVDD 370 380 390 400 410 420 GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW SFGVLLHEVF 430 440 450 460 470 480 TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-73; ARG-75; VAL-88; LEU-301; GLU-377; VAL-397; LEU-452; THR-453; LEU-457 AND THR-465.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL121829 Genomic DNA. Translation: CAC15526.1.
IPI	IPI00024884.
RefSeq	NP_543013.1. NM_080823.2.
UniGene	Hs.411061.
3D structure databases
ProteinModelPortal	Q9H3Y6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000217188.
PTM databases
PhosphoSite	Q9H3Y6.
Polymorphism databases
DMDM	27805732.
Proteomic databases
PaxDb	Q9H3Y6.
PRIDE	Q9H3Y6.
Protocols and materials databases
DNASU	6725.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217188; ENSP00000217188; ENSG00000125508.
GeneID	6725.
KEGG	hsa:6725.
UCSC	uc002yfi.1. human.
Organism-specific databases
CTD	6725.
GeneCards	GC20M062172.
HGNC	HGNC:11298. SRMS.
neXtProt	NX_Q9H3Y6.
PharmGKB	PA36122.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233858.
HOVERGEN	HBG008761.
InParanoid	Q9H3Y6.
KO	K08895.
OMA	LYEVFTY.
OrthoDB	EOG4229K0.
PhylomeDB	Q9H3Y6.
Gene expression databases
Bgee	Q9H3Y6.
CleanEx	HS_SRMS.
Genevestigator	Q9H3Y6.
GermOnline	ENSG00000125508. Homo sapiens.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9H3Y6.
ChEMBL	CHEMBL5703.
GenomeRNAi	6725.
NextBio	26232.

Entry information

Entry name

SRMS_HUMAN

Accession

Primary (citable) accession number: Q9H3Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.