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Q9H3Y6

- SRMS_HUMAN

UniProt

Q9H3Y6 - SRMS_HUMAN

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Protein

Tyrosine-protein kinase Srms

Gene

SRMS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei258 – 2581ATP
Active sitei350 – 3501Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi236 – 2449ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine autophosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiQ9H3Y6.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Srms (EC:2.7.10.2)
Gene namesi
Name:SRMS
Synonyms:C20orf148
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11298. SRMS.

Subcellular locationi

Cytoplasm 1 Publication
Note: Localizes to punctate cytoplasmic structures.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi223 – 2231W → A: Loss of kinase activity. 1 Publication
Mutagenesisi258 – 2581K → M: Loss of kinase activity. Exhibits a diffused cytoplasmic localization. 1 Publication
Mutagenesisi380 – 3801Y → F: Significant reduction in phosphorylation. 1 Publication

Organism-specific databases

PharmGKBiPA36122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Tyrosine-protein kinase SrmsPRO_0000088160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei380 – 3801Phosphotyrosine; by autocatalysis1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H3Y6.
PaxDbiQ9H3Y6.
PRIDEiQ9H3Y6.

PTM databases

PhosphoSiteiQ9H3Y6.

Expressioni

Tissue specificityi

Highly expressed in most breast cancers (at protein level).

Gene expression databases

BgeeiQ9H3Y6.
CleanExiHS_SRMS.
GenevestigatoriQ9H3Y6.

Organism-specific databases

HPAiCAB044668.
CAB044669.

Interactioni

Subunit structurei

Interacts (via the SH2 and SH3 domains) with DOK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DOK1Q997047EBI-8541270,EBI-1384360

Protein-protein interaction databases

BioGridi112603. 2 interactions.
IntActiQ9H3Y6. 1 interaction.
STRINGi9606.ENSP00000217188.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y6.
SMRiQ9H3Y6. Positions 56-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11262SH3PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 21293SH2PROSITE-ProRule annotationAdd
BLAST
Domaini230 – 488259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5151N-terminalAdd
BLAST

Domaini

The N-terminal region regulates its kinase activity.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ9H3Y6.
KOiK08895.
OMAiLYEVFTY.
OrthoDBiEOG7KM5SC.
PhylomeDBiQ9H3Y6.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H3Y6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS
60 70 80 90 100
PFPQLFLALY DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG
110 120 130 140 150
LVPITHVAKA SPETLSDQPW YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE
160 170 180 190 200
SSLGGYSLSV RAQAKVCHYR VSMAADGSLY LQKGRLFPGL EELLTYYKAN
210 220 230 240 250
WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY FGEVWEGLWL
260 270 280 290 300
GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI
310 320 330 340 350
VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD
360 370 380 390 400
LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY
410 420 430 440 450
RVFSQKSDVW SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA
460 470 480
CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP
Length:488
Mass (Da):54,507
Last modified:March 1, 2001 - v1
Checksum:i83193AD26C5F6F68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731R → C.1 Publication
Corresponds to variant rs56053583 [ dbSNP | Ensembl ].
VAR_041831
Natural varianti75 – 751G → R.1 Publication
Corresponds to variant rs55863722 [ dbSNP | Ensembl ].
VAR_041832
Natural varianti88 – 881I → V.1 Publication
Corresponds to variant rs35558836 [ dbSNP | Ensembl ].
VAR_041833
Natural varianti218 – 2181P → L.
Corresponds to variant rs378483 [ dbSNP | Ensembl ].
VAR_051700
Natural varianti255 – 2551V → M.
Corresponds to variant rs34969822 [ dbSNP | Ensembl ].
VAR_051701
Natural varianti301 – 3011V → L.1 Publication
Corresponds to variant rs310657 [ dbSNP | Ensembl ].
VAR_041834
Natural varianti325 – 3251P → L.
Corresponds to variant rs8122355 [ dbSNP | Ensembl ].
VAR_051702
Natural varianti377 – 3771D → E.1 Publication
Corresponds to variant rs55838540 [ dbSNP | Ensembl ].
VAR_041835
Natural varianti397 – 3971A → V.1 Publication
Corresponds to variant rs6011889 [ dbSNP | Ensembl ].
VAR_041836
Natural varianti452 – 4521P → L.1 Publication
Corresponds to variant rs8120713 [ dbSNP | Ensembl ].
VAR_041837
Natural varianti453 – 4531A → T.1 Publication
Corresponds to variant rs310655 [ dbSNP | Ensembl ].
VAR_041838
Natural varianti457 – 4571V → L.1 Publication
Corresponds to variant rs310654 [ dbSNP | Ensembl ].
VAR_041839
Natural varianti465 – 4651S → T.1 Publication
Corresponds to variant rs33933649 [ dbSNP | Ensembl ].
VAR_041840

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121829 Genomic DNA. Translation: CAC15526.1.
CCDSiCCDS13525.1.
RefSeqiNP_543013.1. NM_080823.3.

Genome annotation databases

EnsembliENST00000217188; ENSP00000217188; ENSG00000125508.
GeneIDi6725.
KEGGihsa:6725.
UCSCiuc002yfi.1. human.

Polymorphism databases

DMDMi27805732.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121829 Genomic DNA. Translation: CAC15526.1 .
CCDSi CCDS13525.1.
RefSeqi NP_543013.1. NM_080823.3.

3D structure databases

ProteinModelPortali Q9H3Y6.
SMRi Q9H3Y6. Positions 56-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112603. 2 interactions.
IntActi Q9H3Y6. 1 interaction.
STRINGi 9606.ENSP00000217188.

Chemistry

BindingDBi Q9H3Y6.
ChEMBLi CHEMBL2363074.
GuidetoPHARMACOLOGYi 2207.

PTM databases

PhosphoSitei Q9H3Y6.

Polymorphism databases

DMDMi 27805732.

Proteomic databases

MaxQBi Q9H3Y6.
PaxDbi Q9H3Y6.
PRIDEi Q9H3Y6.

Protocols and materials databases

DNASUi 6725.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217188 ; ENSP00000217188 ; ENSG00000125508 .
GeneIDi 6725.
KEGGi hsa:6725.
UCSCi uc002yfi.1. human.

Organism-specific databases

CTDi 6725.
GeneCardsi GC20M062172.
HGNCi HGNC:11298. SRMS.
HPAi CAB044668.
CAB044669.
neXtProti NX_Q9H3Y6.
PharmGKBi PA36122.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118938.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi Q9H3Y6.
KOi K08895.
OMAi LYEVFTY.
OrthoDBi EOG7KM5SC.
PhylomeDBi Q9H3Y6.
TreeFami TF351634.

Enzyme and pathway databases

Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinki Q9H3Y6.

Miscellaneous databases

GenomeRNAii 6725.
NextBioi 26232.
PROi Q9H3Y6.

Gene expression databases

Bgeei Q9H3Y6.
CleanExi HS_SRMS.
Genevestigatori Q9H3Y6.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1."
    Goel R.K., Miah S., Black K., Kalra N., Dai C., Lukong K.E.
    FEBS J. 280:4539-4559(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DOK1, N-TERMINAL REGION, PHOSPHORYLATION AT TYR-380, MUTAGENESIS OF TRP-223; LYS-258 AND TYR-380.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-73; ARG-75; VAL-88; LEU-301; GLU-377; VAL-397; LEU-452; THR-453; LEU-457 AND THR-465.

Entry informationi

Entry nameiSRMS_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3