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Q9H3P2

- NELFA_HUMAN

UniProt

Q9H3P2 - NELFA_HUMAN

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Protein

Negative elongation factor A

Gene

NELFA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: Ensembl

GO - Biological processi

  1. gene expression Source: Reactome
  2. multicellular organismal development Source: ProtInc
  3. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of viral transcription Source: Reactome
  5. transcription elongation from RNA polymerase II promoter Source: Reactome
  6. transcription from RNA polymerase II promoter Source: Reactome
  7. viral process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
REACT_6143. Pausing and recovery of Tat-mediated HIV elongation.
REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
REACT_6244. Pausing and recovery of HIV elongation.
REACT_6259. HIV elongation arrest and recovery.
REACT_6261. Abortive elongation of HIV-1 transcript in the absence of Tat.
REACT_6319. Formation of the HIV-1 Early Elongation Complex.
REACT_6344. Tat-mediated HIV elongation arrest and recovery.
REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
REACT_833. RNA Polymerase II Transcription Elongation.
REACT_846. Formation of the Early Elongation Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Negative elongation factor A
Short name:
NELF-A
Alternative name(s):
Wolf-Hirschhorn syndrome candidate 2 protein
Gene namesi
Name:NELFA
Synonyms:WHSC2
ORF Names:P/OKcl.15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12768. NELFA.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. NELF complex Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti280. Wolf-Hirschhorn syndrome.
PharmGKBiPA37371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Negative elongation factor APRO_0000219126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Phosphothreonine3 Publications
Modified residuei277 – 2771Phosphothreonine1 Publication
Modified residuei363 – 3631Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H3P2.
PaxDbiQ9H3P2.
PRIDEiQ9H3P2.

PTM databases

PhosphoSiteiQ9H3P2.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.3 Publications

Gene expression databases

BgeeiQ9H3P2.
CleanExiHS_WHSC2.
ExpressionAtlasiQ9H3P2. baseline and differential.
GenevestigatoriQ9H3P2.

Organism-specific databases

HPAiCAB009960.
HPA039858.
HPA043931.

Interactioni

Subunit structurei

The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with the RNA polymerase II complex when it is not phosphorylated by P-TEFb.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NELFCDQ8IXH7-43EBI-5461341,EBI-6109710

Protein-protein interaction databases

BioGridi113307. 12 interactions.
DIPiDIP-48478N.
IntActiQ9H3P2. 6 interactions.
MINTiMINT-3067399.
STRINGi9606.ENSP00000372335.

Structurei

3D structure databases

ProteinModelPortaliQ9H3P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini189 – 24860HDAg-likeAdd
BLAST

Domaini

The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.1 Publication

Sequence similaritiesi

Belongs to the NELF-A family.Curated
Contains 1 HDAg-like domain.Curated

Phylogenomic databases

eggNOGiNOG10551.
GeneTreeiENSGT00390000005342.
HOGENOMiHOG000113765.
HOVERGENiHBG052595.
InParanoidiQ9H3P2.
KOiK15179.
OrthoDBiEOG708VZQ.
PhylomeDBiQ9H3P2.
TreeFamiTF324956.

