Q9H3R0 (KDM4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysine-specific demethylase 4C
EC=1.14.11.-

Alternative name(s):
Gene amplified in squamous cell carcinoma 1 protein
Short name=GASC-1 protein
JmjC domain-containing histone demethylation protein 3C
Jumonji domain-containing protein 2C

Gene names

Name:	KDM4C
Synonyms:	GASC1, JHDM3C, JMJD2C, KIAA0780

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1056 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Ref.6
Cofactor	Binds 1 Fe2+ ion per subunit. Ref.7
Subcellular location	Nucleus By similarity.
Tissue specificity	Overexpressed in several esophageal squamous cell carcinomas (ESCs). Ref.1
Domain	The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails By similarity.
Sequence similarities	Belongs to the JHDM3 histone demethylase family. Contains 1 JmjC domain. Contains 1 JmjN domain. Contains 2 PHD-type zinc fingers. Contains 2 Tudor domains.
Sequence caution	The sequence BAA34500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI39608.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cell proliferation Inferred from mutant phenotype PubMed 17277772. Source: BHF-UCL regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17277772. Source: BHF-UCL transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear chromatin Inferred from direct assay PubMed 17277772. Source: BHF-UCL
Molecular_function	histone demethylase activity (H3-K9 specific) Inferred from direct assay PubMed 18066052. Source: UniProtKB oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H3R0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H3R0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     999-1056: STASDMRFED...SFQKKCQKRQ → VSAGRCHLGT...QCNIFLSGTY

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H3R0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: KCIFC → GRLGI
     814-1056: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9H3R0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKHYGLPWKRTEEAAADTALTIM
     809-813: KCIFC → GRLGI
     814-1056: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1056

1056

Lysine-specific demethylase 4C

PRO_0000183177

Regions

Domain

16 – 58

43

JmjN

Domain

144 – 310

167

JmjC

Domain

877 – 934

58

Tudor 1

Domain

935 – 991

57

Tudor 2

Zinc finger

689 – 747

59

PHD-type 1

Zinc finger

809 – 865

57

PHD-type 2

Sites

Metal binding

190

1

Iron; catalytic

Metal binding

192

1

Iron; catalytic

Metal binding

236

1

Zinc

Metal binding

242

1

Zinc

Metal binding

278

1

Iron; catalytic

Metal binding

308

1

Zinc

Metal binding

310

1

Zinc

Binding site

134

1

Alpha-ketoglutarate By similarity

Binding site

200

1

Alpha-ketoglutarate By similarity

Binding site

208

1

Alpha-ketoglutarate By similarity

Natural variations

Alternative sequence

1

1

M → MKHYGLPWKRTEEAAADTAL TIM in isoform 4.

VSP_046113

Alternative sequence

809 – 813

5

KCIFC → GRLGI in isoform 3 and isoform 4.

VSP_045462

Alternative sequence

814 – 1056

243

Missing in isoform 3 and isoform 4.

VSP_045463

Alternative sequence

999 – 1056

58

STASD…CQKRQ → VSAGRCHLGTCQVNSLSSPH VSQAQQETYLGFWINSKKSQ CNIFLSGTY in isoform 2.

VSP_018311

Natural variant

206

1

E → D.
Corresponds to variant rs7864351 [ dbSNP | Ensembl ].

VAR_049660

Natural variant

396

1

D → N.
Corresponds to variant rs2296067 [ dbSNP | Ensembl ].

VAR_020340

Natural variant

492

1

S → T. Ref.1 Ref.2 Ref.3
Corresponds to variant rs35826653 [ dbSNP | Ensembl ].

VAR_049661

Natural variant

697

1

N → S.
Corresponds to variant rs35389625 [ dbSNP | Ensembl ].

VAR_049662

Natural variant

767

1

Q → E.
Corresponds to variant rs1407856 [ dbSNP | Ensembl ].

VAR_024681

Natural variant

772

1

K → R. Ref.1
Corresponds to variant rs1417290 [ dbSNP | Ensembl ].

VAR_049663

Natural variant

1039

1

V → I. Ref.5
Corresponds to variant rs913588 [ dbSNP | Ensembl ].

VAR_024682

Experimental info

Sequence conflict

155

1

L → I in BAB16102. Ref.1

Sequence conflict

514

1

C → S in BAG64946. Ref.3

Sequence conflict

807

1

K → R in BAG64946. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1056

Helix Strand Turn

Details...

