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Protein

BolA-like protein 2

Gene

BOLA2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169627-MONOMER.
ZFISH:ENSG00000174984-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 2
Gene namesi
Name:BOLA2
Synonyms:BOLA2A
ORF Names:My016
AND
Name:BOLA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29488. BOLA2.
HGNC:32479. BOLA2B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485317.

Polymorphism and mutation databases

DMDMi46577124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012361 – 86BolA-like protein 2Add BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H3K6.
MaxQBiQ9H3K6.
PaxDbiQ9H3K6.
PeptideAtlasiQ9H3K6.
PRIDEiQ9H3K6.
TopDownProteomicsiQ9H3K6-1. [Q9H3K6-1]

PTM databases

iPTMnetiQ9H3K6.
PhosphoSitePlusiQ9H3K6.

Expressioni

Gene expression databases

BgeeiENSG00000169627.
CleanExiHS_BOLA2.
HS_BOLA2B.
ExpressionAtlasiQ9H3K6. baseline and differential.
GenevisibleiQ9H3K6. HS.

Organism-specific databases

HPAiHPA046696.

Interactioni

Protein-protein interaction databases

BioGridi139268. 12 interactors.
576388. 5 interactors.
IntActiQ9H3K6. 4 interactors.
MINTiMINT-5006599.
STRINGi9606.ENSP00000331127.

Structurei

3D structure databases

ProteinModelPortaliQ9H3K6.
SMRiQ9H3K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
KOG3348. Eukaryota.
COG0271. LUCA.
HOGENOMiHOG000255170.
HOVERGENiHBG080902.
InParanoidiQ9H3K6.
OrthoDBiEOG091G0AVE.
PhylomeDBiQ9H3K6.
TreeFamiTF313141.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
PIRSFiPIRSF003113. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3K6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSAEYLRE KLQRDLEAEH VEVEDTTLNR CSCSFRVLVV SAKFEGKPLL
60 70 80
QRHRLVNACL AEELPHIHAF EQKTLTPDQW ARERQK
Length:86
Mass (Da):10,117
Last modified:March 1, 2001 - v1
Checksum:iCA95C76A225B5384
GO
Isoform 2 (identifier: Q9H3K6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-58: LVNA → FCTE
     59-86: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:58
Mass (Da):6,842
Checksum:i3BF3A0799235408E
GO

Sequence cautioni

The sequence AAH22832 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI30402 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI30404 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI37533 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI37535 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI44689 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01009255 – 58LVNA → FCTE in isoform 2. 1 Publication4
Alternative sequenceiVSP_01009359 – 86Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060511 mRNA. Translation: AAG43129.1.
BC022832 mRNA. Translation: AAH22832.1. Different initiation.
BC062756 mRNA. No translation available.
BC130401 mRNA. Translation: AAI30402.1. Different initiation.
BC130403 mRNA. Translation: AAI30404.1. Different initiation.
BC137532 mRNA. Translation: AAI37533.1. Different initiation.
BC137534 mRNA. Translation: AAI37535.1. Different initiation.
BC144688 mRNA. Translation: AAI44689.1. Different initiation.
RefSeqiNP_001026997.1. NM_001031827.2.
NP_001034271.1. NM_001039182.2.
NP_001307508.1. NM_001320579.1.
XP_016855107.1. XM_016999618.1.
UniGeneiHs.444600.
Hs.647333.
Hs.655267.
Hs.745100.

Genome annotation databases

EnsembliENST00000305321; ENSP00000306752; ENSG00000169627.
ENST00000330978; ENSP00000331127; ENSG00000183336.
GeneIDi107984053.
552900.
654483.
KEGGihsa:552900.
hsa:654483.
UCSCiuc002dss.3. human. [Q9H3K6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060511 mRNA. Translation: AAG43129.1.
BC022832 mRNA. Translation: AAH22832.1. Different initiation.
BC062756 mRNA. No translation available.
BC130401 mRNA. Translation: AAI30402.1. Different initiation.
BC130403 mRNA. Translation: AAI30404.1. Different initiation.
BC137532 mRNA. Translation: AAI37533.1. Different initiation.
BC137534 mRNA. Translation: AAI37535.1. Different initiation.
BC144688 mRNA. Translation: AAI44689.1. Different initiation.
RefSeqiNP_001026997.1. NM_001031827.2.
NP_001034271.1. NM_001039182.2.
NP_001307508.1. NM_001320579.1.
XP_016855107.1. XM_016999618.1.
UniGeneiHs.444600.
Hs.647333.
Hs.655267.
Hs.745100.

3D structure databases

ProteinModelPortaliQ9H3K6.
SMRiQ9H3K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139268. 12 interactors.
576388. 5 interactors.
IntActiQ9H3K6. 4 interactors.
MINTiMINT-5006599.
STRINGi9606.ENSP00000331127.

PTM databases

iPTMnetiQ9H3K6.
PhosphoSitePlusiQ9H3K6.

Polymorphism and mutation databases

DMDMi46577124.

Proteomic databases

EPDiQ9H3K6.
MaxQBiQ9H3K6.
PaxDbiQ9H3K6.
PeptideAtlasiQ9H3K6.
PRIDEiQ9H3K6.
TopDownProteomicsiQ9H3K6-1. [Q9H3K6-1]

Protocols and materials databases

DNASUi552900.
654483.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305321; ENSP00000306752; ENSG00000169627.
ENST00000330978; ENSP00000331127; ENSG00000183336.
GeneIDi107984053.
552900.
654483.
KEGGihsa:552900.
hsa:654483.
UCSCiuc002dss.3. human. [Q9H3K6-1]

Organism-specific databases

CTDi552900.
654483.
GeneCardsiBOLA2.
BOLA2B.
HGNCiHGNC:29488. BOLA2.
HGNC:32479. BOLA2B.
HPAiHPA046696.
MIMi613182. gene.
neXtProtiNX_Q9H3K6.
PharmGKBiPA143485317.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
KOG3348. Eukaryota.
COG0271. LUCA.
HOGENOMiHOG000255170.
HOVERGENiHBG080902.
InParanoidiQ9H3K6.
OrthoDBiEOG091G0AVE.
PhylomeDBiQ9H3K6.
TreeFamiTF313141.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169627-MONOMER.
ZFISH:ENSG00000174984-MONOMER.

Miscellaneous databases

ChiTaRSiBOLA2. human.
PROiQ9H3K6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169627.
CleanExiHS_BOLA2.
HS_BOLA2B.
ExpressionAtlasiQ9H3K6. baseline and differential.
GenevisibleiQ9H3K6. HS.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
PIRSFiPIRSF003113. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBOLA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3K6
Secondary accession number(s): A1L454, A7YDY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.