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Q9H3Q1

- BORG4_HUMAN

UniProt

Q9H3Q1 - BORG4_HUMAN

Protein

Cdc42 effector protein 4

Gene

CDC42EP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

    GO - Molecular functioni

    1. GTP-Rho binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of pseudopodium assembly Source: UniProtKB
    2. regulation of cell shape Source: UniProtKB
    3. Rho protein signal transduction Source: Ensembl

    Keywords - Biological processi

    Cell shape

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cdc42 effector protein 4
    Alternative name(s):
    Binder of Rho GTPases 4
    Gene namesi
    Name:CDC42EP4
    Synonyms:BORG4, CEP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17147. CDC42EP4.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: HPA
    2. cytoplasm Source: UniProtKB-KW
    3. endomembrane system Source: UniProtKB-SubCell
    4. microtubule cytoskeleton Source: HPA
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Cdc42 effector protein 4PRO_0000212655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641Phosphoserine2 Publications
    Modified residuei118 – 1181Phosphoserine1 Publication
    Modified residuei138 – 1381Phosphoserine1 Publication
    Modified residuei140 – 1401Phosphoserine1 Publication
    Modified residuei142 – 1421Phosphoserine1 Publication
    Modified residuei174 – 1741Phosphoserine3 Publications
    Modified residuei292 – 2921Phosphoserine2 Publications
    Modified residuei295 – 2951Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H3Q1.
    PaxDbiQ9H3Q1.
    PeptideAtlasiQ9H3Q1.
    PRIDEiQ9H3Q1.

    PTM databases

    PhosphoSiteiQ9H3Q1.

    Expressioni

    Tissue specificityi

    Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.

    Gene expression databases

    ArrayExpressiQ9H3Q1.
    BgeeiQ9H3Q1.
    CleanExiHS_CDC42EP4.
    GenevestigatoriQ9H3Q1.

    Organism-specific databases

    HPAiHPA023335.
    HPA024797.

    Interactioni

    Subunit structurei

    Interacts with CDC42 and RHOQ, in a GTP-dependent manner.By similarity

    Protein-protein interaction databases

    BioGridi117115. 10 interactions.
    IntActiQ9H3Q1. 5 interactions.
    MINTiMINT-1464445.
    STRINGi9606.ENSP00000338258.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3Q1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 4115CRIBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi70 – 745Poly-Ser

    Sequence similaritiesi

    Belongs to the BORG/CEP family.Curated
    Contains 1 CRIB domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG44582.
    HOGENOMiHOG000231054.
    HOVERGENiHBG052803.
    InParanoidiQ9H3Q1.
    OMAiKEFSFMD.
    PhylomeDBiQ9H3Q1.
    TreeFamiTF331725.

    Family and domain databases

    InterProiIPR029273. Cdc42_effect.
    IPR000095. CRIB_dom.
    [Graphical view]
    PfamiPF14957. BORG_CEP. 1 hit.
    PF00786. PBD. 1 hit.
    [Graphical view]
    PROSITEiPS50108. CRIB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H3Q1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPILKQLVSS SVHSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT    50
    SFLNSKAGEP DGESLDEQPS SSSSKRSLLS RKFRGSKRSQ SVTRGEREQR 100
    DMLGSLRDSA LFVKNAMSLP QLNEKEAAEK GTSKLPKSLS SSPVKKANDG 150
    EGGDEEAGTE EAVPRRNGAA GPHSPDPLLD EQAFGDLTDL PVVPKATYGL 200
    KHAESIMSFH IDLGPSMLGD VLSIMDKEEW DPEEGEGGYH GDEGAAGTIT 250
    QAPPYAVAAP PLARQEGKAG PDLPSLPSHA LEDEGWAAAA PSPGSARSMG 300
    SHTTRDSSSL SSCTSGILEE RSPAFRGPDR ARAAVSRQPD KEFSFMDEEE 350
    EDEIRV 356
    Length:356
    Mass (Da):37,980
    Last modified:March 1, 2001 - v1
    Checksum:i2CF677C60C6EF1B5
    GO
    Isoform 2 (identifier: Q9H3Q1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-126: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):30,214
    Checksum:i7DAD551791D000F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21P → L in AAH10451. (PubMed:15489334)Curated
    Sequence conflicti33 – 331D → T in AAD16299. (PubMed:11035016)Curated
    Sequence conflicti288 – 2881A → T in AAD16299. (PubMed:11035016)Curated
    Sequence conflicti296 – 2961A → T in AAD16299. (PubMed:11035016)Curated
    Sequence conflicti339 – 3391P → PP in AAD16299. (PubMed:11035016)Curated
    Sequence conflicti355 – 3551Missing in AAD16299. (PubMed:11035016)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei57 – 12670Missing in isoform 2. 1 PublicationVSP_055544Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042237 mRNA. Translation: BAB17272.1.
    AF099664 mRNA. Translation: AAD16299.1.
    AK097835 mRNA. Translation: BAG53539.1.
    AC087301 Genomic DNA. No translation available.
    BC002774 mRNA. Translation: AAH02774.1.
    BC010451 mRNA. Translation: AAH10451.1.
    CCDSiCCDS11695.1.
    RefSeqiNP_036253.2. NM_012121.4.
    XP_005257239.1. XM_005257182.2.
    UniGeneiHs.3903.

