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Protein

Transmembrane protease serine 5

Gene

TMPRSS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hearing.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei258Charge relay systemBy similarity1
Active sitei308Charge relay systemBy similarity1
Active sitei405Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: UniProtKB
  • scavenger receptor activity Source: InterPro
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166682-MONOMER.

Protein family/group databases

MEROPSiS01.313.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 5 (EC:3.4.21.-)
Alternative name(s):
Spinesin
Gene namesi
Name:TMPRSS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14908. TMPRSS5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 457ExtracellularSequence analysisAdd BLAST387

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in TMPRSS5 may be a cause of deafness.

Organism-specific databases

OpenTargetsiENSG00000166682.
PharmGKBiPA37920.

Polymorphism and mutation databases

BioMutaiTMPRSS5.
DMDMi296452845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000886941 – 457Transmembrane protease serine 5Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi135 ↔ 196PROSITE-ProRule annotation
Disulfide bondi148 ↔ 206PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi209 ↔ 328PROSITE-ProRule annotation
Disulfide bondi243 ↔ 259PROSITE-ProRule annotation
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi342 ↔ 411PROSITE-ProRule annotation
Disulfide bondi374 ↔ 390PROSITE-ProRule annotation
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi401 ↔ 429PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei217 – 218CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H3S3.
PeptideAtlasiQ9H3S3.
PRIDEiQ9H3S3.

PTM databases

PhosphoSitePlusiQ9H3S3.

Expressioni

Tissue specificityi

Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord.

Gene expression databases

BgeeiENSG00000166682.
CleanExiHS_TMPRSS5.
ExpressionAtlasiQ9H3S3. baseline and differential.
GenevisibleiQ9H3S3. HS.

Organism-specific databases

HPAiHPA010992.

Interactioni

Protein-protein interaction databases

BioGridi123345. 7 interactors.
IntActiQ9H3S3. 1 interactor.
STRINGi9606.ENSP00000299882.

Structurei

3D structure databases

ProteinModelPortaliQ9H3S3.
SMRiQ9H3S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 207SRCRAdd BLAST96
Domaini218 – 453Peptidase S1PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251822.
HOVERGENiHBG013304.
InParanoidiQ9H3S3.
KOiK09636.
OMAiGSRHTCG.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9H3S3.
TreeFamiTF351678.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H3S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMLDDQPP MEAQYAEEGP GPGIFRAEPG DQQHPISQAV CWRSMRRGCA
60 70 80 90 100
VLGALGLLAG AGVGSWLLVL YLCPAASQPI SGTLQDEEIT LSCSEASAEE
110 120 130 140 150
ALLPALPKTV SFRINSEDFL LEAQVRDQPR WLLVCHEGWS PALGLQICWS
160 170 180 190 200
LGHLRLTHHK GVNLTDIKLN SSQEFAQLSP RLGGFLEEAW QPRNNCTSGQ
210 220 230 240 250
VVSLRCSECG ARPLASRIVG GQSVAPGRWP WQASVALGFR HTCGGSVLAP
260 270 280 290 300
RWVVTAAHCM HSFRLARLSS WRVHAGLVSH SAVRPHQGAL VERIIPHPLY
310 320 330 340 350
SAQNHDYDVA LLRLQTALNF SDTVGAVCLP AKEQHFPKGS RCWVSGWGHT
360 370 380 390 400
HPSHTYSSDM LQDTVVPLFS TQLCNSSCVY SGALTPRMLC AGYLDGRADA
410 420 430 440 450
CQGDSGGPLV CPDGDTWRLV GVVSWGRGCA EPNHPGVYAK VAEFLDWIHD

TAQDSLL
Length:457
Mass (Da):49,560
Last modified:May 18, 2010 - v2
Checksum:i64406AB4985C4637
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428G → A in BAB20375 (PubMed:11741986).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03800531D → V in patients with sporadic hearing loss. 1 Publication1
Natural variantiVAR_03800646R → Q.1 PublicationCorresponds to variant rs11601425dbSNPEnsembl.1
Natural variantiVAR_038007125V → M.Corresponds to variant rs7939917dbSNPEnsembl.1
Natural variantiVAR_038008249A → V.1 Publication1
Natural variantiVAR_038009317A → S in patients with sporadic hearing loss; no detectable proteolytic activity in a yeast-based protease assay. 1 Publication1
Natural variantiVAR_038010337P → S.1 Publication1
Natural variantiVAR_038011369F → L Common polymorphism; reduced proteolytic activity in a yeast-based protease assay. 1 PublicationCorresponds to variant rs7110736dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028140 mRNA. Translation: BAB20375.1.
AP002436 Genomic DNA. No translation available.
AP003402 Genomic DNA. No translation available.
CCDSiCCDS44735.1.
RefSeqiNP_001275678.1. NM_001288749.1.
NP_001275679.1. NM_001288750.1.
NP_001275680.1. NM_001288751.1.
NP_001275681.1. NM_001288752.1.
NP_110397.2. NM_030770.3.
UniGeneiHs.46720.

Genome annotation databases

EnsembliENST00000299882; ENSP00000299882; ENSG00000166682.
GeneIDi80975.
KEGGihsa:80975.
UCSCiuc001poc.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028140 mRNA. Translation: BAB20375.1.
AP002436 Genomic DNA. No translation available.
AP003402 Genomic DNA. No translation available.
CCDSiCCDS44735.1.
RefSeqiNP_001275678.1. NM_001288749.1.
NP_001275679.1. NM_001288750.1.
NP_001275680.1. NM_001288751.1.
NP_001275681.1. NM_001288752.1.
NP_110397.2. NM_030770.3.
UniGeneiHs.46720.

3D structure databases

ProteinModelPortaliQ9H3S3.
SMRiQ9H3S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123345. 7 interactors.
IntActiQ9H3S3. 1 interactor.
STRINGi9606.ENSP00000299882.

Protein family/group databases

MEROPSiS01.313.

PTM databases

PhosphoSitePlusiQ9H3S3.

Polymorphism and mutation databases

BioMutaiTMPRSS5.
DMDMi296452845.

Proteomic databases

PaxDbiQ9H3S3.
PeptideAtlasiQ9H3S3.
PRIDEiQ9H3S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299882; ENSP00000299882; ENSG00000166682.
GeneIDi80975.
KEGGihsa:80975.
UCSCiuc001poc.6. human.

Organism-specific databases

CTDi80975.
GeneCardsiTMPRSS5.
H-InvDBHIX0035816.
HGNCiHGNC:14908. TMPRSS5.
HPAiHPA010992.
MIMi606751. gene.
neXtProtiNX_Q9H3S3.
OpenTargetsiENSG00000166682.
PharmGKBiPA37920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251822.
HOVERGENiHBG013304.
InParanoidiQ9H3S3.
KOiK09636.
OMAiGSRHTCG.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9H3S3.
TreeFamiTF351678.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166682-MONOMER.

Miscellaneous databases

GenomeRNAii80975.
PROiQ9H3S3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166682.
CleanExiHS_TMPRSS5.
ExpressionAtlasiQ9H3S3. baseline and differential.
GenevisibleiQ9H3S3. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMPS5_HUMAN
AccessioniPrimary (citable) accession number: Q9H3S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.