Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semaphorin-6B

Gene

SEMA6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in both peripheral and central nervous system development.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-6B
Alternative name(s):
Semaphorin-Z
Short name:
Sema Z
Gene namesi
Name:SEMA6B
Synonyms:SEMAN, SEMAZ
ORF Names:UNQ1907/PRO4353
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10739. SEMA6B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 603ExtracellularSequence analysisAdd BLAST578
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 888CytoplasmicSequence analysisAdd BLAST264

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10501.
OpenTargetsiENSG00000167680.
PharmGKBiPA35661.

Polymorphism and mutation databases

BioMutaiSEMA6B.
DMDMi116242786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000003234126 – 888Semaphorin-6BAdd BLAST863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 126PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi267 ↔ 378PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi292 ↔ 337PROSITE-ProRule annotation
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi462N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi486 ↔ 517PROSITE-ProRule annotation
Disulfide bondi526 ↔ 544PROSITE-ProRule annotation
Disulfide bondi532 ↔ 578PROSITE-ProRule annotation
Disulfide bondi536 ↔ 552PROSITE-ProRule annotation
Modified residuei665Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

EPDiQ9H3T3.
MaxQBiQ9H3T3.
PaxDbiQ9H3T3.
PeptideAtlasiQ9H3T3.
PRIDEiQ9H3T3.

PTM databases

iPTMnetiQ9H3T3.
PhosphoSitePlusiQ9H3T3.

Expressioni

Gene expression databases

BgeeiENSG00000167680.
CleanExiHS_SEMA6B.
GenevisibleiQ9H3T3. HS.

Organism-specific databases

HPAiCAB025157.
HPA055778.
HPA058523.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-5005626.
STRINGi9606.ENSP00000301293.

Structurei

3D structure databases

ProteinModelPortaliQ9H3T3.
SMRiQ9H3T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 523SemaPROSITE-ProRule annotationAdd BLAST493

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi661 – 674Poly-GlyAdd BLAST14
Compositional biasi750 – 753Poly-Leu4

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
InParanoidiQ9H3T3.
KOiK06842.
OMAiFLIMPNQ.
OrthoDBiEOG091G014B.
PhylomeDBiQ9H3T3.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 2 hits.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTPRASPPR PALLLLLLLL GGAHGLFPEE PPPLSVAPRD YLNHYPVFVG
60 70 80 90 100
SGPGRLTPAE GADDLNIQRV LRVNRTLFIG DRDNLYRVEL EPPTSTELRY
110 120 130 140 150
QRKLTWRSNP SDINVCRMKG KQEGECRNFV KVLLLRDEST LFVCGSNAFN
160 170 180 190 200
PVCANYSIDT LQPVGDNISG MARCPYDPKH ANVALFSDGM LFTATVTDFL
210 220 230 240 250
AIDAVIYRSL GDRPTLRTVK HDSKWFKEPY FVHAVEWGSH VYFFFREIAM
260 270 280 290 300
EFNYLEKVVV SRVARVCKND VGGSPRVLEK QWTSFLKARL NCSVPGDSHF
310 320 330 340 350
YFNVLQAVTG VVSLGGRPVV LAVFSTPSNS IPGSAVCAFD LTQVAAVFEG
360 370 380 390 400
RFREQKSPES IWTPVPEDQV PRPRPGCCAA PGMQYNASSA LPDDILNFVK
410 420 430 440 450
THPLMDEAVP SLGHAPWILR TLMRHQLTRV AVDVGAGPWG NQTVVFLGSE
460 470 480 490 500
AGTVLKFLVR PNASTSGTSG LSVFLEEFET YRPDRCGRPG GGETGQRLLS
510 520 530 540 550
LELDAASGGL LAAFPRCVVR VPVARCQQYS GCMKNCIGSQ DPYCGWAPDG
560 570 580 590 600
SCIFLSPGTR AAFEQDVSGA STSGLGDCTG LLRASLSEDR AGLVSVNLLV
610 620 630 640 650
TSSVAAFVVG AVVSGFSVGW FVGLRERREL ARRKDKEAIL AHGAGEAVLS
660 670 680 690 700
VSRLGERRAQ GPGGRGGGGG GGAGVPPEAL LAPLMQNGWA KATLLQGGPH
710 720 730 740 750
DLDSGLLPTP EQTPLPQKRL PTPHPHPHAL GPRAWDHGHP LLPASASSSL
760 770 780 790 800
LLLAPARAPE QPPAPGEPTP DGRLYAARPG RASHGDFPLT PHASPDRRRV
810 820 830 840 850
VSAPTGPLDP ASAADGLPRP WSPPPTGSLR RPLGPHAPPA ATLRRTHTFN
860 870 880
SGEARPGDRH RGCHARPGTD LAHLLPYGGA DRTAPPVP
Length:888
Mass (Da):95,285
Last modified:October 17, 2006 - v4
Checksum:iEF34843A4A7A4E1C
GO
Isoform 2 (identifier: Q9H3T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-677: WFVGLRERRE...GGGGGAGVPP → VCVRASEGCC...RGSPRCRLGV
     678-888: Missing.