Family and domain databases

InterProiIPR026305. NELF-A.
[Graphical view]
PANTHERiPTHR13328. PTHR13328. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H3P2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASMRESDTG LWLHNKLGAT DELWAPPSIA SLLTAAVIDN IRLCFHGLSS
60 70 80 90 100
AVKLKLLLGT LHLPRRTVDE MKGALMEIIQ LASLDSDPWV LMVADILKSF
110 120 130 140 150
PDTGSLNLEL EEQNPNVQDI LGELREKVGE CEASAMLPLE CQYLNKNALT
160 170 180 190 200
TLAGPLTPPV KHFQLKRKPK SATLRAELLQ KSTETAQQLK RSAGVPFHAK
210 220 230 240 250
GRGLLRKMDT TTPLKGIPKQ APFRSPTAPS VFSPTGNRTP IPPSRTLLRK
260 270 280 290 300
ERGVKLLDIS ELDMVGAGRE AKRRRKTLDA EVVEKPAKEE TVVENATPDY
310 320 330 340 350
AAGLVSTQKL GSLNNEPALP STSYLPSTPS VVPASSYIPS SETPPAPSSR
360 370 380 390 400
EASRPPEEPS APSPTLPAQF KQRAPMYNSG LSPATPTPAA PTSPLTPTTP
410 420 430 440 450
PAVAPTTQTP PVAMVAPQTQ APAQQQPKKN LSLTREQMFA AQEMFKTANK
460 470 480 490 500
VTRPEKALIL GFMAGSRENP CQEQGDVIQI KLSEHTEDLP KADGQGSTTM
510 520
LVDTVFEMNY ATGQWTRFKK YKPMTNVS
Length:528
Mass (Da):57,277
Last modified:November 4, 2008 - v3
Checksum:i4F33C3BC68BDC798
GO
Isoform 2 (identifier: Q9H3P2-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.

Show »
Length:265
Mass (Da):28,416
Checksum:i66F97A90BF7F1C62
GO

Sequence cautioni

The sequence AAC72982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG54283.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAM15219.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW82546.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → I in BAB18651. (PubMed:11280764)Curated
Sequence conflicti40 – 401N → NIRLCFHGLSSASLLTAAVI DN in BAB18651. (PubMed:11280764)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti335 – 3351S → A.
Corresponds to variant rs2234569 [ dbSNP | Ensembl ].
VAR_059459

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 263263Missing in isoform 2. 1 PublicationVSP_035589Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101434 mRNA. Translation: AAC72982.1. Different initiation.
AB044549 mRNA. Translation: BAB18651.1.
AF131751 mRNA. Translation: AAD20034.1.
AK126056 mRNA. Translation: BAG54283.1. Different initiation.
AL132868 Genomic DNA. Translation: CAM15219.1. Different initiation.
CH471131 Genomic DNA. Translation: EAW82546.1. Different initiation.
BC002764 mRNA. Translation: AAH02764.2.
RefSeqiNP_005654.3. NM_005663.4.
UniGeneiHs.21771.

Genome annotation databases

EnsembliENST00000382882; ENSP00000372335; ENSG00000185049.
ENST00000411638; ENSP00000399165; ENSG00000185049. [Q9H3P2-1]
ENST00000542778; ENSP00000445757; ENSG00000185049.
GeneIDi7469.
KEGGihsa:7469.
UCSCiuc003gek.3. human. [Q9H3P2-1]

Polymorphism databases

DMDMi212276499.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101434 mRNA. Translation: AAC72982.1 . Different initiation.
AB044549 mRNA. Translation: BAB18651.1 .
AF131751 mRNA. Translation: AAD20034.1 .
AK126056 mRNA. Translation: BAG54283.1 . Different initiation.
AL132868 Genomic DNA. Translation: CAM15219.1 . Different initiation.
CH471131 Genomic DNA. Translation: EAW82546.1 . Different initiation.
BC002764 mRNA. Translation: AAH02764.2 .
RefSeqi NP_005654.3. NM_005663.4.
UniGenei Hs.21771.

3D structure databases

ProteinModelPortali Q9H3P2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113307. 12 interactions.
DIPi DIP-48478N.
IntActi Q9H3P2. 6 interactions.
MINTi MINT-3067399.
STRINGi 9606.ENSP00000372335.

PTM databases

PhosphoSitei Q9H3P2.

Polymorphism databases

DMDMi 212276499.

Proteomic databases

MaxQBi Q9H3P2.
PaxDbi Q9H3P2.
PRIDEi Q9H3P2.

