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Protein

Peptidase inhibitor R3HDML

Gene

R3HDML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative serine protease inhibitor.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor R3HDML
Alternative name(s):
Cysteine-rich secretory protein R3HDML
Gene namesi
Name:R3HDML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16249. R3HDML.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34099.

Polymorphism and mutation databases

DMDMi74752628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 5632By similarityPRO_0000287635Add
BLAST
Chaini57 – 253197Peptidase inhibitor R3HDMLPRO_0000287636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H3Y0.
PeptideAtlasiQ9H3Y0.
PRIDEiQ9H3Y0.

PTM databases

PhosphoSiteiQ9H3Y0.

Expressioni

Gene expression databases

BgeeiQ9H3Y0.
CleanExiHS_R3HDML.
GenevisibleiQ9H3Y0. HS.

Interactioni

Protein-protein interaction databases

BioGridi126761. 1 interaction.
STRINGi9606.ENSP00000217043.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y0.
SMRiQ9H3Y0. Positions 79-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 207141SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiQ9H3Y0.
OMAiSNMCFSG.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ9H3Y0.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP
60 70 80 90 100
RYRRKRHISV RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW
110 120 130 140 150
ATQCIWAHGP SQLMRYVGQN LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP
160 170 180 190 200
RDCNPHCPWR CDGPTCSHYT QMVWASSNRL GCAIHTCSSI SVWGNTWHRA
210 220 230 240 250
AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM CFKGLKSNKF

TWF
Length:253
Mass (Da):28,605
Last modified:March 1, 2001 - v1
Checksum:i28976C6F32E3887E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151F → C.
Corresponds to variant rs11699901 [ dbSNP | Ensembl ].
VAR_032339
Natural varianti68 – 681D → N.
Corresponds to variant rs36117710 [ dbSNP | Ensembl ].
VAR_048834

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA. Translation: CAC04190.1.
BC107048 mRNA. Translation: AAI07049.1.
CCDSiCCDS13329.1.
RefSeqiNP_848586.1. NM_178491.3.
UniGeneiHs.580807.

Genome annotation databases

EnsembliENST00000217043; ENSP00000217043; ENSG00000101074.
GeneIDi140902.
KEGGihsa:140902.
UCSCiuc002xls.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA. Translation: CAC04190.1.
BC107048 mRNA. Translation: AAI07049.1.
CCDSiCCDS13329.1.
RefSeqiNP_848586.1. NM_178491.3.
UniGeneiHs.580807.

3D structure databases

ProteinModelPortaliQ9H3Y0.
SMRiQ9H3Y0. Positions 79-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126761. 1 interaction.
STRINGi9606.ENSP00000217043.

PTM databases

PhosphoSiteiQ9H3Y0.

Polymorphism and mutation databases

DMDMi74752628.

Proteomic databases

PaxDbiQ9H3Y0.
PeptideAtlasiQ9H3Y0.
PRIDEiQ9H3Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217043; ENSP00000217043; ENSG00000101074.
GeneIDi140902.
KEGGihsa:140902.
UCSCiuc002xls.3. human.

Organism-specific databases

CTDi140902.
GeneCardsiR3HDML.
HGNCiHGNC:16249. R3HDML.
neXtProtiNX_Q9H3Y0.
PharmGKBiPA34099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiQ9H3Y0.
OMAiSNMCFSG.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ9H3Y0.
TreeFamiTF316148.

Miscellaneous databases

ChiTaRSiR3HDML. human.
GenomeRNAii140902.
PROiQ9H3Y0.

Gene expression databases

BgeeiQ9H3Y0.
CleanExiHS_R3HDML.
GenevisibleiQ9H3Y0. HS.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCRSPL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a R3H domain.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.