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Q9H3Q3

- G3ST2_HUMAN

UniProt

Q9H3Q3 - G3ST2_HUMAN

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Protein

Galactose-3-O-sulfotransferase 2

Gene
GAL3ST2, GP3ST
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Enzyme regulationi

Strongly inhibited by Cu2+ and Zn2+.1 Publication

pH dependencei

Optimum pH is 6.0-6.5.

Pathwayi

GO - Molecular functioni

  1. galactosylceramide sulfotransferase activity Source: InterPro
  2. sulfotransferase activity Source: UniProtKB

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

UniPathwayiUPA00353.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-3-O-sulfotransferase 2 (EC:2.8.2.-)
Short name:
Gal3ST-2
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 2
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2
Glycoprotein beta-Gal 3'-sulfotransferase 2
Gene namesi
Name:GAL3ST2
Synonyms:GP3ST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24869. GAL3ST2.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein Inferred 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini32 – 398367Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Galactose-3-O-sulfotransferase 2PRO_0000085203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H3Q3.
PaxDbiQ9H3Q3.
PRIDEiQ9H3Q3.

PTM databases

PhosphoSiteiQ9H3Q3.

Expressioni

Tissue specificityi

Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.1 Publication

Gene expression databases

BgeeiQ9H3Q3.
CleanExiHS_GAL3ST2.
GenevestigatoriQ9H3Q3.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Q3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 315105Arg-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26344.
HOGENOMiHOG000232148.
HOVERGENiHBG051681.
InParanoidiQ9H3Q3.
KOiK09675.
OMAiKRWCALD.
OrthoDBiEOG7K0ZF1.
PhylomeDBiQ9H3Q3.
TreeFamiTF314802.

Family and domain databases

InterProiIPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR14647. PTHR14647. 1 hit.
PfamiPF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H3Q3-1 [UniParc]FASTAAdd to Basket

« Hide

MMSMLGGLQR YFRVILLLLL ALTLLLLAGF LHSDLELDTP LFGGQAEGPP    50
VTNIMFLKTH KTASSTVLNI LYRFAETHNL SVALPAGSRV HLGYPWLFLA 100
RYVEGVGSQQ RFNIMCNHLR FNLPQVQKVM PNDTFYFSIL RNPVFQLESS 150
FIYYKTYAPA FRGAPSLDAF LASPRTFYND SRHLRNVYAK NNMWFDFGFD 200
PNAQCEEGYV RARIAEVERR FRLVLIAEHL DESLVLLRRR LRWALDDVVA 250
FRLNSRSARS VARLSPETRE RARSWCALDW RLYEHFNRTL WAQLRAELGP 300
RRLRGEVERL RARRRELASL CLQDGGALKN HTQIRDPRLR PYQSGKADIL 350
GYNLRPGLDN QTLGVCQRLV MPELQYMARL YALQFPEKPL KNIPFLGA 398
Length:398
Mass (Da):46,110
Last modified:November 4, 2008 - v2
Checksum:i900FF26B515E82D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → L.2 Publications
Corresponds to variant rs12469459 [ dbSNP | Ensembl ].
VAR_047060

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040610 mRNA. Translation: BAB16844.1.
AC114730 Genomic DNA. Translation: AAX82021.1.
CH471063 Genomic DNA. Translation: EAW71293.1.
BC117293 mRNA. Translation: AAI17294.1.
BC117295 mRNA. Translation: AAI17296.1.
CCDSiCCDS33427.1.
RefSeqiNP_071417.2. NM_022134.2.
UniGeneiHs.632556.

Genome annotation databases

EnsembliENST00000192314; ENSP00000192314; ENSG00000154252.
GeneIDi64090.
KEGGihsa:64090.
UCSCiuc002wcj.1. human.

Polymorphism databases

DMDMi212276434.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040610 mRNA. Translation: BAB16844.1 .
AC114730 Genomic DNA. Translation: AAX82021.1 .
CH471063 Genomic DNA. Translation: EAW71293.1 .
BC117293 mRNA. Translation: AAI17294.1 .
BC117295 mRNA. Translation: AAI17296.1 .
CCDSi CCDS33427.1.
RefSeqi NP_071417.2. NM_022134.2.
UniGenei Hs.632556.

3D structure databases

ProteinModelPortali Q9H3Q3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9H3Q3.

Polymorphism databases

DMDMi 212276434.

Proteomic databases

MaxQBi Q9H3Q3.
PaxDbi Q9H3Q3.
PRIDEi Q9H3Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000192314 ; ENSP00000192314 ; ENSG00000154252 .
GeneIDi 64090.
KEGGi hsa:64090.
UCSCi uc002wcj.1. human.

Organism-specific databases

CTDi 64090.
GeneCardsi GC02P242716.
HGNCi HGNC:24869. GAL3ST2.
MIMi 608237. gene.
neXtProti NX_Q9H3Q3.
PharmGKBi PA134913637.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26344.
HOGENOMi HOG000232148.
HOVERGENi HBG051681.
InParanoidi Q9H3Q3.
KOi K09675.
OMAi KRWCALD.
OrthoDBi EOG7K0ZF1.
PhylomeDBi Q9H3Q3.
TreeFami TF314802.

Enzyme and pathway databases

UniPathwayi UPA00353 .

Miscellaneous databases

GeneWikii GAL3ST2.
GenomeRNAii 64090.
NextBioi 65896.
PROi Q9H3Q3.
SOURCEi Search...

Gene expression databases

Bgeei Q9H3Q3.
CleanExi HS_GAL3ST2.
Genevestigatori Q9H3Q3.

Family and domain databases

InterProi IPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR14647. PTHR14647. 1 hit.
Pfami PF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides."
    Honke K., Tsuda M., Koyota S., Wada Y., Iida-Tanaka N., Ishizuka I., Nakayama J., Taniguchi N.
    J. Biol. Chem. 276:267-274(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ENZYME REGULATION, VARIANT LEU-4.
    Tissue: Colon.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-4.

Entry informationi

Entry nameiG3ST2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Q3
Secondary accession number(s): Q17RK0, Q57Z52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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