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Q9H3K6

- BOLA2_HUMAN

UniProt

Q9H3K6 - BOLA2_HUMAN

Protein

BolA-like protein 2

Gene

BOLA2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    BolA-like protein 2
    Gene namesi
    Name:BOLA2
    Synonyms:BOLA2A
    ORF Names:My016
    AND
    Name:BOLA2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:29488. BOLA2.
    HGNC:32479. BOLA2B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485317.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8686BolA-like protein 2PRO_0000201236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H3K6.
    PaxDbiQ9H3K6.
    PRIDEiQ9H3K6.

    Expressioni

    Gene expression databases

    BgeeiQ9H3K6.
    CleanExiHS_BOLA2.
    HS_BOLA2B.
    GenevestigatoriQ9H3K6.

    Organism-specific databases

    HPAiHPA045380.

    Interactioni

    Protein-protein interaction databases

    BioGridi139268. 11 interactions.
    576388. 6 interactions.
    IntActiQ9H3K6. 3 interactions.
    MINTiMINT-5006599.
    STRINGi9606.ENSP00000306752.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3K6.
    SMRiQ9H3K6. Positions 1-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bolA/yrbA family.Curated

    Phylogenomic databases

    eggNOGiNOG278560.
    HOGENOMiHOG000255170.
    HOVERGENiHBG080902.
    InParanoidiQ9H3K6.
    OrthoDBiEOG7HTHKJ.
    PhylomeDBiQ9H3K6.
    TreeFamiTF313141.

    Family and domain databases

    Gene3Di3.30.300.90. 1 hit.
    InterProiIPR002634. BolA.
    [Graphical view]
    PfamiPF01722. BolA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003113. BolA. 1 hit.
    SUPFAMiSSF82657. SSF82657. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H3K6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELSAEYLRE KLQRDLEAEH VEVEDTTLNR CSCSFRVLVV SAKFEGKPLL   50
    QRHRLVNACL AEELPHIHAF EQKTLTPDQW ARERQK 86
    Length:86
    Mass (Da):10,117
    Last modified:March 1, 2001 - v1
    Checksum:iCA95C76A225B5384
    GO
    Isoform 2 (identifier: Q9H3K6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         55-58: LVNA → FCTE
         59-86: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:58
    Mass (Da):6,842
    Checksum:i3BF3A0799235408E
    GO

    Sequence cautioni

    The sequence AAH22832.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI30402.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI30404.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI37533.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI37535.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI44689.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei55 – 584LVNA → FCTE in isoform 2. 1 PublicationVSP_010092
    Alternative sequencei59 – 8628Missing in isoform 2. 1 PublicationVSP_010093Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060511 mRNA. Translation: AAG43129.1.
    BC022832 mRNA. Translation: AAH22832.1. Different initiation.
    BC062756 mRNA. No translation available.
    BC130401 mRNA. Translation: AAI30402.1. Different initiation.
    BC130403 mRNA. Translation: AAI30404.1. Different initiation.
    BC137532 mRNA. Translation: AAI37533.1. Different initiation.
    BC137534 mRNA. Translation: AAI37535.1. Different initiation.
    BC144688 mRNA. Translation: AAI44689.1. Different initiation.
    RefSeqiNP_001026997.1. NM_001031827.1.
    NP_001034271.1. NM_001039182.1.
    XP_006726687.1. XM_006726624.1.
    UniGeneiHs.444600.
    Hs.647333.
    Hs.655267.
    Hs.745100.

    Genome annotation databases

    EnsembliENST00000305321; ENSP00000306752; ENSG00000169627.
    ENST00000330978; ENSP00000331127; ENSG00000183336.
    GeneIDi102725214.
    552900.
    654483.
    KEGGihsa:102725214.
    hsa:552900.
    hsa:654483.

    Polymorphism databases

    DMDMi46577124.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060511 mRNA. Translation: AAG43129.1 .
    BC022832 mRNA. Translation: AAH22832.1 . Different initiation.
    BC062756 mRNA. No translation available.
    BC130401 mRNA. Translation: AAI30402.1 . Different initiation.
    BC130403 mRNA. Translation: AAI30404.1 . Different initiation.
    BC137532 mRNA. Translation: AAI37533.1 . Different initiation.
    BC137534 mRNA. Translation: AAI37535.1 . Different initiation.
    BC144688 mRNA. Translation: AAI44689.1 . Different initiation.
    RefSeqi NP_001026997.1. NM_001031827.1.
    NP_001034271.1. NM_001039182.1.
    XP_006726687.1. XM_006726624.1.
    UniGenei Hs.444600.
    Hs.647333.
    Hs.655267.
    Hs.745100.

    3D structure databases

    ProteinModelPortali Q9H3K6.
    SMRi Q9H3K6. Positions 1-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 139268. 11 interactions.
    576388. 6 interactions.
    IntActi Q9H3K6. 3 interactions.
    MINTi MINT-5006599.
    STRINGi 9606.ENSP00000306752.

    Polymorphism databases

    DMDMi 46577124.

    Proteomic databases

    MaxQBi Q9H3K6.
    PaxDbi Q9H3K6.
    PRIDEi Q9H3K6.

    Protocols and materials databases

    DNASUi 552900.
    654483.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305321 ; ENSP00000306752 ; ENSG00000169627 .
    ENST00000330978 ; ENSP00000331127 ; ENSG00000183336 .
    GeneIDi 102725214.
    552900.
    654483.
    KEGGi hsa:102725214.
    hsa:552900.
    hsa:654483.

    Organism-specific databases

    CTDi 552900.
    654483.
    GeneCardsi GC16M029465.
    GC16M030205.
    HGNCi HGNC:29488. BOLA2.
    HGNC:32479. BOLA2B.
    HPAi HPA045380.
    MIMi 613182. gene.
    neXtProti NX_Q9H3K6.
    PharmGKBi PA143485317.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278560.
    HOGENOMi HOG000255170.
    HOVERGENi HBG080902.
    InParanoidi Q9H3K6.
    OrthoDBi EOG7HTHKJ.
    PhylomeDBi Q9H3K6.
    TreeFami TF313141.

    Miscellaneous databases

    ChiTaRSi BOLA2. human.
    NextBioi 112366.
    PROi Q9H3K6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H3K6.
    CleanExi HS_BOLA2.
    HS_BOLA2B.
    Genevestigatori Q9H3K6.

    Family and domain databases

    Gene3Di 3.30.300.90. 1 hit.
    InterProi IPR002634. BolA.
    [Graphical view ]
    Pfami PF01722. BolA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003113. BolA. 1 hit.
    SUPFAMi SSF82657. SSF82657. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Mao Y.M., Xie Y., Huang X.Y., Ying K., Dai J.L.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye and Kidney.
    3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-9, ACETYLATION AT MET-1.
      Tissue: Platelet.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBOLA2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3K6
    Secondary accession number(s): A1L454, A7YDY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3