Beta strand

17 – 19

3

Helix

23 – 26

4

Helix

29 – 38

10

Helix

41 – 44

4

Beta strand

45 – 49

5

Helix

62 – 66

5

Beta strand

68 – 71

4

Beta strand

73 – 80

8

Beta strand

83 – 90

8

Helix

96 – 104

9

Turn

106 – 108

3

Helix

116 – 126

11

Beta strand

133 – 139

7

Helix

158 – 166

9

Beta strand

172 – 175

4

Beta strand

177 – 181

5

Beta strand

186 – 190

5

Helix

193 – 195

3

Beta strand

197 – 206

10

Beta strand

208 – 213

6

Helix

215 – 217

3

Helix

218 – 228

11

Helix

230 – 235

6

Helix

239 – 242

4

Beta strand

245 – 247

3

Helix

249 – 254

6

Beta strand

260 – 264

5

Beta strand

269 – 272

4

Beta strand

277 – 282

6

Beta strand

284 – 293

10

Helix

296 – 298

3

Helix

299 – 302

4

Helix

320 – 326

7

Turn

328 – 330

3

Helix

331 – 335

5

Beta strand

898 – 912

15

Beta strand

917 – 921

5

Helix

923 – 925

3

Helix

931 – 934

4

Beta strand

942 – 946

5

Beta strand

952 – 969

18

Beta strand

975 – 979

5

Helix

980 – 982

3

Beta strand

986 – 988

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: CBE871D4FAADD06D	FASTA	1,056	119,982
	10 20 30 40 50 60 MEVAEVESPL NPSCKIMTFR PSMEEFREFN KYLAYMESKG AHRAGLAKVI PPKEWKPRQC 70 80 90 100 110 120 YDDIDNLLIP APIQQMVTGQ SGLFTQYNIQ KKAMTVKEFR QLANSGKYCT PRYLDYEDLE 130 140 150 160 170 180 RKYWKNLTFV APIYGADING SIYDEGVDEW NIARLNTVLD VVEEECGISI EGVNTPYLYF 190 200 210 220 230 240 GMWKTTFAWH TEDMDLYSIN YLHFGEPKSW YAIPPEHGKR LERLAQGFFP SSSQGCDAFL 250 260 270 280 290 300 RHKMTLISPS VLKKYGIPFD KITQEAGEFM ITFPYGYHAG FNHGFNCAES TNFATVRWID 310 320 330 340 350 360 YGKVAKLCTC RKDMVKISMD IFVRKFQPDR YQLWKQGKDI YTIDHTKPTP ASTPEVKAWL 370 380 390 400 410 420 QRRRKVRKAS RSFQCARSTS KRPKADEEEE VSDEVDGAEV PNPDSVTDDL KVSEKSEAAV 430 440 450 460 470 480 KLRNTEASSE EESSASRMQV EQNLSDHIKL SGNSCLSTSV TEDIKTEDDK AYAYRSVPSI 490 500 510 520 530 540 SSEADDSIPL SSGYEKPEKS DPSELSWPKS PESCSSVAES NGVLTEGEES DVESHGNGLE 550 560 570 580 590 600 PGEIPAVPSG ERNSFKVPSI AEGENKTSKS WRHPLSRPPA RSPMTLVKQQ APSDEELPEV 610 620 630 640 650 660 LSIEEEVEET ESWAKPLIHL WQTKSPNFAA EQEYNATVAR MKPHCAICTL LMPYHKPDSS 670 680 690 700 710 720 NEENDARWET KLDEVVTSEG KTKPLIPEMC FIYSEENIEY SPPNAFLEED GTSLLISCAK 730 740 750 760 770 780 CCVRVHASCY GIPSHEICDG WLCARCKRNA WTAECCLCNL RGGALKQTKN NKWAHVMCAV 790 800 810 820 830 840 AVPEVRFTNV PERTQIDVGR IPLQRLKLKC IFCRHRVKRV SGACIQCSYG RCPASFHVTC 850 860 870 880 890 900 AHAAGVLMEP DDWPYVVNIT CFRHKVNPNV KSKACEKVIS VGQTVITKHR NTRYYSCRVM 910 920 930 940 950 960 AVTSQTFYEV MFDDGSFSRD TFPEDIVSRD CLKLGPPAEG EVVQVKWPDG KLYGAKYFGS 970 980 990 1000 1010 1020 NIAHMYQVEF EDGSQIAMKR EDIYTLDEEL PKRVKARFST ASDMRFEDTF YGADIIQGER 1030 1040 1050 KRQRVLSSRF KNEYVADPVY RTFLKSSFQK KCQKRQ
	Isoform 2 [UniParc]. Checksum: 5A6E06262786B259	FASTA	1,047	118,416
