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Q9H3Q3

- G3ST2_HUMAN

UniProt

Q9H3Q3 - G3ST2_HUMAN

Protein

Galactose-3-O-sulfotransferase 2

Gene

GAL3ST2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

    Enzyme regulationi

    Strongly inhibited by Cu2+ and Zn2+.1 Publication

    pH dependencei

    Optimum pH is 6.0-6.5.

    Pathwayi

    GO - Molecular functioni

    1. galactosylceramide sulfotransferase activity Source: InterPro
    2. sulfotransferase activity Source: UniProtKB

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00353.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactose-3-O-sulfotransferase 2 (EC:2.8.2.-)
    Short name:
    Gal3ST-2
    Alternative name(s):
    Beta-galactose-3-O-sulfotransferase 2
    Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
    Glycoprotein beta-Gal 3'-sulfotransferase 2
    Gene namesi
    Name:GAL3ST2
    Synonyms:GP3ST
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24869. GAL3ST2.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Galactose-3-O-sulfotransferase 2PRO_0000085203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9H3Q3.
    PaxDbiQ9H3Q3.
    PRIDEiQ9H3Q3.

    PTM databases

    PhosphoSiteiQ9H3Q3.

    Expressioni

    Tissue specificityi

    Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.1 Publication

    Gene expression databases

    BgeeiQ9H3Q3.
    CleanExiHS_GAL3ST2.
    GenevestigatoriQ9H3Q3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 398367LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi211 – 315105Arg-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26344.
    HOGENOMiHOG000232148.
    HOVERGENiHBG051681.
    InParanoidiQ9H3Q3.
    KOiK09675.
    OMAiKRWCALD.
    OrthoDBiEOG7K0ZF1.
    PhylomeDBiQ9H3Q3.
    TreeFamiTF314802.

    Family and domain databases

    InterProiIPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR14647. PTHR14647. 1 hit.
    PfamiPF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H3Q3-1 [UniParc]FASTAAdd to Basket

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    MMSMLGGLQR YFRVILLLLL ALTLLLLAGF LHSDLELDTP LFGGQAEGPP    50
    VTNIMFLKTH KTASSTVLNI LYRFAETHNL SVALPAGSRV HLGYPWLFLA 100
    RYVEGVGSQQ RFNIMCNHLR FNLPQVQKVM PNDTFYFSIL RNPVFQLESS 150
    FIYYKTYAPA FRGAPSLDAF LASPRTFYND SRHLRNVYAK NNMWFDFGFD 200
    PNAQCEEGYV RARIAEVERR FRLVLIAEHL DESLVLLRRR LRWALDDVVA 250
    FRLNSRSARS VARLSPETRE RARSWCALDW RLYEHFNRTL WAQLRAELGP 300
    RRLRGEVERL RARRRELASL CLQDGGALKN HTQIRDPRLR PYQSGKADIL 350
    GYNLRPGLDN QTLGVCQRLV MPELQYMARL YALQFPEKPL KNIPFLGA 398
    Length:398
    Mass (Da):46,110
    Last modified:November 4, 2008 - v2
    Checksum:i900FF26B515E82D5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41M → L.2 Publications
    Corresponds to variant rs12469459 [ dbSNP | Ensembl ].
    VAR_047060

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040610 mRNA. Translation: BAB16844.1.
    AC114730 Genomic DNA. Translation: AAX82021.1.
    CH471063 Genomic DNA. Translation: EAW71293.1.
    BC117293 mRNA. Translation: AAI17294.1.
    BC117295 mRNA. Translation: AAI17296.1.
    CCDSiCCDS33427.1.
    RefSeqiNP_071417.2. NM_022134.2.
    UniGeneiHs.632556.

    Genome annotation databases

    EnsembliENST00000192314; ENSP00000192314; ENSG00000154252.
    GeneIDi64090.
    KEGGihsa:64090.
    UCSCiuc002wcj.1. human.

    Polymorphism databases

    DMDMi212276434.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040610 mRNA. Translation: BAB16844.1 .
    AC114730 Genomic DNA. Translation: AAX82021.1 .
    CH471063 Genomic DNA. Translation: EAW71293.1 .
    BC117293 mRNA. Translation: AAI17294.1 .
    BC117295 mRNA. Translation: AAI17296.1 .
    CCDSi CCDS33427.1.
    RefSeqi NP_071417.2. NM_022134.2.
    UniGenei Hs.632556.

    3D structure databases

    ProteinModelPortali Q9H3Q3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9H3Q3.

    Polymorphism databases

    DMDMi 212276434.

    Proteomic databases

    MaxQBi Q9H3Q3.
    PaxDbi Q9H3Q3.
    PRIDEi Q9H3Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000192314 ; ENSP00000192314 ; ENSG00000154252 .
    GeneIDi 64090.
    KEGGi hsa:64090.
    UCSCi uc002wcj.1. human.

    Organism-specific databases

    CTDi 64090.
    GeneCardsi GC02P242716.
    HGNCi HGNC:24869. GAL3ST2.
    MIMi 608237. gene.
    neXtProti NX_Q9H3Q3.
    PharmGKBi PA134913637.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26344.
    HOGENOMi HOG000232148.
    HOVERGENi HBG051681.
    InParanoidi Q9H3Q3.
    KOi K09675.
    OMAi KRWCALD.
    OrthoDBi EOG7K0ZF1.
    PhylomeDBi Q9H3Q3.
    TreeFami TF314802.

    Enzyme and pathway databases

    UniPathwayi UPA00353 .

    Miscellaneous databases

    GeneWikii GAL3ST2.
    GenomeRNAii 64090.
    NextBioi 65896.
    PROi Q9H3Q3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H3Q3.
    CleanExi HS_GAL3ST2.
    Genevestigatori Q9H3Q3.

    Family and domain databases

    InterProi IPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR14647. PTHR14647. 1 hit.
    Pfami PF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides."
      Honke K., Tsuda M., Koyota S., Wada Y., Iida-Tanaka N., Ishizuka I., Nakayama J., Taniguchi N.
      J. Biol. Chem. 276:267-274(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ENZYME REGULATION, VARIANT LEU-4.
      Tissue: Colon.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-4.

    Entry informationi

    Entry nameiG3ST2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3Q3
    Secondary accession number(s): Q17RK0, Q57Z52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3