Q9H3Y0 (CRSPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidase inhibitor R3HDML

Alternative name(s):
Cysteine-rich secretory protein R3HDML

Gene names

Name:

R3HDML

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative serine protease inhibitor By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the CRISP family.
Caution	Despite its name, it does not contain a R3H domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Propeptide	25 – 56	32	By similarity		PRO_0000287635
	Chain	57 – 253	197	Peptidase inhibitor R3HDML		PRO_0000287636
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	15	1	F → C. Corresponds to variant rs11699901 [ dbSNP | Ensembl ].		VAR_032339
	Natural variant	68	1	D → N. Corresponds to variant rs36117710 [ dbSNP | Ensembl ].		VAR_048834

Sequences

	Sequence		Length	Mass (Da)
	Q9H3Y0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 28976C6F32E3887E	FASTA	253	28,605
	10 20 30 40 50 60 MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP RYRRKRHISV 70 80 90 100 110 120 RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW ATQCIWAHGP SQLMRYVGQN 130 140 150 160 170 180 LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP RDCNPHCPWR CDGPTCSHYT QMVWASSNRL 190 200 210 220 230 240 GCAIHTCSSI SVWGNTWHRA AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM 250 CFKGLKSNKF TWF

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL117382 Genomic DNA. Translation: CAC04190.1. BC107048 mRNA. Translation: AAI07049.1.
IPI	IPI00024338.
RefSeq	NP_848586.1. NM_178491.2.
UniGene	Hs.580807.
3D structure databases
HSSP	HSSP built from PDB template 1RC9 based on UniProtKB P60623.
ProteinModelPortal	Q9H3Y0.
SMR	Q9H3Y0. Positions 58-247.
ModBase	Search...
Polymorphism databases
DMDM	74752628.
Proteomic databases
PeptideAtlas	Q9H3Y0.
PRIDE	Q9H3Y0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217043; ENSP00000217043; ENSG00000101074.
GeneID	140902.
KEGG	hsa:140902.
UCSC	uc002xls.1. human.
Organism-specific databases
CTD	140902.
GeneCards	GC20P042965.
HGNC	HGNC:16249. R3HDML.
neXtProt	NX_Q9H3Y0.
PharmGKB	PA34099.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17840.
GeneTree	ENSGT00560000077066.
HOGENOM	HBG445512.
HOVERGEN	HBG079090.
InParanoid	Q9H3Y0.
OMA	LFWAGQT.
OrthoDB	EOG4X6C8W.
PhylomeDB	Q9H3Y0.
Gene expression databases
ArrayExpress	Q9H3Y0.
CleanEx	HS_R3HDML.
Genevestigator	Q9H3Y0.
Family and domain databases
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR014044. CAP_domain. [Graphical view]
Gene3D	G3DSA:3.40.33.10. CAP_domain. 1 hit.
PANTHER	PTHR10334. Allrgn_V5/Tpx1. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. False negative. PS01010. CRISP_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	84571.

Entry information

Entry name

CRSPL_HUMAN

Accession

Primary (citable) accession number: Q9H3Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.