	10 20 30 40 50 60 MEVAEVESPL NPSCKIMTFR PSMEEFREFN KYLAYMESKG AHRAGLAKVI PPKEWKPRQC 70 80 90 100 110 120 YDDIDNLLIP APIQQMVTGQ SGLFTQYNIQ KKAMTVKEFR QLANSGKYCT PRYLDYEDLE 130 140 150 160 170 180 RKYWKNLTFV APIYGADING SIYDEGVDEW NIARLNTVLD VVEEECGISI EGVNTPYLYF 190 200 210 220 230 240 GMWKTTFAWH TEDMDLYSIN YLHFGEPKSW YAIPPEHGKR LERLAQGFFP SSSQGCDAFL 250 260 270 280 290 300 RHKMTLISPS VLKKYGIPFD KITQEAGEFM ITFPYGYHAG FNHGFNCAES TNFATVRWID 310 320 330 340 350 360 YGKVAKLCTC RKDMVKISMD IFVRKFQPDR YQLWKQGKDI YTIDHTKPTP ASTPEVKAWL 370 380 390 400 410 420 QRRRKVRKAS RSFQCARSTS KRPKADEEEE VSDEVDGAEV PNPDSVTDDL KVSEKSEAAV 430 440 450 460 470 480 KLRNTEASSE EESSASRMQV EQNLSDHIKL SGNSCLSTSV TEDIKTEDDK AYAYRSVPSI 490 500 510 520 530 540 SSEADDSIPL SSGYEKPEKS DPSELSWPKS PESCSSVAES NGVLTEGEES DVESHGNGLE 550 560 570 580 590 600 PGEIPAVPSG ERNSFKVPSI AEGENKTSKS WRHPLSRPPA RSPMTLVKQQ APSDEELPEV 610 620 630 640 650 660 LSIEEEVEET ESWAKPLIHL WQTKSPNFAA EQEYNATVAR MKPHCAICTL LMPYHKPDSS 670 680 690 700 710 720 NEENDARWET KLDEVVTSEG KTKPLIPEMC FIYSEENIEY SPPNAFLEED GTSLLISCAK 730 740 750 760 770 780 CCVRVHASCY GIPSHEICDG WLCARCKRNA WTAECCLCNL RGGALKQTKN NKWAHVMCAV 790 800 810 820 830 840 AVPEVRFTNV PERTQIDVGR IPLQRLKLKC IFCRHRVKRV SGACIQCSYG RCPASFHVTC 850 860 870 880 890 900 AHAAGVLMEP DDWPYVVNIT CFRHKVNPNV KSKACEKVIS VGQTVITKHR NTRYYSCRVM 910 920 930 940 950 960 AVTSQTFYEV MFDDGSFSRD TFPEDIVSRD CLKLGPPAEG EVVQVKWPDG KLYGAKYFGS 970 980 990 1000 1010 1020 NIAHMYQVEF EDGSQIAMKR EDIYTLDEEL PKRVKARFVS AGRCHLGTCQ VNSLSSPHVS 1030 1040 QAQQETYLGF WINSKKSQCN IFLSGTY
	Isoform 3 [UniParc]. Checksum: 672012048DEE27AC	FASTA	813	91,891
	10 20 30 40 50 60 MEVAEVESPL NPSCKIMTFR PSMEEFREFN KYLAYMESKG AHRAGLAKVI PPKEWKPRQC 70 80 90 100 110 120 YDDIDNLLIP APIQQMVTGQ SGLFTQYNIQ KKAMTVKEFR QLANSGKYCT PRYLDYEDLE 130 140 150 160 170 180 RKYWKNLTFV APIYGADING SIYDEGVDEW NIARLNTVLD VVEEECGISI EGVNTPYLYF 190 200 210 220 230 240 GMWKTTFAWH TEDMDLYSIN YLHFGEPKSW YAIPPEHGKR LERLAQGFFP SSSQGCDAFL 250 260 270 280 290 300 RHKMTLISPS VLKKYGIPFD KITQEAGEFM ITFPYGYHAG FNHGFNCAES TNFATVRWID 310 320 330 340 350 360 YGKVAKLCTC RKDMVKISMD IFVRKFQPDR YQLWKQGKDI YTIDHTKPTP ASTPEVKAWL 370 380 390 400 410 420 QRRRKVRKAS RSFQCARSTS KRPKADEEEE VSDEVDGAEV PNPDSVTDDL KVSEKSEAAV 430 440 450 460 470 480 KLRNTEASSE EESSASRMQV EQNLSDHIKL SGNSCLSTSV TEDIKTEDDK AYAYRSVPSI 490 500 510 520 530 540 SSEADDSIPL SSGYEKPEKS DPSELSWPKS PESCSSVAES NGVLTEGEES DVESHGNGLE 550 560 570 580 590 600 PGEIPAVPSG ERNSFKVPSI AEGENKTSKS WRHPLSRPPA RSPMTLVKQQ APSDEELPEV 610 620 630 640 650 660 LSIEEEVEET ESWAKPLIHL WQTKSPNFAA EQEYNATVAR MKPHCAICTL LMPYHKPDSS 670 680 690 700 710 720 NEENDARWET KLDEVVTSEG KTKPLIPEMC FIYSEENIEY SPPNAFLEED GTSLLISCAK 730 740 750 760 770 780 CCVRVHASCY GIPSHEICDG WLCARCKRNA WTAECCLCNL RGGALKQTKN NKWAHVMCAV 790 800 810 AVPEVRFTNV PERTQIDVGR IPLQRLKLGR LGI
	Isoform 4 [UniParc]. Checksum: B08576383C57FE4B	FASTA	835	94,376