Show »
Length:677
Mass (Da):73,952
Checksum:i99B68C53C88E80C2
GO

Sequence cautioni

The sequence AAF87661 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30E → D in BAB20669 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047625620 – 677WFVGL…AGVPP → VCVRASEGCCGRVCQVGHAC RVCVHERRSWWPQRPGRWLS RRWGFQKARGSPRCRLGV in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_047626678 – 888Missing in isoform 2. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022433 mRNA. Translation: BAB20669.1.
AF216389 mRNA. Translation: AAF87661.1. Sequence problems.
FR839673 mRNA. Translation: CCA61013.1.
AY358939 mRNA. Translation: AAQ89298.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69208.1.
BC142617 mRNA. Translation: AAI42618.1.
CCDSiCCDS12131.1. [Q9H3T3-1]
RefSeqiNP_115484.2. NM_032108.3. [Q9H3T3-1]
UniGeneiHs.465642.

Genome annotation databases

EnsembliENST00000586582; ENSP00000467290; ENSG00000167680. [Q9H3T3-1]
ENST00000586965; ENSP00000465722; ENSG00000167680. [Q9H3T3-3]
GeneIDi10501.
KEGGihsa:10501.
UCSCiuc010dud.3. human. [Q9H3T3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022433 mRNA. Translation: BAB20669.1.
AF216389 mRNA. Translation: AAF87661.1. Sequence problems.
FR839673 mRNA. Translation: CCA61013.1.
AY358939 mRNA. Translation: AAQ89298.1.
AC011498 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69208.1.
BC142617 mRNA. Translation: AAI42618.1.
CCDSiCCDS12131.1. [Q9H3T3-1]
RefSeqiNP_115484.2. NM_032108.3. [Q9H3T3-1]
UniGeneiHs.465642.

3D structure databases

ProteinModelPortaliQ9H3T3.
SMRiQ9H3T3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5005626.
STRINGi9606.ENSP00000301293.

PTM databases

iPTMnetiQ9H3T3.
PhosphoSitePlusiQ9H3T3.

Polymorphism and mutation databases

BioMutaiSEMA6B.
DMDMi116242786.

Proteomic databases

EPDiQ9H3T3.
MaxQBiQ9H3T3.
PaxDbiQ9H3T3.
PeptideAtlasiQ9H3T3.
PRIDEiQ9H3T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586582; ENSP00000467290; ENSG00000167680. [Q9H3T3-1]
ENST00000586965; ENSP00000465722; ENSG00000167680. [Q9H3T3-3]
GeneIDi10501.
KEGGihsa:10501.
UCSCiuc010dud.3. human. [Q9H3T3-1]

Organism-specific databases

CTDi10501.
DisGeNETi10501.
GeneCardsiSEMA6B.
HGNCiHGNC:10739. SEMA6B.
HPAiCAB025157.
HPA055778.
HPA058523.
MIMi608873. gene.
neXtProtiNX_Q9H3T3.
OpenTargetsiENSG00000167680.
PharmGKBiPA35661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
InParanoidiQ9H3T3.
KOiK06842.
OMAiFLIMPNQ.
OrthoDBiEOG091G014B.
PhylomeDBiQ9H3T3.
TreeFamiTF316102.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167680-MONOMER.

Miscellaneous databases

GenomeRNAii10501.
PROiQ9H3T3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167680.
CleanExiHS_SEMA6B.
GenevisibleiQ9H3T3. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 2 hits.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM6B_HUMAN
AccessioniPrimary (citable) accession number: Q9H3T3
Secondary accession number(s): A5PKU4, F6IB19, Q9NRK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.