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Q9H3X6

- Q9H3X6_HUMAN

UniProt

Q9H3X6 - Q9H3X6_HUMAN

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Protein
Submitted name:

T200 leukocyte common antigen

Gene
PTPRC
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. B cell differentiation Source: Ensembl
  3. B cell proliferation Source: Ensembl
  4. B cell receptor signaling pathway Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. heterotypic cell-cell adhesion Source: Ensembl
  7. leukocyte cell-cell adhesion Source: Ensembl
  8. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
  9. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  10. negative regulation of protein autophosphorylation Source: Ensembl
  11. negative regulation of T cell mediated cytotoxicity Source: Ensembl
  12. negative thymic T cell selection Source: Ensembl
  13. positive regulation of alpha-beta T cell proliferation Source: Ensembl
  14. positive regulation of antigen receptor-mediated signaling pathway Source: Ensembl
  15. positive regulation of B cell proliferation Source: Ensembl
  16. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  17. positive regulation of gamma-delta T cell differentiation Source: Ensembl
  18. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  19. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  20. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  21. positive thymic T cell selection Source: Ensembl
  22. protein dephosphorylation Source: Ensembl
  23. regulation of B cell differentiation Source: Ensembl
  24. regulation of B cell receptor signaling pathway Source: Ensembl
  25. regulation of cell cycle Source: Ensembl
  26. release of sequestered calcium ion into cytosol Source: Ensembl
  27. response to gamma radiation Source: Ensembl
  28. T cell proliferation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
T200 leukocyte common antigenImported
Gene namesi
Name:PTPRCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini32 – ›34›3T200 leukocyte common antigenImportedPRO_5000143176

Expressioni

Gene expression databases

ArrayExpressiQ9H3X6.
BgeeiQ9H3X6.

Family & Domainsi

Family and domain databases

InterProiIPR024739. PTP_recept_N.
[Graphical view]
PfamiPF12453. PTP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9H3X6-1 [UniParc]FASTAAdd to Basket

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MYLWLKLLAF GFAFLDTEVF VTGQSPTPSP TGLT                    34
Length:34
Mass (Da):3,749
Last modified:March 1, 2001 - v1
Checksum:i0C261F8943734758
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei34 – 341Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23463, M23461, M23462 Genomic DNA. Translation: AAG26082.1.
UniGeneiHs.654514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23463 , M23461 , M23462 Genomic DNA. Translation: AAG26082.1 .
UniGenei Hs.654514.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi PTPRC. human.

Gene expression databases

ArrayExpressi Q9H3X6.
Bgeei Q9H3X6.

Family and domain databases

InterProi IPR024739. PTP_recept_N.
[Graphical view ]
Pfami PF12453. PTP_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete exon-intron organization of the human leukocyte common antigen (CD45) gene."
    Hall L.R., Streuli M., Schlossman S.F., Saito H.
    J. Immunol. 141:2781-2787(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ9H3X6_HUMAN
AccessioniPrimary (citable) accession number: Q9H3X6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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