	10 20 30 40 50 60 MKHYGLPWKR TEEAAADTAL TIMEVAEVES PLNPSCKIMT FRPSMEEFRE FNKYLAYMES 70 80 90 100 110 120 KGAHRAGLAK VIPPKEWKPR QCYDDIDNLL IPAPIQQMVT GQSGLFTQYN IQKKAMTVKE 130 140 150 160 170 180 FRQLANSGKY CTPRYLDYED LERKYWKNLT FVAPIYGADI NGSIYDEGVD EWNIARLNTV 190 200 210 220 230 240 LDVVEEECGI SIEGVNTPYL YFGMWKTTFA WHTEDMDLYS INYLHFGEPK SWYAIPPEHG 250 260 270 280 290 300 KRLERLAQGF FPSSSQGCDA FLRHKMTLIS PSVLKKYGIP FDKITQEAGE FMITFPYGYH 310 320 330 340 350 360 AGFNHGFNCA ESTNFATVRW IDYGKVAKLC TCRKDMVKIS MDIFVRKFQP DRYQLWKQGK 370 380 390 400 410 420 DIYTIDHTKP TPASTPEVKA WLQRRRKVRK ASRSFQCARS TSKRPKADEE EEVSDEVDGA 430 440 450 460 470 480 EVPNPDSVTD DLKVSEKSEA AVKLRNTEAS SEEESSASRM QVEQNLSDHI KLSGNSCLST 490 500 510 520 530 540 SVTEDIKTED DKAYAYRSVP SISSEADDSI PLSSGYEKPE KSDPSELSWP KSPESCSSVA 550 560 570 580 590 600 ESNGVLTEGE ESDVESHGNG LEPGEIPAVP SGERNSFKVP SIAEGENKTS KSWRHPLSRP 610 620 630 640 650 660 PARSPMTLVK QQAPSDEELP EVLSIEEEVE ETESWAKPLI HLWQTKSPNF AAEQEYNATV 670 680 690 700 710 720 ARMKPHCAIC TLLMPYHKPD SSNEENDARW ETKLDEVVTS EGKTKPLIPE MCFIYSEENI 730 740 750 760 770 780 EYSPPNAFLE EDGTSLLISC AKCCVRVHAS CYGIPSHEIC DGWLCARCKR NAWTAECCLC 790 800 810 820 830 NLRGGALKQT KNNKWAHVMC AVAVPEVRFT NVPERTQIDV GRIPLQRLKL GRLGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines." Yang Z.Q., Imoto I., Fukuda Y., Pimkhaokham A., Shimada Y., Imamura M., Sugano S., Nakamura Y., Inazawa J. Cancer Res. 60:4735-4739(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS THR-492 AND ARG-772.
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-492. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT THR-492. Tissue: Testis and Trachea.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-1039. Tissue: Liver.
[6]	"Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases." Whetstine J.R., Nottke A., Lan F., Huarte M., Smolikov S., Chen Z., Spooner E., Li E., Zhang G., Colaiacovo M., Shi Y. Cell 125:467-481(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ENZYME ACTIVITY.
[7]	"Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family." Hillringhaus L., Yue W.W., Rose N.R., Ng S.S., Gileadi C., Loenarz C., Bello S.H., Bray J.E., Schofield C.J., Oppermann U. J. Biol. Chem. 286:41616-41625(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-347 IN COMPLEX WITH ZINC AND NICKEL ION, COFACTOR, SUBSTRATE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB037901 mRNA. Translation: BAB16102.1.
AB018323 mRNA. Translation: BAA34500.1. Different initiation.
AK304032 mRNA. Translation: BAG64946.1.
AK310439 mRNA. No translation available.
AL354707 , AL137020, AL161443, AL445592, AL513412 Genomic DNA. Translation: CAH73283.1.
AL354707 , AL137020, AL161443, AL513412, AL445592 Genomic DNA. Translation: CAH73284.1.
AL445592 , AL161443, AL513412, AL354707, AL137020 Genomic DNA. Translation: CAI16322.1.
AL445592 , AL137020, AL354707, AL513412, AL161443 Genomic DNA. Translation: CAI16323.1.
AL161443 , AL137020, AL354707, AL513412, AL445592 Genomic DNA. Translation: CAI39606.1.
AL161443 , AL513412, AL445592, AL354707, AL137020 Genomic DNA. Translation: CAI39607.1.
AL161443, AL137020, AL513412 Genomic DNA. Translation: CAI39608.1. Sequence problems.
BC104859 mRNA. Translation: AAI04860.1.
BC104861 mRNA. Translation: AAI04862.1.
BC143571 mRNA. Translation: AAI43572.1.

