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Q9H3S1

- SEM4A_HUMAN

UniProt

Q9H3S1 - SEM4A_HUMAN

Protein

Semaphorin-4A

Gene

SEMA4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. axon guidance Source: Reactome
    3. negative regulation of angiogenesis Source: Ensembl
    4. regulation of cell shape Source: Ensembl
    5. regulation of endothelial cell migration Source: Ensembl
    6. semaphorin-plexin signaling pathway Source: Ensembl
    7. T-helper 1 cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Adaptive immunity, Angiogenesis, Differentiation, Immunity, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_19200. Other semaphorin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-4A
    Alternative name(s):
    Semaphorin-B
    Short name:
    Sema B
    Gene namesi
    Name:SEMA4A
    Synonyms:SEMAB, SEMB
    ORF Names:UNQ783/PRO1317
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10729. SEMA4A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Retinitis pigmentosa 35 (RP35) [MIM:610282]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti345 – 3451D → H in RP35 and CORD10; heterozygous compound with C-350. 1 Publication
    VAR_028322
    Natural varianti350 – 3501F → C in RP35 and CORD10; heterozygous compound with H-345. 1 Publication
    VAR_028323
    Natural varianti713 – 7131R → Q in RP35; also in a patient with congenital blindness. 1 Publication
    Corresponds to variant rs41265017 [ dbSNP | Ensembl ].
    VAR_028325
    Cone-rod dystrophy 10 (CORD10) [MIM:610283]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti345 – 3451D → H in RP35 and CORD10; heterozygous compound with C-350. 1 Publication
    VAR_028322
    Natural varianti350 – 3501F → C in RP35 and CORD10; heterozygous compound with H-345. 1 Publication
    VAR_028323

    Keywords - Diseasei

    Cone-rod dystrophy, Disease mutation, Retinitis pigmentosa

    Organism-specific databases

    MIMi610282. phenotype.
    610283. phenotype.
    Orphaneti1872. Cone rod dystrophy.
    791. Retinitis pigmentosa.
    PharmGKBiPA35651.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 761729Semaphorin-4APRO_0000032322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi113 ↔ 124PROSITE-ProRule annotation
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 151PROSITE-ProRule annotation
    Disulfide bondi269 ↔ 379PROSITE-ProRule annotation
    Disulfide bondi293 ↔ 339PROSITE-ProRule annotation
    Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi497 ↔ 514PROSITE-ProRule annotation
    Disulfide bondi506 ↔ 523PROSITE-ProRule annotation
    Disulfide bondi580 ↔ 624PROSITE-ProRule annotation
    Glycosylationi607 – 6071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9H3S1.
    PaxDbiQ9H3S1.
    PRIDEiQ9H3S1.

    PTM databases

    PhosphoSiteiQ9H3S1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H3S1.
    BgeeiQ9H3S1.
    CleanExiHS_SEMA4A.
    GenevestigatoriQ9H3S1.

    Interactioni

    Subunit structurei

    Interacts with PLXNB1, PLXNB2, PLXNB3 and PLXND1. Probable ligand for TIMD2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLXND1Q9Y4D72EBI-3924922,EBI-310731

