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Protein

Transcription elongation factor A protein-like 2

Gene

TCEAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 2
Short name:
TCEA-like protein 2
Alternative name(s):
Transcription elongation factor S-II protein-like 2
Gene namesi
Name:TCEAL2
ORF Names:My048, MY0876G0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29818. TCEAL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922072.

Polymorphism and mutation databases

BioMutaiTCEAL2.
DMDMi74752614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Transcription elongation factor A protein-like 2PRO_0000239206Add
BLAST

Proteomic databases

EPDiQ9H3H9.
MaxQBiQ9H3H9.
PaxDbiQ9H3H9.
PRIDEiQ9H3H9.

PTM databases

iPTMnetiQ9H3H9.
PhosphoSiteiQ9H3H9.

Expressioni

Gene expression databases

BgeeiQ9H3H9.
CleanExiHS_TCEAL2.
GenevisibleiQ9H3H9. HS.

Organism-specific databases

HPAiHPA059048.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126630. 12 interactions.
IntActiQ9H3H9. 10 interactions.
STRINGi9606.ENSP00000332359.

Structurei

3D structure databases

ProteinModelPortaliQ9H3H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

eggNOGiENOG410KDY0. Eukaryota.
ENOG4111ECD. LUCA.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ9H3H9.
OMAiVACILED.
OrthoDBiEOG79KPGM.
PhylomeDBiQ9H3H9.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H3H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLFNENEG MPSNQGKIDN EEQPPHEGKP EVACILEDKK LENEGNTENT
60 70 80 90 100
GKRVEEPLKD KEKPESAGKA KGEGKSERKG KSEMQGGSKT EGKPERGGRA
110 120 130 140 150
EGEGEPDSER EPESEGEPES ETRAAGKRPA EDDIPRKAKR KTNKGLAQYL
160 170 180 190 200
KQYKEAIHDM NFSNEDMIRE FDNMARVEDK RRKSKQKLGA FLWMQRNLQD
210 220
PFYPRGPREF RGGCRAPRRD TEDIPYV
Length:227
Mass (Da):25,850
Last modified:March 1, 2001 - v1
Checksum:i32663547AA13FA63
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191D → G.
Corresponds to variant rs34924423 [ dbSNP | Ensembl ].
VAR_034546
Natural varianti68 – 681G → A.1 Publication
Corresponds to variant rs5944856 [ dbSNP | Ensembl ].
VAR_034547

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063606 mRNA. Translation: AAG43164.1.
AF325115 mRNA. Translation: AAL37355.1.
AK312138 mRNA. Translation: BAG35074.1.
AL035214 Genomic DNA. Translation: CAI42278.1.
BC104764 mRNA. Translation: AAI04765.1.
BC093932 mRNA. Translation: AAH93932.1.
CCDSiCCDS14496.1.
RefSeqiNP_525129.1. NM_080390.3.
UniGeneiHs.401835.

Genome annotation databases

EnsembliENST00000329035; ENSP00000332359; ENSG00000184905.
ENST00000372780; ENSP00000361866; ENSG00000184905.
GeneIDi140597.
KEGGihsa:140597.
UCSCiuc004eip.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063606 mRNA. Translation: AAG43164.1.
AF325115 mRNA. Translation: AAL37355.1.
AK312138 mRNA. Translation: BAG35074.1.
AL035214 Genomic DNA. Translation: CAI42278.1.
BC104764 mRNA. Translation: AAI04765.1.
BC093932 mRNA. Translation: AAH93932.1.
CCDSiCCDS14496.1.
RefSeqiNP_525129.1. NM_080390.3.
UniGeneiHs.401835.

3D structure databases

ProteinModelPortaliQ9H3H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126630. 12 interactions.
IntActiQ9H3H9. 10 interactions.
STRINGi9606.ENSP00000332359.

PTM databases

iPTMnetiQ9H3H9.
PhosphoSiteiQ9H3H9.

Polymorphism and mutation databases

BioMutaiTCEAL2.
DMDMi74752614.

Proteomic databases

EPDiQ9H3H9.
MaxQBiQ9H3H9.
PaxDbiQ9H3H9.
PRIDEiQ9H3H9.

Protocols and materials databases

DNASUi140597.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329035; ENSP00000332359; ENSG00000184905.
ENST00000372780; ENSP00000361866; ENSG00000184905.
GeneIDi140597.
KEGGihsa:140597.
UCSCiuc004eip.4. human.

Organism-specific databases

CTDi140597.
GeneCardsiTCEAL2.
HGNCiHGNC:29818. TCEAL2.
HPAiHPA059048.
neXtProtiNX_Q9H3H9.
PharmGKBiPA134922072.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDY0. Eukaryota.
ENOG4111ECD. LUCA.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ9H3H9.
OMAiVACILED.
OrthoDBiEOG79KPGM.
PhylomeDBiQ9H3H9.
TreeFamiTF336871.

Miscellaneous databases

ChiTaRSiTCEAL2. human.
GenomeRNAii140597.
PROiQ9H3H9.

Gene expression databases

BgeeiQ9H3H9.
CleanExiHS_TCEAL2.
GenevisibleiQ9H3H9. HS.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of full-length cDNA clones from human fetal brain cDNA library."
    Mao Y., Xie Y., Tang R., Zhou Z., Huang Y., Zhao W., Wang W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "Cloning and characterization of a novel human gene."
    Mao Y., Xie Y., Tang R., Zhou Z., Huang Y., Zhao W., Wang W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-68.
    Tissue: Cerebellum.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTCAL2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3H9
Secondary accession number(s): B2R5C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.