IPI

IPI00027642.
IPI00645825.
IPI00878778.
IPI00929542.

RefSeq

NP_001140166.1. NM_001146694.1.
NP_001140167.1. NM_001146695.1.
NP_001140168.1. NM_001146696.1.
NP_055876.2. NM_015061.3.

UniGene

Hs.709425.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XDP	X-ray	1.56	A	875-995	[»]
2XML	X-ray	2.55	A/B	1-347	[»]

ProteinModelPortal

Q9H3R0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9H3R0. 1 interaction.

STRING

9606.ENSP00000370710.

PTM databases

PhosphoSite

Q9H3R0.

Polymorphism databases

DMDM

97536525.

Proteomic databases

PaxDb

Q9H3R0.

PRIDE

Q9H3R0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000381306; ENSP00000370707; ENSG00000107077.
ENST00000381309; ENSP00000370710; ENSG00000107077.
ENST00000420847; ENSP00000400127; ENSG00000107077.
ENST00000535193; ENSP00000442382; ENSG00000107077.
ENST00000543771; ENSP00000445427; ENSG00000107077.

GeneID

23081.

KEGG

hsa:23081.

UCSC

uc003zkg.3. human.
uc003zkh.3. human.

Organism-specific databases

CTD

23081.

GeneCards

GC09P006720.

H-InvDB

HIX0017555.

HGNC

HGNC:17071. KDM4C.

MIM

605469. gene.

neXtProt

NX_Q9H3R0.

PharmGKB

PA164721503.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5141.

HOGENOM

HOG000231125.

InParanoid

Q9H3R0.

KO

K06709.

OMA

DIIQGER.

OrthoDB

EOG4N5VW5.

PhylomeDB

Q9H3R0.

Enzyme and pathway databases

Pathway_Interaction_DB

ar_pathway. Coregulation of Androgen receptor activity.

Gene expression databases

ArrayExpress

Q9H3R0.

Bgee

Q9H3R0.

CleanEx

HS_JMJD2C.

Genevestigator

Q9H3R0.

GermOnline

ENSG00000107077. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR003347. JmjC_dom.
IPR003349. TF_JmjN.
IPR002999. Tudor.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
[Graphical view]

SMART

SM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
SM00249. PHD. 2 hits.
SM00333. TUDOR. 2 hits.
[Graphical view]

PROSITE

PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
PS50304. TUDOR. False negative.
PS01359. ZF_PHD_1. False negative.
PS50016. ZF_PHD_2. False negative.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q9H3R0.

ChEMBL

CHEMBL6175.

ChiTaRS

KDM4C. human.

EvolutionaryTrace

Q9H3R0.

GenomeRNAi

23081.

NextBio

44205.

SOURCE

Search...

Entry information

Entry name

KDM4C_HUMAN

Accession

Primary (citable) accession number: Q9H3R0
Secondary accession number(s): B4E1Y4 , B7ZL46, F5H347, F5H7P0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.