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Q9H3R5

- CENPH_HUMAN

UniProt

Q9H3R5 - CENPH_HUMAN

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Protein

Centromere protein H

Gene
CENPH, ICEN35
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.3 Publications

GO - Molecular functioni

  1. kinetochore binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. centromere-specific nucleosome assembly Source: Reactome
  2. kinetochore assembly Source: InterPro
  3. kinetochore organization Source: UniProtKB
  4. mitotic cell cycle Source: Reactome
  5. nucleosome assembly Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein H
Short name:
CENP-H
Alternative name(s):
Interphase centromere complex protein 35
Gene namesi
Name:CENPH
Synonyms:ICEN35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17268. CENPH.

Subcellular locationi

Nucleus. Chromosomecentromerekinetochore
Note: Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.3 Publications

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. kinetochore Source: UniProtKB
  4. nucleoplasm Source: Reactome
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Centromere protein HPRO_0000089478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H3R5.
PaxDbiQ9H3R5.
PRIDEiQ9H3R5.

PTM databases

PhosphoSiteiQ9H3R5.

Expressioni

Gene expression databases

ArrayExpressiQ9H3R5.
BgeeiQ9H3R5.
CleanExiHS_CENPH.
GenevestigatoriQ9H3R5.

Organism-specific databases

HPAiHPA036494.

Interactioni

Subunit structurei

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 By similarity.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NDC80O147773EBI-1003700,EBI-715849

Protein-protein interaction databases

BioGridi122355. 17 interactions.
IntActiQ9H3R5. 1 interaction.
MINTiMINT-4988967.
STRINGi9606.ENSP00000283006.

Structurei

3D structure databases

ProteinModelPortaliQ9H3R5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 192146 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG10470.
HOGENOMiHOG000013068.
HOVERGENiHBG081083.
InParanoidiQ9H3R5.
KOiK11500.
OMAiQMEIKIT.
OrthoDBiEOG7JQBRQ.
PhylomeDBiQ9H3R5.
TreeFamiTF101134.

Family and domain databases

InterProiIPR008426. CENP-H.
[Graphical view]
PfamiPF05837. CENP-H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H3R5-1 [UniParc]FASTAAdd to Basket

« Hide

MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT    50
KQQLLEYKSM VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK 100
LALDRMRLST ALKKNLEKIS RQSSVLMDNM KHLLELNKLI MKSQQESWDL 150
EEKLLDIRKK RLQLKQASES KLLEIQTEKN KQKIDLDSME NSERIKIIRQ 200
NLQMEIKITT VIQHVFQNLI LGSKVNWAED PALKEIVLQL EKNVDMM 247
Length:247
Mass (Da):28,481
Last modified:March 1, 2001 - v1
Checksum:iE1BCD4022710168F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036167

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035124 mRNA. Translation: BAB18635.1.
AK290746 mRNA. Translation: BAF83435.1.
CH471137 Genomic DNA. Translation: EAW51304.1.
BC015355 mRNA. Translation: AAH15355.1.
BC012024 mRNA. Translation: AAH12024.1.
CCDSiCCDS3998.1.
RefSeqiNP_075060.1. NM_022909.3.
UniGeneiHs.631967.

Genome annotation databases

EnsembliENST00000283006; ENSP00000283006; ENSG00000153044.
GeneIDi64946.
KEGGihsa:64946.
UCSCiuc003jvp.3. human.

Polymorphism databases

DMDMi74733576.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035124 mRNA. Translation: BAB18635.1 .
AK290746 mRNA. Translation: BAF83435.1 .
CH471137 Genomic DNA. Translation: EAW51304.1 .
BC015355 mRNA. Translation: AAH15355.1 .
BC012024 mRNA. Translation: AAH12024.1 .
CCDSi CCDS3998.1.
RefSeqi NP_075060.1. NM_022909.3.
UniGenei Hs.631967.

3D structure databases

ProteinModelPortali Q9H3R5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122355. 17 interactions.
IntActi Q9H3R5. 1 interaction.
MINTi MINT-4988967.
STRINGi 9606.ENSP00000283006.

PTM databases

PhosphoSitei Q9H3R5.

Polymorphism databases

DMDMi 74733576.

Proteomic databases

MaxQBi Q9H3R5.
PaxDbi Q9H3R5.
PRIDEi Q9H3R5.

Protocols and materials databases

DNASUi 64946.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283006 ; ENSP00000283006 ; ENSG00000153044 .
GeneIDi 64946.
KEGGi hsa:64946.
UCSCi uc003jvp.3. human.

Organism-specific databases

CTDi 64946.
GeneCardsi GC05P068496.
HGNCi HGNC:17268. CENPH.
HPAi HPA036494.
MIMi 605607. gene.
neXtProti NX_Q9H3R5.
PharmGKBi PA26402.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG10470.
HOGENOMi HOG000013068.
HOVERGENi HBG081083.
InParanoidi Q9H3R5.
KOi K11500.
OMAi QMEIKIT.
OrthoDBi EOG7JQBRQ.
PhylomeDBi Q9H3R5.
TreeFami TF101134.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi CENPH. human.
GeneWikii CENPH.
GenomeRNAii 64946.
NextBioi 67122.
PROi Q9H3R5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H3R5.
Bgeei Q9H3R5.
CleanExi HS_CENPH.
Genevestigatori Q9H3R5.

Family and domain databases

InterProi IPR008426. CENP-H.
[Graphical view ]
Pfami PF05837. CENP-H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes."
    Sugata N., Li S., Earnshaw W.C., Yen T.J., Yoda K., Masumoto H., Munekata E., Warburton P.E., Todokoro K.
    Hum. Mol. Genet. 9:2919-2926(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH KIF2C, SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  5. Cited for: FUNCTION.
  6. "The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis."
    Mikami Y., Hori T., Kimura H., Fukagawa T.
    Mol. Cell. Biol. 25:1958-1970(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NDC80.
  7. Cited for: FUNCTION.
  8. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
    Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
    Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  9. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ; CENPR AND CENPU.
  10. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPM; CENPN; CENPT AND CENPU.
  11. "The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity."
    McClelland S.E., Borusu S., Amaro A.C., Winter J.R., Belwal M., McAinsh A.D., Meraldi P.
    EMBO J. 26:5033-5047(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres."
    Alonso A., Fritz B., Hasson D., Abrusan G., Cheung F., Yoda K., Radlwimmer B., Ladurner A.G., Warburton P.E.
    Genome Biol. 8:R148.1-R148.19(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "CENP-K and CENP-H may form coiled-coils in the kinetochores."
    Qiu S., Wang J., Yu C., He D.
    Sci. China, Ser. C, Life Sci. 52:352-359(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CENPK.
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-2.

Entry informationi

Entry nameiCENPH_HUMAN
AccessioniPrimary (citable) accession number: Q9H3R5
Secondary accession number(s): A8K3Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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