Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H3K6 (BOLA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BolA-like protein 2
Gene names
Name:BOLA2
Synonyms:BOLA2A
ORF Names:My016
AND
Name:BOLA2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length86 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the bolA/yrbA family.

Sequence caution

The sequence AAH22832.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI30402.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI30404.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI37533.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI37535.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI44689.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H3K6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H3K6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     55-58: LVNA → FCTE
     59-86: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8686BolA-like protein 2
PRO_0000201236

Amino acid modifications

Modified residue11N-acetylmethionine Ref.3

Natural variations

Alternative sequence55 – 584LVNA → FCTE in isoform 2.
VSP_010092
Alternative sequence59 – 8628Missing in isoform 2.
VSP_010093

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CA95C76A225B5384

FASTA8610,117
        10         20         30         40         50         60 
MELSAEYLRE KLQRDLEAEH VEVEDTTLNR CSCSFRVLVV SAKFEGKPLL QRHRLVNACL 

        70         80 
AEELPHIHAF EQKTLTPDQW ARERQK 

« Hide

Isoform 2 [UniParc].

Checksum: 3BF3A0799235408E
Show »

FASTA586,842

References

« Hide 'large scale' references
[1]Mao Y.M., Xie Y., Huang X.Y., Ying K., Dai J.L.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Eye and Kidney.
[3]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-9, ACETYLATION AT MET-1.
Tissue: Platelet.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF060511 mRNA. Translation: AAG43129.1.
BC022832 mRNA. Translation: AAH22832.1. Different initiation.
BC062756 mRNA. No translation available.
BC130401 mRNA. Translation: AAI30402.1. Different initiation.
BC130403 mRNA. Translation: AAI30404.1. Different initiation.
BC137532 mRNA. Translation: AAI37533.1. Different initiation.
BC137534 mRNA. Translation: AAI37535.1. Different initiation.
BC144688 mRNA. Translation: AAI44689.1. Different initiation.
RefSeqNP_001026997.1. NM_001031827.1.
NP_001034271.1. NM_001039182.1.
UniGeneHs.444600.
Hs.647333.
Hs.655267.
Hs.745100.

3D structure databases

ProteinModelPortalQ9H3K6.
SMRQ9H3K6. Positions 1-86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid139268. 11 interactions.
576388. 6 interactions.
IntActQ9H3K6. 3 interactions.
MINTMINT-5006599.
STRING9606.ENSP00000306752.

Polymorphism databases

DMDM46577124.

Proteomic databases

PaxDbQ9H3K6.
PRIDEQ9H3K6.

Protocols and materials databases

DNASU552900.
654483.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305321; ENSP00000306752; ENSG00000169627.
ENST00000330978; ENSP00000331127; ENSG00000183336.
GeneID552900.
654483.
KEGGhsa:552900.
hsa:654483.

Organism-specific databases

CTD552900.
654483.
GeneCardsGC16M029465.
GC16M030205.
HGNCHGNC:29488. BOLA2.
HGNC:32479. BOLA2B.
HPAHPA045380.
MIM613182. gene.
neXtProtNX_Q9H3K6.
PharmGKBPA143485317.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278560.
HOGENOMHOG000255170.
HOVERGENHBG080902.
InParanoidQ9H3K6.
OrthoDBEOG7HTHKJ.
PhylomeDBQ9H3K6.
TreeFamTF313141.

Gene expression databases

BgeeQ9H3K6.
CleanExHS_BOLA2.
HS_BOLA2B.
GenevestigatorQ9H3K6.

Family and domain databases

Gene3D3.30.300.90. 1 hit.
InterProIPR002634. BolA.
[Graphical view]
PfamPF01722. BolA. 1 hit.
[Graphical view]
PIRSFPIRSF003113. BolA. 1 hit.
SUPFAMSSF82657. SSF82657. 1 hit.
ProtoNetSearch...

Other

ChiTaRSBOLA2. human.
NextBio112366.
PROQ9H3K6.
SOURCESearch...

Entry information

Entry nameBOLA2_HUMAN
AccessionPrimary (citable) accession number: Q9H3K6
Secondary accession number(s): A1L454, A7YDY3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM