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Protein

Peptidase inhibitor R3HDML

Gene

R3HDML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative serine protease inhibitor.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor R3HDML
Alternative name(s):
Cysteine-rich secretory protein R3HDML
Gene namesi
Name:R3HDML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101074.3.
HGNCiHGNC:16249. R3HDML.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140902.
OpenTargetsiENSG00000101074.
PharmGKBiPA34099.

Polymorphism and mutation databases

DMDMi74752628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000028763525 – 56By similarityAdd BLAST32
ChainiPRO_000028763657 – 253Peptidase inhibitor R3HDMLAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H3Y0.
PRIDEiQ9H3Y0.

Expressioni

Gene expression databases

BgeeiENSG00000101074.
CleanExiHS_R3HDML.
GenevisibleiQ9H3Y0. HS.

Organism-specific databases

HPAiHPA070264.

Interactioni

Protein-protein interaction databases

BioGridi126761. 3 interactors.
IntActiQ9H3Y0. 2 interactors.
STRINGi9606.ENSP00000217043.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 207SCPAdd BLAST141

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiQ9H3Y0.
OMAiHIRASVH.
OrthoDBiEOG091G048D.
PhylomeDBiQ9H3Y0.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiView protein in InterPro
IPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
IPR035940. CAP_sf.
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiView protein in Pfam
PF00188. CAP. 1 hit.
PRINTSiPR00837. V5TPXLIKE.
SMARTiView protein in SMART
SM00198. SCP. 1 hit.
SUPFAMiSSF55797. SSF55797. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP
60 70 80 90 100
RYRRKRHISV RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW
110 120 130 140 150
ATQCIWAHGP SQLMRYVGQN LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP
160 170 180 190 200
RDCNPHCPWR CDGPTCSHYT QMVWASSNRL GCAIHTCSSI SVWGNTWHRA
210 220 230 240 250
AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM CFKGLKSNKF

TWF
Length:253
Mass (Da):28,605
Last modified:March 1, 2001 - v1
Checksum:i28976C6F32E3887E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03233915F → C. Corresponds to variant dbSNP:rs11699901Ensembl.1
Natural variantiVAR_04883468D → N. Corresponds to variant dbSNP:rs36117710Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA. No translation available.
BC107048 mRNA. Translation: AAI07049.1.
CCDSiCCDS13329.1.
RefSeqiNP_848586.1. NM_178491.3.
UniGeneiHs.580807.

Genome annotation databases

EnsembliENST00000217043; ENSP00000217043; ENSG00000101074.
GeneIDi140902.
KEGGihsa:140902.
UCSCiuc002xls.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCRSPL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a R3H domain.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families