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Protein

Leucine-rich repeat neuronal protein 3

Gene

LRRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 3
Alternative name(s):
Neuronal leucine-rich repeat protein 3
Short name:
NLRR-3
Gene namesi
Name:LRRN3
ORF Names:Nbla10363, UNQ194/PRO220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17200. LRRN3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 628ExtracellularSequence analysisAdd BLAST606
Transmembranei629 – 649HelicalSequence analysisAdd BLAST21
Topological domaini650 – 708CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54674.
OpenTargetsiENSG00000173114.
PharmGKBiPA30468.

Polymorphism and mutation databases

BioMutaiLRRN3.
DMDMi74761421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004582323 – 708Leucine-rich repeat neuronal protein 3Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi444 ↔ 496PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi579N-linked (GlcNAc...)Sequence analysis1
Glycosylationi608N-linked (GlcNAc...)Sequence analysis1
Glycosylationi624N-linked (GlcNAc...)Sequence analysis1
Glycosylationi625N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H3W5.
PaxDbiQ9H3W5.
PeptideAtlasiQ9H3W5.
PRIDEiQ9H3W5.

PTM databases

PhosphoSitePlusiQ9H3W5.

Expressioni

Gene expression databases

BgeeiENSG00000173114.
CleanExiHS_LRRN3.
ExpressionAtlasiQ9H3W5. baseline and differential.
GenevisibleiQ9H3W5. HS.

Organism-specific databases

HPAiHPA043820.
HPA046792.

Interactioni

Protein-protein interaction databases

BioGridi120095. 3 interactors.
STRINGi9606.ENSP00000312001.

Structurei

3D structure databases

ProteinModelPortaliQ9H3W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69LRRNTAdd BLAST47
Repeati70 – 91LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati189 – 210LRR 6Add BLAST22
Repeati213 – 234LRR 7Add BLAST22
Repeati237 – 258LRR 8Add BLAST22
Repeati261 – 282LRR 9Add BLAST22
Repeati285 – 304LRR 10Add BLAST20
Repeati310 – 332LRR 11Add BLAST23
Repeati335 – 358LRR 12Add BLAST24
Domaini368 – 421LRRCTAdd BLAST54
Domaini421 – 514Ig-like C2-typeAdd BLAST94
Domaini523 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
OMAiPQLCTCE.
OrthoDBiEOG091G066E.
PhylomeDBiQ9H3W5.
TreeFamiTF334360.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA
60 70 80 90 100
STVDCNDLGL LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS
110 120 130 140 150
QNNLSSVTNI NVKKMPQLLS VYLEENKLTE LPEKCLSELS NLQELYINHN
160 170 180 190 200
LLSTISPGAF IGLHNLLRLH LNSNRLQMIN SKWFDALPNL EILMIGENPI
210 220 230 240 250
IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES ISFYDNRLIK
260 270 280 290 300
VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
310 320 330 340 350
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY
360 370 380 390 400
HGTIESLPNL KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP
410 420 430 440 450
EFQGQNVRQV HFRDMMEICL PLIAPESFPS NLNVEAGSYV SFHCRATAEP
460 470 480 490 500
QPEIYWITPS GQKLLPNTLT DKFYVHSEGT LDINGVTPKE GGLYTCIATN
510 520 530 540 550
LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS WKASSKILKS
560 570 580 590 600
SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
610 620 630 640 650
KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS
660 670 680 690 700
PEMNCDGGHS YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV

IGLPTNMS
Length:708
Mass (Da):79,424
Last modified:March 1, 2001 - v1
Checksum:i24710478D6B124D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96G → S in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti533Q → H in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti541W → R in CAG33678 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04990124D → G.Corresponds to variant rs9942557dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA. Translation: AAP97258.1.
AB060967 mRNA. Translation: BAB47184.1.
AY358280 mRNA. Translation: AAQ88647.1.
CR457397 mRNA. Translation: CAG33678.1.
AL442092 mRNA. Translation: CAC09450.1.
BC035133 mRNA. Translation: AAH35133.1.
CCDSiCCDS5754.1.
RefSeqiNP_001093128.1. NM_001099658.1.
NP_001093130.1. NM_001099660.1.
NP_060804.3. NM_018334.4.
UniGeneiHs.3781.

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114.
ENST00000422987; ENSP00000412417; ENSG00000173114.
ENST00000451085; ENSP00000397312; ENSG00000173114.
GeneIDi54674.
KEGGihsa:54674.
UCSCiuc003vfs.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA. Translation: AAP97258.1.
AB060967 mRNA. Translation: BAB47184.1.
AY358280 mRNA. Translation: AAQ88647.1.
CR457397 mRNA. Translation: CAG33678.1.
AL442092 mRNA. Translation: CAC09450.1.
BC035133 mRNA. Translation: AAH35133.1.
CCDSiCCDS5754.1.
RefSeqiNP_001093128.1. NM_001099658.1.
NP_001093130.1. NM_001099660.1.
NP_060804.3. NM_018334.4.
UniGeneiHs.3781.

3D structure databases

ProteinModelPortaliQ9H3W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120095. 3 interactors.
STRINGi9606.ENSP00000312001.

PTM databases

PhosphoSitePlusiQ9H3W5.

Polymorphism and mutation databases

BioMutaiLRRN3.
DMDMi74761421.

Proteomic databases

MaxQBiQ9H3W5.
PaxDbiQ9H3W5.
PeptideAtlasiQ9H3W5.
PRIDEiQ9H3W5.

Protocols and materials databases

DNASUi54674.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114.
ENST00000422987; ENSP00000412417; ENSG00000173114.
ENST00000451085; ENSP00000397312; ENSG00000173114.
GeneIDi54674.
KEGGihsa:54674.
UCSCiuc003vfs.5. human.

Organism-specific databases

CTDi54674.
DisGeNETi54674.
GeneCardsiLRRN3.
HGNCiHGNC:17200. LRRN3.
HPAiHPA043820.
HPA046792.
neXtProtiNX_Q9H3W5.
OpenTargetsiENSG00000173114.
PharmGKBiPA30468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252914.
HOVERGENiHBG052361.
OMAiPQLCTCE.
OrthoDBiEOG091G066E.
PhylomeDBiQ9H3W5.
TreeFamiTF334360.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173114-MONOMER.

Miscellaneous databases

GeneWikiiLRRN3.
GenomeRNAii54674.
PROiQ9H3W5.

Gene expression databases

BgeeiENSG00000173114.
CleanExiHS_LRRN3.
ExpressionAtlasiQ9H3W5. baseline and differential.
GenevisibleiQ9H3W5. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H3W5
Secondary accession number(s): O43377, Q6I9V8, Q8IYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.