Q9H3M0 (KCNF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily F member 1

Alternative name(s):
Voltage-gated potassium channel subunit Kv5.1
kH1

Gene names

Name:

KCNF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative voltage-gated potassium channel.
Subunit structure	Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1. Ref.6
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in heart, brain, liver, skeletal muscle, kidney and pancreas.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	plasma membrane Traceable author statement. Source: Reactome voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Potassium voltage-gated channel subfamily F member 1		PRO_0000054072
Regions
	Topological domain	1 – 183	183	Cytoplasmic Potential
	Transmembrane	184 – 204	21	Helical; Name=Segment S1; Potential
	Transmembrane	224 – 244	21	Helical; Name=Segment S2; Potential
	Topological domain	245 – 249	5	Cytoplasmic Potential
	Transmembrane	250 – 270	21	Helical; Name=Segment S3; Potential
	Transmembrane	290 – 310	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	311 – 324	14	Cytoplasmic Potential
	Transmembrane	325 – 345	21	Helical; Name=Segment S5; Potential
	Intramembrane	358 – 378	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	386 – 406	21	Helical; Name=Segment S6; Potential
	Topological domain	407 – 494	88	Cytoplasmic Potential
	Motif	370 – 375	6	Selectivity filter By similarity
Experimental info
	Sequence conflict	186	1	V → E in AAC05597. Ref.1
	Sequence conflict	202	1	G → D in AAC05597. Ref.1
	Sequence conflict	356	1	S → N in AAC05597. Ref.1
	Sequence conflict	383	1	G → S in AAC05597. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H3M0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 87E2FB117F927F60	FASTA	494	55,584
	10 20 30 40 50 60 MDGSGERSLP EPGSQSSAAS DDIEIVVNVG GVRQVLYGDL LSQYPETRLA ELINCLAGGY 70 80 90 100 110 120 DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM KKGICPICFK NEMDFWKVDL 130 140 150 160 170 180 KFLDDCCKSH LSEKREELEE IARRVQLILD DLGVDAAEGR WRRCQKCVWK FLEKPESSCP 190 200 210 220 230 240 ARVVAVLSFL LILVSSVVMC MGTIPELQVL DAEGNRVEHP TLENVETACI GWFTLEYLLR 250 260 270 280 290 300 LFSSPNKLHF ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI 310 320 330 340 350 360 FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP ETLFKSIPQS 370 380 390 400 410 420 FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL PIHPIINNFV RYYNKQRVLE 430 440 450 460 470 480 TAAKHELELM ELNSSSGGEG KTGGSRSDLD NLPPEPAGKE APSCSSRLKL SHSDTFIPLL 490 TEEKHHRTRL QSCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and mapping of two human potassium channels." Su K., Kyaw H., Fan P., Zeng Z., Shell B.K., Carter K.C., Li Y. Biochem. Biophys. Res. Commun. 241:675-681(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	Chen J., Ptacek J.L. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[6]	"Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium." Godreau D., Vranckx R., Maguy A., Rucker-Martin C., Goyenvalle C., Abdelshafy S., Tessier S., Couetil J.P., Hatem S.N. Cardiovasc. Res. 56:433-442(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DLG1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF033382 mRNA. Translation: AAC05597.1. AF029780 mRNA. Translation: AAG43055.1. AC019041 Genomic DNA. Translation: AAX81991.1. CH471053 Genomic DNA. Translation: EAX00946.1. BC026110 mRNA. Translation: AAH26110.1.
IPI	IPI00100431.
PIR	JC5919.
RefSeq	NP_002227.2. NM_002236.4.
UniGene	Hs.23735.
3D structure databases
ProteinModelPortal	Q9H3M0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000295082.
PTM databases
PhosphoSite	Q9H3M0.
Polymorphism databases
DMDM	24418476.
Proteomic databases
PaxDb	Q9H3M0.
PRIDE	Q9H3M0.
Protocols and materials databases
DNASU	3754.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295082; ENSP00000295082; ENSG00000162975.
GeneID	3754.
KEGG	hsa:3754.
UCSC	uc002rax.3. human.
Organism-specific databases
CTD	3754.
GeneCards	GC02P011052.
HGNC	HGNC:6246. KCNF1.
HPA	CAB004678. HPA014738.
MIM	603787. gene.
neXtProt	NX_Q9H3M0.
PharmGKB	PA30033.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231016.
HOVERGEN	HBG052230.
InParanoid	Q9H3M0.
KO	K04899.
OMA	ICFKSEM.
OrthoDB	EOG4W3SNB.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q9H3M0.
CleanEx	HS_KCNF1.
Genevestigator	Q9H3M0.
GermOnline	ENSG00000162975. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003971. K_chnl_volt-dep_Kv9. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01494. KV9CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	3754.
NextBio	14701.
SOURCE	Search...

Entry information

Entry name

KCNF1_HUMAN

Accession

Primary (citable) accession number: Q9H3M0
Secondary accession number(s): O43527, Q585L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.