Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat neuronal protein 3

Gene

LRRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 3
Alternative name(s):
Neuronal leucine-rich repeat protein 3
Short name:
NLRR-3
Gene namesi
Name:LRRN3
ORF Names:Nbla10363, UNQ194/PRO220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17200. LRRN3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 628606ExtracellularSequence analysisAdd
BLAST
Transmembranei629 – 64921HelicalSequence analysisAdd
BLAST
Topological domaini650 – 70859CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30468.

Polymorphism and mutation databases

BioMutaiLRRN3.
DMDMi74761421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 708686Leucine-rich repeat neuronal protein 3PRO_0000045823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi444 ↔ 496PROSITE-ProRule annotation
Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence analysis
Glycosylationi608 – 6081N-linked (GlcNAc...)Sequence analysis
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence analysis
Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H3W5.
PeptideAtlasiQ9H3W5.
PRIDEiQ9H3W5.

Expressioni

Gene expression databases

BgeeiQ9H3W5.
CleanExiHS_LRRN3.
ExpressionAtlasiQ9H3W5. baseline and differential.
GenevisibleiQ9H3W5. HS.

Organism-specific databases

HPAiHPA043820.
HPA046792.

Interactioni

Protein-protein interaction databases

BioGridi120095. 3 interactions.
STRINGi9606.ENSP00000312001.

Structurei

3D structure databases

ProteinModelPortaliQ9H3W5.
SMRiQ9H3W5. Positions 29-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 6947LRRNTAdd
BLAST
Repeati70 – 9122LRR 1Add
BLAST
Repeati93 – 11422LRR 2Add
BLAST
Repeati117 – 13822LRR 3Add
BLAST
Repeati141 – 16222LRR 4Add
BLAST
Repeati165 – 18622LRR 5Add
BLAST
Repeati189 – 21022LRR 6Add
BLAST
Repeati213 – 23422LRR 7Add
BLAST
Repeati237 – 25822LRR 8Add
BLAST
Repeati261 – 28222LRR 9Add
BLAST
Repeati285 – 30420LRR 10Add
BLAST
Repeati310 – 33223LRR 11Add
BLAST
Repeati335 – 35824LRR 12Add
BLAST
Domaini368 – 42154LRRCTAdd
BLAST
Domaini421 – 51494Ig-like C2-typeAdd
BLAST
Domaini523 – 61795Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
OMAiPQLCTCE.
OrthoDBiEOG7WDN1W.
PhylomeDBiQ9H3W5.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA
60 70 80 90 100
STVDCNDLGL LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS
110 120 130 140 150
QNNLSSVTNI NVKKMPQLLS VYLEENKLTE LPEKCLSELS NLQELYINHN
160 170 180 190 200
LLSTISPGAF IGLHNLLRLH LNSNRLQMIN SKWFDALPNL EILMIGENPI
210 220 230 240 250
IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES ISFYDNRLIK
260 270 280 290 300
VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
310 320 330 340 350
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY
360 370 380 390 400
HGTIESLPNL KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP
410 420 430 440 450
EFQGQNVRQV HFRDMMEICL PLIAPESFPS NLNVEAGSYV SFHCRATAEP
460 470 480 490 500
QPEIYWITPS GQKLLPNTLT DKFYVHSEGT LDINGVTPKE GGLYTCIATN
510 520 530 540 550
LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS WKASSKILKS
560 570 580 590 600
SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
610 620 630 640 650
KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS
660 670 680 690 700
PEMNCDGGHS YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV

IGLPTNMS
Length:708
Mass (Da):79,424
Last modified:March 1, 2001 - v1
Checksum:i24710478D6B124D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961G → S in AAH35133 (PubMed:15489334).Curated
Sequence conflicti533 – 5331Q → H in AAH35133 (PubMed:15489334).Curated
Sequence conflicti541 – 5411W → R in CAG33678 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241D → G.
Corresponds to variant rs9942557 [ dbSNP | Ensembl ].
VAR_049901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA. Translation: AAP97258.1.
AB060967 mRNA. Translation: BAB47184.1.
AY358280 mRNA. Translation: AAQ88647.1.
CR457397 mRNA. Translation: CAG33678.1.
AL442092 mRNA. Translation: CAC09450.1.
BC035133 mRNA. Translation: AAH35133.1.
CCDSiCCDS5754.1.
RefSeqiNP_001093128.1. NM_001099658.1.
NP_001093130.1. NM_001099660.1.
NP_060804.3. NM_018334.4.
UniGeneiHs.3781.

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114.
ENST00000422987; ENSP00000412417; ENSG00000173114.
ENST00000451085; ENSP00000397312; ENSG00000173114.
GeneIDi54674.
KEGGihsa:54674.
UCSCiuc003vfs.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA. Translation: AAP97258.1.
AB060967 mRNA. Translation: BAB47184.1.
AY358280 mRNA. Translation: AAQ88647.1.
CR457397 mRNA. Translation: CAG33678.1.
AL442092 mRNA. Translation: CAC09450.1.
BC035133 mRNA. Translation: AAH35133.1.
CCDSiCCDS5754.1.
RefSeqiNP_001093128.1. NM_001099658.1.
NP_001093130.1. NM_001099660.1.
NP_060804.3. NM_018334.4.
UniGeneiHs.3781.

3D structure databases

ProteinModelPortaliQ9H3W5.
SMRiQ9H3W5. Positions 29-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120095. 3 interactions.
STRINGi9606.ENSP00000312001.

Polymorphism and mutation databases

BioMutaiLRRN3.
DMDMi74761421.

Proteomic databases

PaxDbiQ9H3W5.
PeptideAtlasiQ9H3W5.
PRIDEiQ9H3W5.

Protocols and materials databases

DNASUi54674.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114.
ENST00000422987; ENSP00000412417; ENSG00000173114.
ENST00000451085; ENSP00000397312; ENSG00000173114.
GeneIDi54674.
KEGGihsa:54674.
UCSCiuc003vfs.5. human.

Organism-specific databases

CTDi54674.
GeneCardsiLRRN3.
HGNCiHGNC:17200. LRRN3.
HPAiHPA043820.
HPA046792.
neXtProtiNX_Q9H3W5.
PharmGKBiPA30468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
OMAiPQLCTCE.
OrthoDBiEOG7WDN1W.
PhylomeDBiQ9H3W5.
TreeFamiTF334360.

Miscellaneous databases

GeneWikiiLRRN3.
GenomeRNAii54674.
PROiQ9H3W5.

Gene expression databases

BgeeiQ9H3W5.
CleanExiHS_LRRN3.
ExpressionAtlasiQ9H3W5. baseline and differential.
GenevisibleiQ9H3W5. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new human cDNA homologous to Mus musculus leucine-rich repeat protein."
    Jin L., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human neuronal leucine-rich repeat protein-3 (NLRR-3)."
    Hamano S., Inuzuka H., Morohashi A., Ohira M., Nakagawara A.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLRRN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H3W5
Secondary accession number(s): O43377, Q6I9V8, Q8IYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.