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Protein

Cdc42 effector protein 4

Gene

CDC42EP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • GTP-Rho binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 4
Alternative name(s):
Binder of Rho GTPases 4
Gene namesi
Name:CDC42EP4
Synonyms:BORG4, CEP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000179604.9.
HGNCiHGNC:17147. CDC42EP4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23580.
OpenTargetsiENSG00000179604.
PharmGKBiPA38439.

Polymorphism and mutation databases

BioMutaiCDC42EP4.
DMDMi21362403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126551 – 356Cdc42 effector protein 4Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-methyllysineCombined sources1
Modified residuei18PhosphoserineBy similarity1
Modified residuei64PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H3Q1.
MaxQBiQ9H3Q1.
PaxDbiQ9H3Q1.
PeptideAtlasiQ9H3Q1.
PRIDEiQ9H3Q1.

PTM databases

iPTMnetiQ9H3Q1.
PhosphoSitePlusiQ9H3Q1.

Expressioni

Tissue specificityi

Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.

Gene expression databases

BgeeiENSG00000179604.
CleanExiHS_CDC42EP4.
ExpressionAtlasiQ9H3Q1. baseline and differential.
GenevisibleiQ9H3Q1. HS.

Organism-specific databases

HPAiHPA023335.
HPA024797.

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ, in a GTP-dependent manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-744665,EBI-10175124

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117115. 29 interactors.
IntActiQ9H3Q1. 10 interactors.
MINTiMINT-1464445.
STRINGi9606.ENSP00000338258.

Structurei

3D structure databases

ProteinModelPortaliQ9H3Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 41CRIBPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 74Poly-Ser5

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IJDS. Eukaryota.
ENOG4111HZ4. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000231054.
HOVERGENiHBG052803.
InParanoidiQ9H3Q1.
OMAiQPDKEFS.
OrthoDBiEOG091G0CZS.
PhylomeDBiQ9H3Q1.
TreeFamiTF331725.

Family and domain databases

InterProiView protein in InterPro
IPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
PfamiView protein in Pfam
PF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
SMARTiView protein in SMART
SM00285. PBD. 1 hit.
PROSITEiView protein in PROSITE
PS50108. CRIB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPILKQLVSS SVHSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT
60 70 80 90 100
SFLNSKAGEP DGESLDEQPS SSSSKRSLLS RKFRGSKRSQ SVTRGEREQR
110 120 130 140 150
DMLGSLRDSA LFVKNAMSLP QLNEKEAAEK GTSKLPKSLS SSPVKKANDG
160 170 180 190 200
EGGDEEAGTE EAVPRRNGAA GPHSPDPLLD EQAFGDLTDL PVVPKATYGL
210 220 230 240 250
KHAESIMSFH IDLGPSMLGD VLSIMDKEEW DPEEGEGGYH GDEGAAGTIT
260 270 280 290 300
QAPPYAVAAP PLARQEGKAG PDLPSLPSHA LEDEGWAAAA PSPGSARSMG
310 320 330 340 350
SHTTRDSSSL SSCTSGILEE RSPAFRGPDR ARAAVSRQPD KEFSFMDEEE

EDEIRV
Length:356
Mass (Da):37,980
Last modified:March 1, 2001 - v1
Checksum:i2CF677C60C6EF1B5
GO
Isoform 2 (identifier: Q9H3Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-126: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):30,214
Checksum:i7DAD551791D000F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → L in AAH10451 (PubMed:15489334).Curated1
Sequence conflicti33D → T in AAD16299 (PubMed:11035016).Curated1
Sequence conflicti288A → T in AAD16299 (PubMed:11035016).Curated1
Sequence conflicti296A → T in AAD16299 (PubMed:11035016).Curated1
Sequence conflicti339P → PP in AAD16299 (PubMed:11035016).Curated1
Sequence conflicti355Missing in AAD16299 (PubMed:11035016).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05554457 – 126Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042237 mRNA. Translation: BAB17272.1.
AF099664 mRNA. Translation: AAD16299.1.
AK097835 mRNA. Translation: BAG53539.1.
AC087301 Genomic DNA. No translation available.
BC002774 mRNA. Translation: AAH02774.1.
BC010451 mRNA. Translation: AAH10451.1.
CCDSiCCDS11695.1. [Q9H3Q1-1]
RefSeqiNP_036253.2. NM_012121.4. [Q9H3Q1-1]
XP_005257239.1. XM_005257182.2. [Q9H3Q1-1]
UniGeneiHs.3903.

Genome annotation databases

EnsembliENST00000335793; ENSP00000338258; ENSG00000179604. [Q9H3Q1-1]
ENST00000439510; ENSP00000404270; ENSG00000179604. [Q9H3Q1-2]
GeneIDi23580.
KEGGihsa:23580.
UCSCiuc002jjo.4. human. [Q9H3Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBORG4_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Q1
Secondary accession number(s): B3KUS7, O95828, Q96FT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families