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Protein

Centromere protein H

Gene

CENPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.3 Publications

GO - Molecular functioni

  • kinetochore binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein H
Short name:
CENP-H
Alternative name(s):
Interphase centromere complex protein 35
Gene namesi
Name:CENPHImported
Synonyms:ICEN35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17268. CENPH.

Subcellular locationi

  • Nucleus
  • Chromosomecentromerekinetochore

  • Note: Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • kinetochore Source: MGI
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64946.
OpenTargetsiENSG00000153044.
PharmGKBiPA26402.

Polymorphism and mutation databases

BioMutaiCENPH.
DMDMi74733576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894781 – 247Centromere protein HAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei68PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H3R5.
MaxQBiQ9H3R5.
PaxDbiQ9H3R5.
PeptideAtlasiQ9H3R5.
PRIDEiQ9H3R5.

PTM databases

iPTMnetiQ9H3R5.
PhosphoSitePlusiQ9H3R5.

Expressioni

Gene expression databases

BgeeiENSG00000153044.
CleanExiHS_CENPH.
ExpressionAtlasiQ9H3R5. baseline and differential.
GenevisibleiQ9H3R5. HS.

Organism-specific databases

HPAiHPA036494.

Interactioni

Subunit structurei

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • kinetochore binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122355. 39 interactors.
IntActiQ9H3R5. 32 interactors.
MINTiMINT-4988967.
STRINGi9606.ENSP00000283006.

Structurei

3D structure databases

ProteinModelPortaliQ9H3R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 192Sequence analysisAdd BLAST146

Sequence similaritiesi

Belongs to the centromere protein H family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9S. Eukaryota.
ENOG410Y6WK. LUCA.
GeneTreeiENSGT00390000009578.
HOGENOMiHOG000013068.
HOVERGENiHBG081083.
InParanoidiQ9H3R5.
KOiK11500.
OMAiKVNWAED.
OrthoDBiEOG091G1AJR.
PhylomeDBiQ9H3R5.
TreeFamiTF101134.

Family and domain databases

InterProiView protein in InterPro
IPR008426. CENP-H.
PfamiView protein in Pfam
PF05837. CENP-H. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H3R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT
60 70 80 90 100
KQQLLEYKSM VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK
110 120 130 140 150
LALDRMRLST ALKKNLEKIS RQSSVLMDNM KHLLELNKLI MKSQQESWDL
160 170 180 190 200
EEKLLDIRKK RLQLKQASES KLLEIQTEKN KQKIDLDSME NSERIKIIRQ
210 220 230 240
NLQMEIKITT VIQHVFQNLI LGSKVNWAED PALKEIVLQL EKNVDMM
Length:247
Mass (Da):28,481
Last modified:March 1, 2001 - v1
Checksum:iE1BCD4022710168F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0361672E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777698677Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035124 mRNA. Translation: BAB18635.1.
AK290746 mRNA. Translation: BAF83435.1.
CH471137 Genomic DNA. Translation: EAW51304.1.
BC015355 mRNA. Translation: AAH15355.1.
BC012024 mRNA. Translation: AAH12024.1.
CCDSiCCDS3998.1.
RefSeqiNP_075060.1. NM_022909.3.
UniGeneiHs.631967.

Genome annotation databases

EnsembliENST00000283006; ENSP00000283006; ENSG00000153044.
GeneIDi64946.
KEGGihsa:64946.
UCSCiuc003jvp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCENPH_HUMAN
AccessioniPrimary (citable) accession number: Q9H3R5
Secondary accession number(s): A8K3Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families