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Protein

Protein unc-45 homolog A

Gene

UNC45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).By similarityCurated2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140553-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
GCUNC-45
Smooth muscle cell-associated protein 1
Short name:
SMAP-1
Gene namesi
Name:UNC45A
Synonyms:SMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30594. UNC45A.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33K → E: Abolishes interaction with HSP90AB1; when associated with D-40. No effect on interaction with PGR. 1 Publication1
Mutagenesisi40A → D: Abolishes interaction with HSP90AB1; when associated with E-33. No effect on interaction with PGR. 1 Publication1
Mutagenesisi70K → E: Abolishes interaction with HSP90AB1; when associated with D-77. No effect on interaction with PGR. 1 Publication1
Mutagenesisi77A → D: Abolishes interaction with HSP90AB1; when associated with E-70. No effect on interaction with PGR. 1 Publication1

Organism-specific databases

DisGeNETi55898.
OpenTargetsiENSG00000140553.
PharmGKBiPA142670638.

Polymorphism and mutation databases

BioMutaiUNC45A.
DMDMi74761419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498881 – 944Protein unc-45 homolog AAdd BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineCombined sources1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei483N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H3U1.
MaxQBiQ9H3U1.
PaxDbiQ9H3U1.
PeptideAtlasiQ9H3U1.
PRIDEiQ9H3U1.

PTM databases

iPTMnetiQ9H3U1.
PhosphoSitePlusiQ9H3U1.
SwissPalmiQ9H3U1.

Expressioni

Tissue specificityi

Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.1 Publication

Gene expression databases

BgeeiENSG00000140553.
CleanExiHS_SMAP1.
HS_UNC45A.
GenevisibleiQ9H3U1. HS.

Organism-specific databases

HPAiHPA039228.

Interactioni

Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MARCH10Q8NA825EBI-1048763,EBI-2341554
MAXP612443EBI-1048763,EBI-751711
MAXP61244-23EBI-1048763,EBI-10218525
MEOX2A4D1275EBI-1048763,EBI-10172134
MID2Q9UJV3-23EBI-1048763,EBI-10172526

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120986. 80 interactors.
IntActiQ9H3U1. 56 interactors.
MINTiMINT-1186575.
STRINGi9606.ENSP00000407487.

Structurei

Secondary structure

1944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 32Combined sources12
Turni33 – 35Combined sources3
Helixi37 – 48Combined sources12
Helixi54 – 70Combined sources17
Helixi74 – 87Combined sources14
Helixi92 – 105Combined sources14
Helixi108 – 121Combined sources14
Helixi126 – 135Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBANMR-A1-135[»]
ProteinModelPortaliQ9H3U1.
SMRiQ9H3U1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H3U1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 54TPR 1Add BLAST34
Repeati58 – 91TPR 2Add BLAST34
Repeati92 – 125TPR 3Add BLAST34

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00860000133805.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ9H3U1.
OMAiTFPGERI.
OrthoDBiEOG091G02FM.
PhylomeDBiQ9H3U1.
TreeFamiTF314096.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3U1-1) [UniParc]FASTAAdd to basket
Also known as: 2, SMAP-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVSGPGTPE PRPATPGASS VEQLRKEGNE LFKCGDYGGA LAAYTQALGL
60 70 80 90 100
DATPQDQAVL HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLQRCVS LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPEEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDMGETD LMLAALRTLV GICSEHQSRT VATLSILGTR RVVSILGVES
260 270 280 290 300
QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLD
310 320 330 340 350
LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSLQDPPGE LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK
410 420 430 440 450
SWFEGQGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASEQ
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVS LLKDLYKCSE KDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDAAA LKALFQLSRL EERSVLFAVA SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMVC
660 670 680 690 700
MVKTESPVLT SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLNCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLQRAAAG GLAMLTSMRP
860 870 880 890 900
TLCSRIPQVT THWLEILQAL LLSSNQELQH RGAVVVLNMV EASREIASTL
910 920 930 940
MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN QDGE
Length:944
Mass (Da):103,077
Last modified:March 1, 2001 - v1
Checksum:i398707D0FF2A703D
GO
Isoform 2 (identifier: Q9H3U1-2) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTVSGPGTPEPRPATPG → MT

Show »
Length:929
Mass (Da):101,675
Checksum:iE5008C816362B094
GO
Isoform 3 (identifier: Q9H3U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-722: Missing.