Protocols and materials databases

DNASUi 7469.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382882 ; ENSP00000372335 ; ENSG00000185049 .
ENST00000411638 ; ENSP00000399165 ; ENSG00000185049 . [Q9H3P2-1 ]
ENST00000542778 ; ENSP00000445757 ; ENSG00000185049 .
GeneIDi 7469.
KEGGi hsa:7469.
UCSCi uc003gek.3. human. [Q9H3P2-1 ]

Organism-specific databases

CTDi 7469.
GeneCardsi GC04M001985.
HGNCi HGNC:12768. NELFA.
HPAi CAB009960.
HPA039858.
HPA043931.
MIMi 606026. gene.
neXtProti NX_Q9H3P2.
Orphaneti 280. Wolf-Hirschhorn syndrome.
PharmGKBi PA37371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG10551.
GeneTreei ENSGT00390000005342.
HOGENOMi HOG000113765.
HOVERGENi HBG052595.
InParanoidi Q9H3P2.
KOi K15179.
OrthoDBi EOG708VZQ.
PhylomeDBi Q9H3P2.
TreeFami TF324956.

Enzyme and pathway databases

Reactomei REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
REACT_6143. Pausing and recovery of Tat-mediated HIV elongation.
REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
REACT_6244. Pausing and recovery of HIV elongation.
REACT_6259. HIV elongation arrest and recovery.
REACT_6261. Abortive elongation of HIV-1 transcript in the absence of Tat.
REACT_6319. Formation of the HIV-1 Early Elongation Complex.
REACT_6344. Tat-mediated HIV elongation arrest and recovery.
REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
REACT_833. RNA Polymerase II Transcription Elongation.
REACT_846. Formation of the Early Elongation Complex.

Miscellaneous databases

GeneWikii WHSC2.
GenomeRNAii 7469.
NextBioi 29260.
PROi Q9H3P2.
SOURCEi Search...

Gene expression databases

Bgeei Q9H3P2.
CleanExi HS_WHSC2.
ExpressionAtlasi Q9H3P2. baseline and differential.
Genevestigatori Q9H3P2.

Family and domain databases

InterProi IPR026305. NELF-A.
[Graphical view ]
PANTHERi PTHR13328. PTHR13328. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region."
    Wright T.J., Costa J.L., Naranjo C., Francis-West P., Altherr M.R.
    Genomics 59:203-212(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."
    Ito M., Shichijo S., Tsuda N., Ochi M., Harashima N., Saito N., Itoh K.
    Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreatic cancer.
  3. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  8. "Stimulation of RNA polymerase II elongation by hepatitis delta antigen."
    Yamaguchi Y., Filipovska J., Yano K., Furuya A., Inukai N., Narita T., Wada T., Sugimoto S., Konarska M.M., Handa H.
    Science 293:124-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 212-221; 309-321 AND 503-513, IDENTIFICATION IN THE NELF COMPLEX.
  9. "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation."
    Yamaguchi Y., Takagi T., Wada T., Yano K., Furuya A., Sugimoto S., Hasegawa J., Handa H.
    Cell 97:41-51(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NELF COMPLEX.
  10. "Modulation of WHSC2 expression in human endothelial cells."
    Mariotti M., Manganini M., Maier J.A.M.
    FEBS Lett. 487:166-170(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2."
    Zollino M., Lecce R., Fischetto R., Murdolo M., Faravelli F., Selicorni A., Butte C., Memo L., Capovilla G., Neri G.
    Am. J. Hum. Genet. 72:590-597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex."
    Narita T., Yamaguchi Y., Yano K., Sugimoto S., Chanarat S., Wada T., Kim D.-K., Hasegawa J., Omori M., Inukai N., Endoh M., Yamada T., Handa H.
    Mol. Cell. Biol. 23:1863-1873(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DOMAIN.
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-157, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-157, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-157; THR-277 AND SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNELFA_HUMAN
AccessioniPrimary (citable) accession number: Q9H3P2
Secondary accession number(s): A2A2T1, O95392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:12612062 has shown that it is not involved in Wolf-Hirschhorn syndrome.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3