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Q9H3K6

- BOLA2_HUMAN

UniProt

Q9H3K6 - BOLA2_HUMAN

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Protein

BolA-like protein 2

Gene

BOLA2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 2
Gene namesi
Name:BOLA2
Synonyms:BOLA2A
ORF Names:My016
AND
Name:BOLA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:29488. BOLA2.
HGNC:32479. BOLA2B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8686BolA-like protein 2PRO_0000201236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H3K6.
PaxDbiQ9H3K6.
PRIDEiQ9H3K6.

Expressioni

Gene expression databases

BgeeiQ9H3K6.
CleanExiHS_BOLA2.
HS_BOLA2B.
ExpressionAtlasiQ9H3K6. baseline.
GenevestigatoriQ9H3K6.

Organism-specific databases

HPAiHPA045380.

Interactioni

Protein-protein interaction databases

BioGridi139268. 11 interactions.
576388. 6 interactions.
IntActiQ9H3K6. 3 interactions.
MINTiMINT-5006599.
STRINGi9606.ENSP00000306752.

Structurei

3D structure databases

ProteinModelPortaliQ9H3K6.
SMRiQ9H3K6. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bolA/yrbA family.Curated

Phylogenomic databases

eggNOGiNOG278560.
GeneTreeiENSGT00510000047760.
ENSGT00770000120527.
HOGENOMiHOG000255170.
HOVERGENiHBG080902.
InParanoidiQ9H3K6.
OrthoDBiEOG7HTHKJ.
PhylomeDBiQ9H3K6.
TreeFamiTF313141.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
PIRSFiPIRSF003113. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H3K6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSAEYLRE KLQRDLEAEH VEVEDTTLNR CSCSFRVLVV SAKFEGKPLL
60 70 80
QRHRLVNACL AEELPHIHAF EQKTLTPDQW ARERQK
Length:86
Mass (Da):10,117
Last modified:March 1, 2001 - v1
Checksum:iCA95C76A225B5384
GO
Isoform 2 (identifier: Q9H3K6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-58: LVNA → FCTE
     59-86: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:58
Mass (Da):6,842
Checksum:i3BF3A0799235408E
GO

Sequence cautioni

The sequence AAH22832.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI30402.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI30404.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI37533.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI37535.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI44689.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 584LVNA → FCTE in isoform 2. 1 PublicationVSP_010092
Alternative sequencei59 – 8628Missing in isoform 2. 1 PublicationVSP_010093Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060511 mRNA. Translation: AAG43129.1.
BC022832 mRNA. Translation: AAH22832.1. Different initiation.
BC062756 mRNA. No translation available.
BC130401 mRNA. Translation: AAI30402.1. Different initiation.
BC130403 mRNA. Translation: AAI30404.1. Different initiation.
BC137532 mRNA. Translation: AAI37533.1. Different initiation.
BC137534 mRNA. Translation: AAI37535.1. Different initiation.
BC144688 mRNA. Translation: AAI44689.1. Different initiation.
RefSeqiNP_001026997.1. NM_001031827.1.
NP_001034271.1. NM_001039182.1.
XP_006726687.1. XM_006726624.1.
UniGeneiHs.444600.
Hs.647333.
Hs.655267.
Hs.745100.

Genome annotation databases

EnsembliENST00000305321; ENSP00000306752; ENSG00000169627.
ENST00000330978; ENSP00000331127; ENSG00000183336.
GeneIDi102725214.
552900.
654483.
KEGGihsa:102725214.
hsa:552900.
hsa:654483.

Polymorphism databases

DMDMi46577124.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060511 mRNA. Translation: AAG43129.1 .
BC022832 mRNA. Translation: AAH22832.1 . Different initiation.
BC062756 mRNA. No translation available.
BC130401 mRNA. Translation: AAI30402.1 . Different initiation.
BC130403 mRNA. Translation: AAI30404.1 . Different initiation.
BC137532 mRNA. Translation: AAI37533.1 . Different initiation.
BC137534 mRNA. Translation: AAI37535.1 . Different initiation.
BC144688 mRNA. Translation: AAI44689.1 . Different initiation.
RefSeqi NP_001026997.1. NM_001031827.1.
NP_001034271.1. NM_001039182.1.
XP_006726687.1. XM_006726624.1.
UniGenei Hs.444600.
Hs.647333.
Hs.655267.
Hs.745100.

3D structure databases

ProteinModelPortali Q9H3K6.
SMRi Q9H3K6. Positions 1-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 139268. 11 interactions.
576388. 6 interactions.
IntActi Q9H3K6. 3 interactions.
MINTi MINT-5006599.
STRINGi 9606.ENSP00000306752.

Polymorphism databases

DMDMi 46577124.

Proteomic databases

MaxQBi Q9H3K6.
PaxDbi Q9H3K6.
PRIDEi Q9H3K6.

Protocols and materials databases

DNASUi 552900.
654483.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305321 ; ENSP00000306752 ; ENSG00000169627 .
ENST00000330978 ; ENSP00000331127 ; ENSG00000183336 .
GeneIDi 102725214.
552900.
654483.
KEGGi hsa:102725214.
hsa:552900.
hsa:654483.

Organism-specific databases

CTDi 552900.
654483.
GeneCardsi GC16M029465.
GC16M030205.
HGNCi HGNC:29488. BOLA2.
HGNC:32479. BOLA2B.
HPAi HPA045380.
MIMi 613182. gene.
neXtProti NX_Q9H3K6.
PharmGKBi PA143485317.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278560.
GeneTreei ENSGT00510000047760.
ENSGT00770000120527.
HOGENOMi HOG000255170.
HOVERGENi HBG080902.
InParanoidi Q9H3K6.
OrthoDBi EOG7HTHKJ.
PhylomeDBi Q9H3K6.
TreeFami TF313141.

Miscellaneous databases

ChiTaRSi BOLA2. human.
NextBioi 112366.
PROi Q9H3K6.
SOURCEi Search...

Gene expression databases

Bgeei Q9H3K6.
CleanExi HS_BOLA2.
HS_BOLA2B.
ExpressionAtlasi Q9H3K6. baseline.
Genevestigatori Q9H3K6.

Family and domain databases

Gene3Di 3.30.300.90. 1 hit.
InterProi IPR002634. BolA.
[Graphical view ]
Pfami PF01722. BolA. 1 hit.
[Graphical view ]
PIRSFi PIRSF003113. BolA. 1 hit.
SUPFAMi SSF82657. SSF82657. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mao Y.M., Xie Y., Huang X.Y., Ying K., Dai J.L.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Kidney.
  3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-9, ACETYLATION AT MET-1.
    Tissue: Platelet.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOLA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3K6
Secondary accession number(s): A1L454, A7YDY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3