    Genome annotation databases

    EnsembliENST00000335793; ENSP00000338258; ENSG00000179604. [Q9H3Q1-1]
    ENST00000439510; ENSP00000404270; ENSG00000179604. [Q9H3Q1-2]
    GeneIDi23580.
    KEGGihsa:23580.
    UCSCiuc002jjn.3. human.

    Polymorphism databases

    DMDMi21362403.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042237 mRNA. Translation: BAB17272.1 .
    AF099664 mRNA. Translation: AAD16299.1 .
    AK097835 mRNA. Translation: BAG53539.1 .
    AC087301 Genomic DNA. No translation available.
    BC002774 mRNA. Translation: AAH02774.1 .
    BC010451 mRNA. Translation: AAH10451.1 .
    CCDSi CCDS11695.1.
    RefSeqi NP_036253.2. NM_012121.4.
    XP_005257239.1. XM_005257182.2.
    UniGenei Hs.3903.

    3D structure databases

    ProteinModelPortali Q9H3Q1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117115. 10 interactions.
    IntActi Q9H3Q1. 5 interactions.
    MINTi MINT-1464445.
    STRINGi 9606.ENSP00000338258.

    PTM databases

    PhosphoSitei Q9H3Q1.

    Polymorphism databases

    DMDMi 21362403.

    Proteomic databases

    MaxQBi Q9H3Q1.
    PaxDbi Q9H3Q1.
    PeptideAtlasi Q9H3Q1.
    PRIDEi Q9H3Q1.

    Protocols and materials databases

    DNASUi 23580.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335793 ; ENSP00000338258 ; ENSG00000179604 . [Q9H3Q1-1 ]
    ENST00000439510 ; ENSP00000404270 ; ENSG00000179604 . [Q9H3Q1-2 ]
    GeneIDi 23580.
    KEGGi hsa:23580.
    UCSCi uc002jjn.3. human.

    Organism-specific databases

    CTDi 23580.
    GeneCardsi GC17M071279.
    HGNCi HGNC:17147. CDC42EP4.
    HPAi HPA023335.
    HPA024797.
    MIMi 605468. gene.
    neXtProti NX_Q9H3Q1.
    PharmGKBi PA38439.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44582.
    HOGENOMi HOG000231054.
    HOVERGENi HBG052803.
    InParanoidi Q9H3Q1.
    OMAi KEFSFMD.
    PhylomeDBi Q9H3Q1.
    TreeFami TF331725.

    Miscellaneous databases

    ChiTaRSi CDC42EP4. human.
    GeneWikii CDC42EP4.
    GenomeRNAii 23580.
    NextBioi 46182.
    PROi Q9H3Q1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H3Q1.
    Bgeei Q9H3Q1.
    CleanExi HS_CDC42EP4.
    Genevestigatori Q9H3Q1.

    Family and domain databases

    InterProi IPR029273. Cdc42_effect.
    IPR000095. CRIB_dom.
    [Graphical view ]
    Pfami PF14957. BORG_CEP. 1 hit.
    PF00786. PBD. 1 hit.
    [Graphical view ]
    PROSITEi PS50108. CRIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue."
      Osada N., Kusuda J., Suzuki Y., Sugano S., Hashimoto K.
      J. Hum. Genet. 45:374-377(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ileal mucosa.
    2. "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."
      Hirsch D.S., Pirone D.M., Burbelo P.D.
      J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Eye.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Skin.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-292 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-138; SER-174; SER-292 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-118; SER-140; SER-142; SER-174 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiBORG4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3Q1
    Secondary accession number(s): B3KUS7, O95828, Q96FT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3