    Protein-protein interaction databases

    BioGridi122108. 1 interaction.
    IntActiQ9H3S1. 5 interactions.
    MINTiMINT-4507832.
    STRINGi9606.ENSP00000347117.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3S1.
    SMRiQ9H3S1. Positions 37-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 683651ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini705 – 76157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei684 – 70421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 494459SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 54853PSIAdd
    BLAST
    Domaini573 – 63159Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287504.
    HOGENOMiHOG000116087.
    HOVERGENiHBG061165.
    InParanoidiQ9H3S1.
    KOiK06521.
    OMAiFAFSPAC.
    OrthoDBiEOG7H791Q.
    PhylomeDBiQ9H3S1.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H3S1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALPALGLDP WSLLGLFLFQ LLQLLLPTTT AGGGGQGPMP RVRYYAGDER    50
    RALSFFHQKG LQDFDTLLLS GDGNTLYVGA REAILALDIQ DPGVPRLKNM 100
    IPWPASDRKK SECAFKKKSN ETQCFNFIRV LVSYNVTHLY TCGTFAFSPA 150
    CTFIELQDSY LLPISEDKVM EGKGQSPFDP AHKHTAVLVD GMLYSGTMNN 200
    FLGSEPILMR TLGSQPVLKT DNFLRWLHHD ASFVAAIPST QVVYFFFEET 250
    ASEFDFFERL HTSRVARVCK NDVGGEKLLQ KKWTTFLKAQ LLCTQPGQLP 300
    FNVIRHAVLL PADSPTAPHI YAVFTSQWQV GGTRSSAVCA FSLLDIERVF 350
    KGKYKELNKE TSRWTTYRGP ETNPRPGSCS VGPSSDKALT FMKDHFLMDE 400
    QVVGTPLLVK SGVEYTRLAV ETAQGLDGHS HLVMYLGTTT GSLHKAVVSG 450
    DSSAHLVEEI QLFPDPEPVR NLQLAPTQGA VFVGFSGGVW RVPRANCSVY 500
    ESCVDCVLAR DPHCAWDPES RTCCLLSAPN LNSWKQDMER GNPEWACASG 550
    PMSRSLRPQS RPQIIKEVLA VPNSILELPC PHLSALASYY WSHGPAAVPE 600
    ASSTVYNGSL LLIVQDGVGG LYQCWATENG FSYPVISYWV DSQDQTLALD 650
    PELAGIPREH VKVPLTRVSG GAALAAQQSY WPHFVTVTVL FALVLSGALI 700
    ILVASPLRAL RARGKVQGCE TLRPGEKAPL SREQHLQSPK ECRTSASDVD 750
    ADNNCLGTEV A 761
    Length:761
    Mass (Da):83,574
    Last modified:April 11, 2003 - v2
    Checksum:i5BCB889AA32A2BB3
    GO
    Isoform 2 (identifier: Q9H3S1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-99: Missing.
         122-154: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:629
    Mass (Da):69,104
    Checksum:i3B97BA202D33502B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 32836CTQPG…FTSQW → SAPSRGSCPSTSSATRSCSP PILPQLPTSTQSSPPSG1 PublicationCuratedAdd
    BLAST
    Sequence conflicti354 – 3541Y → F in BAB20087. 1 PublicationCurated
    Sequence conflicti641 – 6411D → G in BAG52288. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti345 – 3451D → H in RP35 and CORD10; heterozygous compound with C-350. 1 Publication
    VAR_028322
    Natural varianti350 – 3501F → C in RP35 and CORD10; heterozygous compound with H-345. 1 Publication
    VAR_028323
    Natural varianti510 – 5101R → Q.
    Corresponds to variant rs2075164 [ dbSNP | Ensembl ].
    VAR_028324
    Natural varianti713 – 7131R → Q in RP35; also in a patient with congenital blindness. 1 Publication
    Corresponds to variant rs41265017 [ dbSNP | Ensembl ].
    VAR_028325

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9999Missing in isoform 2. 1 PublicationVSP_046381Add
    BLAST
    Alternative sequencei122 – 15433Missing in isoform 2. 1 PublicationVSP_046382Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029394 mRNA. Translation: BAB20087.1.
    AY358531 mRNA. Translation: AAQ88895.1.
    AK091127 mRNA. Translation: BAG52288.1.
    AK315547 mRNA. Translation: BAG37925.1.
    AL135927 Genomic DNA. Translation: CAI15530.1.
    AL135927 Genomic DNA. Translation: CAI15533.1.
    BC020974 mRNA. Translation: AAH20974.1.
    CCDSiCCDS1132.1. [Q9H3S1-1]
    CCDS53378.1. [Q9H3S1-2]
    RefSeqiNP_001180229.1. NM_001193300.1. [Q9H3S1-1]
    NP_001180230.1. NM_001193301.1. [Q9H3S1-1]
    NP_001180231.1. NM_001193302.1. [Q9H3S1-2]
    NP_071762.2. NM_022367.3. [Q9H3S1-1]
    UniGeneiHs.408846.

    Genome annotation databases

    EnsembliENST00000355014; ENSP00000347117; ENSG00000196189. [Q9H3S1-1]
    ENST00000368282; ENSP00000357265; ENSG00000196189. [Q9H3S1-1]
    ENST00000368284; ENSP00000357267; ENSG00000196189. [Q9H3S1-2]
    ENST00000368285; ENSP00000357268; ENSG00000196189. [Q9H3S1-1]
    ENST00000368286; ENSP00000357269; ENSG00000196189. [Q9H3S1-2]
    GeneIDi64218.
    KEGGihsa:64218.
    UCSCiuc001fnl.3. human. [Q9H3S1-1]
    uc001fnn.3. human.

