Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily F member 1

Gene

KCNF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative voltage-gated potassium channel.

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • potassium channel activity Source: ProtInc

GO - Biological processi

  • potassium ion transport Source: ProtInc
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162975-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.18. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily F member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv5.1
kH1
Gene namesi
Name:KCNF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6246. KCNF1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 183CytoplasmicSequence analysisAdd BLAST183
Transmembranei184 – 204Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei224 – 244Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini245 – 249CytoplasmicSequence analysis5
Transmembranei250 – 270Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei290 – 310Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini311 – 324CytoplasmicSequence analysisAdd BLAST14
Transmembranei325 – 345Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei358 – 378Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei386 – 406Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini407 – 494CytoplasmicSequence analysisAdd BLAST88

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162975.
PharmGKBiPA30033.

Chemistry databases

ChEMBLiCHEMBL2362996.

Polymorphism and mutation databases

BioMutaiKCNF1.
DMDMi24418476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540721 – 494Potassium voltage-gated channel subfamily F member 1Add BLAST494

Proteomic databases

PaxDbiQ9H3M0.
PeptideAtlasiQ9H3M0.
PRIDEiQ9H3M0.

PTM databases

iPTMnetiQ9H3M0.
PhosphoSitePlusiQ9H3M0.

Expressioni

Tissue specificityi

Detected in heart, brain, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000162975.
CleanExiHS_KCNF1.
GenevisibleiQ9H3M0. HS.

Organism-specific databases

HPAiCAB004678.
HPA014738.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1.1 Publication

Protein-protein interaction databases

BioGridi109956. 4 interactors.
IntActiQ9H3M0. 1 interactor.
STRINGi9606.ENSP00000295082.

Structurei

3D structure databases

ProteinModelPortaliQ9H3M0.
SMRiQ9H3M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi370 – 375Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9H3M0.
KOiK04899.
OMAiNEMEFWK.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ9H3M0.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H3M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSGERSLP EPGSQSSAAS DDIEIVVNVG GVRQVLYGDL LSQYPETRLA
60 70 80 90 100
ELINCLAGGY DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM
110 120 130 140 150
KKGICPICFK NEMDFWKVDL KFLDDCCKSH LSEKREELEE IARRVQLILD
160 170 180 190 200
DLGVDAAEGR WRRCQKCVWK FLEKPESSCP ARVVAVLSFL LILVSSVVMC
210 220 230 240 250
MGTIPELQVL DAEGNRVEHP TLENVETACI GWFTLEYLLR LFSSPNKLHF
260 270 280 290 300
ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI
310 320 330 340 350
FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP
360 370 380 390 400
ETLFKSIPQS FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL
410 420 430 440 450
PIHPIINNFV RYYNKQRVLE TAAKHELELM ELNSSSGGEG KTGGSRSDLD
460 470 480 490
NLPPEPAGKE APSCSSRLKL SHSDTFIPLL TEEKHHRTRL QSCK
Length:494
Mass (Da):55,584
Last modified:March 1, 2001 - v1
Checksum:i87E2FB117F927F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186V → E in AAC05597 (PubMed:9434767).Curated1
Sequence conflicti202G → D in AAC05597 (PubMed:9434767).Curated1
Sequence conflicti356S → N in AAC05597 (PubMed:9434767).Curated1
Sequence conflicti383G → S in AAC05597 (PubMed:9434767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033382 mRNA. Translation: AAC05597.1.
AF029780 mRNA. Translation: AAG43055.1.
AC019041 Genomic DNA. Translation: AAX81991.1.
CH471053 Genomic DNA. Translation: EAX00946.1.
BC026110 mRNA. Translation: AAH26110.1.
CCDSiCCDS1676.1.
PIRiJC5919.
RefSeqiNP_002227.2. NM_002236.4.
UniGeneiHs.23735.

Genome annotation databases

EnsembliENST00000295082; ENSP00000295082; ENSG00000162975.
GeneIDi3754.
KEGGihsa:3754.
UCSCiuc002rax.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033382 mRNA. Translation: AAC05597.1.
AF029780 mRNA. Translation: AAG43055.1.
AC019041 Genomic DNA. Translation: AAX81991.1.
CH471053 Genomic DNA. Translation: EAX00946.1.
BC026110 mRNA. Translation: AAH26110.1.
CCDSiCCDS1676.1.
PIRiJC5919.
RefSeqiNP_002227.2. NM_002236.4.
UniGeneiHs.23735.

3D structure databases

ProteinModelPortaliQ9H3M0.
SMRiQ9H3M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109956. 4 interactors.
IntActiQ9H3M0. 1 interactor.
STRINGi9606.ENSP00000295082.

Chemistry databases

ChEMBLiCHEMBL2362996.

Protein family/group databases

TCDBi1.A.1.2.18. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ9H3M0.
PhosphoSitePlusiQ9H3M0.

Polymorphism and mutation databases

BioMutaiKCNF1.
DMDMi24418476.

Proteomic databases

PaxDbiQ9H3M0.
PeptideAtlasiQ9H3M0.
PRIDEiQ9H3M0.

Protocols and materials databases

DNASUi3754.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295082; ENSP00000295082; ENSG00000162975.
GeneIDi3754.
KEGGihsa:3754.
UCSCiuc002rax.3. human.

Organism-specific databases

CTDi3754.
GeneCardsiKCNF1.
HGNCiHGNC:6246. KCNF1.
HPAiCAB004678.
HPA014738.
MIMi603787. gene.
neXtProtiNX_Q9H3M0.
OpenTargetsiENSG00000162975.
PharmGKBiPA30033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9H3M0.
KOiK04899.
OMAiNEMEFWK.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ9H3M0.
TreeFamiTF313103.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162975-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNF1.
GenomeRNAii3754.
PROiQ9H3M0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162975.
CleanExiHS_KCNF1.
GenevisibleiQ9H3M0. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H3M0
Secondary accession number(s): O43527, Q585L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.