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Protein
Submitted name:

T200 leukocyte common antigen

Gene

PTPRC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. B cell differentiation Source: Ensembl
  3. B cell proliferation Source: Ensembl
  4. B cell receptor signaling pathway Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. heterotypic cell-cell adhesion Source: Ensembl
  7. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
  8. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  9. negative regulation of protein autophosphorylation Source: Ensembl
  10. negative regulation of T cell mediated cytotoxicity Source: Ensembl
  11. negative thymic T cell selection Source: Ensembl
  12. positive regulation of alpha-beta T cell proliferation Source: Ensembl
  13. positive regulation of antigen receptor-mediated signaling pathway Source: Ensembl
  14. positive regulation of B cell proliferation Source: Ensembl
  15. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  16. positive regulation of gamma-delta T cell differentiation Source: Ensembl
  17. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  18. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  19. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  20. positive thymic T cell selection Source: Ensembl
  21. protein dephosphorylation Source: Ensembl
  22. regulation of B cell differentiation Source: Ensembl
  23. regulation of B cell receptor signaling pathway Source: Ensembl
  24. regulation of cell cycle Source: Ensembl
  25. release of sequestered calcium ion into cytosol Source: Ensembl
  26. response to gamma radiation Source: Ensembl
  27. T cell proliferation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
T200 leukocyte common antigenImported
Gene namesi
Name:PTPRCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini32 – ›34›3T200 leukocyte common antigenImportedPRO_5000143176

Expressioni

Gene expression databases

BgeeiQ9H3X6.
ExpressionAtlasiQ9H3X6. baseline and differential.

Family & Domainsi

Family and domain databases

InterProiIPR024739. PTP_recept_N.
[Graphical view]
PfamiPF12453. PTP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9H3X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MYLWLKLLAF GFAFLDTEVF VTGQSPTPSP TGLT
Length:34
Mass (Da):3,749
Last modified:March 1, 2001 - v1
Checksum:i0C261F8943734758
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei34 – 341Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23463, M23461, M23462 Genomic DNA. Translation: AAG26082.1.
UniGeneiHs.654514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23463, M23461, M23462 Genomic DNA. Translation: AAG26082.1.
UniGeneiHs.654514.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiPTPRC. human.

Gene expression databases

BgeeiQ9H3X6.
ExpressionAtlasiQ9H3X6. baseline and differential.

Family and domain databases

InterProiIPR024739. PTP_recept_N.
[Graphical view]
PfamiPF12453. PTP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete exon-intron organization of the human leukocyte common antigen (CD45) gene."
    Hall L.R., Streuli M., Schlossman S.F., Saito H.
    J. Immunol. 141:2781-2787(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ9H3X6_HUMAN
AccessioniPrimary (citable) accession number: Q9H3X6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.