    Polymorphism databases

    DMDMi29840871.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029394 mRNA. Translation: BAB20087.1 .
    AY358531 mRNA. Translation: AAQ88895.1 .
    AK091127 mRNA. Translation: BAG52288.1 .
    AK315547 mRNA. Translation: BAG37925.1 .
    AL135927 Genomic DNA. Translation: CAI15530.1 .
    AL135927 Genomic DNA. Translation: CAI15533.1 .
    BC020974 mRNA. Translation: AAH20974.1 .
    CCDSi CCDS1132.1. [Q9H3S1-1 ]
    CCDS53378.1. [Q9H3S1-2 ]
    RefSeqi NP_001180229.1. NM_001193300.1. [Q9H3S1-1 ]
    NP_001180230.1. NM_001193301.1. [Q9H3S1-1 ]
    NP_001180231.1. NM_001193302.1. [Q9H3S1-2 ]
    NP_071762.2. NM_022367.3. [Q9H3S1-1 ]
    UniGenei Hs.408846.

    3D structure databases

    ProteinModelPortali Q9H3S1.
    SMRi Q9H3S1. Positions 37-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122108. 1 interaction.
    IntActi Q9H3S1. 5 interactions.
    MINTi MINT-4507832.
    STRINGi 9606.ENSP00000347117.

    PTM databases

    PhosphoSitei Q9H3S1.

    Polymorphism databases

    DMDMi 29840871.

    Proteomic databases

    MaxQBi Q9H3S1.
    PaxDbi Q9H3S1.
    PRIDEi Q9H3S1.

    Protocols and materials databases

    DNASUi 64218.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355014 ; ENSP00000347117 ; ENSG00000196189 . [Q9H3S1-1 ]
    ENST00000368282 ; ENSP00000357265 ; ENSG00000196189 . [Q9H3S1-1 ]
    ENST00000368284 ; ENSP00000357267 ; ENSG00000196189 . [Q9H3S1-2 ]
    ENST00000368285 ; ENSP00000357268 ; ENSG00000196189 . [Q9H3S1-1 ]
    ENST00000368286 ; ENSP00000357269 ; ENSG00000196189 . [Q9H3S1-2 ]
    GeneIDi 64218.
    KEGGi hsa:64218.
    UCSCi uc001fnl.3. human. [Q9H3S1-1 ]
    uc001fnn.3. human.

    Organism-specific databases

    CTDi 64218.
    GeneCardsi GC01P156119.
    GeneReviewsi SEMA4A.
    HGNCi HGNC:10729. SEMA4A.
    MIMi 607292. gene.
    610282. phenotype.
    610283. phenotype.
    neXtProti NX_Q9H3S1.
    Orphaneti 1872. Cone rod dystrophy.
    791. Retinitis pigmentosa.
    PharmGKBi PA35651.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287504.
    HOGENOMi HOG000116087.
    HOVERGENi HBG061165.
    InParanoidi Q9H3S1.
    KOi K06521.
    OMAi FAFSPAC.
    OrthoDBi EOG7H791Q.
    PhylomeDBi Q9H3S1.
    TreeFami TF316102.

    Enzyme and pathway databases

    Reactomei REACT_19200. Other semaphorin interactions.

    Miscellaneous databases

    GeneWikii SEMA4A.
    GenomeRNAii 64218.
    NextBioi 66131.
    PROi Q9H3S1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H3S1.
    Bgeei Q9H3S1.
    CleanExi HS_SEMA4A.
    Genevestigatori Q9H3S1.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human semaphorin B."
      Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Tongue.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    6. "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases."
      Abid A., Ismail M., Mehdi S.Q., Khaliq S.
      J. Med. Genet. 43:378-381(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS RP35 HIS-345; CYS-350 AND GLN-713, VARIANTS CORD10 HIS-345 AND CYS-350.

    Entry informationi

    Entry nameiSEM4A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3S1
    Secondary accession number(s): B2RDH8
    , B3KR76, Q5TCI5, Q5TCJ6, Q8WUA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3