##gff-version 3 Q9H3H5 UniProtKB Chain 1 408 . . . ID=PRO_0000108761;Note=UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Q9H3H5 UniProtKB Topological domain 1 10 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 11 38 . . . Note=Helical%3B Name%3DHelix 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 39 58 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 59 78 . . . Note=Helical%3B Name%3DHelix 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 79 91 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 92 118 . . . Note=Helical%3B Name%3DHelix 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 119 121 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 122 143 . . . Note=Helical%3B Name%3DHelix 4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 144 166 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 167 186 . . . Note=Helical%3B Name%3DHelix 5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 187 192 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 193 213 . . . Note=Helical%3B Name%3DHelix 6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 214 218 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 219 242 . . . Note=Helical%3B Name%3DHelix 7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 243 250 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 251 269 . . . Note=Helical%3B Name%3DHelix 8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 270 271 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 272 293 . . . Note=Helical%3B Name%3DHelix 9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 294 375 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Transmembrane 376 400 . . . Note=Helical%3B Name%3DHelix 10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Topological domain 401 408 . . . Note=Lumenal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29459785;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Binding site 44 46 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 46 46 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:29459785,ECO:0007744|PDB:6BW5,ECO:0007744|PDB:6BW6;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Binding site 56 56 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 119 119 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29459785,ECO:0007744|PDB:6BW5;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Binding site 125 125 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 178 186 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 185 185 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30388443,ECO:0007744|PDB:6FWZ;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 185 185 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29459785,ECO:0007744|PDB:6BW6;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Binding site 191 191 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 252 252 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30388443,ECO:0007744|PDB:6FWZ;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 252 252 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29459785,ECO:0007744|PDB:6BW5;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Binding site 301 303 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Binding site 303 303 . . . Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:29459785,ECO:0007744|PDB:6BW5,ECO:0007744|PDB:6BW6;Dbxref=PMID:29459785 Q9H3H5 UniProtKB Glycosylation 146 146 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9H3H5 UniProtKB Alternative sequence 1 107 . . . ID=VSP_008886;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9H3H5 UniProtKB Alternative sequence 1 8 . . . ID=VSP_001803;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9451016;Dbxref=PMID:9451016 Q9H3H5 UniProtKB Natural variant 9 9 . . . ID=VAR_036422;Note=In a breast cancer sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q9H3H5 UniProtKB Natural variant 108 108 . . . ID=VAR_068810;Note=In CMS13%3B strongly reduced enzyme activity. M->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs376039938,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 117 117 . . . ID=VAR_068811;Note=In CMS13%3B mildly reduced enzyme activity. V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs387907243,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 120 120 . . . ID=VAR_068812;Note=In CMS13%3B strongly reduced enzyme activity. L->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs387907244,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 160 160 . . . ID=VAR_068813;Note=In CMS13%3B increased enzyme activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs762676399,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 170 170 . . . ID=VAR_017243;Note=In CDG1J%3B strongly reduced enzyme activity. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12872255,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs28934876,PMID:12872255,PMID:30388443 Q9H3H5 UniProtKB Natural variant 192 192 . . . ID=VAR_068814;Note=In CMS13%3B strongly reduced enzyme activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs768464558,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 264 264 . . . ID=VAR_068815;Note=In CMS13%3B increased enzyme activity. V->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22742743,ECO:0000269|PubMed:30388443;Dbxref=dbSNP:rs387907245,PMID:22742743,PMID:30388443 Q9H3H5 UniProtKB Natural variant 393 393 . . . ID=VAR_011391;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs643788,PMID:15489334 Q9H3H5 UniProtKB Mutagenesis 30 30 . . . Note=Mildly reduced enzyme activity. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 69 69 . . . Note=No significant effect on enzyme activity. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 103 103 . . . Note=Impairs protein stability. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 114 114 . . . Note=No significant effect on enzyme activity. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 115 115 . . . Note=Strongly reduced enzyme activity. D->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 115 115 . . . Note=Mildly reduced enzyme activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 116 116 . . . Note=Strongly reduced enzyme activity. D->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 122 122 . . . Note=Strongly reduced enzyme activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 125 125 . . . Note=Loss of enzyme activity. K->A%2CE%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 168 168 . . . Note=Strongly reduced enzyme activity. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 182 182 . . . Note=Loss of enzyme activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 185 185 . . . Note=Loss of enzyme activity. N->A%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 252 252 . . . Note=Reduces binding to inhibitor. Nearly abolishes enzyme activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29459785,ECO:0000269|PubMed:30388443;Dbxref=PMID:29459785,PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 264 264 . . . Note=No significant effect on enzyme activity. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 301 301 . . . Note=Loss of enzyme activity. R->C%2CH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 302 302 . . . Note=Loss of enzyme activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 303 303 . . . Note=Reduced enzyme activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Mutagenesis 385 385 . . . Note=No significant effect on enzyme activity. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388443;Dbxref=PMID:30388443 Q9H3H5 UniProtKB Sequence conflict 33 33 . . . Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H3H5 UniProtKB Sequence conflict 129 129 . . . Note=P->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H3H5 UniProtKB Helix 9 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 33 38 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 42 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 53 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 59 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 76 78 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 92 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 122 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Turn 155 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5O5E Q9H3H5 UniProtKB Helix 167 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 193 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 214 216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 219 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 243 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 251 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 272 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 280 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 290 293 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 306 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Turn 309 312 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 313 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 318 321 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Turn 323 325 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 328 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Beta strand 345 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW5 Q9H3H5 UniProtKB Beta strand 356 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 363 371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6 Q9H3H5 UniProtKB Helix 376 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BW6