Show »
Length:222
Mass (Da):24,689
Checksum:iF4A24767BC104FE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti921T → R in CAB93429 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052629796T → M.Corresponds to variant rs8041035dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205841 – 722Missing in isoform 3. 1 PublicationAdd BLAST722
Alternative sequenceiVSP_0205851 – 17MTVSG…PATPG → MT in isoform 2. 4 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014729 mRNA. Translation: BAB20266.1.
AB014736 mRNA. Translation: BAB20273.1.
AL357537 mRNA. Translation: CAB93428.1.
AL357538 mRNA. Translation: CAB93429.1.
AK291622 mRNA. Translation: BAF84311.1.
AK125721 mRNA. Translation: BAG54239.1.
CH471101 Genomic DNA. Translation: EAX02127.1.
BC006214 mRNA. Translation: AAH06214.1.
BC010995 mRNA. Translation: AAH10995.2.
BC037992 mRNA. Translation: AAH37992.1.
BC045635 mRNA. Translation: AAH45635.1.
CCDSiCCDS10367.1. [Q9H3U1-1]
CCDS42082.1. [Q9H3U1-2]
RefSeqiNP_001034764.1. NM_001039675.1. [Q9H3U1-2]
NP_001310548.1. NM_001323619.1. [Q9H3U1-1]
NP_001310550.1. NM_001323621.1. [Q9H3U1-2]
NP_061141.2. NM_018671.4. [Q9H3U1-1]
XP_011520081.1. XM_011521779.2. [Q9H3U1-1]
UniGeneiHs.389461.

Genome annotation databases

EnsembliENST00000394275; ENSP00000377816; ENSG00000140553. [Q9H3U1-2]
ENST00000418476; ENSP00000407487; ENSG00000140553. [Q9H3U1-1]
GeneIDi55898.
KEGGihsa:55898.
UCSCiuc002bqd.3. human. [Q9H3U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014729 mRNA. Translation: BAB20266.1.
AB014736 mRNA. Translation: BAB20273.1.
AL357537 mRNA. Translation: CAB93428.1.
AL357538 mRNA. Translation: CAB93429.1.
AK291622 mRNA. Translation: BAF84311.1.
AK125721 mRNA. Translation: BAG54239.1.
CH471101 Genomic DNA. Translation: EAX02127.1.
BC006214 mRNA. Translation: AAH06214.1.
BC010995 mRNA. Translation: AAH10995.2.
BC037992 mRNA. Translation: AAH37992.1.
BC045635 mRNA. Translation: AAH45635.1.
CCDSiCCDS10367.1. [Q9H3U1-1]
CCDS42082.1. [Q9H3U1-2]
RefSeqiNP_001034764.1. NM_001039675.1. [Q9H3U1-2]
NP_001310548.1. NM_001323619.1. [Q9H3U1-1]
NP_001310550.1. NM_001323621.1. [Q9H3U1-2]
NP_061141.2. NM_018671.4. [Q9H3U1-1]
XP_011520081.1. XM_011521779.2. [Q9H3U1-1]
UniGeneiHs.389461.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBANMR-A1-135[»]
ProteinModelPortaliQ9H3U1.
SMRiQ9H3U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120986. 80 interactors.
IntActiQ9H3U1. 56 interactors.
MINTiMINT-1186575.
STRINGi9606.ENSP00000407487.

PTM databases

iPTMnetiQ9H3U1.
PhosphoSitePlusiQ9H3U1.
SwissPalmiQ9H3U1.

Polymorphism and mutation databases

BioMutaiUNC45A.
DMDMi74761419.

Proteomic databases

EPDiQ9H3U1.
MaxQBiQ9H3U1.
PaxDbiQ9H3U1.
PeptideAtlasiQ9H3U1.
PRIDEiQ9H3U1.

Protocols and materials databases

DNASUi55898.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394275; ENSP00000377816; ENSG00000140553. [Q9H3U1-2]
ENST00000418476; ENSP00000407487; ENSG00000140553. [Q9H3U1-1]
GeneIDi55898.
KEGGihsa:55898.
UCSCiuc002bqd.3. human. [Q9H3U1-1]

Organism-specific databases

CTDi55898.
DisGeNETi55898.
GeneCardsiUNC45A.
HGNCiHGNC:30594. UNC45A.
HPAiHPA039228.
MIMi611219. gene.
neXtProtiNX_Q9H3U1.
OpenTargetsiENSG00000140553.
PharmGKBiPA142670638.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00860000133805.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ9H3U1.
OMAiTFPGERI.
OrthoDBiEOG091G02FM.
PhylomeDBiQ9H3U1.
TreeFamiTF314096.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140553-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9H3U1.
GeneWikiiUNC45A.
GenomeRNAii55898.
PROiQ9H3U1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140553.
CleanExiHS_SMAP1.
HS_UNC45A.
GenevisibleiQ9H3U1. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUN45A_HUMAN
AccessioniPrimary (citable) accession number: Q9H3U1
Secondary accession number(s): A8K6F7
, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.